{"id":"https://openalex.org/W36409839","doi":null,"title":"Cellular expression of xanthine oxidoreductase protein in normal human tissues.","display_name":"Cellular expression of xanthine oxidoreductase protein in normal human tissues.","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W36409839","mag":"36409839","pmid":"https://pubmed.ncbi.nlm.nih.gov/10462034"},"language":"en","primary_location":{"id":"pmid:10462034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10462034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049991876","display_name":"Nina Linder","orcid":"https://orcid.org/0000-0003-3930-0513","observed_orcids":["https://orcid.org/0000-0003-3930-0513"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"N Linder","raw_affiliation_strings":["Research Laboratory, Hospital for Children and Adolescents, University of Helsinki, Finland. nina.linder@huch.fi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory, Hospital for Children and Adolescents, University of Helsinki, Finland. nina.linder@huch.fi","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004547090","display_name":"Juhani Rapola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Rapola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111861493","display_name":"Kari O. Raivio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K O Raivio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3017,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.91614907,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"79","issue":"8","first_page":"967","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-oxidoreductase","display_name":"xanthine oxidoreductase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.7789999842643738},{"id":"https://openalex.org/keywords/normal-human-tissues","display_name":"normal human tissues","score":0.7940000295639038},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.550000011920929},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.7879999876022339},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8970000147819519},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6463544368743896},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.48355647921562195},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4647049009799957},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4482373297214508},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4144956171512604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4057009816169739},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37806883454322815},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.331814169883728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32781121134757996},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13848033547401428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08883988857269287}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10462034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10462034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:36409839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10462034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092122190","https://openalex.org/W2034878415","https://openalex.org/W2058881562","https://openalex.org/W2015379175","https://openalex.org/W3046400799","https://openalex.org/W2326687029","https://openalex.org/W1991707890","https://openalex.org/W2086483283","https://openalex.org/W4388247590","https://openalex.org/W2431808600"],"abstract_inverted_index":{"Xanthine":[0],"oxidoreductase":[1,146],"is":[2,148],"an":[3],"important":[4],"cytoplasmic":[5],"source":[6],"of":[7,18,25,109,143],"reactive":[8],"oxygen":[9],"species,":[10],"and":[11,55,74,93,114],"has":[12],"been":[13],"implicated":[14],"in":[15,37,60,90,120,130,155],"the":[16,22,50,63,65,71,79,83,86,110,121,131,137,144,156],"pathogenesis":[17],"ischemia-reperfusion":[19],"damage.":[20],"Because":[21],"cellular":[23],"localization":[24,142,163],"this":[26],"protein":[27,51,66,87,147],"remains":[28],"unclear,":[29],"our":[30],"aim":[31],"was":[32,67,76,88],"to":[33,70,164,171],"study":[34],"its":[35],"distribution":[36],"fresh":[38],"normal":[39],"human":[40,53],"tissue":[41],"obtained":[42],"at":[43],"surgery.":[44],"For":[45],"immunohistochemical":[46],"studies":[47],"we":[48],"purified":[49],"from":[52,78],"milk":[54],"raised":[56],"a":[57],"polyclonal":[58],"antibody":[59],"rabbits.":[61],"In":[62,82],"liver":[64],"preferentially":[68],"localized":[69],"periportal":[72],"hepatocytes":[73],"it":[75],"absent":[77],"perivenous":[80],"region.":[81],"proximal":[84],"intestine,":[85,111],"expressed":[89,136],"epithelial":[91],"cells":[92,100,108,125,129],"goblet":[94],"cells.":[95],"Lactating":[96],"mammary":[97,112],"gland":[98],"acinar":[99],"showed":[101,117],"intense":[102],"staining.":[103],"Small":[104],"vessel":[105],"vascular":[106],"endothelial":[107,124],"gland,":[113],"skeletal":[115],"muscle":[116],"immunoreactivity,":[118],"but":[119],"kidney,":[122],"glomerular":[123],"were":[126],"negative.":[127],"No":[128],"heart,":[132],"brain,":[133],"or":[134],"lung":[135],"enzyme":[138,153],"protein.":[139],"The":[140,159],"observed":[141,152],"xanthine":[145],"consistent":[149],"with":[150],"previously":[151],"activities":[154],"organs":[157],"studied.":[158],"widely":[160],"assumed":[161],"exclusive":[162],"capillary":[165],"endothelium":[166],"obviously":[167],"does":[168],"not":[169],"apply":[170],"humans.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
