{"id":"https://openalex.org/W35390099","doi":null,"title":"Drug Transport and Metabolism in Rat and Human Intestine","display_name":"Drug Transport and Metabolism in Rat and Human Intestine","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W35390099","mag":"35390099"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-7229","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7229","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057629242","display_name":"Sofia Berggren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sofia Berggren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057629242"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-drug-transport","display_name":"intestinal drug transport","score":0.9340000152587891},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6290000081062317},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9169999957084656},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9750000238418579},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ropivacaine","display_name":"ropivacaine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bupivacaine","display_name":"bupivacaine","score":1.0},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.6740000247955322},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ussing-chamber","display_name":"Ussing chamber","score":0.7239999771118164},{"id":"https://openalex.org/keywords/single-pass-perfusion","display_name":"single-pass perfusion","score":0.878000020980835},{"id":"https://openalex.org/keywords/rat-intestine","display_name":"rat intestine","score":0.6179999709129333},{"id":"https://openalex.org/keywords/human-intestine","display_name":"human intestine","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.7420739531517029},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.6930652856826782},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.6873511075973511},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5904531478881836},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.45204004645347595},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4460563659667969},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.42323800921440125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3731077313423157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3218020796775818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27975761890411377},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.08500668406486511},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-7229","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:35390099","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-7229","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W1397264","https://openalex.org/W12736801","https://openalex.org/W113583849","https://openalex.org/W133928591","https://openalex.org/W148420461","https://openalex.org/W158024441","https://openalex.org/W184713255","https://openalex.org/W261488291","https://openalex.org/W299766652","https://openalex.org/W562317020","https://openalex.org/W1489601464","https://openalex.org/W1498305210","https://openalex.org/W1513692286","https://openalex.org/W1515560591","https://openalex.org/W1545401674","https://openalex.org/W1551725906","https://openalex.org/W1552183320","https://openalex.org/W1556355067","https://openalex.org/W1560296987","https://openalex.org/W1560709301","https://openalex.org/W1566211379","https://openalex.org/W1587951740","https://openalex.org/W1588110413","https://openalex.org/W1596283370","https://openalex.org/W1605785874","https://openalex.org/W1775749144","https://openalex.org/W1790955152","https://openalex.org/W1892194801","https://openalex.org/W1911655428","https://openalex.org/W1928127114","https://openalex.org/W1929292775","https://openalex.org/W1957549334","https://openalex.org/W1964470226","https://openalex.org/W1965129145","https://openalex.org/W1969119815","https://openalex.org/W1973286433","https://openalex.org/W1979196526","https://openalex.org/W1987449219","https://openalex.org/W1997211805","https://openalex.org/W1999021046","https://openalex.org/W2002619956","https://openalex.org/W2006896008","https://openalex.org/W2007788734","https://openalex.org/W2009740943","https://openalex.org/W2009962320","https://openalex.org/W2014359221","https://openalex.org/W2015336605","https://openalex.org/W2015591449","https://openalex.org/W2017411996","https://openalex.org/W2018022126","https://openalex.org/W2018445772","https://openalex.org/W2020630456","https://openalex.org/W2021550176","https://openalex.org/W2021759214","https://openalex.org/W2023424961","https://openalex.org/W2028533496","https://openalex.org/W2028912886","https://openalex.org/W2035000881","https://openalex.org/W2035865178","https://openalex.org/W2037621239","https://openalex.org/W2039603044","https://openalex.org/W2039744247","https://openalex.org/W2042066665","https://openalex.org/W2047895356","https://openalex.org/W2049520769","https://openalex.org/W2050895048","https://openalex.org/W2051087515","https://openalex.org/W2055645153","https://openalex.org/W2058273909","https://openalex.org/W2065072706","https://openalex.org/W2066406186","https://openalex.org/W2066654540","https://openalex.org/W2068885497","https://openalex.org/W2069388748","https://openalex.org/W2071728786","https://openalex.org/W2073965718","https://openalex.org/W2076048206","https://openalex.org/W2077163008","https://openalex.org/W2077229986","https://openalex.org/W2077371309","https://openalex.org/W2077510533","https://openalex.org/W2080445885","https://openalex.org/W2080561646","https://openalex.org/W2080654035","https://openalex.org/W2081735653","https://openalex.org/W2082997934","https://openalex.org/W2084462922","https://openalex.org/W2088199024","https://openalex.org/W2089407496","https://openalex.org/W2089597425","https://openalex.org/W2090632754","https://openalex.org/W2092815169","https://openalex.org/W2093064121","https://openalex.org/W2093328959","https://openalex.org/W2094001933","https://openalex.org/W2094323693","https://openalex.org/W2097502628","https://openalex.org/W2099078767","https://openalex.org/W2103400377","https://openalex.org/W2112001901","https://openalex.org/W2112728948","https://openalex.org/W2114903378","https://openalex.org/W2121689079","https://openalex.org/W2128733408","https://openalex.org/W2135732933","https://openalex.org/W2136564762","https://openalex.org/W2136904160","https://openalex.org/W2140661985","https://openalex.org/W2140744545","https://openalex.org/W2147104041","https://openalex.org/W2151155243","https://openalex.org/W2152813897","https://openalex.org/W2153982638","https://openalex.org/W2156321359","https://openalex.org/W2157893300","https://openalex.org/W2158245905","https://openalex.org/W2162097287","https://openalex.org/W2162438271","https://openalex.org/W2166082449","https://openalex.org/W2167979733","https://openalex.org/W2168070336","https://openalex.org/W2171875038","https://openalex.org/W2172134989","https://openalex.org/W2187718168","https://openalex.org/W2214374021","https://openalex.org/W2252991923","https://openalex.org/W2261197970","https://openalex.org/W2263612566","https://openalex.org/W2279936106","https://openalex.org/W2285524653","https://openalex.org/W2415576173","https://openalex.org/W2797323304","https://openalex.org/W4406962746","https://openalex.org/W4407031952"],"related_works":["https://openalex.org/W218853631","https://openalex.org/W2046793768","https://openalex.org/W2094977785","https://openalex.org/W2169870385","https://openalex.org/W603009950","https://openalex.org/W2168858467","https://openalex.org/W2924431860","https://openalex.org/W1510465827","https://openalex.org/W2501149656","https://openalex.org/W2027292745"],"abstract_inverted_index":{"One":[0],"of":[1,4,12,27,37,90,128,133,144,149,161,184,233,244,252,291,294],"the":[2,10,17,21,28,31,91,98,108,114,122,126,131,150,158,162,192,231,256,292],"aims":[3],"this":[5,44],"thesis":[6],"was":[7,51,81,111,155,173,200,220,238,259],"to":[8,79,83,116,157,241,255],"investigate":[9],"involvement":[11,106,127],"efflux":[13,105,129,187,242,295],"proteins,":[14],"such":[15,70],"as":[16,71,107,218,277,279],"P-glycoprotein":[18],"(Pgp),":[19],"in":[20,24,113,121,130,140,195,204,211,222],"drug":[22,109],"transport":[23,118,243,251],"different":[25],"regions":[26,89],"rat":[29,92,145,167,212,223],"and":[30,74,93,168,172,186,207,209,236,296],"human":[32,94,169,196,205,227],"intestine.":[33,95,197,213],"The":[34,54,76,147,181,250,265],"intestinal":[35,77,88,170,248,275,280],"extrusion":[36,45,148],"intracellularly":[38],"formed":[39,221],"CYP3A4":[40,185,203],"metabolites,":[41],"including":[42],"whether":[43],"might":[46],"be":[47,84,137],"mediated":[48,201,262],"by":[49,177,202,263],"Pgp,":[50],"also":[52],"studied.":[53],"model":[55,101,268,288],"drugs":[56],"used":[57],"were":[58,189,216],"local":[59],"anaesthetics":[60],"(LA),":[61],"which":[62],"have":[63],"been":[64],"evaluated":[65],"for":[66,165,246,289],"inflammatory":[67],"bowel":[68],"disease,":[69],"ropivacaine,":[72,234],"lidocaine":[73,235],"bupivacaine.":[75],"permeability":[78,110,232],"LAs":[80,134],"found":[82],"high":[85],"throughout":[86],"all":[87],"Results":[96],"from":[97,274],"Ussing":[99,163,266],"chamber":[100,164,267],"indicated":[102],"only":[103],"minor":[104],"higher":[112],"serosa":[115],"mucosa":[117],"direction":[119],"than":[120],"opposite":[123],"direction.":[124],"However,":[125],"absorption":[132],"could":[135],"not":[136,175,226,239,261],"verified":[138],"using":[139],"situ":[141],"single-pass":[142],"perfusion":[143],"jejunum.":[146],"ropivacaine":[151,253],"metabolite,":[152],"2\u00b4,6\u00b4-pipecoloxylidide":[153],"(PPX),":[154],"polarized":[156],"mucosal":[159,257],"reservoir":[160],"both":[166],"samples,":[171],"probably":[174,260],"caused":[176],"any":[178],"Pgp":[179],"involvement.":[180],"expression":[182],"levels":[183],"transporters":[188],"consistent":[190,270],"with":[191,272],"enzymes\u2019":[193],"activity":[194],"PPX":[198,219],"formation":[199],"intestine,":[206],"cyp2c":[208],"cyp2d":[210],"Species":[214],"differences":[215],"observed,":[217],"colon,":[224],"but":[225],"colon.":[228],"In":[229],"conclusion,":[230],"bupivacaine":[237],"subjected":[240],"significance":[245],"their":[247],"uptake.":[249],"metabolites":[254],"compartment":[258],"Pgp.":[264],"showed":[269],"results":[271],"those":[273],"microsomes":[276],"far":[278],"metabolism":[281],"is":[282],"concerned,":[283],"making":[284],"it":[285],"a":[286],"suitable":[287],"investigations":[290],"interplay":[293],"metabolism.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}