{"id":"https://openalex.org/W353112152","doi":"https://doi.org/10.1007/978-3-642-74197-5_21","title":"The Role of Cytokines in the Normal and Abnormal Growth of Hemopoietic Cells","display_name":"The Role of Cytokines in the Normal and Abnormal Growth of Hemopoietic Cells","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W353112152","doi":"https://doi.org/10.1007/978-3-642-74197-5_21","mag":"353112152"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-74197-5_21","doi":"https://doi.org/10.1007/978-3-642-74197-5_21","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-74197-5_21","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W607321299","display_name":"Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050259451","display_name":"John W. Schrader","orcid":"https://orcid.org/0000-0002-3381-3695","observed_orcids":["https://orcid.org/0000-0002-3381-3695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. W. Schrader","raw_affiliation_strings":["The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085130088","display_name":"Paul C. Orban","orcid":"https://orcid.org/0000-0002-2251-7153","observed_orcids":["https://orcid.org/0000-0002-2251-7153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. C. Orban","raw_affiliation_strings":["The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111596035","display_name":"Kevin B. Leslie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. B. Leslie","raw_affiliation_strings":["The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112837123","display_name":"Hermann J. Ziltener","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. J. Ziltener","raw_affiliation_strings":["The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biomedical Research Centre, Vancouver, B.C., V6T 1W5, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"221","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colony-stimulating-factors","display_name":"colony-stimulating factors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.8140000104904175},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9610000252723694},{"id":"https://openalex.org/keywords/colony-stimulating-factor-1","display_name":"colony-stimulating factor 1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6449999809265137},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.3659999966621399},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6868106126785278},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6226937174797058},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5755950212478638},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.5704070329666138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5631651878356934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5509606003761292},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5015897750854492},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.48332998156547546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4701058268547058},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.43423306941986084},{"id":"https://openalex.org/C116024289","wikidata":"https://www.wikidata.org/wiki/Q18039820","display_name":"Interleukin 20","level":5,"score":0.42913684248924255},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4194723963737488},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3745654821395874},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.20185422897338867},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.18311339616775513},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.17046523094177246},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.08900558948516846},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08880919218063354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06340587139129639}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-74197-5_21","doi":"https://doi.org/10.1007/978-3-642-74197-5_21","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-74197-5_21","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W30300769","https://openalex.org/W1507230123","https://openalex.org/W1807143116","https://openalex.org/W1973312385","https://openalex.org/W1977593769","https://openalex.org/W1983324362","https://openalex.org/W2010639752","https://openalex.org/W2036631709","https://openalex.org/W2042619726","https://openalex.org/W2084135506","https://openalex.org/W2096953370","https://openalex.org/W2413360126"],"related_works":["https://openalex.org/W1984083141","https://openalex.org/W2411116525","https://openalex.org/W1500396336","https://openalex.org/W4233247237","https://openalex.org/W2184949645","https://openalex.org/W3094804349","https://openalex.org/W4256472398","https://openalex.org/W1003295486","https://openalex.org/W941834445","https://openalex.org/W953442273"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}