{"id":"https://openalex.org/W35280411","doi":null,"title":"Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles","display_name":"Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W35280411","mag":"35280411"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/1307","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/1307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067101935","display_name":"Christian A. Kunder","orcid":"https://orcid.org/0000-0003-1514-7550","observed_orcids":["https://orcid.org/0000-0003-1514-7550"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christian A. Kunder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1514-7550","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067101935"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.6000000238418579},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lymph-node-drainage","display_name":"lymph node drainage","score":0.4819999933242798},{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.5149999856948853},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.7350000143051147},{"id":"https://openalex.org/keywords/extracellular-chaperones","display_name":"extracellular chaperones","score":0.7020000219345093},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dendritic-cell-migration","display_name":"dendritic cell migration","score":0.7400000095367432},{"id":"https://openalex.org/keywords/lymphocyte-recruitment","display_name":"lymphocyte recruitment","score":0.5170000195503235},{"id":"https://openalex.org/keywords/synthetic-particles","display_name":"synthetic particles","score":0.5009999871253967},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6200000047683716},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.5770000219345093},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.8137819766998291},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7523449659347534},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.688315212726593},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.616923451423645},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5655511021614075},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40478429198265076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3726882338523865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34421825408935547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3258240222930908},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23643550276756287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06132012605667114}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/1307","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/1307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:35280411","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/1307/1/D_Kunder_Christian_a_200908.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":313,"referenced_works":["https://openalex.org/W45973083","https://openalex.org/W70343244","https://openalex.org/W79975380","https://openalex.org/W92982204","https://openalex.org/W100325461","https://openalex.org/W108899424","https://openalex.org/W127647660","https://openalex.org/W138609106","https://openalex.org/W156887710","https://openalex.org/W177128174","https://openalex.org/W184730276","https://openalex.org/W185984262","https://openalex.org/W284597358","https://openalex.org/W348875195","https://openalex.org/W613360632","https://openalex.org/W1482145361","https://openalex.org/W1485406840","https://openalex.org/W1499161051","https://openalex.org/W1509309781","https://openalex.org/W1516543286","https://openalex.org/W1517879640","https://openalex.org/W1519030262","https://openalex.org/W1519269060","https://openalex.org/W1525925511","https://openalex.org/W1526388221","https://openalex.org/W1527174508","https://openalex.org/W1528764883","https://openalex.org/W1534485474","https://openalex.org/W1535993489","https://openalex.org/W1536042050","https://openalex.org/W1541467765","https://openalex.org/W1544520932","https://openalex.org/W1553712313","https://openalex.org/W1557019060","https://openalex.org/W1560426633","https://openalex.org/W1561886676","https://openalex.org/W1565642676","https://openalex.org/W1569773602","https://openalex.org/W1571543101","https://openalex.org/W1572914688","https://openalex.org/W1573702255","https://openalex.org/W1576073826","https://openalex.org/W1582826730","https://openalex.org/W1585774598","https://openalex.org/W1587142652","https://openalex.org/W1589182876","https://openalex.org/W1591702766","https://openalex.org/W1599496006","https://openalex.org/W1604445632","https://openalex.org/W1606765836","https://openalex.org/W1612455342","https://openalex.org/W1622558337","https://openalex.org/W1628984902","https://openalex.org/W1636878974","https://openalex.org/W1680126513","https://openalex.org/W1723301197","https://openalex.org/W1764686129","https://openalex.org/W1765943816","https://openalex.org/W1790375900","https://openalex.org/W1795089629","https://openalex.org/W1821655649","https://openalex.org/W1833006606","https://openalex.org/W1869562643","https://openalex.org/W1872008999","https://openalex.org/W1891076224","https://openalex.org/W1902340997","https://openalex.org/W1905549345","https://openalex.org/W1930831294","https://openalex.org/W1937155133","https://openalex.org/W1942540255","https://openalex.org/W1960225347","https://openalex.org/W1963572696","https://openalex.org/W1965985032","https://openalex.org/W1966903065","https://openalex.org/W1967312698","https://openalex.org/W1970311921","https://openalex.org/W1970480071","https://openalex.org/W1970499429","https://openalex.org/W1971161270","https://openalex.org/W1971705349","https://openalex.org/W1972181804","https://openalex.org/W1972439638","https://openalex.org/W1973166414","https://openalex.org/W1973195685","https://openalex.org/W1973816170","https://openalex.org/W1974185057","https://openalex.org/W1974400821","https://openalex.org/W1975068237","https://openalex.org/W1975417599","https://openalex.org/W1975965422","https://openalex.org/W1977518668","https://openalex.org/W1978713305","https://openalex.org/W1979398938","https://openalex.org/W1980741458","https://openalex.org/W1981930064","https://openalex.org/W1982021298","https://openalex.org/W1982322400","https://openalex.org/W1983117705","https://openalex.org/W1983666616","https://openalex.org/W1983829903","https://openalex.org/W1983893679","https://openalex.org/W1989237374","https://openalex.org/W1989975786","https://openalex.org/W1990132839","https://openalex.org/W1992730818","https://openalex.org/W1994634350","https://openalex.org/W1994891225","https://openalex.org/W1995595769","https://openalex.org/W1995604283","https://openalex.org/W1998783767","https://openalex.org/W1998825910","https://openalex.org/W1998899602","https://openalex.org/W2001720727","https://openalex.org/W2002519082","https://openalex.org/W2002547070","https://openalex.org/W2002969740","https://openalex.org/W2003376585","https://openalex.org/W2004556731","https://openalex.org/W2005325254","https://openalex.org/W2006073149","https://openalex.org/W2007446673","https://openalex.org/W2008771013","https://openalex.org/W2009623114","https://openalex.org/W2010251832","https://openalex.org/W2010453183","https://openalex.org/W2010465872","https://openalex.org/W2011040273","https://openalex.org/W2011497254","https://openalex.org/W2012549004","https://openalex.org/W2012564074","https://openalex.org/W2012645636","https://openalex.org/W2013140943","https://openalex.org/W2013944173","https://openalex.org/W2015319167","https://openalex.org/W2015745413","https://openalex.org/W2017614092","https://openalex.org/W2017973506","https://openalex.org/W2019843900","https://openalex.org/W2020666279","https://openalex.org/W2021709330","https://openalex.org/W2022094318","https://openalex.org/W2023137798","https://openalex.org/W2023213942","https://openalex.org/W2023435913","https://openalex.org/W2024787221","https://openalex.org/W2025745642","https://openalex.org/W2026479454","https://openalex.org/W2027568211","https://openalex.org/W2028068697","https://openalex.org/W2028273868","https://openalex.org/W2028365275","https://openalex.org/W2028923586","https://openalex.org/W2029030860","https://openalex.org/W2034222095","https://openalex.org/W2034586064","https://openalex.org/W2034925526","https://openalex.org/W2038575244","https://openalex.org/W2038811742","https://openalex.org/W2040094431","https://openalex.org/W2040854254","https://openalex.org/W2041747892","https://openalex.org/W2041865547","https://openalex.org/W2042973929","https://openalex.org/W2043138031","https://openalex.org/W2045895652","https://openalex.org/W2047688511","https://openalex.org/W2048249323","https://openalex.org/W2048299050","https://openalex.org/W2048749810","https://openalex.org/W2048780951","https://openalex.org/W2050742125","https://openalex.org/W2051011620","https://openalex.org/W2051360348","https://openalex.org/W2051880735","https://openalex.org/W2052143230","https://openalex.org/W2053841726","https://openalex.org/W2055089196","https://openalex.org/W2056225363","https://openalex.org/W2057203934","https://openalex.org/W2057905142","https://openalex.org/W2058096742","https://openalex.org/W2058531625","https://openalex.org/W2059330899","https://openalex.org/W2059684444","https://openalex.org/W2061308953","https://openalex.org/W2061443292","https://openalex.org/W2061457759","https://openalex.org/W2061574141","https://openalex.org/W2064670850","https://openalex.org/W2065126426","https://openalex.org/W2065375178","https://openalex.org/W2068452392","https://openalex.org/W2068918480","https://openalex.org/W2069111751","https://openalex.org/W2069695308","https://openalex.org/W2071783575","https://openalex.org/W2072036820","https://openalex.org/W2072643381","https://openalex.org/W2072691077","https://openalex.org/W2072841091","https://openalex.org/W2073623140","https://openalex.org/W2074634746","https://openalex.org/W2074743157","https://openalex.org/W2074936672","https://openalex.org/W2078188806","https://openalex.org/W2081019830","https://openalex.org/W2081166085","https://openalex.org/W2081615703","https://openalex.org/W2081753893","https://openalex.org/W2082139104","https://openalex.org/W2086554319","https://openalex.org/W2091504429","https://openalex.org/W2092957238","https://openalex.org/W2093013241","https://openalex.org/W2093456571","https://openalex.org/W2095111536","https://openalex.org/W2096156778","https://openalex.org/W2097871689","https://openalex.org/W2098392844","https://openalex.org/W2098518381","https://openalex.org/W2098950295","https://openalex.org/W2100590935","https://openalex.org/W2104680298","https://openalex.org/W2107396956","https://openalex.org/W2107970551","https://openalex.org/W2111268138","https://openalex.org/W2111522106","https://openalex.org/W2111695773","https://openalex.org/W2112916667","https://openalex.org/W2113335029","https://openalex.org/W2114780139","https://openalex.org/W2115392273","https://openalex.org/W2117833280","https://openalex.org/W2118722633","https://openalex.org/W2120782801","https://openalex.org/W2123789903","https://openalex.org/W2123963664","https://openalex.org/W2127217689","https://openalex.org/W2127921247","https://openalex.org/W2128662183","https://openalex.org/W2129081579","https://openalex.org/W2129356601","https://openalex.org/W2130207035","https://openalex.org/W2131567916","https://openalex.org/W2132053883","https://openalex.org/W2132104068","https://openalex.org/W2134254929","https://openalex.org/W2135431568","https://openalex.org/W2137583122","https://openalex.org/W2137890682","https://openalex.org/W2138843392","https://openalex.org/W2140832530","https://openalex.org/W2143883286","https://openalex.org/W2146717075","https://openalex.org/W2147155368","https://openalex.org/W2147702939","https://openalex.org/W2149328732","https://openalex.org/W2149501430","https://openalex.org/W2150661557","https://openalex.org/W2151623302","https://openalex.org/W2151923841","https://openalex.org/W2152907506","https://openalex.org/W2153150879","https://openalex.org/W2154060015","https://openalex.org/W2154419859","https://openalex.org/W2154648495","https://openalex.org/W2155309819","https://openalex.org/W2155461712","https://openalex.org/W2156700198","https://openalex.org/W2158659385","https://openalex.org/W2160748953","https://openalex.org/W2161948102","https://openalex.org/W2162853874","https://openalex.org/W2163170931","https://openalex.org/W2163380226","https://openalex.org/W2167237954","https://openalex.org/W2167273192","https://openalex.org/W2169389121","https://openalex.org/W2171863036","https://openalex.org/W2200276621","https://openalex.org/W2231494321","https://openalex.org/W2259680091","https://openalex.org/W2260101877","https://openalex.org/W2264275627","https://openalex.org/W2269348110","https://openalex.org/W2271429882","https://openalex.org/W2272339894","https://openalex.org/W2284720850","https://openalex.org/W2289293329","https://openalex.org/W2291378105","https://openalex.org/W2292425217","https://openalex.org/W2334625687","https://openalex.org/W2337041635","https://openalex.org/W2344675314","https://openalex.org/W2344899618","https://openalex.org/W2397449992","https://openalex.org/W2398699046","https://openalex.org/W2405096887","https://openalex.org/W2405570394","https://openalex.org/W2406011238","https://openalex.org/W2414292574","https://openalex.org/W2414413552","https://openalex.org/W2414984764","https://openalex.org/W2416463195","https://openalex.org/W2417955171","https://openalex.org/W2419512059","https://openalex.org/W2421843025","https://openalex.org/W2431436445","https://openalex.org/W2471171553","https://openalex.org/W3184643209","https://openalex.org/W4313333821","https://openalex.org/W4313376947","https://openalex.org/W4322384827"],"related_works":["https://openalex.org/W2108237409","https://openalex.org/W1965129316","https://openalex.org/W7036553056","https://openalex.org/W2036581935","https://openalex.org/W2470531925","https://openalex.org/W3035969189","https://openalex.org/W2602331000","https://openalex.org/W2740440293","https://openalex.org/W2034222095","https://openalex.org/W2790862653"],"abstract_inverted_index":{"Mast":[0],"cells,":[1,85],"best":[2],"known":[3],"for":[4,102,236,352,376],"their":[5],"pathologic":[6],"role":[7],"in":[8,18,118,147,161,185,202,398],"allergy,":[9],"have":[10,15,89,108],"recently":[11],"been":[12,109,502],"shown":[13,110],"to":[14,60,80,111,124,131,181,204,289,333,368,408,411,474,514,528,538],"key":[16,54],"roles":[17],"the":[19,30,67,81,113,126,152,156,166,175,183,191,244,324,399,412,415,424,434,437,490,507,521],"initiation":[20],"of":[21,48,64,83,115,128,158,165,171,219,300,326,362,414,426,436,449,456,464,471,486,492,494,510,523],"adaptive":[22,142,327,384],"immune":[23,91,143,416,478],"responses.":[24],"These":[25,53],"cells":[26,107,130,200,253,262],"are":[27,145,268],"located":[28],"throughout":[29],"body":[31],"just":[32],"beneath":[33],"barriers":[34],"separating":[35],"host":[36,252,487],"from":[37,155,174,241,286,443],"environment,":[38],"possess":[39],"multiple":[40],"pathogen":[41,74],"recognition":[42],"systems,":[43],"and":[44,93,123,177,221,248,254,281,467],"store":[45],"large":[46],"quantities":[47],"fully":[49],"active":[50],"inflammatory":[51,237,472],"mediators.":[52,517],"features":[55],"make":[56],"them":[57,240],"uniquely":[58],"situated":[59],"act":[61,98,232,431],"as":[62,99,209,233],"sentinels":[63],"immunity,":[65,328],"releasing":[66,205],"very":[68],"earliest":[69],"alarm":[70],"signals":[71,154,189,344],"when":[72,440],"a":[73,78,419,511],"is":[75,194,309,452,506,520],"present.":[76],"As":[77],"testament":[79],"importance":[82],"these":[84,230],"mast":[86,94,106,199,261,302,369,524],"cell-deficient":[87],"mice":[88],"suboptimal":[90],"responses,":[92],"cell":[95],"activators":[96],"can":[97,284,314],"potent":[100],"adjuvants":[101,428],"experimental":[103],"immunizations.":[104],"Specifically,":[105],"enhance":[112],"number":[114],"naive":[116,172],"lymphocytes":[117,173],"infection":[119,159],"site-draining":[120],"lymph":[121,133,149,192,291,316,335,378,401,438,475,499],"nodes,":[122],"encourage":[125],"migration":[127],"dendritic":[129],"responding":[132],"nodes.":[134,150,336],"Although":[135,489],"infections":[136],"usually":[137],"occur":[138],"at":[139,433],"peripheral":[140,287,331,495],"sites,":[141,347],"responses":[144,479],"initiated":[146],"distant":[148,346],"Despite":[151],"distance,":[153],"site":[157],"result":[160],"dramatic,":[162],"rapid":[163],"reorganization":[164],"node,":[167],"including":[168],"massive":[169],"recruitment":[170],"circulation":[176],"extensive":[178,297],"vascular":[179],"restructuring":[180],"accommodate":[182],"increase":[184],"size.":[186],"How":[187],"such":[188,208,264,312,516],"reach":[190],"node":[193,317,379,402,439],"not":[195],"well":[196],"understood.":[197],"When":[198],"degranulate,":[201],"addition":[203],"soluble":[206],"mediators":[207,473,493],"histamine,":[210],"they":[211,267,272,283],"expel":[212],"large,":[213],"stable,":[214,270],"insoluble":[215],"particles":[216,231,304,313,341,366,371,526],"composed":[217],"primarily":[218],"heparin":[220],"cationic":[222],"proteins.":[223],"The":[224,256,355,469],"work":[225],"presented":[226,310,357],"herein":[227],"demonstrates":[228],"that":[229,260,266,271,282,311,322,340,360,383,394,429,453],"extracellular":[234],"chaperones":[235],"mediators,":[238],"protecting":[239],"dilution":[242],"into":[243,364],"interstitial":[245],"space,":[246],"degradation,":[247],"interaction":[249],"with":[250],"non-target":[251],"molecules.":[255],"data":[257],"show":[258],"clearly":[259],"release":[263],"particles,":[265],"highly":[269],"contain":[273],"tumor":[274],"necrosis":[275],"factor":[276],"(a":[277],"critically":[278],"important":[279,350,483,527],"immunomodulator),":[280],"traffic":[285],"sites":[288],"draining":[290,334,400,498],"nodes":[292,476,500],"via":[293],"lymphatic":[294],"vessels.":[295],"Furthermore,":[296],"biochemical":[298],"characterization":[299,522],"purified":[301],"cell-derived":[303,370,525],"was":[305],"performed.":[306],"Finally,":[307],"evidence":[308,356],"elicit":[315],"enlargement,":[318,380],"an":[319,381,482],"infection-associated":[320],"phenomenon":[321],"favors":[323],"development":[325,413],"by":[329],"delivering":[330],"TNF":[332,363],"This":[337,389],"signaling":[338],"concept,":[339],"may":[342,386,459,480,535],"chaperone":[343],"between":[345],"also":[348,422,536],"has":[349,501],"implications":[351],"adjuvant":[353,396],"design.":[354],"here":[358],"shows":[359],"encapsulation":[361,451],"synthetic":[365],"similar":[367],"greatly":[372],"enhances":[373],"its":[374],"potency":[375],"eliciting":[377],"indication":[382],"immunity":[385],"be":[387,481],"improved.":[388],"delivery":[390,425,470],"system":[391,420],"should":[392],"ensure":[393],"more":[395],"arrives":[397],"intact,":[403],"where":[404],"it":[405],"would":[406,421,430],"lead":[407,537],"changes":[409],"favorable":[410],"response.":[417],"Such":[418],"facilitate":[423],"multi-component":[427],"synergistically":[432],"level":[435],"gradually":[441],"released":[442],"microparticle":[444,450],"carriers.":[445],"An":[446],"additional":[447],"advantage":[448],"vaccine":[454],"formulations":[455],"this":[457,505,533],"type":[458],"require":[460],"much":[461],"lower":[462],"doses":[463],"expensive":[465],"antigen":[466],"adjuvants.":[468],"during":[477],"general":[484],"feature":[485],"defense.":[488],"action":[491],"origin":[496],"on":[497],"described":[503],"before,":[504],"first":[508],"demonstration":[509],"specific":[512],"adaptation":[513,534],"deliver":[515],"Not":[518],"only":[519],"basic":[529],"immunology,":[530],"but":[531],"mimicking":[532],"improved":[539],"therapeutics.":[540]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
