{"id":"https://openalex.org/W36672519","doi":null,"title":"Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization.","display_name":"Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization.","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W36672519","mag":"36672519","pmid":"https://pubmed.ncbi.nlm.nih.gov/10464713"},"language":"en","primary_location":{"id":"pmid:10464713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110359194","display_name":"XU Shen-hua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Shenhua","raw_affiliation_strings":["Zhejiang Cancer Research Institute, Hangzhou, P.R. of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Research Institute, Hangzhou, P.R. of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010943394","display_name":"Q Lijuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Lijuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002445715","display_name":"N Hanzhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Hanzhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000301431","display_name":"Xing-hao Ni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Xinghao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Z Chihong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Chihong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101825534","display_name":"Zhiliang Gu","orcid":"https://orcid.org/0000-0002-8356-9926","observed_orcids":["https://orcid.org/0000-0002-8356-9926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065400583","display_name":"D Weifang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Weifang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"G Yongliang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Yongliang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1737,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.49398422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"233","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/metastatic-cell-lines","display_name":"metastatic cell lines","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hyperdiploidy","display_name":"hyperdiploidy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/oncoprotein-expression","display_name":"oncoprotein expression","score":0.843999981880188},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.550000011920929},{"id":"https://openalex.org/keywords/cell-doubling-time","display_name":"cell doubling time","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6604810357093811},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.6348919868469238},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5322743654251099},{"id":"https://openalex.org/C2776127477","wikidata":"https://www.wikidata.org/wiki/Q17093220","display_name":"Plating efficiency","level":3,"score":0.5093911290168762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49958229064941406},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4899381995201111},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48006781935691833},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.47184112668037415},{"id":"https://openalex.org/C48900799","wikidata":"https://www.wikidata.org/wiki/Q1424376","display_name":"Doubling time","level":3,"score":0.46856382489204407},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4556872844696045},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.450821191072464},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.44953233003616333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4283742308616638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4078047573566437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3331781029701233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26240217685699463},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19600209593772888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06601226329803467}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009174","descriptor_name":"Mycoplasma","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10464713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"mag:36672519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2120260610","https://openalex.org/W2412222921","https://openalex.org/W2439299348"],"related_works":["https://openalex.org/W2025845506","https://openalex.org/W2384184165","https://openalex.org/W2415766831","https://openalex.org/W2385122087","https://openalex.org/W2366844414","https://openalex.org/W2414076294","https://openalex.org/W2386114683","https://openalex.org/W2100005809","https://openalex.org/W2059368759","https://openalex.org/W2063147847"],"abstract_inverted_index":{"To":[0],"establish":[1],"a":[2,21,130,258],"highly":[3,29],"metastatic":[4],"human":[5,31],"ovarian":[6,32],"cancer":[7,33,242],"cell":[8,42,48,72,120,209,214,224,227],"line":[9,43,49,215,228],"and":[10,40,55,65,78,91,108,151,229,251,254],"to":[11],"study":[12,237],"its":[13],"characteristics":[14],"tissue":[15],"from":[16],"the":[17,28,41,56,79,157,162,170,184,196,219,222,239],"tumor":[18,173],"mass":[19],"of":[20,24,27,88,93,96,132,145,161,169,183,187,238,241],"nude":[22,166],"mouse":[23],"7th":[25],"subtransplantation":[26],"metastasizing":[30],"model":[34,231],"(NSMO)":[35],"was":[36,45,75,82,117,139,211],"cultured":[37],"in":[38,114,123,156,177,195,206,236,244,256],"vitro":[39],"HO-8910PM":[44,216],"established.":[46],"The":[47,71,84,111,119,136,198,213],"grew":[50],"well":[51],"through":[52],"87":[53],"passages":[54],"mitotic":[57,80],"index,":[58],"chromosome":[59],"analysis,":[60],"morphology":[61],"under":[62],"electron":[63],"microscope":[64],"some":[66],"oncoprotein":[67,188],"expression":[68],"were":[69,86,95,154,193],"studied.":[70],"doubling":[73],"time":[74],"34.5":[76],"h":[77],"index":[81,138],"44.3%.":[83],"cells":[85,163],"all":[87,168],"epithelial":[89],"type":[90],"most":[92],"them":[94,146],"polygonal":[97],"shape.":[98],"Electron":[99],"microscopic":[100],"examination":[101],"showed":[102,147,172,202],"malignant":[103],"nuclei":[104],"with":[105,175],"enlarged":[106],"nucleoli":[107],"abundant":[109],"microvilli.":[110],"plating":[112],"efficiency":[113],"soft":[115],"agar":[116],"31.2%.":[118],"agglutination":[121],"appeared":[122],"4":[124],"ug/ml":[125],"PHA.":[126],"Chromosomal":[127],"analysis":[128],"revealed":[129],"mode":[131],"54":[133],"per":[134],"cell.":[135],"DNA":[137],"1.57":[140],"measured":[141],"by":[142,190],"FCM.":[143],"Both":[144],"hyperdiploid.":[148],"Positive":[149],"ER":[150],"PR":[152],"granules":[153],"found":[155,194],"cells.":[158,197],"After":[159,204],"hetero-transplantation":[160],"into":[164],"three":[165],"mice":[167],"latter":[171],"growth":[174,210],"metastasis":[176,243,253],"lungs":[178],"or":[179],"lymph":[180],"nodes.":[181],"Eight":[182],"nine":[185],"kinds":[186],"detected":[189],"immnohistochemical":[191],"method":[192],"detection":[199],"for":[200,221,261],"mycoplasma":[201],"negative.":[203],"storage":[205],"liquid":[207],"nitrogen":[208],"stable.":[212],"can":[217],"meet":[218],"criteria":[220],"establishment":[223],"lines.":[225],"This":[226],"NSMO":[230],"would":[232],"be":[233],"very":[234],"useful":[235],"mechanism":[240],"identifying":[245],"various":[246],"cellular":[247],"factors":[248],"regulating":[249],"local":[250],"distant":[252],"also":[255],"establishing":[257],"rational":[259],"approach":[260],"searching":[262],"after":[263],"anti-metastatic":[264],"agents.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}