{"id":"https://openalex.org/W3586383","doi":null,"title":"[IDH1/2 mutations in gliomas].","display_name":"[IDH1/2 mutations in gliomas].","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W3586383","mag":"3586383","pmid":"https://pubmed.ncbi.nlm.nih.gov/22147457"},"language":"ja","primary_location":{"id":"pmid:22147457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22147457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and nerve = Shinkei kenkyu no shinpo","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051624965","display_name":"Sumihito Nobusawa","orcid":"https://orcid.org/0000-0001-9434-8400","observed_orcids":["https://orcid.org/0000-0001-9434-8400"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumihito Nobusawa","raw_affiliation_strings":["Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075869021","display_name":"Hideaki Yokoo","orcid":"https://orcid.org/0000-0003-1046-6827","observed_orcids":["https://orcid.org/0000-0003-1046-6827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideaki Yokoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1622,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5484913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"63","issue":"12","first_page":"1378","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/idh2-mutation","display_name":"IDH2 mutation","score":1.0},{"id":"https://openalex.org/keywords/isocitrate-dehydrogenase","display_name":"isocitrate dehydrogenase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/anaplastic-glioma","display_name":"anaplastic glioma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/secondary-glioblastoma","display_name":"secondary glioblastoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prognostic-impact","display_name":"prognostic impact","score":0.8420000076293945},{"id":"https://openalex.org/keywords/gliomagenesis","display_name":"gliomagenesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.9749804735183716},{"id":"https://openalex.org/C2776059313","wikidata":"https://www.wikidata.org/wiki/Q21116031","display_name":"IDH2","level":5,"score":0.9673856496810913},{"id":"https://openalex.org/C2779634684","wikidata":"https://www.wikidata.org/wiki/Q3818578","display_name":"Oxidative decarboxylation","level":3,"score":0.7611160278320312},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.7368831038475037},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6849552989006042},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5033754706382751},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.4518328905105591},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42016831040382385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4033207893371582},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.30912676453590393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29209887981414795},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1526796817779541},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11624273657798767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11125725507736206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09637507796287537}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22147457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22147457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and nerve = Shinkei kenkyu no shinpo","raw_type":"Journal Article"},{"id":"mag:3586383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22147457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069303197","https://openalex.org/W2766401178","https://openalex.org/W2154242317","https://openalex.org/W2157219413","https://openalex.org/W1993605227","https://openalex.org/W2310653790","https://openalex.org/W1994756194","https://openalex.org/W3185195364","https://openalex.org/W1574091519","https://openalex.org/W2732180926"],"abstract_inverted_index":{"The":[0],"NADP+-dependent":[1],"isocitrate":[2,13],"dehydrogenases":[3],"1":[4],"and":[5,18,41,47],"2":[6],"(IDH1/2)":[7],"catalyze":[8],"the":[9,60,75,100],"oxidative":[10],"decarboxylation":[11],"of":[12,28,53,62,78,102],"into":[14],"\u03b1-ketoglutarate":[15],"(\u03b1-KG).":[16],"IDH1":[17],"IDH2":[19],"mutations":[20,80,104],"have":[21,48,67],"been":[22,85],"frequently":[23],"found":[24],"in":[25,81,105],"some":[26],"types":[27],"gliomas":[29,32,37,83,94],"(low-grade":[30],"diffuse":[31,93],"WHO":[33,38,44],"grade":[34,39,45],"II,":[35],"anaplastic":[36],"III,":[40],"secondary":[42],"glioblastomas":[43],"IV),":[46],"received":[49],"significant":[50],"attention":[51],"because":[52],"their":[54,69,88],"specificity":[55],"to":[56,108,115],"single":[57],"codons.":[58],"Since":[59],"unveiling":[61],"IDH1/2":[63,103],"mutations,":[64],"many":[65],"studies":[66],"investigated":[68],"clinical":[70],"impact":[71,90],"on":[72,91],"gliomas.":[73,120],"While":[74,99],"favorable":[76],"influence":[77],"these":[79],"high-grade":[82],"has":[84],"well":[86],"established,":[87],"prognostic":[89],"low-grade":[92],"is":[95],"much":[96],"less":[97],"clear.":[98],"mechanism":[101],"gliomagenesis":[106],"remains":[107],"be":[109],"clarified,":[110],"its":[111],"elucidation":[112],"might":[113],"lead":[114],"novel":[116],"therapeutic":[117],"strategies":[118],"against":[119]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
