{"id":"https://openalex.org/W36280277","doi":null,"title":"ANGIOMOTIN IS A NOVEL CADHERIN-11 INTERACTING PROTEIN THAT MEDIATES MIGRATION IN PROSTATE CANCER CELLS","display_name":"ANGIOMOTIN IS A NOVEL CADHERIN-11 INTERACTING PROTEIN THAT MEDIATES MIGRATION IN PROSTATE CANCER CELLS","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W36280277","mag":"36280277"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1545","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/505","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1545&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1545&context=utgsbs_dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076759654","display_name":"Ang\u00e9lica Ortiz","orcid":"https://orcid.org/0000-0003-4008-7203","observed_orcids":["https://orcid.org/0000-0003-4008-7203"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ang\u00e9lica Ortiz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4008-7203","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076759654"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiomotin","display_name":"angiomotin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cadherin-11","display_name":"cadherin-11","score":0.953000009059906},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/epithelial-cell-polarity","display_name":"epithelial polarity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/c-terminal-binding-domain","display_name":"C-terminal binding domain","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.743735671043396},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.5413004159927368},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.503433883190155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4196586608886719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38392189145088196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31931453943252563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21734938025474548},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.157548189163208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14376208186149597}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1545","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/505","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1545&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:36280277","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1545&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1545","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/505","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1545&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W36280277.pdf","grobid_xml":"https://content.openalex.org/works/W36280277.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W188798909","https://openalex.org/W1522708790","https://openalex.org/W1587777046","https://openalex.org/W1625279067","https://openalex.org/W1730182343","https://openalex.org/W1850975011","https://openalex.org/W1901437611","https://openalex.org/W1936594415","https://openalex.org/W1964081206","https://openalex.org/W1964185212","https://openalex.org/W1966113252","https://openalex.org/W1968375977","https://openalex.org/W1968445925","https://openalex.org/W1969292038","https://openalex.org/W1975772628","https://openalex.org/W1976061123","https://openalex.org/W1986275950","https://openalex.org/W1989134354","https://openalex.org/W1999910107","https://openalex.org/W2006127440","https://openalex.org/W2010589579","https://openalex.org/W2011448168","https://openalex.org/W2014923522","https://openalex.org/W2021856025","https://openalex.org/W2025702763","https://openalex.org/W2030752121","https://openalex.org/W2034469841","https://openalex.org/W2047665175","https://openalex.org/W2054079210","https://openalex.org/W2055184276","https://openalex.org/W2058066258","https://openalex.org/W2059182780","https://openalex.org/W2062684010","https://openalex.org/W2089370460","https://openalex.org/W2090484067","https://openalex.org/W2093507882","https://openalex.org/W2095086052","https://openalex.org/W2095761465","https://openalex.org/W2098180445","https://openalex.org/W2098585582","https://openalex.org/W2099280507","https://openalex.org/W2101547995","https://openalex.org/W2119609292","https://openalex.org/W2121863482","https://openalex.org/W2123055653","https://openalex.org/W2123575778","https://openalex.org/W2125696837","https://openalex.org/W2127347832","https://openalex.org/W2128971155","https://openalex.org/W2129953433","https://openalex.org/W2130104786","https://openalex.org/W2132756167","https://openalex.org/W2135463143","https://openalex.org/W2137581290","https://openalex.org/W2139676627","https://openalex.org/W2142758559","https://openalex.org/W2144298794","https://openalex.org/W2145617194","https://openalex.org/W2148008686","https://openalex.org/W2160972423","https://openalex.org/W2161246942","https://openalex.org/W2161315124","https://openalex.org/W2162614357","https://openalex.org/W2168850532","https://openalex.org/W2171466904","https://openalex.org/W2175151170"],"related_works":["https://openalex.org/W2021935021","https://openalex.org/W2118796350","https://openalex.org/W2099280507","https://openalex.org/W2160853823","https://openalex.org/W2127200384","https://openalex.org/W7099252786","https://openalex.org/W2604116523","https://openalex.org/W2044241236","https://openalex.org/W2093507882","https://openalex.org/W2598616305"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,28],"(PCa),":[2],"the":[3,13,17,39,98,110,143,159,163,180,190],"second":[4],"leading":[5],"cause":[6,32],"of":[7,73,97,106,126,166,189],"cancer-related":[8],"deaths":[9],"among":[10],"men":[11],"in":[12,24,49,67,104,149,200],"United":[14],"States,":[15],"has":[16],"proclivity":[18],"to":[19,21,43,51,94,207],"metastasize":[20],"bone":[22,30,33,45],"resulting":[23],"sclerotic":[25],"lesions.":[26],"These":[27],"induced":[29],"growths":[31],"pain":[34],"and":[35,56,92,130,203,216],"fractures.":[36],"Therefore,":[37],"understanding":[38],"molecular":[40],"mechanisms":[41],"contributing":[42],"PCa":[44,80,86,228],"metastasis":[46,60,93],"is":[47,117],"required":[48],"order":[50],"find":[52],"better":[53],"prognostic":[54],"tools":[55],"suitable":[57],"targets":[58],"for":[59],"treatment":[61],"and/":[62],"or":[63,185],"prevention.":[64],"Previous":[65],"work":[66],"our":[68,213],"laboratory":[69],"showed":[70,141,169],"increased":[71,89],"expression":[72,84],"cadherin-11":[74],"(Cad11),":[75],"a":[76,124,135,220],"mesenchymal":[77],"cadherin,":[78],"during":[79],"progression.":[81],"Furthermore,":[82],"Cad11":[83,99,111,136,150,155,174,193,222],"endows":[85],"cells":[87,208],"with":[88,158,173],"migratory":[90],"potential":[91],"bone.":[95],"Deletion":[96,139,188],"cytoplasmic":[100,112],"region":[101],"(cyto)":[102],"resulted":[103],"loss":[105],"cell":[107,115,128,132,198,229],"migration.":[108,230],"How":[109],"domain":[113],"mediates":[114],"migration":[116,129,199],"unknown.":[118],"We":[119],"have":[120],"identified":[121,215],"angiomotin":[122],"(Amot),":[123],"regulator":[125],"endothelial":[127],"epithelial":[131],"polarity,":[133],"as":[134,219],"interacting":[137],"protein.":[138],"analysis":[140],"that":[142,170,225],"last":[144,191],"C-terminal":[145],"10":[146],"amino":[147],"acids":[148],"mediated":[151],"Amot":[152,167],"binding.":[153],"Further,":[154],"preferentially":[156],"interacts":[157,172],"Amot-p80":[160,171,218],"isoform":[161],"than":[162],"Amot-p130.":[164],"Analysis":[165],"mutants":[168],"through":[175],"its":[176],"middle":[177],"domain,":[178],"not":[179],"well":[181],"characterized":[182,217],"coiled-coil":[183],"domains":[184],"PDZ":[186],"motif.":[187],"ten":[192],"residues":[194],"significantly":[195],"reduced":[196],"Cad11-mediated":[197,227],"C4-2B4,":[201],"PC3-mm2,":[202],"HEK293T":[204],"cells,":[205],"compared":[206],"expressing":[209],"wild-type":[210],"Cad11.":[211],"Together,":[212],"studies":[214],"novel":[221],"binding":[223],"protein":[224],"promotes":[226]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
