{"id":"https://openalex.org/W359361044","doi":null,"title":"Posttranscriptional Gene Regulation: From Global Models to Functional Mechanisms","display_name":"Posttranscriptional Gene Regulation: From Global Models to Functional Mechanisms","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W359361044","mag":"359361044"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8748","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8748","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002434465","display_name":"Marshall A Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marshall Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002434465"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pum1","display_name":"PUM1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/translation-elongation","display_name":"translation elongation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/transcription-factor-targets","display_name":"transcription factor targets","score":0.5379999876022339},{"id":"https://openalex.org/keywords/polysome-profiling","display_name":"polysome profiling","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5244519710540771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3697681427001953},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3354222774505615}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8748","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8748","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:359361044","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/8748/1/Thompson_duke_0066D_12395.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W233806587","https://openalex.org/W1507545655","https://openalex.org/W1519953847","https://openalex.org/W1528632786","https://openalex.org/W1542686183","https://openalex.org/W1587891756","https://openalex.org/W1904537313","https://openalex.org/W1964170234","https://openalex.org/W1964628768","https://openalex.org/W1965557392","https://openalex.org/W1966985603","https://openalex.org/W1969528530","https://openalex.org/W1970339917","https://openalex.org/W1975926030","https://openalex.org/W1979119703","https://openalex.org/W1979521848","https://openalex.org/W1981001162","https://openalex.org/W1982512914","https://openalex.org/W1982925662","https://openalex.org/W1987636603","https://openalex.org/W1988097332","https://openalex.org/W1989263240","https://openalex.org/W1992935306","https://openalex.org/W1993009001","https://openalex.org/W1994778192","https://openalex.org/W1998989083","https://openalex.org/W2001320847","https://openalex.org/W2003478746","https://openalex.org/W2003787418","https://openalex.org/W2003911773","https://openalex.org/W2011368877","https://openalex.org/W2012112428","https://openalex.org/W2013091180","https://openalex.org/W2015175027","https://openalex.org/W2019522436","https://openalex.org/W2019824435","https://openalex.org/W2020081155","https://openalex.org/W2028583641","https://openalex.org/W2032619610","https://openalex.org/W2033509582","https://openalex.org/W2034046460","https://openalex.org/W2036598706","https://openalex.org/W2038622868","https://openalex.org/W2038747540","https://openalex.org/W2040108707","https://openalex.org/W2041549964","https://openalex.org/W2042392327","https://openalex.org/W2045830695","https://openalex.org/W2046726975","https://openalex.org/W2048085228","https://openalex.org/W2048383058","https://openalex.org/W2049003872","https://openalex.org/W2049402769","https://openalex.org/W2049917981","https://openalex.org/W2050256969","https://openalex.org/W2050433648","https://openalex.org/W2052703210","https://openalex.org/W2053003053","https://openalex.org/W2053961182","https://openalex.org/W2054546933","https://openalex.org/W2058220225","https://openalex.org/W2058691182","https://openalex.org/W2059646461","https://openalex.org/W2064492560","https://openalex.org/W2066484804","https://openalex.org/W2070672503","https://openalex.org/W2072300667","https://openalex.org/W2073424121","https://openalex.org/W2077906921","https://openalex.org/W2078819000","https://openalex.org/W2080182910","https://openalex.org/W2080498142","https://openalex.org/W2090759199","https://openalex.org/W2091095457","https://openalex.org/W2095974123","https://openalex.org/W2096212056","https://openalex.org/W2096259566","https://openalex.org/W2099029060","https://openalex.org/W2101888232","https://openalex.org/W2102107106","https://openalex.org/W2102687059","https://openalex.org/W2104783138","https://openalex.org/W2107594198","https://openalex.org/W2109821031","https://openalex.org/W2111069555","https://openalex.org/W2117391818","https://openalex.org/W2118577784","https://openalex.org/W2118994852","https://openalex.org/W2121583448","https://openalex.org/W2121596680","https://openalex.org/W2121604817","https://openalex.org/W2123079914","https://openalex.org/W2123171788","https://openalex.org/W2123969459","https://openalex.org/W2124164469","https://openalex.org/W2125471952","https://openalex.org/W2125593267","https://openalex.org/W2126602684","https://openalex.org/W2128920732","https://openalex.org/W2129414453","https://openalex.org/W2129615992","https://openalex.org/W2130615249","https://openalex.org/W2132770871","https://openalex.org/W2135070076","https://openalex.org/W2135084953","https://openalex.org/W2138630554","https://openalex.org/W2139044529","https://openalex.org/W2139956963","https://openalex.org/W2142040566","https://openalex.org/W2142395890","https://openalex.org/W2145299132","https://openalex.org/W2146443458","https://openalex.org/W2146472503","https://openalex.org/W2147211787","https://openalex.org/W2147647489","https://openalex.org/W2149480306","https://openalex.org/W2150566147","https://openalex.org/W2151936673","https://openalex.org/W2152136268","https://openalex.org/W2153368605","https://openalex.org/W2154179678","https://openalex.org/W2155088319","https://openalex.org/W2155146718","https://openalex.org/W2155984955","https://openalex.org/W2156602474","https://openalex.org/W2157338279","https://openalex.org/W2159094949","https://openalex.org/W2159376549","https://openalex.org/W2161820095","https://openalex.org/W2162293366","https://openalex.org/W2162674813","https://openalex.org/W2168806010","https://openalex.org/W2169300762","https://openalex.org/W2170778160","https://openalex.org/W2170949754","https://openalex.org/W2258494853","https://openalex.org/W4299497796"],"related_works":["https://openalex.org/W2256956200","https://openalex.org/W2023061112","https://openalex.org/W28028471","https://openalex.org/W2703739553","https://openalex.org/W2118761833","https://openalex.org/W2142040566","https://openalex.org/W2611376248","https://openalex.org/W7097038559","https://openalex.org/W2148542126","https://openalex.org/W7099077784"],"abstract_inverted_index":{"Precise":[0],"regulation":[1,177,339],"of":[2,6,14,20,45,55,60,68,77,87,102,112,120,126,134,137,166,171,200,208,216,220,231,246,258,277,306,322,325,333,340,348,360,366,373,386,394,397,427,432,439,455,464,470,485],"the":[3,26,56,69,75,84,88,108,113,135,186,201,217,226,232,275,323,326,331,337,346,355,367,371,392,413,425,436,450,453,462,465,479,486],"complex":[4,481],"process":[5],"gene":[7,46,167,188,221,374,487],"expression":[8,47,76,168,189,488],"is":[9,23,38],"essential":[10],"for":[11,181,287,363,389,424],"all":[12],"aspects":[13],"life,":[15],"and":[16,31,66,110,129,131,142,149,228,239,248,255,281,289,329,415,441,452,482],"a":[17,99,118,197,206,213,244,285,302,309,319,361,387,422,428],"large":[18],"degree":[19],"this":[21,172,334,418,471],"precision":[22],"mediated":[24],"at":[25],"posttranscriptional":[27,36,89,103,114,176,202,218,433],"level.":[28],"The":[29],"global":[30,85,100,121,124,157,256,429],"individual":[32,61,78,138],"mechanisms":[33,70,227],"by":[34,71],"which":[35,72],"control":[37,219,393],"coordinated":[39],"to":[40,185,272,380,476],"maintain":[41],"or":[42],"alter":[43],"levels":[44],"as":[48],"necessary":[49,475],"are":[50,270],"not":[51],"fully":[52,273,477],"understood.":[53],"Identification":[54],"mRNA":[57,127,268,401],"target":[58,153,241,343],"sets":[59],"RNA":[62,259],"binding":[63],"proteins":[64],"(RBPs)":[65],"characterization":[67],"RBPs":[73],"regulate":[74],"mRNAs":[79,344],"provide":[80,421],"some":[81],"insight":[82],"into":[83,98],"structure":[86,109,210],"environment.":[90],"However,":[91,376],"few":[92],"studies":[93,125,133,158],"have":[94,106],"integrated":[95,164,430,468],"these":[96,456],"findings":[97,295,416],"model":[101,165,173,262,431],"control.":[104,434],"We":[105,352],"explored":[107,225],"function":[111,136,324,407],"regulatory":[115,406,489],"system":[116,312],"through":[117,243,345],"combination":[119,245],"modeling":[122,247],"approaches,":[123,250],"translation":[128,307,395],"decay,":[130],"mechanistic":[132,320],"RBPs,":[139],"specifically":[140],"HuR":[141,280,299],"Pum1.":[143],"By":[144],"combining":[145],"RBP-mRNA":[146],"association":[147,234,278],"data":[148,154],"transcription":[150],"factor":[151],"(TF)":[152],"from":[155],"separate":[156],"in":[159,266,304,308,336,357,370,383,391,399,417,449],"yeast,":[160],"we":[161,195,224,317,377],"developed":[162],"an":[163,236],"regulation.":[169,193],"Evaluation":[170],"indicates":[174,263],"that":[175,204,264,298,404],"may":[178,211,300,408],"be":[179,212,409,445,474],"responsible":[180],"substantially":[182],"greater":[183],"contributions":[184],"overall":[187],"program":[190],"than":[191],"transcriptional":[192],"Further,":[194],"identified":[196],"self-regulatory":[198],"feature":[199,215],"network":[203],"suggests":[205],"`regulators":[207],"regulators'":[209],"defining":[214],"expression.":[222,375],"Additionally,":[223],"functional":[229],"consequences":[230],"dynamic":[233,310],"between":[235,279],"RBP,":[237],"HuR,":[238],"its":[240,282],"RNAs":[242],"experimental":[249],"including":[251],"polysome":[252],"profile":[253],"analysis":[254,321],"measurement":[257],"stability.":[260],"Our":[261,294],"changes":[265],"total":[267],"abundance":[269],"insufficient":[271],"explain":[274],"dynamics":[276],"targets,":[283,402],"suggesting":[284,403],"role":[286,303,332,362,388],"competition":[288],"cooperation":[290],"with":[291],"other":[292],"RBPs.":[293],"also":[296,353],"indicate":[297],"play":[301],"inhibition":[305],"immunological":[311],"(T":[313],"cell":[314],"activation).":[315],"Finally,":[316],"performed":[318],"Pum1":[327,368,390],"RBP":[328],"characterized":[330],"protein":[335,369],"translational":[338],"several":[341],"important":[342],"use":[347],"luciferase":[349],"reporter":[350],"assays.":[351],"provided":[354],"first":[356],"vivo":[358,400],"evidence":[359],"specific":[364],"regions":[365],"mediation":[372],"were":[378],"unable":[379],"verify":[381],"previous":[382],"vitro":[384],"reports":[385],"elongation":[396],"verified":[398],"Pum1's":[405],"context":[410],"dependent.":[411],"Ultimately,":[412],"approaches":[414],"study":[419],"will":[420,458,473],"framework":[423],"development":[426,438,463],"Through":[435],"iterative":[437],"models":[440],"experimentation,":[442],"hypotheses":[443],"can":[444],"generated":[446],"and,":[447],"tested":[448],"laboratory,":[451],"results":[454],"experiments":[457],"then":[459],"further":[460],"improve":[461],"models.":[466],"An":[467],"approach":[469],"type":[472],"understand":[478],"highly":[480],"interconnected":[483],"nature":[484],"system.":[490]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
