{"id":"https://openalex.org/W3620037","doi":null,"title":"[Acute porphyria and multiple organ failure during treatment with lamotrigine].","display_name":"[Acute porphyria and multiple organ failure during treatment with lamotrigine].","publication_year":1996,"publication_date":"1996-07-08","ids":{"openalex":"https://openalex.org/W3620037","mag":"3620037","pmid":"https://pubmed.ncbi.nlm.nih.gov/8701527"},"language":"da","primary_location":{"id":"pmid:8701527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8701527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ugeskrift for laeger","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060244358","display_name":"Hans N. Gregersen","orcid":"https://orcid.org/0000-0002-5792-2845","observed_orcids":["https://orcid.org/0000-0002-5792-2845"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Gregersen","raw_affiliation_strings":["Medicinsk-haematologisk afdeling, Arhus Amtssygehus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinsk-haematologisk afdeling, Arhus Amtssygehus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113678212","display_name":"J S Nielsen","orcid":"https://orcid.org/0000-0003-0631-0010","observed_orcids":["https://orcid.org/0000-0003-0631-0010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Nielsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037517173","display_name":"N A Peterslund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Peterslund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.00023711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"158","issue":"28","first_page":"4091","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-porphyria","display_name":"acute porphyria","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-induced-porphyria","display_name":"drug-induced porphyria","score":0.8119999766349792},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8730000257492065},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":1.0},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9390000104904175},{"id":"https://openalex.org/keywords/porphobilinogen","display_name":"porphobilinogen","score":0.9829999804496765},{"id":"https://openalex.org/keywords/coproporphyrin-iii","display_name":"coproporphyrin III","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hereditary-coproporphyria","display_name":"hereditary coproporphyria","score":0.902999997138977},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.9473987221717834},{"id":"https://openalex.org/C2779028619","wikidata":"https://www.wikidata.org/wiki/Q424247","display_name":"Acute intermittent porphyria","level":3,"score":0.8771897554397583},{"id":"https://openalex.org/C2777940757","wikidata":"https://www.wikidata.org/wiki/Q271759","display_name":"Porphyria","level":2,"score":0.783919095993042},{"id":"https://openalex.org/C2776682811","wikidata":"https://www.wikidata.org/wiki/Q421178","display_name":"Porphobilinogen","level":3,"score":0.770212709903717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.636587917804718},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.49235546588897705},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3851926326751709},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3812546730041504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.365756630897522},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.2519051432609558},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09935986995697021}],"mesh":[{"descriptor_ui":"D000077213","descriptor_name":"Lamotrigine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017118","descriptor_name":"Porphyria, Acute Intermittent","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8701527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8701527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ugeskrift for laeger","raw_type":"Case Reports"},{"id":"mag:3620037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8701527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1984620311","https://openalex.org/W1971341908","https://openalex.org/W2023104046","https://openalex.org/W2138896551","https://openalex.org/W2008305494","https://openalex.org/W1964754837","https://openalex.org/W2066569467","https://openalex.org/W2147369142","https://openalex.org/W1995605571"],"related_works":["https://openalex.org/W143053229","https://openalex.org/W7038918367","https://openalex.org/W4367600970","https://openalex.org/W2137494535","https://openalex.org/W51954723","https://openalex.org/W4403108547","https://openalex.org/W2413666744","https://openalex.org/W4387253363","https://openalex.org/W2412203314","https://openalex.org/W2011720601"],"abstract_inverted_index":{"A":[0],"38-year-old":[1],"female":[2],"suffered":[3],"from":[4],"an":[5],"acute":[6],"porphyric":[7,27],"attack,":[8],"multi-organ":[9],"failure":[10],"and":[11,41],"disseminated":[12],"intravascular":[13],"coagulation":[14],"(DIC)":[15],"within":[16],"two":[17],"weeks":[18],"of":[19,35],"starting":[20],"lamotrigine,":[21],"a":[22,44,72],"new":[23],"antiepileptic":[24],"drug.":[25],"The":[26],"attack":[28],"was":[29],"characterized":[30],"by":[31],"excess":[32],"urinary":[33],"excretion":[34],"aminolevulinic":[36],"acid":[37],"(ALA),":[38],"porphobilinogen":[39],"(PBG)":[40],"coproporphyrin":[42],"III,":[43],"pattern":[45],"similar":[46],"to":[47,76],"that":[48,66],"seen":[49],"in":[50],"hereditary":[51],"coproporphyria,":[52],"however":[53],"the":[54,67],"diagnostic":[55],"criteria":[56],"for":[57],"this":[58],"specific":[59],"porphyria":[60],"were":[61],"not":[62],"fulfilled.":[63],"We":[64],"suggest":[65],"observed":[68],"clinical":[69],"picture":[70],"represents":[71],"rare":[73],"adverse":[74],"reaction":[75],"lamotrigine.":[77]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}