{"id":"https://openalex.org/W359096941","doi":null,"title":"The crosstalk between B-cell receptor mediated signaling and the actin cytoskeleton","display_name":"The crosstalk between B-cell receptor mediated signaling and the actin cytoskeleton","publication_year":2008,"publication_date":"2008-08-15","ids":{"openalex":"https://openalex.org/W359096941","mag":"359096941"},"language":"en","primary_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/8617","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1903/8617","pdf_url":null,"source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027717686","display_name":"Shruti Sharma","orcid":"https://orcid.org/0000-0001-5423-1072","observed_orcids":["https://orcid.org/0000-0001-5423-1072"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shruti Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5423-1072","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027717686"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.19679999351501465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/wasps","display_name":"wasps","score":0.9879999756813049},{"id":"https://openalex.org/keywords/n-wasp","display_name":"N-WASP","score":1.0},{"id":"https://openalex.org/keywords/vav","display_name":"Vav","score":0.8669999837875366},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9359999895095825},{"id":"https://openalex.org/keywords/antigen-uptake","display_name":"antigen uptake","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8629999756813049},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tec-kinase","display_name":"Tec kinase","score":0.5690000057220459},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.903698205947876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6376047730445862},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5571333765983582},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5438668131828308},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5258845686912537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34679704904556274},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24617621302604675},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18555527925491333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15890014171600342},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.058717191219329834}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:drum.lib.umd.edu:1903/8617","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1903/8617","pdf_url":null,"source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:359096941","doi":null,"is_oa":false,"landing_page_url":"https://drum.lib.umd.edu/bitstream/1903/8617/1/umi-umd-5729.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":323,"referenced_works":["https://openalex.org/W18817743","https://openalex.org/W24559370","https://openalex.org/W136542906","https://openalex.org/W164293537","https://openalex.org/W199132020","https://openalex.org/W1482761126","https://openalex.org/W1483162601","https://openalex.org/W1487500734","https://openalex.org/W1489480103","https://openalex.org/W1492832985","https://openalex.org/W1492937665","https://openalex.org/W1498435062","https://openalex.org/W1509485250","https://openalex.org/W1509530066","https://openalex.org/W1512595753","https://openalex.org/W1513093379","https://openalex.org/W1520610591","https://openalex.org/W1521019157","https://openalex.org/W1522219769","https://openalex.org/W1522396134","https://openalex.org/W1522802573","https://openalex.org/W1537427513","https://openalex.org/W1560969625","https://openalex.org/W1561490090","https://openalex.org/W1564861448","https://openalex.org/W1566581202","https://openalex.org/W1571886555","https://openalex.org/W1572252280","https://openalex.org/W1575892864","https://openalex.org/W1576377498","https://openalex.org/W1578154430","https://openalex.org/W1586171131","https://openalex.org/W1592440579","https://openalex.org/W1595108998","https://openalex.org/W1595316528","https://openalex.org/W1598444116","https://openalex.org/W1599980536","https://openalex.org/W1608613084","https://openalex.org/W1613664762","https://openalex.org/W1626251921","https://openalex.org/W1635630008","https://openalex.org/W1652473508","https://openalex.org/W1666706706","https://openalex.org/W1667545291","https://openalex.org/W1785108662","https://openalex.org/W1829865624","https://openalex.org/W1861660397","https://openalex.org/W1900791279","https://openalex.org/W1918941425","https://openalex.org/W1922523492","https://openalex.org/W1930598094","https://openalex.org/W1942264103","https://openalex.org/W1945926236","https://openalex.org/W1965802234","https://openalex.org/W1965917728","https://openalex.org/W1966408108","https://openalex.org/W1967139887","https://openalex.org/W1968134126","https://openalex.org/W1969457486","https://openalex.org/W1970417260","https://openalex.org/W1970663543","https://openalex.org/W1971178765","https://openalex.org/W1972933543","https://openalex.org/W1975500397","https://openalex.org/W1975852922","https://openalex.org/W1975910030","https://openalex.org/W1976073214","https://openalex.org/W1976710138","https://openalex.org/W1977156769","https://openalex.org/W1978599968","https://openalex.org/W1978790143","https://openalex.org/W1980004909","https://openalex.org/W1980316109","https://openalex.org/W1980834655","https://openalex.org/W1981628302","https://openalex.org/W1981881077","https://openalex.org/W1982022868","https://openalex.org/W1982289564","https://openalex.org/W1982879347","https://openalex.org/W1983503431","https://openalex.org/W1986905293","https://openalex.org/W1988407512","https://openalex.org/W1989686043","https://openalex.org/W1990689709","https://openalex.org/W1991460507","https://openalex.org/W1991497659","https://openalex.org/W1992133410","https://openalex.org/W1994602344","https://openalex.org/W1995062641","https://openalex.org/W1995522742","https://openalex.org/W1996319732","https://openalex.org/W1999477899","https://openalex.org/W2001064691","https://openalex.org/W2001988677","https://openalex.org/W2005398131","https://openalex.org/W2005511164","https://openalex.org/W2006881610","https://openalex.org/W2007417599","https://openalex.org/W2007750331","https://openalex.org/W2008117836","https://openalex.org/W2008488946","https://openalex.org/W2008810169","https://openalex.org/W2009289049","https://openalex.org/W2010220105","https://openalex.org/W2010797082","https://openalex.org/W2016055373","https://openalex.org/W2016253390","https://openalex.org/W2017106676","https://openalex.org/W2018534420","https://openalex.org/W2019590129","https://openalex.org/W2020281512","https://openalex.org/W2021158172","https://openalex.org/W2021329171","https://openalex.org/W2021716242","https://openalex.org/W2022399016","https://openalex.org/W2024060173","https://openalex.org/W2024316397","https://openalex.org/W2024878957","https://openalex.org/W2025412364","https://openalex.org/W2026236404","https://openalex.org/W2026336857","https://openalex.org/W2027226325","https://openalex.org/W2028744022","https://openalex.org/W2029022457","https://openalex.org/W2031026925","https://openalex.org/W2031119298","https://openalex.org/W2031183440","https://openalex.org/W2031263707","https://openalex.org/W2032920854","https://openalex.org/W2032984787","https://openalex.org/W2033145757","https://openalex.org/W2033619721","https://openalex.org/W2034013604","https://openalex.org/W2034146282","https://openalex.org/W2034946023","https://openalex.org/W2035277099","https://openalex.org/W2036068614","https://openalex.org/W2036574499","https://openalex.org/W2036767516","https://openalex.org/W2038744634","https://openalex.org/W2039266510","https://openalex.org/W2039475088","https://openalex.org/W2041437399","https://openalex.org/W2041971745","https://openalex.org/W2042130821","https://openalex.org/W2042209841","https://openalex.org/W2042324409","https://openalex.org/W2042581201","https://openalex.org/W2043763151","https://openalex.org/W2043875007","https://openalex.org/W2043935445","https://openalex.org/W2044654378","https://openalex.org/W2045594979","https://openalex.org/W2045641853","https://openalex.org/W2045708448","https://openalex.org/W2046211031","https://openalex.org/W2046530526","https://openalex.org/W2046590074","https://openalex.org/W2047154687","https://openalex.org/W2047167078","https://openalex.org/W2048949455","https://openalex.org/W2049070107","https://openalex.org/W2049195726","https://openalex.org/W2049367579","https://openalex.org/W2050130095","https://openalex.org/W2051406306","https://openalex.org/W2052006994","https://openalex.org/W2052101498","https://openalex.org/W2052178337","https://openalex.org/W2052302030","https://openalex.org/W2053463045","https://openalex.org/W2053507081","https://openalex.org/W2053541596","https://openalex.org/W2054526083","https://openalex.org/W2057150846","https://openalex.org/W2057413183","https://openalex.org/W2057525817","https://openalex.org/W2057618822","https://openalex.org/W2058629167","https://openalex.org/W2058671009","https://openalex.org/W2059253071","https://openalex.org/W2060382742","https://openalex.org/W2060630008","https://openalex.org/W2061625698","https://openalex.org/W2061728533","https://openalex.org/W2063192139","https://openalex.org/W2068709446","https://openalex.org/W2068984345","https://openalex.org/W2069809502","https://openalex.org/W2070263067","https://openalex.org/W2070561533","https://openalex.org/W2071030911","https://openalex.org/W2071165514","https://openalex.org/W2071670289","https://openalex.org/W2072034032","https://openalex.org/W2072522584","https://openalex.org/W2073706728","https://openalex.org/W2074143045","https://openalex.org/W2074932405","https://openalex.org/W2075353764","https://openalex.org/W2075675512","https://openalex.org/W2075787303","https://openalex.org/W2075878891","https://openalex.org/W2076485183","https://openalex.org/W2076743305","https://openalex.org/W2076747220","https://openalex.org/W2077839196","https://openalex.org/W2077874976","https://openalex.org/W2079980816","https://openalex.org/W2081064697","https://openalex.org/W2081579806","https://openalex.org/W2082821194","https://openalex.org/W2083319707","https://openalex.org/W2083735008","https://openalex.org/W2086015876","https://openalex.org/W2086223697","https://openalex.org/W2086285294","https://openalex.org/W2087139409","https://openalex.org/W2087419010","https://openalex.org/W2088195013","https://openalex.org/W2088741694","https://openalex.org/W2090324342","https://openalex.org/W2090640877","https://openalex.org/W2091901955","https://openalex.org/W2092781921","https://openalex.org/W2093049001","https://openalex.org/W2093390493","https://openalex.org/W2093487975","https://openalex.org/W2094177427","https://openalex.org/W2094391240","https://openalex.org/W2094463103","https://openalex.org/W2094525699","https://openalex.org/W2096084302","https://openalex.org/W2096234619","https://openalex.org/W2096613739","https://openalex.org/W2097139362","https://openalex.org/W2097302710","https://openalex.org/W2097747132","https://openalex.org/W2097767970","https://openalex.org/W2098062162","https://openalex.org/W2098680102","https://openalex.org/W2099555659","https://openalex.org/W2099573412","https://openalex.org/W2100034730","https://openalex.org/W2101882317","https://openalex.org/W2105336865","https://openalex.org/W2106172084","https://openalex.org/W2108852246","https://openalex.org/W2109675261","https://openalex.org/W2110202168","https://openalex.org/W2110575428","https://openalex.org/W2111202304","https://openalex.org/W2111344966","https://openalex.org/W2111481536","https://openalex.org/W2111528051","https://openalex.org/W2112249032","https://openalex.org/W2113148417","https://openalex.org/W2113249117","https://openalex.org/W2113847305","https://openalex.org/W2114245938","https://openalex.org/W2114780139","https://openalex.org/W2115534911","https://openalex.org/W2115607127","https://openalex.org/W2115974508","https://openalex.org/W2117018068","https://openalex.org/W2117123429","https://openalex.org/W2117455815","https://openalex.org/W2119421814","https://openalex.org/W2120587073","https://openalex.org/W2120673613","https://openalex.org/W2121042036","https://openalex.org/W2121756055","https://openalex.org/W2123525329","https://openalex.org/W2126440988","https://openalex.org/W2126873850","https://openalex.org/W2127534803","https://openalex.org/W2129708174","https://openalex.org/W2130343520","https://openalex.org/W2134835707","https://openalex.org/W2135715200","https://openalex.org/W2136611642","https://openalex.org/W2137157133","https://openalex.org/W2137858707","https://openalex.org/W2138302399","https://openalex.org/W2139094884","https://openalex.org/W2140204568","https://openalex.org/W2142214654","https://openalex.org/W2142241097","https://openalex.org/W2144535282","https://openalex.org/W2146576073","https://openalex.org/W2147585056","https://openalex.org/W2147922459","https://openalex.org/W2148759300","https://openalex.org/W2149241258","https://openalex.org/W2151042873","https://openalex.org/W2151171591","https://openalex.org/W2153014356","https://openalex.org/W2153028178","https://openalex.org/W2153274329","https://openalex.org/W2154154147","https://openalex.org/W2154960142","https://openalex.org/W2156802525","https://openalex.org/W2159345791","https://openalex.org/W2161870927","https://openalex.org/W2163407803","https://openalex.org/W2164320307","https://openalex.org/W2164964449","https://openalex.org/W2165364837","https://openalex.org/W2166002768","https://openalex.org/W2166855444","https://openalex.org/W2167158605","https://openalex.org/W2167403404","https://openalex.org/W2168635603","https://openalex.org/W2168734275","https://openalex.org/W2169006700","https://openalex.org/W2171711557","https://openalex.org/W2201242299","https://openalex.org/W2416378933","https://openalex.org/W2417908681","https://openalex.org/W4240451392","https://openalex.org/W4253960665","https://openalex.org/W4313308296","https://openalex.org/W4313377077"],"related_works":["https://openalex.org/W7095685079","https://openalex.org/W195484305","https://openalex.org/W1538100539","https://openalex.org/W6922432609","https://openalex.org/W1497451313","https://openalex.org/W4381611026","https://openalex.org/W7098016090","https://openalex.org/W196028292","https://openalex.org/W2143601035","https://openalex.org/W2015972933"],"abstract_inverted_index":{"Oligomerization":[0],"of":[1,41,61,86,117,129,137,143,153,203,209,224,237,242,258,261,273],"the":[2,28,33,38,52,56,82,87,95,115,127,135,201,222,233,256],"B-cell":[3,219],"receptor":[4],"(BCR)":[5],"by":[6,46,113,133,156,296,310],"antigen":[7,14,190,267,292,316],"leads":[8,183],"to":[9,31,91,97,184,195,285],"both":[10,142],"signal":[11],"transduction":[12],"and":[13,18,59,104,121,131,139,149,176,193,228,239,269,290,294,299,303,318],"internalization":[15,58],"for":[16,37,147,252],"processing":[17,317],"presentation.":[19,319],"Previous":[20],"studies":[21,199],"indicate":[22,276],"that":[23,73,277],"these":[24,274],"processes":[25,36],"intersect":[26],"at":[27],"actin":[29,53,98,111,288],"cytoskeleton":[30,54],"coordinate":[32],"two":[34],"cellular":[35],"optimal":[39],"activation":[40],"B-cells.":[42,124,231],"The":[43],"exact":[44],"mechanism":[45,309],"which":[47,144,279,311],"signals":[48,93],"are":[49,145],"transduced":[50],"via":[51,301],"into":[55],"efficient":[57],"transport":[60],"BCR-antigen":[62],"complexes":[63],"is":[64,89,280],"not":[65],"well":[66,170],"delineated.":[67],"In":[68],"this":[69],"thesis,":[70],"I":[71],"demonstrate":[72],"Bruton's":[74],"tyrosine":[75],"kinase":[76,80],"(Btk),":[77],"a":[78,157,161,185,249,307],"Tec":[79],"in":[81,123,167,172,188,245,255],"early":[83],"signaling":[84,313],"pathway":[85],"BCR,":[88],"able":[90],"transduce":[92],"from":[94],"BCR":[96,107,213,283],"regulatory":[99],"proteins":[100],"such":[101],"as":[102,169,171],"WASP":[103,120,130,148,204,210,216,253,298],"N-WASP.":[105],"Upon":[106],"activation,":[108],"Btk":[109,125,154,179],"modulates":[110],"dynamics":[112,289],"increasing":[114,134],"levels":[116,136,236],"phosphorylated,":[118],"active":[119],"N-WASP":[122,132,150,175,238,300],"regulates":[126,287,314],"activity":[128,155],"PtdIns-4,5-P2":[138,168],"phosphorylated":[140,173],"Vav,":[141],"required":[146],"activation.":[151],"Inhibition":[152],"point":[158],"mutation":[159],"or":[160,181],"specific":[162],"inhibitor":[163],"prevents":[164],"BCR-induced":[165],"increases":[166],"WASP,":[174,243],"Vav.":[177],"Furthermore,":[178],"deficiency":[180,211,217],"inhibition":[182],"severe":[186],"reduction":[187],"BCR-mediated":[189,266,312,315],"internalization,":[191,214],"processing,":[192],"presentation":[194],"cognate":[196],"T-cells.":[197],"Further":[198],"on":[200,212],"role":[202,251],"show":[205],"no":[206],"significant":[207],"effect":[208],"while":[215],"affects":[218],"development,":[220],"decreasing":[221],"numbers":[223],"T1/T2":[225],"immature":[226],"B-cells":[227],"marginal":[229],"zone":[230],"Intriguingly,":[232],"protein":[234],"expression":[235],"WAVE-2,":[240],"homologues":[241,254],"increase":[244],"WASP-/-":[246],"B-cells,":[247],"implicating":[248],"compensatory":[250],"absence":[257],"WASP.":[259],"Over-expression":[260],"N-WASP's":[262],"proline-rich":[263],"domain":[264],"inhibits":[265],"uptake":[268,293],"intracellular":[270],"transport.":[271],"All":[272],"data":[275],"Btk,":[278],"activated":[281],"upon":[282],"binding":[284],"antigen,":[286],"consequently":[291],"transport,":[295],"activating":[297],"Vav":[302],"phosphatidylinositides.":[304],"This":[305],"presents":[306],"novel":[308]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}