{"id":"https://openalex.org/W3582920","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16785","title":"Abstract 16785: Molecular Mechanisms of the Crosstalk Between Mitochondrial and NADPH Oxidase Derived Reactive Oxygen Species in White Blood Cells - Implications for Cardiovascular Diseases","display_name":"Abstract 16785: Molecular Mechanisms of the Crosstalk Between Mitochondrial and NADPH Oxidase Derived Reactive Oxygen Species in White Blood Cells - Implications for Cardiovascular Diseases","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W3582920","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16785","mag":"3582920"},"language":"en","primary_location":{"id":"doi:10.1161/circ.124.suppl_21.a16785","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16785","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.124.suppl_21.a16785","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074883323","display_name":"Philip Wenzel","orcid":"https://orcid.org/0000-0002-5397-2781","observed_orcids":["https://orcid.org/0000-0002-5397-2781"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philip Wenzel","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Philip Wenzel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Philip Wenzel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075380817","display_name":"Swenja Schuhmacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Swenja Schuhmacher","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Swenja Schuhmacher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Swenja Schuhmacher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064993444","display_name":"Matthias Walter Oelze","orcid":"https://orcid.org/0000-0002-5939-7263","observed_orcids":["https://orcid.org/0000-0002-5939-7263"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Oelze","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Matthias Oelze"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Matthias Oelze","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander Scholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Scholz","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Alexander Scholz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Alexander Scholz","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061984411","display_name":"Steffen Daub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Daub","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Steffen Daub"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Steffen Daub","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023789739","display_name":"Maike Knorr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maike Knorr","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Maike Knorr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Maike Knorr","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101413005","display_name":"Ning Xia","orcid":"https://orcid.org/0000-0002-5553-1752","observed_orcids":["https://orcid.org/0000-0002-5553-1752"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ning Xia","raw_affiliation_strings":["Pharmacology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Ning Xia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Ning Xia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christian Otto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Otto","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Christian Otto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Christian Otto","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003051610","display_name":"Benjamin Opitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benjamin Opitz","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Benjamin Opitz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Benjamin Opitz","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107446063","display_name":"Eberhard Schulz","orcid":"https://orcid.org/0000-0003-2031-6662","observed_orcids":["https://orcid.org/0000-0003-2031-6662","https://orcid.org/0000-0002-7791-6901"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eberhard Schulz","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Eberhard Schulz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Eberhard Schulz","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064206049","display_name":"Huige Li","orcid":"https://orcid.org/0000-0003-3458-7391","observed_orcids":["https://orcid.org/0000-0003-3458-7391"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Huige Li","raw_affiliation_strings":["Pharmacology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Huige Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Huige Li","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075174977","display_name":"Karl Johannes Lackner","orcid":"https://orcid.org/0000-0002-1985-7931","observed_orcids":["https://orcid.org/0000-0002-1985-7931"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Lackner","raw_affiliation_strings":["Clinical Chemistry and Laboratory Medicine, Universita\u0308tsmedizin Mainz, Mainz, Germany","Karl Lackner"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry and Laboratory Medicine, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Karl Lackner","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521673","display_name":"Thomas F. M\u00fcnzel","orcid":"https://orcid.org/0000-0001-5503-4150","observed_orcids":["https://orcid.org/0000-0001-5503-4150"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Mu\u0308nzel","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039361810","display_name":"Andreas Daiber","orcid":"https://orcid.org/0000-0002-2769-0094","observed_orcids":["https://orcid.org/0000-0002-2769-0094"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Daiber","raw_affiliation_strings":["Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","Andreas Daiber"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Universita\u0308tsmedizin Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Andreas Daiber","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094062"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"suppl_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8840000033378601},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cyclophilin-d","display_name":"cyclophilin D","score":0.921999990940094},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.8769999742507935},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7089999914169312},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apocynin","display_name":"apocynin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chelerythrine","display_name":"chelerythrine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7900000214576721},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7377499341964722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7231059670448303},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.7094866037368774},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5997647047042847},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4578174650669098},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4262947738170624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36061087250709534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34992921352386475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11385944485664368},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08446758985519409},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.124.suppl_21.a16785","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16785","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.124.suppl_21.a16785","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3177338077","https://openalex.org/W2011963516","https://openalex.org/W3175872484","https://openalex.org/W2194482967","https://openalex.org/W2315500027","https://openalex.org/W2912202666","https://openalex.org/W1968678717","https://openalex.org/W2011124873","https://openalex.org/W3018504577","https://openalex.org/W2092955642"],"abstract_inverted_index":{"Background:":[0],"Many":[1],"diseases":[2,295],"and":[3,20,24,36,64,130,158,173],"drug-induced":[4],"complications":[5],"are":[6],"associated":[7],"or":[8,87,195,217],"even":[9],"based":[10],"on":[11,40,291],"an":[12],"imbalance":[13],"between":[14,43,171],"the":[15,28,50,57,72,109,118,141,152,202,281],"formation":[16,157,162],"of":[17,30,46,74,90,97,126,133,137,154,186,193,201,283,293,304],"reactive":[18],"oxygen":[19],"nitrogen":[21],"species":[22],"(ROS/RNS)":[23],"antioxidant":[25],"enzymes":[26],"catalyzing":[27],"break-down":[29],"these":[31,138],"harmful":[32],"oxidants.":[33],"Previously":[34],"we":[35,53],"others":[37],"have":[38,255,288],"reported":[39],"a":[41,100,297,301],"crosstalk":[42,170,206],"different":[44,106],"sources":[45],"oxidative":[47,76,264,305],"stress.":[48,306],"With":[49],"present":[51],"study":[52,71],"sought":[54],"to":[55,70,84,166,247,267],"determine":[56],"underlying":[58],"mechanism":[59],"for":[60,108,191],"this":[61,169,205],"crosstalk.":[62],"Methods":[63],"results:":[65],"Human":[66],"neutrophils":[67],"were":[68,239],"used":[69,105],"induction":[73],"Nox-dependent":[75],"burst":[77],"by":[78,94,99],"mitochondrial":[79,119,155,263,278],"ROS":[80,98,145,156,279],"(mtROS)":[81],"in":[82,179,209,226,229,235,242],"response":[83],"antimycin":[85,142],"A":[86,116],"myxothiazol.":[88],"Activation":[89],"Nox2":[91],"was":[92,176,207],"measured":[93],"extracellular":[95,144,160],"detection":[96],"peroxidase-coupled":[101],"chemiluminescence":[102],"assay.":[103],"We":[104,221],"inhibitors":[107,139],"involved":[110],"signaling":[111],"cascade":[112],"such":[113],"as":[114,232,234,245],"cyclosporine":[115],"(inhibits":[117],"permeability":[120],"transition":[121],"pore":[122],"[mPTP]),":[123],"chelerythine":[124],"(inhibitor":[125,132],"protein":[127],"kinase":[128],"C)":[129],"apocynin":[131],"NADPH":[134,174,236,258,284],"oxidase).":[135],"All":[136],"suppressed":[140,178],"A/myxothiazol-triggered":[143],"signal,":[146],"whereas":[147,204],"exogenous":[148],"hydrogen":[149],"peroxide":[150],"mimicked":[151],"effect":[153],"caused":[159],"superoxide":[161],"(lucigenin":[163],"ECL).":[164],"According":[165],"preliminary":[167],"data,":[168],"mtROS":[172],"oxidase":[175,237,259],"also":[177,222],"white":[180,210],"blood":[181,211,227],"cells":[182,212],"from":[183,213,218],"mice":[184,216,244],"deficient":[185,215],"p47phox":[187],"(an":[188],"essential":[189],"subunit":[190,200],"activation":[192,282],"Nox2)":[194],"cyclophilin":[196],"D":[197],"(a":[198],"regulatory":[199],"mPTP),":[203],"amplified":[208],"GPx-1":[214],"MnSOD+/-":[219,243],"mice.":[220],"observed":[223],"that":[224,257,277],"increases":[225],"pressure,":[228],"endothelial":[230],"dysfunction":[231],"well":[233],"activity":[238],"more":[240],"pronounced":[241],"compared":[246],"their":[248],"wild":[249],"type":[250],"littermates.":[251],"Conclusions:":[252],"Previous":[253],"data":[254,274],"demonstrated":[256],"derived":[260],"ROS/RNS":[261],"stimulate":[262],"stress":[265],"contributing":[266],"overall":[268],"angiotensin-II":[269],"dependent":[270],"cellular":[271],"dysfunction.":[272],"Our":[273],"now":[275],"show":[276],"trigger":[280],"oxidase,":[285],"which":[286],"may":[287],"severe":[289],"effects":[290],"progression":[292],"cardiovascular":[294],"representing":[296],"feedback":[298],"loop":[299],"creating":[300],"vicious":[302],"circle":[303]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}