{"id":"https://openalex.org/W356005725","doi":null,"title":"Efficacy of Pt-modified TiO(2) nanoparticles in cardiac cells.","display_name":"Efficacy of Pt-modified TiO(2) nanoparticles in cardiac cells.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W356005725","mag":"356005725","pmid":"https://pubmed.ncbi.nlm.nih.gov/21523200","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3076159"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2091017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3076159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3076159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068859761","display_name":"Adiel Mallik","orcid":"https://orcid.org/0000-0002-6792-1061","observed_orcids":["https://orcid.org/0000-0002-6792-1061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adiel Mallik","raw_affiliation_strings":["Biology Department;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sean Bryan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Bryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002874743","display_name":"Stephanie Puukila","orcid":"https://orcid.org/0000-0001-8932-5503","observed_orcids":["https://orcid.org/0000-0001-8932-5503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Puukila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037341278","display_name":"Aicheng Chen","orcid":"https://orcid.org/0000-0002-2239-6785","observed_orcids":["https://orcid.org/0000-0002-2239-6785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aicheng Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043777152","display_name":"Neelam Khaper","orcid":"https://orcid.org/0000-0002-2467-3766","observed_orcids":["https://orcid.org/0000-0002-2467-3766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neelam Khaper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5545,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59384468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"6","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/h9c2-cells","display_name":"H9c2 cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":1.0},{"id":"https://openalex.org/keywords/nanoparticle-synthesis","display_name":"nanoparticle synthesis","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2777402863","wikidata":"https://www.wikidata.org/wiki/Q413357","display_name":"Anatase","level":4,"score":0.7726328372955322},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6914302110671997},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.628145694732666},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.614225447177887},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5423309803009033},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.4388234615325928},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43751275539398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4201722741127014},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3399387001991272},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.228131502866745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2062903344631195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15168681740760803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1307644248008728},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09728410840034485},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2091017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3076159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21523200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21523200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3076159","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3076159/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Clin Cardiol","raw_type":"Text"},{"id":"mag:356005725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21523200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2091017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3076159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1965918911","https://openalex.org/W1969911040","https://openalex.org/W1978653530","https://openalex.org/W2001797110","https://openalex.org/W2003753489","https://openalex.org/W2008830964","https://openalex.org/W2008860621","https://openalex.org/W2013732967","https://openalex.org/W2013788499","https://openalex.org/W2018822649","https://openalex.org/W2044674685","https://openalex.org/W2050081396","https://openalex.org/W2052607700","https://openalex.org/W2053078375","https://openalex.org/W2053123029","https://openalex.org/W2070756781","https://openalex.org/W2081785381","https://openalex.org/W2083404959","https://openalex.org/W2084132208","https://openalex.org/W2092448369","https://openalex.org/W2094622646","https://openalex.org/W2099191918","https://openalex.org/W2101681003","https://openalex.org/W2123838498","https://openalex.org/W2126129355","https://openalex.org/W2131580401","https://openalex.org/W2134979688","https://openalex.org/W2170305113","https://openalex.org/W2302311597","https://openalex.org/W2395295459","https://openalex.org/W2523367608"],"related_works":["https://openalex.org/W2885312427","https://openalex.org/W2075976638","https://openalex.org/W2765272880","https://openalex.org/W1976227626","https://openalex.org/W2127259475","https://openalex.org/W3021356362","https://openalex.org/W2963370178","https://openalex.org/W7096580975","https://openalex.org/W4322721608","https://openalex.org/W2238299915"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"application":[2],"of":[3,19,65,89,111],"TiO(2)":[4,21,31,90],"nanoparticles":[5,32,91],"promises":[6],"to":[7,135],"revolutionize":[8],"cardiac":[9,56,136],"imaging":[10],"and":[11,26,39,50,76],"targeted":[12],"medical":[13],"treatment.":[14],"METHODS:":[15],"A":[16],"novel":[17],"type":[18],"platinum-modified":[20],"(Pt-TiO(2))":[22],"nanoparticle":[23,46],"was":[24,61],"synthesized":[25],"characterized.":[27],"Commercially":[28],"available":[29],"P25":[30],"were":[33,42],"used":[34],"for":[35],"comparison.":[36],"Cellular":[37],"toxicity":[38],"its":[40],"mechanisms":[41],"evaluated":[43],"by":[44],"analyzing":[45],"uptake,":[47],"oxidative":[48,74],"stress":[49,75],"mitochondrial":[51,80],"membrane":[52,81],"potential":[53],"in":[54,73,79,116,126],"rat":[55],"(H9c2)":[57],"cells.":[58],"RESULTS:":[59],"There":[60],"greater":[62,71,77],"cellular":[63],"uptake":[64,118],"Pt-TiO(2).":[66],"Furthermore,":[67],"Pt-TiO(2)":[68],"caused":[69],"a":[70,120,131],"increase":[72,125],"decrease":[78],"potential.":[82],"These":[83],"data":[84],"suggest":[85],"that":[86,130],"Pt":[87,112],"modification":[88],"rendered":[92],"them":[93],"more":[94,102],"cytotoxic":[95],"than":[96],"their":[97],"commercial":[98],"counterparts":[99],"at":[100,119],"lower,":[101],"physiologically":[103],"relevant":[104],"concentrations.":[105],"CONCLUSION:":[106],"Despite":[107],"the":[108,123],"functional":[109],"advantages":[110],"modification,":[113],"which":[114],"results":[115],"increased":[117],"lower":[121],"concentration,":[122],"corresponding":[124],"cardiotoxic":[127],"effect":[128],"indicates":[129],"thoughtful,":[132],"cautious":[133],"approach":[134],"nanotechnologies":[137],"is":[138],"required.":[139]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}