{"id":"https://openalex.org/W35477986","doi":null,"title":"Corticotropin-releasing hormone modulators and depression.","display_name":"Corticotropin-releasing hormone modulators and depression.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W35477986","mag":"35477986","pmid":"https://pubmed.ncbi.nlm.nih.gov/12625028"},"language":"en","primary_location":{"id":"pmid:12625028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Florian Holsboer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Holsboer","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany. holsboer@mpipsykl.mpg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany. holsboer@mpipsykl.mpg.de","institution_ids":["https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210145969"],"apc_list":null,"apc_paid":null,"fwci":5.1126,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.97292724,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"46","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8460000157356262},{"id":"https://openalex.org/keywords/crh-receptor-1","display_name":"CRH receptor 1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.47099998593330383},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.6340000033378601},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6627201437950134},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6614683866500854},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.606719434261322},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5438556671142578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5285398364067078},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5270990133285522},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48818689584732056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4255138337612152},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36231058835983276},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34447920322418213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33742374181747437},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2861480116844177},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099052","descriptor_name":"CRF Receptor, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12625028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:11003","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/11003","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Investigational Drugs, v.4, 46-50 (2003)","raw_type":"Article"},{"id":"mag:35477986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1563098518","https://openalex.org/W2123263258"],"related_works":["https://openalex.org/W2107337535","https://openalex.org/W7140265049","https://openalex.org/W2034767261","https://openalex.org/W2009058487","https://openalex.org/W1995937112","https://openalex.org/W2319758206","https://openalex.org/W2900714423","https://openalex.org/W1988230174","https://openalex.org/W794376169","https://openalex.org/W2378180466"],"abstract_inverted_index":{"Basic":[0],"and":[1,23,44,90,106,152],"clinical":[2,132],"studies":[3],"demonstrate":[4],"that":[5,37,82],"the":[6,27,59,87],"central":[7],"corticotropin-releasing":[8],"hormone":[9],"(CRH)":[10],"circuits":[11],"are":[12,149],"overactive":[13],"among":[14],"depressives,":[15],"a":[16,143,160],"phenomenon":[17],"frequently":[18],"reflected":[19],"by":[20],"enhanced":[21],"cortisol":[22],"corticotropin":[24],"levels":[25],"in":[26,103],"peripheral":[28],"blood":[29],"of":[30,47,112,134,145],"these":[31,113],"patients.":[32],"Behavioral":[33],"pharmacology":[34],"provided":[35],"evidence":[36],"CRH":[38,60,73],"overexpression":[39],"accounts":[40],"for":[41,57],"many":[42,75],"signs":[43],"symptoms":[45],"characteristic":[46],"depression.":[48,110],"CRH-type":[49],"1":[50],"receptors":[51],"(CRHR),":[52],"were":[53],"identified":[54],"as":[55],"responsible":[56],"conveying":[58],"signal":[61],"into":[62],"cellular":[63],"circuitries,":[64],"thereby":[65],"inducing":[66],"depression-related":[67],"symptoms.":[68],"In":[69],"order":[70],"to":[71,159,163],"decrease":[72],"signaling,":[74],"pharmaceutical":[76],"companies":[77],"have":[78,100,136],"developed":[79],"small":[80],"molecules":[81],"after":[83,139],"oral":[84],"ingestion,":[85],"penetrate":[86],"blood-brain":[88],"barrier":[89],"selectively":[91],"bind":[92],"at":[93],"CRHR1":[94,147],"with":[95,108],"high":[96],"affinity.":[97],"These":[98],"compounds":[99],"been":[101,137],"tested":[102],"animal":[104],"models":[105],"patients":[107],"major":[109],"One":[111],"compounds,":[114],"R-121919":[115,135],"(Neurocrine":[116],"Biosciences":[117],"Inc),":[118],"ameliorated":[119],"depressive":[120],"symptomatology":[121],"without":[122],"unwanted":[123],"endocrine":[124],"side":[125],"effects":[126],"or":[127],"other":[128,146],"adverse":[129],"effects.":[130],"While":[131],"trials":[133],"discontinued":[138],"phase":[140],"IIa":[141],"studies,":[142],"number":[144],"antagonists":[148],"being":[150],"developed,":[151],"hopefully":[153],"this":[154],"advance":[155],"will":[156],"ultimately":[157],"lead":[158],"favorable":[161],"alternative":[162],"currently":[164],"available":[165],"antidepressant":[166],"drugs.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
