{"id":"https://openalex.org/W352669868","doi":null,"title":"La represi\u00f3n catab\u00f3lica y NarG como posibles reguladores en la bios\u00edntesis del molibdocofactor de Escherichia coli K12","display_name":"La represi\u00f3n catab\u00f3lica y NarG como posibles reguladores en la bios\u00edntesis del molibdocofactor de Escherichia coli K12","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W352669868","mag":"352669868"},"language":"es","primary_location":{"id":"pmh:oai:cetus.saber.ula.ve:123456789/21664","doi":null,"is_oa":true,"landing_page_url":"http://www.saber.ula.ve/handle/123456789/21664","pdf_url":null,"source":{"id":"https://openalex.org/S4306500644","display_name":"Actualidad Contable FACES","issn_l":"1316-8533","issn":["1316-8533","2244-8772"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.saber.ula.ve/handle/123456789/21664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018913824","display_name":"Mariemma Ortega de L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203303854","display_name":"Universidad de Los Andes","ror":"https://ror.org/02h1b1x27","country_code":"VE","type":"education","lineage":["https://openalex.org/I203303854"]}],"countries":["VE"],"is_corresponding":true,"raw_author_name":"Mariemma Ortega de L\u00f3pez","raw_affiliation_strings":["University of the Andes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Andes","institution_ids":["https://openalex.org/I203303854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018913824"],"corresponding_institution_ids":["https://openalex.org/I203303854"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"1","first_page":"1","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-catabolite-repression","display_name":"catabolite repression","score":0.968999981880188},{"id":"https://openalex.org/keywords/narg","display_name":"narG","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nitrate-reductase","display_name":"nitrate reductase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7080000042915344},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/anaerobic-nitrate-respiration","display_name":"anaerobic nitrate respiration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/escherichia-coli-k-12","display_name":"Escherichia coli K-12","score":0.8379999995231628},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/isogenic-strains","display_name":"isogenic strains","score":0.5130000114440918},{"id":"https://openalex.org/keywords/cytochrome-c550","display_name":"cytochrome c550","score":0.4569999873638153},{"id":"https://openalex.org/keywords/cytochrome-b","display_name":"cytochrome b","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.7419262528419495},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6491907835006714},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4936569631099701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44384995102882385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3941146731376648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1134175956249237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08391740918159485}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:cetus.saber.ula.ve:123456789/21664","doi":null,"is_oa":true,"landing_page_url":"http://www.saber.ula.ve/handle/123456789/21664","pdf_url":null,"source":{"id":"https://openalex.org/S4306500644","display_name":"Actualidad Contable FACES","issn_l":"1316-8533","issn":["1316-8533","2244-8772"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:352669868","doi":null,"is_oa":false,"landing_page_url":"http://www.saber.ula.ve/bitstream/123456789/21664/1/articulo1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306519638","display_name":"MedULA: revista de la Facultad de Medicina","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"MedULA: revista de la Facultad de Medicina","raw_type":null}],"best_oa_location":{"id":"pmh:oai:cetus.saber.ula.ve:123456789/21664","doi":null,"is_oa":true,"landing_page_url":"http://www.saber.ula.ve/handle/123456789/21664","pdf_url":null,"source":{"id":"https://openalex.org/S4306500644","display_name":"Actualidad Contable FACES","issn_l":"1316-8533","issn":["1316-8533","2244-8772"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W197993986","https://openalex.org/W209864347","https://openalex.org/W373797002","https://openalex.org/W1503936652","https://openalex.org/W1509663039","https://openalex.org/W1519207648","https://openalex.org/W1541592150","https://openalex.org/W1546783991","https://openalex.org/W1559508295","https://openalex.org/W1592960253","https://openalex.org/W1606902643","https://openalex.org/W1631792726","https://openalex.org/W1636853739","https://openalex.org/W1676364131","https://openalex.org/W1813750286","https://openalex.org/W1858474008","https://openalex.org/W1889122512","https://openalex.org/W1891358843","https://openalex.org/W1918311340","https://openalex.org/W1964410529","https://openalex.org/W1968163718","https://openalex.org/W1974309223","https://openalex.org/W1976033706","https://openalex.org/W1982970701","https://openalex.org/W1983804506","https://openalex.org/W1985540227","https://openalex.org/W2005064652","https://openalex.org/W2005926447","https://openalex.org/W2016614729","https://openalex.org/W2031423487","https://openalex.org/W2043861217","https://openalex.org/W2056067982","https://openalex.org/W2056872621","https://openalex.org/W2081256230","https://openalex.org/W2082806013","https://openalex.org/W2087092102","https://openalex.org/W2099926472","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2112451028","https://openalex.org/W2118325780","https://openalex.org/W2138156415","https://openalex.org/W2148300059","https://openalex.org/W2154936481","https://openalex.org/W2163932614"],"related_works":["https://openalex.org/W2409692443","https://openalex.org/W2238496833","https://openalex.org/W373797002","https://openalex.org/W2298751873","https://openalex.org/W1981164444","https://openalex.org/W2132284704","https://openalex.org/W7096672849","https://openalex.org/W2045094445","https://openalex.org/W2050911477","https://openalex.org/W1860537557"],"abstract_inverted_index":{"espanolEn":[0],"Escherichia":[1,198],"coli":[2,199],"K12,":[3,200],"la":[4,8,18,27,37,43,65,78,83,86,124,129,162,166,172,183,193],"represion":[5],"catabolica":[6],"y":[7,55,138,189],"region":[9,205],"nar":[10,204],"regulan":[11],"globalmente":[12],"operones":[13],"inducidos":[14],"por":[15,90,121,145],"anaerobiosis.":[16,211],"En":[17],"respiracion":[19],"anaerobica":[20],"del":[21,31,39,52,151,186,195],"nitrato,":[22],"estudios":[23],"previos":[24],"evidenciaron":[25],"a":[26,298,310],"glucosa":[28,163],"como":[29],"regulador":[30,51],"operon":[32,53,152,187,249],"moa,":[33,188],"que":[34,180],"participa":[35],"en":[36,98,128,135,190],"biosintesis":[38,84,194],"molibdocofactor,":[40],"MoCo,":[41,235],"de":[42,77,85,109,117,131,149,161,165,174,176],"Nitrato":[44],"Reductasa":[45],"(NRA).":[46,240],"Para":[47],"identificar":[48],"el":[49,56,91,122],"papel":[50],"narC(GHJI)":[54,248],"AMPc":[57,155],"se":[58],"const":[59],"ruyeron":[60],"cepas":[61,136],"isogenicas":[62],"solo":[63],"presentando":[64],"fusion":[66,79,270],"genomica":[67],"(":[68,260],"moa::lac":[69,261],")25,":[70],"o":[71],"con":[72,101],"mutaciones":[73],"adicionales.":[74],"La":[75,107],"expresion":[76,184],"fue":[80,143],"evaluada":[81],"determinando":[82],"Gal":[87,133,305],",":[88,134],"codificada":[89],"gen":[92,281],"lacZ":[93,282],"fusionado":[94],"al":[95],"promotor":[96],"Pmoa,":[97],"cultivos":[99],"crecidos":[100],"medio":[102],"sintetico":[103],"durante":[104],"una":[105,110],"noche.":[106],"presencia":[108],"mutacion":[111,125,167],"cya":[112,299,323],"disminuyo":[113],"parcialmente":[114],"los":[115,159],"niveles":[116],"actividad":[118],"especifica":[119],"Gal.":[120],"contrario,":[123],"narC-8":[126,311,350],"resulto":[127],"incapacidad":[130],"sintetizar":[132],"cya+":[137,321],"cya.":[139],"Este":[140],"efecto":[141],"no":[142,157],"eliminado":[144],"crecimiento":[146],"bajo":[147],"condiciones":[148],"induccion":[150],"narC.":[153],"El":[154],"exogeno":[156],"abolio":[158],"efectos":[160],"ni":[164],"narC-8.":[168],"Los":[169],"resultados":[170],"apoyan":[171],"participacion":[173],"mas":[175],"un":[177],"control":[178,363],"positivo":[179],"actuaria":[181],"regulando":[182],"transcripcional":[185],"consecuencia":[191],"afectarian":[192],"MoCo.":[196],"EnglishIn":[197],"catabolite":[201],"repression":[202],"and":[203,250,322],"globally":[206],"regulate":[207],"operons":[208],"induced":[209],"by":[210,279,330],"In":[212,308],"the":[213,221,226,232,237,243,247,251,259,275,280,285,303,314,337,347,356,368,372,380],"nitrate":[214,238],"anaerobic":[215],"respiration,":[216],"previous":[217],"studies":[218],"evidenced":[219],"to":[220,284,316],"glucose":[222,348],"as":[223],"regulator":[224,244],"of":[225,236,246,297,358,371],"moa":[227,373],"operon,":[228,374],"which":[229],"participates":[230],"in":[231,288,313,319,375],"molybdocofactor":[233],"biosynthesis,":[234,277],"reductase":[239],"To":[241],"identify":[242],"role":[245],"cAMP,":[252],"were":[253],"constructed":[254],"isogenic":[255],"strains":[256],"carring":[257],"either":[258,343],")25":[262],"genomic":[263],"fusion,":[264],"or":[265],"plus":[266],"additional":[267],"mutations.":[268],"The":[269,295,340,353],"expression":[271,370],"was":[272,327],"evaluated":[273],"determining":[274],"Bgal":[276],"encodied":[278],"united":[283],"Pmoa":[286],"promoter,":[287],"culture":[289],"overnight":[290],"growing":[291],"with":[292],"minimal":[293],"medium.":[294],"presence":[296],"mutation":[300,351],"partially":[301],"decreased":[302],"specific":[304],"activity":[306],"levels.":[307],"contrast,":[309],"resulted":[312],"inability":[315],"synthesize":[317],"Gal,":[318],"both":[320],"strains.":[324],"This":[325],"effect":[326],"not":[328,345],"eliminated":[329],"growin":[331],"g":[332],"under":[333],"conditions":[334],"that":[335,364],"induce":[336],"narC":[338],"operon.":[339],"exogenous":[341],"cAMP":[342],"did":[344],"abolish":[346],"nor":[349],"effects.":[352],"results":[354],"support":[355],"participation":[357],"more":[359],"than":[360],"one":[361],"positive":[362],"should":[365,378],"act":[366],"on":[367],"transcriptional":[369],"consequence":[376],"it":[377],"affect":[379],"MoCo":[381],"biosynthesis.":[382]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}