{"id":"https://openalex.org/W358560299","doi":null,"title":"New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death","display_name":"New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W358560299","mag":"358560299"},"language":"en","primary_location":{"id":"pmh:oai:dc.etsu.edu:etd-2422","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/1782","pdf_url":"https://dc.etsu.edu/etd/1782","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dc.etsu.edu/etd/1782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101429902","display_name":"Zhengke Li","orcid":"https://orcid.org/0000-0001-5560-343X","observed_orcids":["https://orcid.org/0000-0001-5560-343X"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhengke Li","raw_affiliation_strings":["East Tennessee State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101429902"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":null,"apc_paid":null,"fwci":0.2199,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.48495143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/attenuated-total-reflectance","display_name":"ATR","score":0.902999997138977},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9990000128746033},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.8270000219345093},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8389999866485596},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.5040000081062317},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.35600000619888306},{"id":"https://openalex.org/keywords/dna-damage-induced-cell-death","display_name":"DNA damage-induced cell death","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.8531173467636108},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.8237982988357544},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.8236717581748962},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7141416072845459},{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.6249493360519409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5565794110298157},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.5356321930885315},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5076102018356323},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4818783700466156},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.4724947512149811},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.4428475499153137},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43542906641960144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43093717098236084},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.42521360516548157},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.39173176884651184},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.27807891368865967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2517801523208618},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20005828142166138},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15081804990768433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10872000455856323}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dc.etsu.edu:etd-2422","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/1782","pdf_url":"https://dc.etsu.edu/etd/1782","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:358560299","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/cgi/viewcontent.cgi?article=2422&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dc.etsu.edu:etd-2422","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/1782","pdf_url":"https://dc.etsu.edu/etd/1782","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309134","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W358560299.pdf","grobid_xml":"https://content.openalex.org/works/W358560299.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W1237237921","https://openalex.org/W1498528035","https://openalex.org/W1538419182","https://openalex.org/W1722554945","https://openalex.org/W1752089945","https://openalex.org/W1798376596","https://openalex.org/W1926855831","https://openalex.org/W1961406038","https://openalex.org/W1964483580","https://openalex.org/W1965239527","https://openalex.org/W1967049460","https://openalex.org/W1967630574","https://openalex.org/W1967743500","https://openalex.org/W1968516742","https://openalex.org/W1968552183","https://openalex.org/W1968886488","https://openalex.org/W1970858010","https://openalex.org/W1979015046","https://openalex.org/W1979028355","https://openalex.org/W1980438635","https://openalex.org/W1980792888","https://openalex.org/W1981148605","https://openalex.org/W1981504084","https://openalex.org/W1982415372","https://openalex.org/W1983532638","https://openalex.org/W1984353960","https://openalex.org/W1985623956","https://openalex.org/W1986406178","https://openalex.org/W1988051529","https://openalex.org/W1989317177","https://openalex.org/W1990022215","https://openalex.org/W1990850872","https://openalex.org/W1991226544","https://openalex.org/W1993913655","https://openalex.org/W1995979224","https://openalex.org/W1997351836","https://openalex.org/W1997879915","https://openalex.org/W1999317859","https://openalex.org/W2000285763","https://openalex.org/W2000303122","https://openalex.org/W2002891103","https://openalex.org/W2002936090","https://openalex.org/W2003393278","https://openalex.org/W2005284058","https://openalex.org/W2007301739","https://openalex.org/W2007830063","https://openalex.org/W2007942027","https://openalex.org/W2008757142","https://openalex.org/W2009779043","https://openalex.org/W2013000007","https://openalex.org/W2013364831","https://openalex.org/W2013993442","https://openalex.org/W2014894966","https://openalex.org/W2016632539","https://openalex.org/W2017498643","https://openalex.org/W2022811243","https://openalex.org/W2024503639","https://openalex.org/W2026776398","https://openalex.org/W2028307977","https://openalex.org/W2029090108","https://openalex.org/W2029276444","https://openalex.org/W2030861640","https://openalex.org/W2031365072","https://openalex.org/W2042042897","https://openalex.org/W2042779695","https://openalex.org/W2043583113","https://openalex.org/W2043895957","https://openalex.org/W2044079387","https://openalex.org/W2045552152","https://openalex.org/W2046159793","https://openalex.org/W2050293032","https://openalex.org/W2052047151","https://openalex.org/W2056912104","https://openalex.org/W2057834096","https://openalex.org/W2058396982","https://openalex.org/W2059028566","https://openalex.org/W2059078585","https://openalex.org/W2059901912","https://openalex.org/W2059999514","https://openalex.org/W2061505893","https://openalex.org/W2064488040","https://openalex.org/W2065942523","https://openalex.org/W2065986032","https://openalex.org/W2067022597","https://openalex.org/W2067139494","https://openalex.org/W2073235656","https://openalex.org/W2074615071","https://openalex.org/W2074730941","https://openalex.org/W2075234503","https://openalex.org/W2076776668","https://openalex.org/W2077436902","https://openalex.org/W2078842115","https://openalex.org/W2079194083","https://openalex.org/W2080605611","https://openalex.org/W2083874142","https://openalex.org/W2084708321","https://openalex.org/W2087177695","https://openalex.org/W2088529761","https://openalex.org/W2088938515","https://openalex.org/W2090861867","https://openalex.org/W2093814864","https://openalex.org/W2095308878","https://openalex.org/W2095557065","https://openalex.org/W2096053293","https://openalex.org/W2096535852","https://openalex.org/W2096686046","https://openalex.org/W2098935972","https://openalex.org/W2101472561","https://openalex.org/W2102752109","https://openalex.org/W2102991803","https://openalex.org/W2105663975","https://openalex.org/W2106543552","https://openalex.org/W2108309503","https://openalex.org/W2110817748","https://openalex.org/W2111772438","https://openalex.org/W2112451788","https://openalex.org/W2115727327","https://openalex.org/W2116372610","https://openalex.org/W2116594363","https://openalex.org/W2116964110","https://openalex.org/W2117733329","https://openalex.org/W2118411078","https://openalex.org/W2119073219","https://openalex.org/W2120005875","https://openalex.org/W2120784935","https://openalex.org/W2122376329","https://openalex.org/W2126390187","https://openalex.org/W2126530663","https://openalex.org/W2127733528","https://openalex.org/W2128928089","https://openalex.org/W2130013201","https://openalex.org/W2130177169","https://openalex.org/W2131382189","https://openalex.org/W2132536157","https://openalex.org/W2132720521","https://openalex.org/W2134188156","https://openalex.org/W2134487183","https://openalex.org/W2134872883","https://openalex.org/W2137855486","https://openalex.org/W2142544392","https://openalex.org/W2145200068","https://openalex.org/W2149687593","https://openalex.org/W2150072036","https://openalex.org/W2153057184","https://openalex.org/W2156257249","https://openalex.org/W2156354811","https://openalex.org/W2157606357","https://openalex.org/W2159499073","https://openalex.org/W2159747058","https://openalex.org/W2160345685","https://openalex.org/W2162136322","https://openalex.org/W2163229522","https://openalex.org/W2164742545","https://openalex.org/W2165148144","https://openalex.org/W2167498942","https://openalex.org/W2171806736","https://openalex.org/W2400984959","https://openalex.org/W4239885211"],"related_works":["https://openalex.org/W1967049460","https://openalex.org/W2083874142","https://openalex.org/W3175349891","https://openalex.org/W1979028355","https://openalex.org/W2162136322","https://openalex.org/W2767824275","https://openalex.org/W2062564859","https://openalex.org/W2495200680","https://openalex.org/W2065398225","https://openalex.org/W2343054943"],"abstract_inverted_index":{"Integrity":[0],"of":[1,119,128,138,158,163,167,191,218,247,271,283,294,310,314,333],"the":[2,35,63,142,146,172,180,188,192,199,203,213,224,242,269,281,292,299,338],"human":[3],"genome":[4,19],"is":[5,82,116,124,221],"frequently":[6],"threatened":[7],"by":[8,66,241],"endogenous":[9],"and":[10,21,40,50,56,150,165,250,279,288],"exogenous":[11,75],"DNA":[12,30,53,78,130,151,342],"damaging":[13],"reagents":[14],"that":[15,61,96,140,156,179,236],"may":[16,88],"lead":[17],"to":[18,28,33,41,197,212,266,277,319,323,341],"instability":[20],"cancer.":[22],"Cells":[23],"have":[24],"evolved":[25],"multiple":[26],"mechanisms":[27],"repair":[29,39,59,127],"damage":[31,54],"or":[32,73],"eliminate":[34],"damaged":[36],"cells":[37,68],"beyond":[38],"prevent":[42],"diverse":[43],"diseases.":[44],"Among":[45],"these":[46,85],"are":[47,62],"ataxia":[48],"telangiectasia":[49],"Rad3-related":[51],"(ATR)-mediated":[52],"checkpoint":[55,162,244,304],"nucleotide":[57],"excision":[58],"(NER)":[60],"major":[64],"pathways":[65,87],"which":[67],"handle":[69],"ultraviolet":[70],"C":[71],"(UV-C)-":[72],"other":[74],"genotoxin-induced":[76],"bulky":[77],"damage.":[79,131,343],"However,":[80],"it":[81],"unclear":[83],"how":[84],"2":[86],"be":[89,239],"coordinated.":[90],"In":[91,132,195,253],"this":[92],"study":[93,256],"we":[94,154,177,207,257],"show":[95,155,258],"ATR":[97,110,264,295,301,334],"physically":[98],"interacts":[99],"with":[100],"NER":[101,237],"factor":[102],"xeroderma":[103],"pigmentosum":[104],"group":[105],"A":[106],"(XPA)":[107],"where":[108],"an":[109,230],"phosphorylation":[111,149,249],"site":[112],"on":[113,121,296],"serine":[114,122],"196":[115,123],"located.":[117],"Phosphorylation":[118],"XPA":[120,139,148,174,182,204,226,248],"required":[125,222],"for":[126,223],"UV-induced":[129,147,173,225],"addition,":[133],"a":[134,160,254,307,328],"K188A":[135],"point":[136],"mutation":[137],"disrupts":[141],"ATR-XPA":[143],"interaction":[144],"inhibits":[145],"repair.":[152],"Moreover,":[153],"depletion":[157],"p53,":[159],"downstream":[161],"ATR,":[164],"inhibition":[166],"p53":[168],"transcriptional":[169],"activities":[170],"reduced":[171],"import.":[175,252],"Furthermore,":[176],"found":[178,208],"ATR-directed":[181],"nuclear":[183,205,214,227,251,311],"import":[184,228],"happens":[185],"primarily":[186],"in":[187,202,210,229,337],"S":[189],"phase":[190],"cell":[193],"cycle.":[194],"effort":[196],"determine":[198],"mechanism":[200],"involved":[201],"import,":[206],"that,":[209,259],"addition":[211],"localization":[215],"signal":[216],"(NLS)":[217],"XPA,":[219],"importin-\u03b14":[220],"ATR-dependent":[231,243],"manner.":[232],"These":[233,325],"data":[234],"suggest":[235],"could":[238],"regulated":[240],"via":[245],"modulation":[246],"separate":[255],"upon":[260],"UV":[261],"damage,":[262],"cytoplasmic":[263,300],"translocates":[265],"mitochondria,":[267],"blocks":[268],"recruitment":[270],"proapoptotic":[272],"Bcl-2\u2013associated":[273],"X":[274],"(Bax)":[275],"protein":[276],"mitochondria":[278,336],"prevents":[280],"loss":[282],"mitochondrial":[284],"membrane":[285],"potential":[286],"(\u0394\u03a8)":[287],"apoptosis.":[289],"Bax-depletion":[290],"reduces":[291],"effect":[293],"\u0394\u03a8.":[297],"Remarkably,":[298],"exhibits":[302],"no":[303],"kinase":[305,316],"activity,":[306],"hallmark":[308],"function":[309,332],"ATR.":[312],"Silencing":[313],"ATR\u2019s":[315],"activity":[317],"failed":[318],"affect":[320],"Bax":[321],"relocalization":[322],"mitochondria.":[324],"results":[326],"reveal":[327],"novel":[329],"checkpoint-independent":[330],"antiapoptotic":[331],"at":[335],"cellular":[339],"response":[340]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}