{"id":"https://openalex.org/W36652335","doi":"https://doi.org/10.1042/bj2900649","title":"Evidence for involvement of phospholipase C-\u03b32 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells","display_name":"Evidence for involvement of phospholipase C-\u03b32 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells","publication_year":1993,"publication_date":"1993-03-15","ids":{"openalex":"https://openalex.org/W36652335","doi":"https://doi.org/10.1042/bj2900649","mag":"36652335","pmid":"https://pubmed.ncbi.nlm.nih.gov/7681281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1132329"},"language":"en","primary_location":{"id":"doi:10.1042/bj2900649","doi":"https://doi.org/10.1042/bj2900649","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2900649","pdf_url":"https://portlandpress.com/biochemj/article-pdf/290/3/649/610164/bj2900649.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/290/3/649/610164/bj2900649.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101839182","display_name":"Yoshimi Homma","orcid":"https://orcid.org/0009-0007-4437-6308","observed_orcids":["https://orcid.org/0009-0007-4437-6308","https://orcid.org/0000-0002-5920-3596"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Y Homma","raw_affiliation_strings":["Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173, Japan","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Sakamoto","raw_affiliation_strings":["Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001078535","display_name":"Makoto Tsunoda","orcid":"https://orcid.org/0000-0001-9596-5988","observed_orcids":["https://orcid.org/0000-0001-9596-5988"]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Tsunoda","raw_affiliation_strings":["Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037807663","display_name":"Motokuni Aoki","orcid":"https://orcid.org/0000-0002-3912-3222","observed_orcids":["https://orcid.org/0000-0002-3912-3222"]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Aoki","raw_affiliation_strings":["Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010968082","display_name":"T Takenawa","orcid":"https://orcid.org/0000-0001-5642-0117","observed_orcids":["https://orcid.org/0000-0001-5642-0117"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Takenawa","raw_affiliation_strings":["Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030756127","display_name":"Toshiro Ooyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Ooyama","raw_affiliation_strings":["Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depaament of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173, Japan","institution_ids":["https://openalex.org/I4210152580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101839182"],"corresponding_institution_ids":["https://openalex.org/I4210140609"],"apc_list":null,"apc_paid":null,"fwci":2.6139,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91071469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"290","issue":"3","first_page":"649","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plcgamma2","display_name":"PLC\u03b32","score":0.9539999961853027},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9089999794960022},{"id":"https://openalex.org/keywords/smooth-muscle-cell-proliferation","display_name":"smooth muscle cell proliferation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pdgf-receptor","display_name":"PDGF receptor","score":0.859000027179718},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pdgf-ab","display_name":"PDGF-AB","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pdgf-aa","display_name":"PDGF-AA","score":0.8109999895095825},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.8569755554199219},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.7718174457550049},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.7003300786018372},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.6822942495346069},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6241351366043091},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6005722880363464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5880410671234131},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5822414755821228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5679169297218323},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5072307586669922},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4887228012084961},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.44657838344573975},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4388035237789154},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.430513471364975},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38604915142059326},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3086957335472107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.304257869720459},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.15787768363952637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj2900649","doi":"https://doi.org/10.1042/bj2900649","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2900649","pdf_url":"https://portlandpress.com/biochemj/article-pdf/290/3/649/610164/bj2900649.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4425538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1132329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:7681281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7681281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1132329","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1132329/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj2900649","doi":"https://doi.org/10.1042/bj2900649","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2900649","pdf_url":"https://portlandpress.com/biochemj/article-pdf/290/3/649/610164/bj2900649.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W36652335.pdf","grobid_xml":"https://content.openalex.org/works/W36652335.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W104116244","https://openalex.org/W1501666754","https://openalex.org/W1563405664","https://openalex.org/W1775576713","https://openalex.org/W1814785217","https://openalex.org/W1945199177","https://openalex.org/W1968610357","https://openalex.org/W1969702279","https://openalex.org/W1974790290","https://openalex.org/W1983596426","https://openalex.org/W1991892690","https://openalex.org/W1993282564","https://openalex.org/W1997093700","https://openalex.org/W2017100096","https://openalex.org/W2018142079","https://openalex.org/W2018282587","https://openalex.org/W2022129165","https://openalex.org/W2027854877","https://openalex.org/W2037434894","https://openalex.org/W2039221139","https://openalex.org/W2056966297","https://openalex.org/W2057960696","https://openalex.org/W2061755142","https://openalex.org/W2062748780","https://openalex.org/W2063992063","https://openalex.org/W2078835916","https://openalex.org/W2086600284","https://openalex.org/W2089375674","https://openalex.org/W2094891357","https://openalex.org/W2108256295","https://openalex.org/W2109517079","https://openalex.org/W2119859693","https://openalex.org/W2155169715","https://openalex.org/W2164123016","https://openalex.org/W2167622537","https://openalex.org/W2265277925","https://openalex.org/W6611023204"],"related_works":["https://openalex.org/W1512900448","https://openalex.org/W2170974421","https://openalex.org/W2154477619","https://openalex.org/W2322491968","https://openalex.org/W2111023219","https://openalex.org/W1972806702","https://openalex.org/W1775576713","https://openalex.org/W2780315424","https://openalex.org/W2034326832","https://openalex.org/W2048767724"],"abstract_inverted_index":{"In":[0,119],"order":[1],"to":[2],"examine":[3],"the":[4,36,92,121,130,141],"mechanisms":[5],"underlying":[6],"smooth-muscle":[7,24,162],"cell":[8,46],"proliferation,":[9],"we":[10],"investigated":[11],"effect":[12],"of":[13,21,30,51,75,94,105,123,140,148,161],"platelet-derived":[14],"growth":[15],"factor":[16],"(PDGF)":[17],"dimers":[18],"on":[19,87],"proliferation":[20,47,160],"rabbit":[22],"vascular":[23],"cells":[25],"(VSMCs)":[26],"and":[27,40,48,55,65,108,134],"also":[28],"involvement":[29],"phospholipase":[31],"C":[32],"(PLC)":[33],"isoforms":[34,71],"in":[35,129],"signal":[37],"transduction.":[38],"PDGF-BB":[39,96],"-AB,":[41],"but":[42,81],"not":[43,82],"-AA,":[44],"stimulated":[45],"intracellular":[49],"production":[50],"inositol":[52],"trisphosphate.":[53],"Northern":[54],"Western":[56],"analyses":[57],"demonstrated":[58],"that":[59,111,145],"VSMCs":[60],"mainly":[61],"expressed":[62],"PLC-gamma":[63,79,109,124,152],"2":[64,110,125],"PLC-delta":[66,83],"1":[67],"among":[68],"four":[69],"PLC":[70],"tested.":[72],"A":[73],"number":[74],"cellular":[76],"proteins,":[77],"including":[78,151],"2,":[80,153],"1,":[84],"were":[85],"phosphorylated":[86],"a":[88,102],"tyrosine":[89],"residue":[90],"by":[91],"stimulation":[93],"either":[95],"or":[97],"-AB.":[98],"These":[99],"results":[100],"suggest":[101],"functional":[103],"association":[104],"PDGF":[106],"receptor":[107],"might":[112],"be":[113,155],"responsible":[114],"for":[115,159],"PDGF-dependent":[116],"VSMC":[117,132],"growth.":[118],"addition,":[120],"expression":[122],"was":[126,135],"extremely":[127],"low":[128],"primary":[131,142],"cultures":[133],"induced":[136],"during":[137],"further":[138],"cultivation":[139],"cultures,":[143],"indicating":[144],"an":[146,156],"acquisition":[147],"PDGF-signal-transducing":[149],"components,":[150],"may":[154],"important":[157],"step":[158],"cells.":[163]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
