{"id":"https://openalex.org/W36565256","doi":null,"title":"[Clinical evaluation of tulobuterol patch in patients with mild or moderate persistent bronchial asthma-effects of long-term treatment on airway inflammation and hypersensitivity].","display_name":"[Clinical evaluation of tulobuterol patch in patients with mild or moderate persistent bronchial asthma-effects of long-term treatment on airway inflammation and hypersensitivity].","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W36565256","mag":"36565256","pmid":"https://pubmed.ncbi.nlm.nih.gov/15007912"},"language":"ja","primary_location":{"id":"pmid:15007912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15007912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107838293","display_name":"Takahiko Horiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Horiguchi","raw_affiliation_strings":["Division of Respiratory Internal Medicine, Second Educational Hospital of Fujita Health University, Department of Internal Medicine, Fujita Health University Second Hospital, 3-6-10 Otobashi, Nakagawa-ku, Nagoya, Aichi, 454-8509, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Internal Medicine, Second Educational Hospital of Fujita Health University, Department of Internal Medicine, Fujita Health University Second Hospital, 3-6-10 Otobashi, Nakagawa-ku, Nagoya, Aichi, 454-8509, Japan","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110793182","display_name":"Rieko Kondo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rieko Kondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052112864","display_name":"Jun\u2010ichi Miyazaki","orcid":"https://orcid.org/0000-0003-2475-589X","observed_orcids":["https://orcid.org/0000-0003-2475-589X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junichi Miyazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079693908","display_name":"Hiroshi Torigoe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Torigoe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109911249","display_name":"Soichi Tachikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soichi Tachikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9149,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77194059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"2","first_page":"132","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tulobuterol","display_name":"tulobuterol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.8529999852180481},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/beta-2-adrenergic-agonists","display_name":"beta2-adrenergic agonists","score":0.6809999942779541},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/eosinophil-cationic-protein","display_name":"eosinophil cationic protein","score":0.9430000185966492},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.7260000109672546},{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.8870000243186951},{"id":"https://openalex.org/keywords/peak-expiratory-flow","display_name":"peak expiratory flow","score":0.8389999866485596},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tachyphylaxis","display_name":"tachyphylaxis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9615741968154907},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.545096755027771},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5346217751502991},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5088536739349365},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4908631443977356},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44026973843574524},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4338376522064209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30708378553390503}],"mesh":[{"descriptor_ui":"D000068298","descriptor_name":"Fluticasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001507","descriptor_name":"Beclomethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010366","descriptor_name":"Peak Expiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013726","descriptor_name":"Terbutaline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013726","descriptor_name":"Terbutaline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15007912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15007912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Clinical Trial"},{"id":"mag:36565256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15007912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W2296042795","https://openalex.org/W2072511973","https://openalex.org/W2153619896","https://openalex.org/W2746652217","https://openalex.org/W2111117568","https://openalex.org/W2972871679","https://openalex.org/W2015089696","https://openalex.org/W225548568","https://openalex.org/W2213921239","https://openalex.org/W2991233759","https://openalex.org/W2162420979","https://openalex.org/W2138871559","https://openalex.org/W2093113672","https://openalex.org/W2042167360","https://openalex.org/W4214912903","https://openalex.org/W2004816882","https://openalex.org/W3092493436","https://openalex.org/W2746752665","https://openalex.org/W4223423615","https://openalex.org/W2890646393","https://openalex.org/W2076793654","https://openalex.org/W2011307457","https://openalex.org/W3012502394","https://openalex.org/W2922709045","https://openalex.org/W2148661798","https://openalex.org/W2141536491","https://openalex.org/W2138201707","https://openalex.org/W2144446993","https://openalex.org/W1980309199","https://openalex.org/W2999365349","https://openalex.org/W3164255052","https://openalex.org/W3027179734","https://openalex.org/W2035020487","https://openalex.org/W2028732333","https://openalex.org/W2789384915","https://openalex.org/W3067922096","https://openalex.org/W1857670991","https://openalex.org/W2758053316","https://openalex.org/W4220692042","https://openalex.org/W2927010782","https://openalex.org/W2055775726","https://openalex.org/W2582531027","https://openalex.org/W2616084157","https://openalex.org/W2611111199","https://openalex.org/W2741475538","https://openalex.org/W3013454048","https://openalex.org/W3111068976","https://openalex.org/W2915127262"],"related_works":["https://openalex.org/W2322501534","https://openalex.org/W2005518829","https://openalex.org/W1965491374","https://openalex.org/W1997932712","https://openalex.org/W2072851369","https://openalex.org/W1906557031","https://openalex.org/W2390564183","https://openalex.org/W2103225738","https://openalex.org/W2052059166","https://openalex.org/W2148857522"],"abstract_inverted_index":{"The":[0,169],"tulobuterol":[1,24,67,161],"transdermal":[2,12],"therapeutic":[3],"system":[4],"(TTS)":[5],"is":[6,199,224,256],"the":[7,34,104,107,135,181],"world's":[8],"first":[9],"commercially":[10],"available":[11],"preparation":[13],"of":[14,39,75,106,149,206,217,229,233,237,242],"tulobuterol,":[15],"a":[16,37],"beta-2":[17],"stimulant,":[18],"that":[19,187],"can":[20],"maintain":[21],"effective":[22],"blood":[23],"levels":[25],"for":[26,69],"24":[27],"hours":[28],"when":[29],"applied":[30],"once":[31,80],"daily.":[32,81],"In":[33],"present":[35],"study,":[36],"total":[38],"36":[40],"adult":[41],"patients":[42,120,136,182,210],"with":[43,122,160,211],"mildly":[44],"persistent":[45,50],"(Step":[46,51],"2)":[47],"or":[48,123,155],"moderately":[49],"3)":[52],"bronchial":[53,212],"asthma":[54,213],"19":[55],"who":[56,63],"were":[57,64,95],"using":[58,142,183],"inhalational":[59,125,138,143,184,188],"steroids":[60,144,185,189],"and":[61,72,91,100,116,177,222,240,253,260],"17":[62],"not":[65,141,164],"used":[66],"TTS":[68,162,198],"one":[70],"year":[71,102,118,179],"underwent":[73],"measurement":[74],"peak":[76],"expiratory":[77],"flow":[78],"(PEF)":[79],"Peripheral":[82],"eosinophil":[83,86],"count,":[84],"serum":[85,128],"cationic":[87],"protein":[88],"(ECP)":[89],"level":[90],"airway":[92,195,243,247],"responsiveness":[93,248],"(Dmin)":[94],"evaluated":[96],"at":[97,113,151,174],"6":[98,114,153,175],"months":[99,115,154,176],"1":[101,117,156,178],"after":[103,250],"start":[105],"study.":[108],"PEF":[109],"exhibited":[110,145],"significant":[111,147,170],"improvements":[112,171],"in":[119,134,172,180,193,203,209],"treated":[121],"without":[124,245],"steroids,":[126],"while":[127],"ECP":[129],"was":[130],"improved":[131],"significantly":[132,225],"only":[133],"on":[137],"steroids.":[139],"Patients":[140],"no":[146],"exacerbation":[148],"Dmin":[150,173],"either":[152],"year:":[157],"One-year":[158],"treatment":[159],"did":[163],"appear":[165],"to":[166,258],"cause":[167],"tachyphylaxis.":[168],"suggested":[186],"offer":[190],"beneficial":[191,202],"effects":[192,219],"controlling":[194],"inflammation.":[196],"Tulobuterol":[197],"considered":[200],"quite":[201],"improving":[204],"quality":[205],"life":[207],"(QOL)":[208],"because":[214,232,254],"its":[215,234],"incidence":[216],"adverse":[218],"including":[220],"palpitations":[221],"shivering":[223],"lower":[226],"than":[227],"those":[228],"oral":[230],"preparations,":[231],"remarkable":[235],"improvement":[236],"pulmonary":[238],"function":[239],"symptoms":[241],"obstruction":[244],"increasing":[246],"even":[249],"repeated":[251],"use,":[252],"it":[255],"simple":[257],"use":[259],"offers":[261],"excellent":[262],"clinical":[263],"efficacy.":[264]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
