{"id":"https://openalex.org/W36538783","doi":null,"title":"The clearance of theophylline is increased during the initial period of tuberculosis treatment.","display_name":"The clearance of theophylline is increased during the initial period of tuberculosis treatment.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W36538783","mag":"36538783","pmid":"https://pubmed.ncbi.nlm.nih.gov/12797703"},"language":"en","primary_location":{"id":"pmid:12797703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12797703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H C Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H C Ahn","raw_affiliation_strings":["Department of Pharmacy, Chonbuk National University Hospital, Chonju, Chonbuk, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Chonbuk National University Hospital, Chonju, Chonbuk, South Korea","institution_ids":["https://openalex.org/I4210131908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113973756","display_name":"Yu-Chin Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y C Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1805,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.46053926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"7","issue":"6","first_page":"587","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.7310000061988831},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ethambutol","display_name":"ethambutol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":1.0},{"id":"https://openalex.org/keywords/aminophylline","display_name":"aminophylline","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.7020000219345093},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5590000152587891},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/serum-drug-monitoring","display_name":"serum drug concentration monitoring","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.9818179607391357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9530781507492065},{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.9178555607795715},{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.8831550478935242},{"id":"https://openalex.org/C2776202631","wikidata":"https://www.wikidata.org/wiki/Q471763","display_name":"Aminophylline","level":2,"score":0.7258890867233276},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.6750575304031372},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6156167387962341},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.580629825592041},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5002284049987793},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4780586063861847},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.4151625633239746},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.41269612312316895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36002880334854126},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3223503828048706},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07672426104545593}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004977","descriptor_name":"Ethambutol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004977","descriptor_name":"Ethambutol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004977","descriptor_name":"Ethambutol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007538","descriptor_name":"Isoniazid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007538","descriptor_name":"Isoniazid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007538","descriptor_name":"Isoniazid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12797703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12797703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Clinical Trial"},{"id":"mag:36538783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12797703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1995841768","https://openalex.org/W2025347169","https://openalex.org/W2051461779","https://openalex.org/W2055278782","https://openalex.org/W2121680483","https://openalex.org/W2144175542","https://openalex.org/W2161637954","https://openalex.org/W2461102849","https://openalex.org/W2767266730","https://openalex.org/W2915174157","https://openalex.org/W2967044977","https://openalex.org/W3015708294","https://openalex.org/W3015856972","https://openalex.org/W3047527813","https://openalex.org/W3087998856","https://openalex.org/W3090300247","https://openalex.org/W3123992645","https://openalex.org/W3156551532","https://openalex.org/W3163153879","https://openalex.org/W4223437423","https://openalex.org/W4289705152"],"related_works":["https://openalex.org/W2430298410","https://openalex.org/W2351139311","https://openalex.org/W2414804475","https://openalex.org/W2169679518","https://openalex.org/W1895829060","https://openalex.org/W2395860342","https://openalex.org/W2043929828","https://openalex.org/W1977649247","https://openalex.org/W2409180924","https://openalex.org/W1617533287"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,20,25,106,136,161,178],"effects":[4],"of":[5,22,28,46,62,80,108,115,130,155,164,180],"combined":[6,49],"anti-tuberculosis":[7,51,156],"treatment":[8,166],"including":[9],"isoniazid":[10],"(INH),":[11],"rifampicin":[12],"(RMP),":[13],"ethambutol":[14],"(EMB)":[15],"and":[16,66,68,92,95,113,119,158,176],"pyrazinamide":[17],"(PZA),":[18],"on":[19],"pharmacokinetics":[21],"theophylline":[23,55,116,159,174,181],"during":[24,160],"initial":[26,162],"phase":[27,163],"treatment.":[29,81],"DESIGN:":[30],"Prospective,":[31],"controlled":[32],"clinical":[33],"study.":[34],"PATIENTS":[35],"AND":[36],"METHODS:":[37],"Twenty":[38],"patients":[39,83,145],"with":[40,50,89,146],"pulmonary":[41,151],"tuberculosis":[42,165],"received":[43],"7.35":[44],"mg/kg/day":[45],"aminophylline":[47],"intravenously":[48],"agents.":[52],"The":[53,111],"first":[54],"serum":[56],"concentration":[57,112],"was":[58,117,122,138],"measured":[59],"before":[60,135],"administration":[61,129],"INH,":[63],"RMP,":[64],"EMB":[65],"PZA,":[67],"samples":[69],"were":[70,87,97],"obtained":[71],"once":[72],"daily":[73],"for":[74,171],"6":[75],"consecutive":[76],"days":[77,126],"after":[78,128],"initiation":[79],"All":[82],"in":[84,173],"this":[85],"study":[86],"non-smokers":[88],"normal":[90],"hepatic":[91],"renal":[93],"function,":[94],"they":[96],"not":[98],"given":[99],"any":[100],"other":[101],"drugs":[102],"that":[103,144,177],"could":[104],"affect":[105],"clearance":[107,121],"theophylline.":[109],"RESULTS:":[110],"half-life":[114],"decreased":[118],"its":[120],"increased":[123],"significantly":[124],"at":[125],"5-7":[127],"antituberculosis":[131],"agents":[132,157],"compared":[133],"to":[134],"therapy":[137],"started.":[139],"CONCLUSIONS:":[140],"These":[141],"results":[142],"suggest":[143],"asthma":[147],"or":[148],"chronic":[149],"obstructive":[150],"disease":[152],"administered":[153],"combinations":[154],"should":[167,182],"be":[168,183],"monitored":[169],"closely":[170],"changes":[172],"concentration,":[175],"dose":[179],"adjusted":[184],"accordingly.":[185]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
