{"id":"https://openalex.org/W36535965","doi":"https://doi.org/10.1007/978-1-59259-013-1_5","title":"Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice","display_name":"Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W36535965","doi":"https://doi.org/10.1007/978-1-59259-013-1_5","mag":"36535965","pmid":"https://pubmed.ncbi.nlm.nih.gov/36535965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9763358"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-013-1_5","doi":"https://doi.org/10.1007/978-1-59259-013-1_5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-013-1_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Farnesyltransferase Inhibitors in Cancer Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4406323304","display_name":"Farnesyltransferase Inhibitors in Cancer Therapy"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-1-59259-013-1_5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055481417","display_name":"W. Wayt Gibbs","orcid":"https://orcid.org/0000-0003-4757-7336","observed_orcids":["https://orcid.org/0000-0003-4757-7336"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jackson B. Gibbs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403990","display_name":"Samuel Lindsay Graham","orcid":"https://orcid.org/0000-0002-1299-1636","observed_orcids":["https://orcid.org/0000-0002-1299-1636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel L. Graham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031350782","display_name":"George D. Hartman","orcid":"https://orcid.org/0000-0002-8016-8369","observed_orcids":["https://orcid.org/0000-0002-8016-8369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George D. Hartman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084126298","display_name":"Kenneth S. Koblan","orcid":"https://orcid.org/0000-0001-6103-2629","observed_orcids":["https://orcid.org/0000-0001-6103-2629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth S. Koblan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030929043","display_name":"Nancy E. Kohl","orcid":"https://orcid.org/0000-0003-4028-1866","observed_orcids":["https://orcid.org/0000-0003-4028-1866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy E. Kohl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109898147","display_name":"Charles A. Omer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Omer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040175662","display_name":"Angel Pellicier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angel Pellicier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048387240","display_name":"Jolene J. Windle","orcid":"https://orcid.org/0000-0001-6690-385X","observed_orcids":["https://orcid.org/0000-0001-6690-385X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolene Windle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017507332","display_name":"Allen I. Oliff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen Oliff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6146,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.74404762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"65","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1503","display_name":"Catalysis"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1503","display_name":"Catalysis"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesyltransferase-inhibitors","display_name":"farnesyltransferase inhibitors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.859000027179718},{"id":"https://openalex.org/keywords/ionic-liquids","display_name":"ionic liquids","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cell-membrane-interaction","display_name":"cell membrane interaction","score":0.6629999876022339},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.7730000019073486},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2778396349","wikidata":"https://www.wikidata.org/wiki/Q410994","display_name":"Farnesyltransferase","level":4,"score":0.9518568515777588},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.6871724128723145},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.583659291267395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5336635112762451},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.506794273853302},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4727643132209778},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.45598721504211426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45003339648246765},{"id":"https://openalex.org/C2777827897","wikidata":"https://www.wikidata.org/wiki/Q5436005","display_name":"Farnesyltransferase inhibitor","level":5,"score":0.4499909281730652},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3380274176597595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32020819187164307},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21258175373077393}],"mesh":[{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052578","descriptor_name":"Ionic Liquids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052578","descriptor_name":"Ionic Liquids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052578","descriptor_name":"Ionic Liquids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052578","descriptor_name":"Ionic Liquids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/978-1-59259-013-1_5","doi":"https://doi.org/10.1007/978-1-59259-013-1_5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-013-1_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Farnesyltransferase Inhibitors in Cancer Therapy","raw_type":"book-chapter"},{"id":"pmh:oai:pubmedcentral.nih.gov:9763358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9763358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36535965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36535965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"mag:36535965","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-013-1_5.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/978-1-59259-013-1_5","doi":"https://doi.org/10.1007/978-1-59259-013-1_5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-013-1_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Farnesyltransferase Inhibitors in Cancer Therapy","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W88876866","https://openalex.org/W1526004337","https://openalex.org/W1965995529","https://openalex.org/W1966683022","https://openalex.org/W1975702431","https://openalex.org/W1976927505","https://openalex.org/W1993808586","https://openalex.org/W2000692224","https://openalex.org/W2008319612","https://openalex.org/W2017814405","https://openalex.org/W2026490817","https://openalex.org/W2051626784","https://openalex.org/W2055097128","https://openalex.org/W2074154228","https://openalex.org/W2079816467","https://openalex.org/W2083506343","https://openalex.org/W2089642031","https://openalex.org/W2089906643","https://openalex.org/W2091129730","https://openalex.org/W2107666634","https://openalex.org/W2126910886","https://openalex.org/W2128725149","https://openalex.org/W2133362776","https://openalex.org/W2142918195","https://openalex.org/W2156654096","https://openalex.org/W2165533554","https://openalex.org/W2173344695","https://openalex.org/W2406401565","https://openalex.org/W2468063275"],"related_works":["https://openalex.org/W4312093541","https://openalex.org/W4404613029","https://openalex.org/W4390500887","https://openalex.org/W4414967808","https://openalex.org/W2739647903","https://openalex.org/W2781139560","https://openalex.org/W1988854417","https://openalex.org/W7133355477","https://openalex.org/W4391657203","https://openalex.org/W7010619722"],"abstract_inverted_index":{"Designing":[0],"drug":[1,29],"delivery":[2,30],"systems":[3,31],"for":[4],"therapeutic":[5],"compounds":[6],"whose":[7],"receptors":[8],"are":[9,63,69],"located":[10],"in":[11,37,90],"the":[12,34,39,78,87,91,114,123,144],"cytosol":[13],"of":[14,77,98,116],"cells":[15],"is":[16,23],"challenging":[17],"as":[18],"a":[19,141],"bilayer":[20],"cell":[21,59,124],"membrane":[22,40],"negatively":[24],"charged.":[25],"The":[26,74],"newly":[27,100],"designed":[28,101,120],"should":[32],"assist":[33],"mentioned":[35],"drugs":[36],"passing":[38],"barriers":[41],"and":[42,68,94,119,132,135,146],"achieving":[43],"their":[44],"targets.":[45],"This":[46],"study":[47],"concentrated":[48],"on":[49,65],"developing":[50],"novel":[51],"ionic":[52,82,103],"liquids":[53,83],"(ILs)":[54],"that":[55,137],"interact":[56],"effectively":[57],"with":[58,96,122],"membranes.":[60],"These":[61],"ILs":[62,121],"based":[64],"glucose-containing":[66],"choline":[67],"expected":[70],"to":[71,110],"be":[72,140],"non-toxic.":[73],"binding":[75],"energies":[76],"known":[79,118],"pharmaceutically":[80],"active":[81],"were":[84],"calculated":[85],"at":[86],"B3LYP/6-311++G(d,p)":[88],"level":[89],"gas":[92],"phase":[93],"compared":[95],"those":[97],"our":[99,127],"carbohydrate-based":[102],"liquids.":[104],"Subsequently,":[105],"we":[106,129],"employed":[107],"MD":[108,133,147],"simulations":[109],"obtain":[111],"information":[112],"about":[113],"interactions":[115],"these":[117],"membrane.":[125],"In":[126],"approach,":[128],"adopted":[130],"QM":[131,145],"studies":[134],"illustrated":[136],"there":[138],"could":[139],"link":[142],"between":[143],"results.":[148]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}