{"id":"https://openalex.org/W36431963","doi":null,"title":"Peri- and intratumoral T and B lymphocytic infiltration in breast cancer.","display_name":"Peri- and intratumoral T and B lymphocytic infiltration in breast cancer.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W36431963","mag":"36431963","pmid":"https://pubmed.ncbi.nlm.nih.gov/18714562"},"language":"en","primary_location":{"id":"pmid:18714562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18714562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110142069","display_name":"Renato Augusto Menegaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106570","display_name":"Universidade Federal do Tri\u00e2ngulo Mineiro","ror":"https://ror.org/01av3m334","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210106570"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R A Menegaz","raw_affiliation_strings":["Research Institute of Oncology (IPON) / Discipline of Gynecology and Obstetrics, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Uberaba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Oncology (IPON) / Discipline of Gynecology and Obstetrics, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Uberaba, Brazil","institution_ids":["https://openalex.org/I4210106570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085863842","display_name":"M\u00e1rcia Antoniazi Michelin","orcid":"https://orcid.org/0000-0003-0842-8805","observed_orcids":["https://orcid.org/0000-0003-0842-8805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Michelin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015502750","display_name":"Renata Margarida Etchebehere","orcid":"https://orcid.org/0000-0002-2241-5966","observed_orcids":["https://orcid.org/0000-0002-2241-5966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Etchebehere","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075755030","display_name":"Fernandes Pc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P C J\u00fanior Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034198739","display_name":"Eddie Fernando C\u00e2ndido Murta","orcid":"https://orcid.org/0000-0003-4014-1345","observed_orcids":["https://orcid.org/0000-0003-4014-1345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E F C Murta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6665,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.69336688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"29","issue":"4","first_page":"321","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.06780000030994415,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/peritumoral-lymphocytes","display_name":"peritumoral lymphocytes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/intratumoral-lymphocytes","display_name":"intratumoral lymphocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":1.0},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cd20","display_name":"CD20","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8641093969345093},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.8640165328979492},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.8399655818939209},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.7348294258117676},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.669156014919281},{"id":"https://openalex.org/C2908812692","wikidata":"https://www.wikidata.org/wiki/Q3269477","display_name":"Lymphocytic infiltration","level":2,"score":0.6292392015457153},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6151337027549744},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6114526391029358},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5818458795547485},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5481522083282471},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3946802318096161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17533209919929504},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.15408453345298767},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.085137277841568},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18714562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18714562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},{"id":"mag:36431963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18714562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2537456030","https://openalex.org/W1597800007","https://openalex.org/W4412132310","https://openalex.org/W1575500160","https://openalex.org/W2125789181","https://openalex.org/W4293099380","https://openalex.org/W1990208852","https://openalex.org/W630430220","https://openalex.org/W4200309900","https://openalex.org/W2565892955"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"investigate":[2],"peritumoral":[3,97],"and":[4,17,38,42,54,113,116,130,135,140],"intratumoral":[5,81,114,131],"infiltrates":[6,132],"in":[7,50,80,92,106,108,119,123],"surgical":[8,26],"specimens":[9,27],"obtained":[10,28],"from":[11,29],"patients":[12,30],"with":[13,32,56,110],"invasive":[14],"breast":[15,33],"cancer,":[16],"of":[18,126,133],"relating":[19],"these":[20],"to":[21,96],"tumor":[22,58,143],"size.":[23,144],"METHODS:":[24],"Twenty-six":[25],"diagnosed":[31],"cancer":[34],"underwent":[35],"immunohistochemical":[36],"preparation":[37],"CD3,":[39],"CD8,":[40],"CD20":[41],"CD68":[43],"labeling.":[44],"The":[45],"positive":[46],"cells":[47],"were":[48],"counted":[49],"the":[51,57],"tissue":[52],"samples":[53],"correlated":[55],"size":[59],"determined":[60],"by":[61],"imaging":[62],"methods":[63],"(TIA":[64],"<":[65],"or":[66,69],"=":[67],"2":[68,72],"TIB":[70],">":[71],"cm).":[73],"RESULTS:":[74],"There":[75],"was":[76,102],"a":[77,103],"significant":[78,104],"reduction":[79,87,105],"B":[82,136],"lymphocytes":[83,99,137],"(CD20+),":[84],"although":[85],"this":[86],"could":[88],"only":[89],"be":[90],"observed":[91],"TIA.":[93,111],"In":[94],"relation":[95],"T":[98,134],"(CD3+),":[100],"there":[101],"TIB,":[107],"comparison":[109],"Peritumoral":[112,129],"CD3+":[115],"CD68+":[117],"presence":[118],"completely":[120],"opposite":[121],"ways":[122],"both":[124],"sizes":[125],"tumors.":[127],"CONCLUSION:":[128],"are":[138],"different":[139],"depend":[141],"on":[142]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}