{"id":"https://openalex.org/W35459968","doi":null,"title":"Susceptibility of Enterococcus faecalis to twelve antibiotics, time-kill assays, and high-level aminoglycoside resistance in a university hospital in Argentina.","display_name":"Susceptibility of Enterococcus faecalis to twelve antibiotics, time-kill assays, and high-level aminoglycoside resistance in a university hospital in Argentina.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W35459968","mag":"35459968","pmid":"https://pubmed.ncbi.nlm.nih.gov/1815269"},"language":"en","primary_location":{"id":"pmid:1815269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1815269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Argentina de microbiologia","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016142454","display_name":"Silvia C. Predari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"S C Predari","raw_affiliation_strings":["Departamento de Microbiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M A Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Guti\u00e9rrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014688862","display_name":"C Ribas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ribas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086131527","display_name":"Gabriella Molinari","orcid":"https://orcid.org/0000-0002-6781-1292","observed_orcids":["https://orcid.org/0000-0002-6781-1292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Molinari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087927479","display_name":"Jorge E. Santoianni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Santoianni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0034965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"2","first_page":"67","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.9369999766349792},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/high-level-resistance","display_name":"high-level resistance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/time-kill-assay","display_name":"time-kill assay","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/streptomycin","display_name":"streptomycin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.890999972820282},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/piperacillin","display_name":"piperacillin","score":0.753000020980835},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pefloxacin","display_name":"pefloxacin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/norfloxacin","display_name":"norfloxacin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2775843808","wikidata":"https://www.wikidata.org/wiki/Q192717","display_name":"Streptomycin","level":3,"score":0.7815775871276855},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.7709083557128906},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.7324761152267456},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.7178449630737305},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.6946525573730469},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6876469850540161},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.6379797458648682},{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.5343498587608337},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.48083218932151794},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.4545125961303711},{"id":"https://openalex.org/C2778977604","wikidata":"https://www.wikidata.org/wiki/Q2553496","display_name":"Netilmicin","level":5,"score":0.41760775446891785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3777892589569092},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.33658313751220703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3196869492530823},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12405118346214294},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.09731665253639221},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001118","descriptor_name":"Argentina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006785","descriptor_name":"Hospitals, University","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1815269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1815269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Argentina de microbiologia","raw_type":"Comparative Study"},{"id":"mag:35459968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1815269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W1562897391","https://openalex.org/W1795585523","https://openalex.org/W1967273901","https://openalex.org/W1985274289","https://openalex.org/W1993193599","https://openalex.org/W2010088291","https://openalex.org/W2014173070","https://openalex.org/W2029092200","https://openalex.org/W2034069830","https://openalex.org/W2043119688","https://openalex.org/W2085361768","https://openalex.org/W2087800452","https://openalex.org/W2088523080","https://openalex.org/W2091099221","https://openalex.org/W2103449823","https://openalex.org/W2133892291","https://openalex.org/W2138387533","https://openalex.org/W2145002735","https://openalex.org/W2148299440","https://openalex.org/W2220281519","https://openalex.org/W2301541695","https://openalex.org/W2324374452","https://openalex.org/W2332054710","https://openalex.org/W2403600955","https://openalex.org/W2515987409","https://openalex.org/W2525607701","https://openalex.org/W2530566078","https://openalex.org/W2767203923","https://openalex.org/W2768821899","https://openalex.org/W2768927119","https://openalex.org/W2770615613","https://openalex.org/W2779212101","https://openalex.org/W2787398284","https://openalex.org/W2800789139","https://openalex.org/W2806489069","https://openalex.org/W2896862229","https://openalex.org/W2897938300","https://openalex.org/W2903885365","https://openalex.org/W2908304050","https://openalex.org/W2928772646","https://openalex.org/W2939196136","https://openalex.org/W2944246735","https://openalex.org/W2945850802","https://openalex.org/W2947607054","https://openalex.org/W2954207903","https://openalex.org/W2955409949","https://openalex.org/W2963435999","https://openalex.org/W2965413929","https://openalex.org/W2971858655","https://openalex.org/W2972278947","https://openalex.org/W2972563087","https://openalex.org/W2973114892","https://openalex.org/W2973155464","https://openalex.org/W2975218902","https://openalex.org/W2987473186","https://openalex.org/W2990390049","https://openalex.org/W2990706024","https://openalex.org/W2991539392","https://openalex.org/W2996030377","https://openalex.org/W2998576579","https://openalex.org/W3000916039","https://openalex.org/W3005332201","https://openalex.org/W3012347628","https://openalex.org/W3013106828","https://openalex.org/W3013906782","https://openalex.org/W3025632860","https://openalex.org/W3027761339","https://openalex.org/W3034707666","https://openalex.org/W3035591961","https://openalex.org/W3035839778","https://openalex.org/W3037240660","https://openalex.org/W3038034264","https://openalex.org/W3039899941","https://openalex.org/W3041084130","https://openalex.org/W3041148285","https://openalex.org/W3045635183","https://openalex.org/W3047082023","https://openalex.org/W3082763654","https://openalex.org/W3082969065","https://openalex.org/W3083432229","https://openalex.org/W3084043727","https://openalex.org/W3087406616","https://openalex.org/W3087590041","https://openalex.org/W3088724696","https://openalex.org/W3090401823","https://openalex.org/W3109363169","https://openalex.org/W3109623052","https://openalex.org/W3110142538","https://openalex.org/W3120926981","https://openalex.org/W3122547338","https://openalex.org/W3124780494","https://openalex.org/W3135426837","https://openalex.org/W3137558304","https://openalex.org/W3146015894","https://openalex.org/W3153245728","https://openalex.org/W3153812823","https://openalex.org/W3158204103","https://openalex.org/W3158319601","https://openalex.org/W3159698836","https://openalex.org/W3161223033","https://openalex.org/W3161324578","https://openalex.org/W3168347775","https://openalex.org/W3171670357","https://openalex.org/W3171767258","https://openalex.org/W3174206955","https://openalex.org/W3176997502","https://openalex.org/W3178486786","https://openalex.org/W3182127727","https://openalex.org/W3185080241","https://openalex.org/W3185313967","https://openalex.org/W3186405712","https://openalex.org/W3191293820","https://openalex.org/W3194937866","https://openalex.org/W3198266359","https://openalex.org/W3200179105","https://openalex.org/W3200887492","https://openalex.org/W3203022997","https://openalex.org/W3203850116","https://openalex.org/W3205134727","https://openalex.org/W3205929803","https://openalex.org/W3208311184","https://openalex.org/W3209216802","https://openalex.org/W3214866730","https://openalex.org/W3215658609","https://openalex.org/W3215802296","https://openalex.org/W3216266635","https://openalex.org/W4200530882","https://openalex.org/W4240054883","https://openalex.org/W6601637229"],"related_works":["https://openalex.org/W2034834751","https://openalex.org/W1560916437","https://openalex.org/W2401097219","https://openalex.org/W2374437998","https://openalex.org/W6911622127","https://openalex.org/W2396411845","https://openalex.org/W2411073075","https://openalex.org/W2902959660","https://openalex.org/W2113589559","https://openalex.org/W2035325739"],"abstract_inverted_index":{"A":[0],"total":[1],"of":[2,25,43,65,92,106,138,145,150,176,187,271,277,292],"201":[3],"Enterococcus":[4],"faecalis":[5,156,226],"strains":[6,26,55,139,189,200,250,257],"isolated":[7],"from":[8,61,215],"different":[9],"body":[10],"sites":[11],"were":[12,130,140,158,169,201,228,252],"tested":[13],"to":[14,34,70,113,123,163,174,181,211,219,240,261,289],"(i)":[15],"establish":[16],"their":[17],"antibiotic":[18],"susceptibility":[19,66,288],"pattern;":[20],"(ii)":[21],"determine":[22],"the":[23,41,54,62,131,164,192,202,212,256,262,278,287,293,298],"percentage":[24],"highly":[27,170,198,253],"resistant":[28,162,171,199],"(MIC":[29],"greater":[30,80],"than":[31,81,110,120],"2,000":[32,71,290],"micrograms/ml)":[33],"five":[35],"aminoglycosides":[36,213,279],"and":[37,85,97,116,128,147,152,190,205],"(iii)":[38],"know":[39],"if":[40],"combination":[42],"penicillin":[44,127,151,241,299],"or":[45,111,121,160,242,300],"ampicillin":[46,146,243,301],"plus":[47],"an":[48],"aminoglycoside":[49,69,244,294,302],"is":[50],"reliably":[51],"synergistic":[52],"for":[53,67,207,230],"with":[56,78,258,275,281],"low-level":[57,259],"resistance":[58,180,195,210,239,260],"(MICs":[59],"ranged":[60,214],"break":[63],"point":[64],"each":[68,276],"micrograms/ml).":[72],"Erythromycin":[73],"exhibited":[74],"very":[75],"poor":[76],"activity":[77],"MIC90":[79],"128":[82],"micrograms/ml.":[83,101],"Pefloxacin":[84],"norfloxacin":[86],"had":[87],"intermediate":[88],"activity,":[89],"inhibiting":[90],"50%":[91],"isolates":[93,107,157,227],"at":[94,99,108,118,142,172],"4":[95,148],"micrograms/ml":[96,115,149,291],"90%":[98],"8":[100],"Trimethoprim-sulfamethoxazole":[102],"(1:20)":[103],"inhibited":[104,141],"94%":[105],"less":[109,119,203],"equal":[112,122],"2":[114],"87.6%":[117],"0.5":[124],"microgram/ml.":[125],"Ampicillin,":[126],"piperacillin":[129],"most":[132,193],"potent":[133],"agents":[134],"studied.":[135],"Ninety":[136,166],"percent":[137],"1":[143],"microgram/ml":[144],"piperacillin.":[153],"The":[154],"E.":[155,225],"relatively":[159],"totally":[161],"aminoglycosides.":[165],"six":[167],"(47.8%)":[168],"least":[173],"one":[175,224],"them.":[177],"High":[178],"level":[179],"streptomycin":[182],"was":[183,191,234,265],"found":[184],"in":[185,246,268],"47.3%":[186],"all":[188,247],"frequent":[194],"encountered;":[196],"amikacin":[197],"common":[204],"accounted":[206],"4.5%.":[208],"Low-level":[209],"50.2%":[216],"(for":[217,221],"streptomycin)":[218],"94.5%":[220],"amikacin).":[222],"Thirty":[223],"selected":[229],"24-time":[231],"kill-assays.":[232],"There":[233],"a":[235],"good":[236],"correlation":[237],"between":[238],"synergy":[245,267],"but":[248],"3":[249],"which":[251],"resistant.":[254],"Among":[255],"aminoglycosides,":[263],"there":[264],"no":[266],"37":[269],"(63.8%)":[270],"58":[272],"killing":[273],"assays":[274],"combined":[280],"penicillin.":[282],"These":[283],"results":[284],"demonstrate":[285],"that":[286],"does":[295],"not":[296],"assure":[297],"synergism.":[303]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
