{"id":"https://openalex.org/W36288419","doi":null,"title":"Cigarette Smoke Extract-Induced Injury in Alveolar Cells in Model Systems","display_name":"Cigarette Smoke Extract-Induced Injury in Alveolar Cells in Model Systems","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W36288419","mag":"36288419"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/201510","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/201510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041635920","display_name":"Charles A. Downs","orcid":"https://orcid.org/0000-0003-4859-7929","observed_orcids":["https://orcid.org/0000-0003-4859-7929"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charles A. Downs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4859-7929","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041635920"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.10769999772310257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke-extract","display_name":"cigarette smoke extract","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alveolar-type-i-cells","display_name":"alveolar type I cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pulmonary-microvascular-endothelial-cells","display_name":"pulmonary microvascular endothelial cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.902999997138977},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7829999923706055},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.7789999842643738},{"id":"https://openalex.org/keywords/co-culture-model","display_name":"co-culture model","score":0.7570000290870667},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8090000152587891},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.722000002861023},{"id":"https://openalex.org/keywords/passive-smoking","display_name":"passive smoking","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7788978815078735},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.7067167162895203},{"id":"https://openalex.org/C58874564","wikidata":"https://www.wikidata.org/wiki/Q130768","display_name":"Smoke","level":2,"score":0.6584281921386719},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5368365049362183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4975321590900421},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43497079610824585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42307740449905396},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4112454950809479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3820054531097412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32905876636505127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3037876486778259},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.24264511466026306},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/201510","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/201510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:36288419","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/201510","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":179,"referenced_works":["https://openalex.org/W34434962","https://openalex.org/W58451361","https://openalex.org/W112601064","https://openalex.org/W153904168","https://openalex.org/W199921131","https://openalex.org/W1485522487","https://openalex.org/W1498520518","https://openalex.org/W1582948192","https://openalex.org/W1761524483","https://openalex.org/W1774886260","https://openalex.org/W1899678835","https://openalex.org/W1920044084","https://openalex.org/W1939816682","https://openalex.org/W1964440144","https://openalex.org/W1966448300","https://openalex.org/W1968309671","https://openalex.org/W1970232637","https://openalex.org/W1970911936","https://openalex.org/W1972846863","https://openalex.org/W1974560846","https://openalex.org/W1978453301","https://openalex.org/W1978914901","https://openalex.org/W1979175943","https://openalex.org/W1979558674","https://openalex.org/W1980725176","https://openalex.org/W1982153589","https://openalex.org/W1984454286","https://openalex.org/W1984577372","https://openalex.org/W1986005261","https://openalex.org/W1988175420","https://openalex.org/W1989237025","https://openalex.org/W1989966522","https://openalex.org/W1990482858","https://openalex.org/W1991631628","https://openalex.org/W1992584632","https://openalex.org/W1995445783","https://openalex.org/W1999226863","https://openalex.org/W2000181213","https://openalex.org/W2000910567","https://openalex.org/W2003446723","https://openalex.org/W2004728337","https://openalex.org/W2004979192","https://openalex.org/W2007774661","https://openalex.org/W2008160989","https://openalex.org/W2010094123","https://openalex.org/W2011165565","https://openalex.org/W2011348241","https://openalex.org/W2011882274","https://openalex.org/W2012886510","https://openalex.org/W2013073993","https://openalex.org/W2015141049","https://openalex.org/W2016828297","https://openalex.org/W2020038227","https://openalex.org/W2024960729","https://openalex.org/W2028320710","https://openalex.org/W2032712084","https://openalex.org/W2033034935","https://openalex.org/W2036639619","https://openalex.org/W2039025210","https://openalex.org/W2039986214","https://openalex.org/W2040730288","https://openalex.org/W2042071058","https://openalex.org/W2042847551","https://openalex.org/W2044430178","https://openalex.org/W2045616259","https://openalex.org/W2047330128","https://openalex.org/W2048650447","https://openalex.org/W2049315063","https://openalex.org/W2049374111","https://openalex.org/W2051389808","https://openalex.org/W2052571887","https://openalex.org/W2053879426","https://openalex.org/W2054261510","https://openalex.org/W2065652369","https://openalex.org/W2067922574","https://openalex.org/W2068499457","https://openalex.org/W2069204050","https://openalex.org/W2072359622","https://openalex.org/W2076559871","https://openalex.org/W2076574227","https://openalex.org/W2077201251","https://openalex.org/W2077492833","https://openalex.org/W2078860873","https://openalex.org/W2079494090","https://openalex.org/W2080590513","https://openalex.org/W2081755434","https://openalex.org/W2082835152","https://openalex.org/W2085042044","https://openalex.org/W2085465728","https://openalex.org/W2090134402","https://openalex.org/W2091900055","https://openalex.org/W2095109810","https://openalex.org/W2097529540","https://openalex.org/W2098582660","https://openalex.org/W2100148131","https://openalex.org/W2100756422","https://openalex.org/W2101182707","https://openalex.org/W2104672238","https://openalex.org/W2104825524","https://openalex.org/W2104977363","https://openalex.org/W2105161580","https://openalex.org/W2106629880","https://openalex.org/W2108456985","https://openalex.org/W2108482850","https://openalex.org/W2110013605","https://openalex.org/W2110752622","https://openalex.org/W2110934787","https://openalex.org/W2112103467","https://openalex.org/W2112584058","https://openalex.org/W2112772608","https://openalex.org/W2113168077","https://openalex.org/W2113558571","https://openalex.org/W2113831203","https://openalex.org/W2115338196","https://openalex.org/W2118289954","https://openalex.org/W2118749829","https://openalex.org/W2119285879","https://openalex.org/W2119630077","https://openalex.org/W2121612428","https://openalex.org/W2121721745","https://openalex.org/W2123060132","https://openalex.org/W2124098526","https://openalex.org/W2125605790","https://openalex.org/W2126775459","https://openalex.org/W2127089922","https://openalex.org/W2127951128","https://openalex.org/W2128180660","https://openalex.org/W2130052573","https://openalex.org/W2132850519","https://openalex.org/W2132886980","https://openalex.org/W2134676982","https://openalex.org/W2135372620","https://openalex.org/W2135441474","https://openalex.org/W2136630225","https://openalex.org/W2137592705","https://openalex.org/W2137597773","https://openalex.org/W2138094019","https://openalex.org/W2140264378","https://openalex.org/W2140295891","https://openalex.org/W2140511951","https://openalex.org/W2141185701","https://openalex.org/W2142476629","https://openalex.org/W2142926742","https://openalex.org/W2144394390","https://openalex.org/W2144674922","https://openalex.org/W2145859123","https://openalex.org/W2148208559","https://openalex.org/W2150788604","https://openalex.org/W2151233718","https://openalex.org/W2152064695","https://openalex.org/W2155252583","https://openalex.org/W2156634951","https://openalex.org/W2157179744","https://openalex.org/W2158549296","https://openalex.org/W2158873788","https://openalex.org/W2159182794","https://openalex.org/W2159520118","https://openalex.org/W2159536730","https://openalex.org/W2159871194","https://openalex.org/W2160185049","https://openalex.org/W2160621707","https://openalex.org/W2166432084","https://openalex.org/W2166505581","https://openalex.org/W2166704790","https://openalex.org/W2167437135","https://openalex.org/W2169581310","https://openalex.org/W2171103867","https://openalex.org/W2171649568","https://openalex.org/W2171669504","https://openalex.org/W2172249877","https://openalex.org/W2210102360","https://openalex.org/W2341304214","https://openalex.org/W2404686141","https://openalex.org/W2404696820","https://openalex.org/W2413241186","https://openalex.org/W2509570492","https://openalex.org/W3022398249","https://openalex.org/W3111856753","https://openalex.org/W4247088117"],"related_works":["https://openalex.org/W2302324388","https://openalex.org/W1986908337","https://openalex.org/W153904168","https://openalex.org/W2047103924","https://openalex.org/W1989966522","https://openalex.org/W2319580184","https://openalex.org/W1993976409","https://openalex.org/W2355367419","https://openalex.org/W2151233718","https://openalex.org/W1974991396"],"abstract_inverted_index":{"Cigarette":[0,240],"smoke":[1,38,65,100,241],"contributes":[2],"to":[3,26,54,63,94,118,176,193,275,278,286,321,339],"many":[4],"diseases.":[5],"The":[6,29,50,86,161,280],"actions":[7,42],"of":[8,32,60,98,122,126,150,197,219,231,244,253,325],"second":[9],"and":[10,19,76,83,106,113,130,139,143,154,187,238,257,312,334],"third":[11],"hand":[12],"smoke,":[13],"which":[14],"have":[15],"implications":[16],"for":[17,227],"non-smokers":[18],"the":[20,58,111,120,195,322],"very":[21],"young,":[22,82],"are":[23,236,270],"just":[24],"beginning":[25],"be":[27,318],"appreciated.":[28],"overarching":[30],"hypothesis":[31],"this":[33],"project":[34],"is":[35],"that":[36,190,224,268],"cigarette":[37,64,99,341],"has":[39],"different":[40],"injurious":[41],"on":[43,47,73,101,124],"alveolar":[44,61,75,102,133,170,289,315],"cells":[45,62,78,105,109,134,173,205,245,254,292,301,316],"based":[46],"chronological":[48],"age.":[49],"purpose":[51],"here":[52],"was":[53,206],"learn":[55],"more":[56,319],"about":[57],"susceptibility":[59],"extract":[66],"(CSE)-":[67],"induced":[68],"injury":[69],"by":[70,203,209],"performing":[71],"studies":[72,145],"pulmonary":[74],"endothelial":[77,108,204],"derived":[79],"from":[80,110,136,246,255,261],"neonatal,":[81,137],"old":[84,140,258],"rats.":[85,141,259],"aims":[87],"involved:":[88],"1.":[89,167,284],"Developing":[90],"cell":[91,151,179],"culture":[92,180],"models":[93,117],"study":[95,194,340],"age-related":[96,271],"effects":[97,121,196,324],"type":[103,171,290,299],"I":[104,172,213,291,300],"microvascular":[107],"lung,":[112],"2.":[114,199,297],"Using":[115],"these":[116],"examine":[119],"CSE":[123,326],"markers":[125],"oxidative":[127,220,310],"stress,":[128],"inflammation":[129],"aging":[131],"in":[132,273,307],"harvested":[135],"young":[138,256],"Descriptive":[142],"experimental":[144],"involved":[146],"using":[147],"a":[148],"variety":[149],"culture,":[152,185],"biochemical":[153],"molecular":[155],"techniques,":[156],"including":[157,183,327],"gene":[158,264,276],"expression":[159,217,265,277],"arrays.":[160],"most":[162],"significant":[163,281],"findings":[164],"were":[165,174,191],"that:":[166],"primary":[168],"proliferating":[169],"used":[175,192],"develop":[177],"novel":[178,331],"model":[181,332],"systems,":[182],"single":[184],"co-culture":[186],"three-dimensional":[188],"cultures":[189],"CSE;":[198],"Hydrogen":[200],"peroxide":[201],"production":[202,230],"markedly":[207],"reduced":[208],"co-culturing":[210],"with":[211],"AT":[212],"cells;":[214],"3.":[215,313],"Gene":[216],"profiling":[218],"stress-specific":[221],"pathways":[222],"suggest":[223,267],"genes":[225],"responsible":[226],"both":[228],"stopping":[229],"H2O2":[232,235],"or":[233],"mopping-up":[234],"involved;":[237],"4.":[239],"shortens":[242],"telomeres":[243],"neonates,":[247],"but":[248],"unexpectedly":[249],"preserves":[250],"telomere":[251,328],"length":[252],"Data":[260],"telomeric":[262],"pathway-specific":[263],"arrays":[266],"there":[269],"differences":[272],"response":[274],"CSE.":[279],"conclusions":[282],"are:":[283],"Contrary":[285],"prior":[287],"observations,":[288],"demonstrate":[293],"prolonged":[294],"proliferative":[295],"capacity;":[296],"Alveolar":[298],"likely":[302],"play":[303],"an":[304],"important":[305],"role":[306],"ameliorating":[308],"CSE-induced":[309],"stress;":[311],"Neonatal":[314],"may":[317],"susceptible":[320],"deleterious":[323],"shortening.":[329],"These":[330],"systems":[333],"observations":[335],"provide":[336],"new":[337],"ways":[338],"smoke-associated":[342],"lung":[343],"dysfunction.":[344]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}