{"id":"https://openalex.org/W36253616","doi":null,"title":"Metabolic aspects on diabetic nephropathy","display_name":"Metabolic aspects on diabetic nephropathy","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W36253616","mag":"36253616"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-79","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044939013","display_name":"Maria K Eriksson Svensson","orcid":"https://orcid.org/0000-0001-7545-5585","observed_orcids":["https://orcid.org/0000-0001-7545-5585"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Svensson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7545-5585","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044939013"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/insulin-clearance","display_name":"insulin clearance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.7760000228881836},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.847000002861023},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8339999914169312},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5730000138282776},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.6330000162124634},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pediatric-diabetes","display_name":"pediatric diabetes","score":0.5839999914169312},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.4729999899864197},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5080000162124634},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.6039999723434448},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.8355628252029419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7491363286972046},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.7198550701141357},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5964969396591187},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5338600277900696},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48812708258628845},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.4360574781894684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39898648858070374},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35589513182640076},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33618462085723877}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-79","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:36253616","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:144545/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-79","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":287,"referenced_works":["https://openalex.org/W22189248","https://openalex.org/W26288520","https://openalex.org/W26589038","https://openalex.org/W150250187","https://openalex.org/W1449238770","https://openalex.org/W1487463199","https://openalex.org/W1554762746","https://openalex.org/W1587593840","https://openalex.org/W1587875569","https://openalex.org/W1675830194","https://openalex.org/W1806089932","https://openalex.org/W1825417295","https://openalex.org/W1838497045","https://openalex.org/W1882313427","https://openalex.org/W1944492097","https://openalex.org/W1963491507","https://openalex.org/W1963542379","https://openalex.org/W1963802746","https://openalex.org/W1964759196","https://openalex.org/W1965099356","https://openalex.org/W1965441274","https://openalex.org/W1965525479","https://openalex.org/W1965661114","https://openalex.org/W1965787101","https://openalex.org/W1966780199","https://openalex.org/W1968225061","https://openalex.org/W1968692995","https://openalex.org/W1969569538","https://openalex.org/W1969759774","https://openalex.org/W1972898058","https://openalex.org/W1972976777","https://openalex.org/W1974033843","https://openalex.org/W1975654557","https://openalex.org/W1976347558","https://openalex.org/W1977075739","https://openalex.org/W1977301030","https://openalex.org/W1978608905","https://openalex.org/W1979363410","https://openalex.org/W1980111447","https://openalex.org/W1980295850","https://openalex.org/W1980669873","https://openalex.org/W1981694993","https://openalex.org/W1982205510","https://openalex.org/W1982245891","https://openalex.org/W1982554330","https://openalex.org/W1982610111","https://openalex.org/W1983523234","https://openalex.org/W1983628832","https://openalex.org/W1985357249","https://openalex.org/W1986510665","https://openalex.org/W1986664751","https://openalex.org/W1987859523","https://openalex.org/W1991137257","https://openalex.org/W1991427290","https://openalex.org/W1992089240","https://openalex.org/W1992159509","https://openalex.org/W1992609506","https://openalex.org/W1992719998","https://openalex.org/W1993748602","https://openalex.org/W1994498073","https://openalex.org/W1995243968","https://openalex.org/W1997303488","https://openalex.org/W1997735511","https://openalex.org/W1997774629","https://openalex.org/W1998614770","https://openalex.org/W2003510810","https://openalex.org/W2003670762","https://openalex.org/W2004661032","https://openalex.org/W2004791514","https://openalex.org/W2005025846","https://openalex.org/W2005718118","https://openalex.org/W2006076791","https://openalex.org/W2006122998","https://openalex.org/W2006204391","https://openalex.org/W2006672342","https://openalex.org/W2007437966","https://openalex.org/W2008035773","https://openalex.org/W2009239890","https://openalex.org/W2010013710","https://openalex.org/W2012945186","https://openalex.org/W2013093313","https://openalex.org/W2013149999","https://openalex.org/W2013987899","https://openalex.org/W2014424410","https://openalex.org/W2014807353","https://openalex.org/W2017023426","https://openalex.org/W2018145341","https://openalex.org/W2018152764","https://openalex.org/W2019577672","https://openalex.org/W2021501227","https://openalex.org/W2021722695","https://openalex.org/W2021943148","https://openalex.org/W2025772414","https://openalex.org/W2026399893","https://openalex.org/W2026954085","https://openalex.org/W2026980881","https://openalex.org/W2027478328","https://openalex.org/W2028067695","https://openalex.org/W2028222457","https://openalex.org/W2028465222","https://openalex.org/W2033530420","https://openalex.org/W2033665979","https://openalex.org/W2036117545","https://openalex.org/W2038958838","https://openalex.org/W2039217085","https://openalex.org/W2041213396","https://openalex.org/W2041319764","https://openalex.org/W2042963237","https://openalex.org/W2043828707","https://openalex.org/W2044276013","https://openalex.org/W2044773944","https://openalex.org/W2044957350","https://openalex.org/W2045279107","https://openalex.org/W2045420682","https://openalex.org/W2047059660","https://openalex.org/W2047173192","https://openalex.org/W2047440899","https://openalex.org/W2050044633","https://openalex.org/W2053513995","https://openalex.org/W2055456263","https://openalex.org/W2055549402","https://openalex.org/W2056129662","https://openalex.org/W2057224051","https://openalex.org/W2057687534","https://openalex.org/W2057856777","https://openalex.org/W2059298925","https://openalex.org/W2059368542","https://openalex.org/W2059467226","https://openalex.org/W2059996061","https://openalex.org/W2060089863","https://openalex.org/W2062516790","https://openalex.org/W2064927835","https://openalex.org/W2065569245","https://openalex.org/W2065583713","https://openalex.org/W2065711633","https://openalex.org/W2067005197","https://openalex.org/W2067679923","https://openalex.org/W2068553904","https://openalex.org/W2068779473","https://openalex.org/W2068854446","https://openalex.org/W2069337786","https://openalex.org/W2069976863","https://openalex.org/W2070287218","https://openalex.org/W2070614628","https://openalex.org/W2070695357","https://openalex.org/W2071608240","https://openalex.org/W2073441650","https://openalex.org/W2073720638","https://openalex.org/W2074376162","https://openalex.org/W2074950372","https://openalex.org/W2079174508","https://openalex.org/W2080207036","https://openalex.org/W2080214780","https://openalex.org/W2080589906","https://openalex.org/W2081385953","https://openalex.org/W2081841797","https://openalex.org/W2082091147","https://openalex.org/W2082221124","https://openalex.org/W2082232455","https://openalex.org/W2082800289","https://openalex.org/W2083403848","https://openalex.org/W2083669258","https://openalex.org/W2083954739","https://openalex.org/W2084343172","https://openalex.org/W2084473470","https://openalex.org/W2085615957","https://openalex.org/W2087910275","https://openalex.org/W2088009836","https://openalex.org/W2088865109","https://openalex.org/W2089453413","https://openalex.org/W2089465816","https://openalex.org/W2089538498","https://openalex.org/W2089707588","https://openalex.org/W2092303944","https://openalex.org/W2093008889","https://openalex.org/W2093033430","https://openalex.org/W2093320845","https://openalex.org/W2093526768","https://openalex.org/W2094017043","https://openalex.org/W2096120926","https://openalex.org/W2096308832","https://openalex.org/W2097337104","https://openalex.org/W2098154750","https://openalex.org/W2099215676","https://openalex.org/W2100021456","https://openalex.org/W2101337813","https://openalex.org/W2102037528","https://openalex.org/W2102619594","https://openalex.org/W2104451693","https://openalex.org/W2104564587","https://openalex.org/W2105401688","https://openalex.org/W2105504606","https://openalex.org/W2105912552","https://openalex.org/W2113184926","https://openalex.org/W2115809210","https://openalex.org/W2116302195","https://openalex.org/W2116545635","https://openalex.org/W2118631832","https://openalex.org/W2118844178","https://openalex.org/W2119348567","https://openalex.org/W2120073172","https://openalex.org/W2121492829","https://openalex.org/W2122975542","https://openalex.org/W2123376729","https://openalex.org/W2124098523","https://openalex.org/W2124488542","https://openalex.org/W2125803656","https://openalex.org/W2126184059","https://openalex.org/W2127410318","https://openalex.org/W2130172139","https://openalex.org/W2131205383","https://openalex.org/W2134433473","https://openalex.org/W2134524309","https://openalex.org/W2137400632","https://openalex.org/W2139623768","https://openalex.org/W2141416094","https://openalex.org/W2142221153","https://openalex.org/W2143452032","https://openalex.org/W2145027776","https://openalex.org/W2145206814","https://openalex.org/W2146059428","https://openalex.org/W2146162958","https://openalex.org/W2147464835","https://openalex.org/W2147661193","https://openalex.org/W2148217123","https://openalex.org/W2149774780","https://openalex.org/W2150072493","https://openalex.org/W2150305289","https://openalex.org/W2150912407","https://openalex.org/W2151256084","https://openalex.org/W2151831906","https://openalex.org/W2154100179","https://openalex.org/W2154981317","https://openalex.org/W2155931459","https://openalex.org/W2159611761","https://openalex.org/W2159749658","https://openalex.org/W2162154857","https://openalex.org/W2163784004","https://openalex.org/W2164000773","https://openalex.org/W2164239703","https://openalex.org/W2165386872","https://openalex.org/W2167662071","https://openalex.org/W2167978636","https://openalex.org/W2168112867","https://openalex.org/W2171940353","https://openalex.org/W2186184337","https://openalex.org/W2187384809","https://openalex.org/W2201043092","https://openalex.org/W2236273522","https://openalex.org/W2316937684","https://openalex.org/W2317521667","https://openalex.org/W2318993770","https://openalex.org/W2321966902","https://openalex.org/W2322256252","https://openalex.org/W2322552681","https://openalex.org/W2324579467","https://openalex.org/W2325609900","https://openalex.org/W2331866434","https://openalex.org/W2332239235","https://openalex.org/W2335364913","https://openalex.org/W2335477756","https://openalex.org/W2335631045","https://openalex.org/W2337454357","https://openalex.org/W2338413622","https://openalex.org/W2339343999","https://openalex.org/W2340171512","https://openalex.org/W2345903479","https://openalex.org/W2402987151","https://openalex.org/W2409238546","https://openalex.org/W2414148872","https://openalex.org/W2414288172","https://openalex.org/W2414317490","https://openalex.org/W2414624655","https://openalex.org/W2414835254","https://openalex.org/W2414953134","https://openalex.org/W2416593259","https://openalex.org/W2418230365","https://openalex.org/W2418305233","https://openalex.org/W2418788345","https://openalex.org/W2419977109","https://openalex.org/W2769264260","https://openalex.org/W3024678824","https://openalex.org/W3030237074","https://openalex.org/W4249661281","https://openalex.org/W4255882085","https://openalex.org/W4299493480","https://openalex.org/W4366737279"],"related_works":["https://openalex.org/W2153715608","https://openalex.org/W7099535126","https://openalex.org/W2062250486","https://openalex.org/W2091559912","https://openalex.org/W2025004738","https://openalex.org/W2096520873","https://openalex.org/W2113584296","https://openalex.org/W2414842318","https://openalex.org/W2392164532","https://openalex.org/W2171291790"],"abstract_inverted_index":{"Diabetic":[0],"nephropathy":[1,316,320,381],"(DN)":[2],"is":[3,85,162,453,483],"associated":[4,95,484],"with":[5,96,119,165,189,225,278,292,344,365,435,469,485],"morbidity":[6],"and":[7,13,30,47,60,70,91,102,112,123,146,174,181,199,228,238,247,318,329,339,382,388,463,473,493],"mortality":[8],"due":[9],"to":[10,43,77,351,423],"cardiovascular":[11],"disease":[12],"renal":[14,167,194,274,312,353,438],"failure.":[15],"This":[16],"study":[17,78,270],"focused":[18],"on":[19,25],"the":[20,26,31,53,61,107,113,142,223,232,264,271,290,307,330,376,392,403,421,441,451],"impact":[21],"of":[22,28,34,89,115,144,156,193,234,267,273,286,294,306,311,326,391,397,407,418,425],"glycemic":[23,336,446],"control":[24,337],"development":[27,424],"DN":[29,90],"metabolic":[32],"consequences":[33],"DN.":[35],"The":[36],"euglycemic":[37],"hyperinsulinemic":[38],"clamp":[39],"technique":[40],"was":[41,220,409],"used":[42,76],"assess":[44],"insulin":[45,48,98,110,147,172,175,179,182,211,218,245,248,486],"sensitivity":[46,111,173,180,212,246],"clearance.":[49,176],"Two":[50],"different":[51,191],"registries,":[52],"Diabetes":[54,64],"Incidence":[55],"Study":[56],"in":[57,81,100,117,160,184,210,213,217,222,231,252,254,276,296,355,369,386,450,490],"Sweden":[58],"(DISS)":[59],"Swedish":[62],"Childhood":[63],"Registry,":[65],"as":[66,68,457,459],"well":[67,458],"questionnaires":[69],"data":[71],"from":[72,289],"medical":[73],"records":[74],"were":[75,240,250,261,334,348],"diabetic":[79,101,474],"complications":[80],"population-based":[82],"cohorts.":[83],"Microalbuminuria":[84],"an":[86],"early":[87,449],"marker":[88,456],"may":[92,495],"also":[93,401,448],"be":[94,496],"impaired":[97],"sensitiv-ity":[99],"non-diabetic":[103],"subjects.":[104],"We":[105,133,177,302],"studied":[106,178,361],"relationship":[108],"between":[109,141,263],"degree":[114,143],"albuminuria":[116,145],"patients":[118,188,277,308,363,434,468],"type":[120,185,345,366,460,470],"1":[121,186,367,471],"diabetes":[122,187,280,295,347,368,419,431,436,462,472],"micro-":[124],"or":[125],"macroalbuminuria":[126],"but":[127,215,258,480],"normal":[128],"glomerular":[129],"filtration":[130],"rate":[131],"(GFR).":[132],"did":[134],"not":[135,216,481],"find":[136],"a":[137,151,158,284,323,410,454,476],"direct":[138],"quantitative":[139],"association":[140],"resistance,":[148],"arguing":[149],"against":[150],"cause-effect":[152],"relationship.":[153],"With":[154],"progression":[155],"DN,":[157],"decline":[159],"GFR":[161],"seen.":[163],"Patients":[164,343],"severe":[166],"failure":[168],"have":[169,352],"both":[170],"im-paired":[171],"clearance":[183],"three":[190,265],"degrees":[192],"involvement":[195,275,354,439],"(none,":[196],"only":[197],"albuminuria,":[198,482],"slightly":[200,477],"reduced":[201,226,478],"GFR,":[202,227,479],"~40-70":[203],"ml/min/1.73":[204],"m2,":[205],"respectively).":[206],"A":[207],"clear":[208],"reduction":[209],"vivo,":[214],"clearance,":[219],"seen":[221],"group":[224],"concomitant":[229],"changes":[230,489],"levels":[233],"PTH,":[235],"IGF-1,":[236],"IL-6":[237],"TNF-\u03b1":[239],"found.":[241],"In":[242,467],"parallel,":[243],"cellular":[244],"degradation":[249],"examined":[251],"vitro,":[253],"subcutaneous":[255],"fat":[256],"cells":[257],"no":[259],"differences":[260],"found":[262,303],"groups":[266],"patients.":[268],"To":[269],"occurrence":[272],"modern":[279,430],"treatment":[281,432],"we":[282,360],"moni-tored":[283],"cohort":[285],"young":[287],"adults":[288],"DISS-registry":[291],"onset":[293,417],"1987-88":[297],"at":[298,371,375,416],"age":[299,357,372,415],"15-34":[300],"years.":[301,444],"that":[304],"~7%":[305],"had":[309],"signs":[310],"involvement,":[313],"i.e.":[314],"incipient":[315],"(5%)":[317],"overt":[319],"(2%),":[321],"after":[322],"median":[324],"follow-up":[325],"~9":[327],"years":[328,374,396,406],"strongest":[331],"risk":[332,412,455],"markers":[333],"poor":[335],"(HbA1c)":[338],"high":[340,464],"blood":[341,465],"pressure.":[342,466],"2":[346,461],"most":[349],"prone":[350],"this":[356],"group.":[358],"Retrospectively,":[359],"94":[362],"diagnosed":[364],"1981-1992":[370],"0-14":[373],"Ume\u00e5":[377],"University":[378],"Hospital.":[379],"Incipient":[380],"background":[383],"retinopathy":[384],"occurred":[385],"18":[387],"45%,":[389],"respectively,":[390],"patients,":[393],"during":[394,402],"~12":[395],"follow-up.":[398],"Glycemic":[399],"control,":[400,447],"first":[404,442],"five":[405],"diabetes,":[408],"strong":[411],"marker.":[413],"Young":[414],"prolonged":[420],"time":[422],"microvascular":[426],"complications.":[427],"Conclusion:":[428],"Despite":[429],"some":[433],"develop":[437],"within":[440],"ten":[443],"Inadequate":[445],"disease,":[452],"neph-ropathy":[475],"resistance.":[487],"Concomi-tant":[488],"insulin-antagonistic":[491],"hormones":[492],"cytokines":[494],"involved.":[497]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}