{"id":"https://openalex.org/W35547530","doi":"https://doi.org/10.1007/978-1-59745-117-8_7","title":"MALDI/SELDI Protein Profiling of Serum for the Identification of Cancer Biomarkers","display_name":"MALDI/SELDI Protein Profiling of Serum for the Identification of Cancer Biomarkers","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W35547530","doi":"https://doi.org/10.1007/978-1-59745-117-8_7","mag":"35547530","pmid":"https://pubmed.ncbi.nlm.nih.gov/18287771"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-117-8_7","doi":"https://doi.org/10.1007/978-1-59745-117-8_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-117-8_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology\u2122","raw_type":"book-chapter"},"parent_works":[{"id":"https://openalex.org/W4237435323","display_name":"Clinical Proteomics","relationship":"volume"}],"lineage":["https://openalex.org/W35547530","https://openalex.org/W4237435323"],"child_works_count":0,"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081800325","display_name":"Lisa H. Cazares","orcid":"https://orcid.org/0000-0001-5754-6192","observed_orcids":["https://orcid.org/0000-0001-5754-6192"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa H Cazares","raw_affiliation_strings":["George L. Wright Jr. Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, VA, USA","The George L. Wright Jr. Center for Biomedical\nProteomics Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George L. Wright Jr. Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, VA, USA","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"The George L. Wright Jr. Center for Biomedical\nProteomics Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113588994","display_name":"Jos\u00e9 I. Diaz","orcid":"https://orcid.org/0009-0008-5535-5104","observed_orcids":["https://orcid.org/0009-0008-5535-5104"]},"institutions":[{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose I Diaz","raw_affiliation_strings":["Cancer Therapy Research Center\u2019s Institute for Drug\nDevelopment, University of Texas, Health Science Center, Athens, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy Research Center\u2019s Institute for Drug\nDevelopment, University of Texas, Health Science Center, Athens, TX","institution_ids":["https://openalex.org/I16452829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037196327","display_name":"Rick R Drake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick R Drake","raw_affiliation_strings":["Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114013696","display_name":"O. John Semmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O John Semmes","raw_affiliation_strings":["The George L. Wright Jr. Center for Biomedical\nProteomics, Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George L. Wright Jr. Center for Biomedical\nProteomics, Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.754,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.97976081,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"428","issue":null,"first_page":"125","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8040000200271606},{"id":"https://openalex.org/keywords/serum-proteome","display_name":"serum proteome","score":0.921999990940094},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.9160000085830688},{"id":"https://openalex.org/keywords/seldi-tof-ms","display_name":"SELDI-TOF-MS","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-expression-profiling","display_name":"protein expression profiling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6981109976768494},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6784128546714783},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.6713497638702393},{"id":"https://openalex.org/C139883154","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Surface-enhanced laser desorption/ionization","level":5,"score":0.5921362638473511},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5637168884277344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48284655809402466},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.422616571187973},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4126681685447693},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4108024537563324},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34945428371429443},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.25525176525115967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22296077013015747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20456337928771973},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.1879122257232666},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.11561739444732666},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.07979154586791992},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-59745-117-8_7","doi":"https://doi.org/10.1007/978-1-59745-117-8_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-117-8_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology\u2122","raw_type":"book-chapter"},{"id":"pmid:18287771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18287771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8538878680","display_name":"Early Detection of Cancer By Affinity Mass Spectrometry","funder_award_id":"U01CA085067","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1502093883","https://openalex.org/W1965693707","https://openalex.org/W1971654402","https://openalex.org/W1988575792","https://openalex.org/W1989645989","https://openalex.org/W1996923694","https://openalex.org/W2019434020","https://openalex.org/W2040729098","https://openalex.org/W2051301080","https://openalex.org/W2056375314","https://openalex.org/W2057356121","https://openalex.org/W2074197623","https://openalex.org/W2096459935","https://openalex.org/W2108725536","https://openalex.org/W2113334864","https://openalex.org/W2122430069","https://openalex.org/W2124381019","https://openalex.org/W2130213158","https://openalex.org/W2132395789","https://openalex.org/W2134389439","https://openalex.org/W2146146709","https://openalex.org/W2147580973","https://openalex.org/W2169182264","https://openalex.org/W2260383732","https://openalex.org/W2519438632"],"related_works":["https://openalex.org/W2751462343","https://openalex.org/W2106435994","https://openalex.org/W2461030400","https://openalex.org/W2184185403","https://openalex.org/W1998107957","https://openalex.org/W2042729651","https://openalex.org/W2080273654","https://openalex.org/W2051830951","https://openalex.org/W2144356400","https://openalex.org/W2048398689"],"abstract_inverted_index":{"The":[0],"ability":[1,29],"to":[2,30,39,55,86,103],"visualize":[3],"the":[4,8,28,49],"full":[5],"depth":[6],"of":[7,19,44,51,60,71,92],"serum":[9],"proteome":[10],"in":[11,96],"a":[12,16,46,69],"high-throughput":[13],"manner":[14],"is":[15,48,68],"major":[17],"goal":[18],"clinical":[20],"proteomics.":[21],"Methodologies,":[22],"which":[23,106],"combine":[24],"higher":[25],"throughput":[26],"with":[27],"observe":[31],"differential":[32],"protein":[33,88],"expression":[34,89],"levels,":[35],"have":[36,83],"been":[37,84],"applied":[38],"this":[40,66],"goal.":[41],"An":[42],"example":[43],"such":[45],"system":[47],"coupling":[50],"robotic":[52],"sample":[53],"processing":[54],"matrix-assisted":[56],"laser":[57,75],"desorption":[58],"time":[59],"flight":[61],"mass":[62],"spectrometry":[63],"(MALDI-TOF-MS).":[64],"Within":[65],"paradigm":[67],"modification":[70],"MALDI-TOF":[72],"termed":[73],"surface-enhanced":[74],"desorption/ionization-TOF":[76],"(SELDI-TOF).":[77],"Both":[78],"conventional":[79],"MALDI":[80],"and":[81,111],"SELDI":[82],"used":[85,102],"generate":[87],"profiles":[90],"reflective":[91],"potential":[93],"peptide":[94],"changes":[95],"serum.":[97],"This":[98],"information":[99],"can":[100],"be":[101],"identify":[104],"proteins,":[105],"may":[107],"enable":[108],"new":[109],"diagnostic":[110],"therapeutic":[112],"strategies.":[113]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}