{"id":"https://openalex.org/W366089650","doi":null,"title":"Negative Affectivity and Inflammation: Moderation by the Glucocorticoid Receptor-9beta Polymorphism","display_name":"Negative Affectivity and Inflammation: Moderation by the Glucocorticoid Receptor-9beta Polymorphism","publication_year":2014,"publication_date":"2014-05-22","ids":{"openalex":"https://openalex.org/W366089650","mag":"366089650"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:21267","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/21267/1/LIM_ETD_05142014.pdf","pdf_url":"https://d-scholarship.pitt.edu/21267/1/LIM_ETD_05142014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030703128","display_name":"Alvin Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alvin Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030703128"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02296073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/negative-affectivity","display_name":"negative affectivity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/neuroticism","display_name":"neuroticism","score":0.597000002861023},{"id":"https://openalex.org/keywords/genetic-moderation","display_name":"genetic moderation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/negative-emotions","display_name":"negative emotions","score":0.35100001096725464},{"id":"https://openalex.org/keywords/middle-aged-adults","display_name":"middle-aged adults","score":0.7350000143051147},{"id":"https://openalex.org/keywords/european-ancestry","display_name":"European ancestry","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6896453499794006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5618636012077332},{"id":"https://openalex.org/C94612546","wikidata":"https://www.wikidata.org/wiki/Q1540168","display_name":"Neuroticism","level":3,"score":0.5527250170707703},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5184421539306641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49571120738983154},{"id":"https://openalex.org/C2776708433","wikidata":"https://www.wikidata.org/wiki/Q6987190","display_name":"Negative affectivity","level":3,"score":0.46511486172676086},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.44644781947135925},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4419451355934143},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.417497843503952},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4136536419391632},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.39298751950263977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32925355434417725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3006194531917572},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.2984294891357422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22655513882637024},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17505842447280884},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:21267","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/21267/1/LIM_ETD_05142014.pdf","pdf_url":"https://d-scholarship.pitt.edu/21267/1/LIM_ETD_05142014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:366089650","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/21267/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1269562257","https://openalex.org/W1561825033","https://openalex.org/W1605768991","https://openalex.org/W1861696557","https://openalex.org/W1878109538","https://openalex.org/W1950021792","https://openalex.org/W1963647452","https://openalex.org/W1968455941","https://openalex.org/W1971618426","https://openalex.org/W1972285969","https://openalex.org/W1977570615","https://openalex.org/W1979365726","https://openalex.org/W1980224211","https://openalex.org/W1981722357","https://openalex.org/W1982481186","https://openalex.org/W1983446823","https://openalex.org/W1984678874","https://openalex.org/W1986031269","https://openalex.org/W1990048682","https://openalex.org/W1993684142","https://openalex.org/W1995034631","https://openalex.org/W2000119033","https://openalex.org/W2000930695","https://openalex.org/W2002409458","https://openalex.org/W2005297704","https://openalex.org/W2009945236","https://openalex.org/W2019635910","https://openalex.org/W2021392550","https://openalex.org/W2025609239","https://openalex.org/W2035956126","https://openalex.org/W2043724834","https://openalex.org/W2045542163","https://openalex.org/W2045883408","https://openalex.org/W2048445979","https://openalex.org/W2048551934","https://openalex.org/W2050074023","https://openalex.org/W2053091009","https://openalex.org/W2054485811","https://openalex.org/W2054741486","https://openalex.org/W2055049375","https://openalex.org/W2055483225","https://openalex.org/W2057104059","https://openalex.org/W2058806234","https://openalex.org/W2059633037","https://openalex.org/W2065764124","https://openalex.org/W2069471256","https://openalex.org/W2073529494","https://openalex.org/W2074257679","https://openalex.org/W2078619626","https://openalex.org/W2081484203","https://openalex.org/W2087211723","https://openalex.org/W2087331881","https://openalex.org/W2090352420","https://openalex.org/W2092281603","https://openalex.org/W2092818456","https://openalex.org/W2093025551","https://openalex.org/W2094610748","https://openalex.org/W2100785280","https://openalex.org/W2103974370","https://openalex.org/W2106116591","https://openalex.org/W2108262852","https://openalex.org/W2113180182","https://openalex.org/W2116944267","https://openalex.org/W2118278569","https://openalex.org/W2121709253","https://openalex.org/W2125978064","https://openalex.org/W2126795224","https://openalex.org/W2129423257","https://openalex.org/W2129652475","https://openalex.org/W2129785124","https://openalex.org/W2129991789","https://openalex.org/W2131285266","https://openalex.org/W2132539548","https://openalex.org/W2135276646","https://openalex.org/W2138207278","https://openalex.org/W2139190597","https://openalex.org/W2141302415","https://openalex.org/W2146101502","https://openalex.org/W2148905283","https://openalex.org/W2150288735","https://openalex.org/W2151371704","https://openalex.org/W2154712992","https://openalex.org/W2155002669","https://openalex.org/W2157495622","https://openalex.org/W2159316671","https://openalex.org/W2163857054","https://openalex.org/W2167874330","https://openalex.org/W2170458617"],"related_works":["https://openalex.org/W2083411589","https://openalex.org/W2094260805","https://openalex.org/W2168335701","https://openalex.org/W2047217999","https://openalex.org/W2205197144","https://openalex.org/W2074257679","https://openalex.org/W2188292488","https://openalex.org/W2042397087","https://openalex.org/W2110646598","https://openalex.org/W7096545666"],"abstract_inverted_index":{"Growing":[0],"evidence":[1,36,326],"suggests":[2],"that":[3,262,293,327],"negative":[4,89,303],"emotions":[5],"may":[6,40],"play":[7,29],"a":[8,30,67,139],"role":[9,31],"in":[10,32,44,72,105,143,161,310],"the":[11,22,49,73,77,109,122,126,132,144,148,197,203,211,251,254,291,330],"upregulation":[12],"of":[13,51,59,66,81,88,101,108,125,141,147,165,196,202,221,231,250,256,312,318,329,335,339],"innate":[14],"inflammatory":[15,93,204,300],"processes":[16],"and":[17,92,99,112,130,134,173,187,229,260,321,337],"associated":[18,247,267],"disease":[19],"risk.":[20],"Although":[21,242],"hypothalamic-adrenal-pituitary":[23],"(HPA)":[24],"axis":[25],"is":[26,37],"believed":[27],"to":[28,54,56,302],"these":[33,288],"associations,":[34],"empirical":[35],"mixed.":[38],"Inconsistencies":[39],"reflect":[41],"individual":[42],"differences":[43],"glucocorticoid":[45],"receptor":[46],"(GR)":[47],"sensitivity,":[48],"capacity":[50],"immune":[52],"cells":[53],"respond":[55],"anti-inflammatory":[57],"effects":[58],"GC-mediated":[60],"signaling.":[61],"We":[62,323],"examined":[63],"whether":[64],"genotypes":[65,223,328],"single":[68],"nucleotide":[69],"polymorphism":[70,332],"(SNP)":[71],"GR":[74,85],"gene\u2014GR-9beta":[75],"(rs6198),":[76],"minor":[78],"(G)":[79],"allele":[80,214,276,296],"which":[82],"confers":[83],"reduced":[84],"sensitivity\u2014moderated":[86],"associations":[87,334],"affectivity":[90],"(NA)":[91],"activity.":[94],"Subjects":[95],"were":[96],"middle-aged":[97],"men":[98],"women":[100],"European":[102],"ancestry":[103],"participating":[104],"two":[106],"phases":[107],"Adult":[110],"Health":[111],"Behavior":[113],"Project":[114],"(51%":[115,152],"F;":[116,153],"30-54yr).":[117],"NA":[118,177,198,265,336],"was":[119,157,178,245,258,307],"assessed":[120,159,180],"by":[121,131,160,181],"neuroticism":[123],"subscale":[124],"NEO":[127],"Personality":[128],"Inventory":[129],"Positive":[133],"Negative":[135],"Affect":[136],"Schedule.":[137],"In":[138,185],"subset":[140],"participants":[142],"second":[145],"phase":[146],"AHAB":[149],"project":[150],"(AHAB-2)":[151],"30-54yr),":[154],"peripheral":[155,340],"inflammation":[156],"additionally":[158],"vitro":[162],"stimulated":[163,252,316],"production":[164,317],"IL-6,":[166,314,319],"interleukin-1beta":[167],"(IL-1\u03b2),":[168],"tumor":[169],"necrosis":[170],"factor-alpha":[171],"(TNF-\u03b1),":[172],"interleukin-8":[174],"(IL-8),":[175],"while":[176],"also":[179],"ecological":[182],"momentary":[183],"assessment.":[184],"bivariate":[186],"hierarchical":[188],"regression":[189],"analyses":[190,311],"adjusted":[191],"for":[192,210,226],"potential":[193],"covariates,":[194],"none":[195],"measures":[199,338],"predicted":[200],"any":[201,249],"cytokine":[205],"levels.":[206],"However,":[207],"subjects":[208],"homozygous":[209],"GR-9\u03b2":[212,243,257,294,331],"G":[213,275,295],"had":[215],"higher":[216],"IL-6":[217],"levels":[218],"than":[219],"those":[220],"alternate":[222],"after":[224],"adjustment":[225],"age,":[227],"gender,":[228],"years":[230],"school":[232],"(\u03b2":[233,278],"=":[234,237,240,279,282,285],".057,":[235],"p":[236,281],".045,":[238],"R2":[239],".047).":[241],"genotype":[244],"not":[246,308],"with":[248,268],"cytokines,":[253],"interaction":[255],"significant,":[259],"showed":[261],"greater":[263,269],"PANAS":[264],"scores":[266],"IL-1\u03b2":[270],"levels,":[271],"but":[272],"only":[273],"among":[274],"homozygotes":[277,297],".127,":[280],".027,":[283],"\u2206R2":[284],".015).":[286],"While":[287],"results":[289],"raise":[290],"possibility":[292],"show":[298],"increased":[299],"susceptibility":[301],"emotionality,":[304],"this":[305],"pattern":[306],"retained":[309],"circulating":[313],"or":[315],"TNF-\u03b1,":[320],"IL-8.":[322],"found":[324],"limited":[325],"moderated":[333],"inflammation.":[341]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}