{"id":"https://openalex.org/W35430079","doi":null,"title":"Application of Genomic and Epigenomic Methods to Understand Environmental and Dietary Factors in Carcinogenesis.","display_name":"Application of Genomic and Epigenomic Methods to Understand Environmental and Dietary Factors in Carcinogenesis.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W35430079","mag":"35430079"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/109055","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/109055","pdf_url":"https://hdl.handle.net/2027.42/109055","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/109055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017815080","display_name":"Justin A. Colacino","orcid":"https://orcid.org/0000-0002-5882-4569","observed_orcids":["https://orcid.org/0000-0002-5882-4569"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Justin A. Colacino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5882-4569","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017815080"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/environmental-carcinogens","display_name":"environmental carcinogens","score":0.5839999914169312},{"id":"https://openalex.org/keywords/dietary-factors","display_name":"dietary factors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.722000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chemically-induced-tumors","display_name":"chemically induced tumors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/breast-stem-cells","display_name":"breast stem cells","score":0.6779999732971191},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.8930000066757202},{"id":"https://openalex.org/keywords/breast-reduction","display_name":"breast reduction","score":0.6399999856948853},{"id":"https://openalex.org/keywords/genome-wide-screen","display_name":"genome-wide screen","score":0.5450000166893005},{"id":"https://openalex.org/keywords/stem-cell-culture","display_name":"stem cell culture","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.8818318247795105},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.593058168888092},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5143890976905823},{"id":"https://openalex.org/C2992444039","wikidata":"https://www.wikidata.org/wiki/Q17145598","display_name":"Genomic selection","level":5,"score":0.46485698223114014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4366518259048462},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34303152561187744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32771411538124084},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.22684317827224731},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16243800520896912},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08437272906303406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07032546401023865},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/109055","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/109055","pdf_url":"https://hdl.handle.net/2027.42/109055","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:35430079","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/2027.42/109055/1/colacino_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/109055","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/109055","pdf_url":"https://hdl.handle.net/2027.42/109055","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W35430079.pdf","grobid_xml":"https://content.openalex.org/works/W35430079.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1572223496","https://openalex.org/W1575074099","https://openalex.org/W1767177186","https://openalex.org/W1908404715","https://openalex.org/W1963624040","https://openalex.org/W1964726348","https://openalex.org/W1964895626","https://openalex.org/W1965391917","https://openalex.org/W1967602605","https://openalex.org/W1981989535","https://openalex.org/W2001144553","https://openalex.org/W2004556090","https://openalex.org/W2011243629","https://openalex.org/W2014691022","https://openalex.org/W2015175257","https://openalex.org/W2015784790","https://openalex.org/W2020773529","https://openalex.org/W2023397305","https://openalex.org/W2023427658","https://openalex.org/W2024819383","https://openalex.org/W2025508129","https://openalex.org/W2029030998","https://openalex.org/W2029377777","https://openalex.org/W2030867114","https://openalex.org/W2033061169","https://openalex.org/W2034222878","https://openalex.org/W2036433420","https://openalex.org/W2038287336","https://openalex.org/W2041263494","https://openalex.org/W2050646440","https://openalex.org/W2052197720","https://openalex.org/W2056978350","https://openalex.org/W2060662813","https://openalex.org/W2078509389","https://openalex.org/W2081098333","https://openalex.org/W2082161467","https://openalex.org/W2082323504","https://openalex.org/W2082572336","https://openalex.org/W2085626804","https://openalex.org/W2085917447","https://openalex.org/W2089787496","https://openalex.org/W2092032160","https://openalex.org/W2095225188","https://openalex.org/W2096534598","https://openalex.org/W2099680351","https://openalex.org/W2100489386","https://openalex.org/W2103825558","https://openalex.org/W2103953940","https://openalex.org/W2104942162","https://openalex.org/W2106605216","https://openalex.org/W2107709622","https://openalex.org/W2110065044","https://openalex.org/W2110608362","https://openalex.org/W2111817980","https://openalex.org/W2114104545","https://openalex.org/W2115435456","https://openalex.org/W2120021843","https://openalex.org/W2121053107","https://openalex.org/W2127605299","https://openalex.org/W2127617517","https://openalex.org/W2128103604","https://openalex.org/W2128560408","https://openalex.org/W2130410032","https://openalex.org/W2131011879","https://openalex.org/W2132798049","https://openalex.org/W2133183695","https://openalex.org/W2133462508","https://openalex.org/W2133519088","https://openalex.org/W2138271749","https://openalex.org/W2139151018","https://openalex.org/W2141647078","https://openalex.org/W2143680521","https://openalex.org/W2143821976","https://openalex.org/W2150763392","https://openalex.org/W2151709086","https://openalex.org/W2152679371","https://openalex.org/W2155475233","https://openalex.org/W2158734599","https://openalex.org/W2159409293","https://openalex.org/W2165286055","https://openalex.org/W2165638033","https://openalex.org/W2165816035","https://openalex.org/W2169449395","https://openalex.org/W2169456326","https://openalex.org/W2406213538","https://openalex.org/W2496036998","https://openalex.org/W3148685323"],"related_works":["https://openalex.org/W6998617785","https://openalex.org/W7095928220","https://openalex.org/W2170493345","https://openalex.org/W2110486307","https://openalex.org/W2522964070","https://openalex.org/W2910570084","https://openalex.org/W2237332527","https://openalex.org/W2132181746","https://openalex.org/W1972420016","https://openalex.org/W4255469991"],"abstract_inverted_index":{"Sporadic":[0],"cancers":[1,32],"comprise":[2],"the":[3,55,67,72,81,100,140,145,218,253,269,285,288,307,310],"vast":[4],"majority":[5],"of":[6,57,65,69,87,102,125,142,172,287,290,309],"diagnosed":[7,34],"cancer":[8,24,40,58,150,214,255,294],"cases,":[9],"many":[10,38],"with":[11,152,168,203,252],"a":[12,153,210,229,262],"largely":[13],"environmental":[14,21,118],"etiology.":[15],"The":[16,122,278],"mechanisms":[17],"by":[18,232,275],"which":[19,233],"specific":[20,103,272],"factors":[22],"influence":[23],"risk,":[25],"however,":[26],"remain":[27],"widely":[28],"uncharacterized.":[29],"Because":[30],"sporadic":[31],"are":[33],"later":[35],"in":[36,74,147,181,185,217,300,312],"life,":[37],"incident":[39],"studies":[41],"poorly":[42],"quantify":[43],"previous":[44],"exposures":[45],"or":[46,60,188],"utilize":[47],"methodologies":[48],"that":[49,112,209],"may":[50,113],"not":[51],"be":[52,114],"appropriate":[53],"for":[54,99],"study":[56,101],"initiation":[59],"prevention.":[61],"Developing":[62],"novel":[63,90,133],"methods":[64,137],"studying":[66],"role":[68,308],"nutrition":[70,143],"and":[71,85,104,119,131,135,144,149,163,174,212,259,261,280],"environment":[73,146,311],"carcinogenesis":[75,148],"will":[76,97],"provide":[77],"essential":[78],"insight":[79],"towards":[80],"prevention,":[82,151],"early":[83],"identification,":[84],"treatment":[86],"cancer.":[88,313],"Incorporating":[89],"culture":[91],"methods,":[92,292],"including":[93,109],"primary":[94],"tissue":[95,249],"culture,":[96,304],"allow":[98],"relevant":[105],"normal":[106,241,298],"cell":[107,271,303],"populations,":[108],"stem":[110,244,270,302],"cells,":[111],"particularly":[115],"sensitive":[116],"to":[117,129,138,177,207,267,297,305],"nutritional":[120],"factors.":[121],"overarching":[123],"goal":[124],"this":[126],"dissertation":[127],"was":[128,201,265],"develop":[130],"apply":[132],"statistical":[134],"experimental":[136],"characterize":[139],"roles":[141],"focus":[154],"on":[155,197],"epigenetic":[156,205,226],"change.":[157],"In":[158,193,238],"Chapter":[159,194,239],"2,":[160],"comprehensive":[161],"epidemiological":[162],"clinical":[164],"information":[165],"were":[166,250],"paired":[167,202],"DNA":[169,183],"methylation":[170,184],"profiling":[171],"head":[173,211],"neck":[175,213],"tumors":[176],"identify":[178,208,268],"significant":[179],"differences":[180],"tumor":[182,204,225],"chemically":[186],"induced":[187,191,274],"human":[189,242,299],"papillomavirus":[190],"tumors.":[192],"3,":[195],"data":[196],"average":[198],"dietary":[199],"intake":[200],"measurements":[206],"patient\u2019s":[215],"diet":[216,234],"year":[219],"before":[220],"diagnosis":[221],"can":[222],"significantly":[223],"affect":[224],"profiles,":[227],"providing":[228],"potential":[230],"mechanism":[231],"affects":[235],"disease":[236],"prognosis.":[237],"4,":[240],"breast":[243],"cells":[245],"from":[246,293],"reduction":[247],"mammoplasty":[248],"treated":[251],"putatively":[254],"prevention":[256],"compounds":[257],"curcumin":[258],"piperine,":[260],"genome-wide":[263],"screen":[264],"conducted":[266],"changes":[273],"these":[276,291],"compounds.":[277],"results":[279],"conclusions":[281],"presented":[282],"here":[283],"reflect":[284],"utility":[286],"application":[289],"molecular":[295],"epidemiology":[296],"vitro":[301],"understand":[306]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}