{"id":"https://openalex.org/W3526224","doi":"https://doi.org/10.1007/978-1-59259-032-2_20","title":"The Mechanism of Action of Steroid Hormone Receptors","display_name":"The Mechanism of Action of Steroid Hormone Receptors","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W3526224","doi":"https://doi.org/10.1007/978-1-59259-032-2_20","mag":"3526224"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-032-2_20","doi":"https://doi.org/10.1007/978-1-59259-032-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-032-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Molecular Regulation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W588978490","display_name":"Principles of Molecular Regulation"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062055452","display_name":"Donald Patrick McDonnell","orcid":"https://orcid.org/0000-0002-7331-4700","observed_orcids":["https://orcid.org/0000-0002-7331-4700"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donald P. McDonnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062055452"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2581,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7795082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"351","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7179999947547913},{"id":"https://openalex.org/keywords/progestins","display_name":"progestins","score":0.9940000176429749},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":1.0},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mineralocorticoids","display_name":"mineralocorticoids","score":1.0},{"id":"https://openalex.org/keywords/sex-steroids","display_name":"sex steroids","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.652999997138977},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/reproductive-function","display_name":"reproductive function","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7540168166160583},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.7273383140563965},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.683905839920044},{"id":"https://openalex.org/C15660099","wikidata":"https://www.wikidata.org/wiki/Q7458508","display_name":"Sex hormone receptor","level":5,"score":0.5447912216186523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4804743826389313},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4665876030921936},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4654778838157654},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4623035490512848},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4419747591018677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40770506858825684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38533085584640503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1683710217475891},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.11828014254570007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08435210585594177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07332271337509155},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04642915725708008},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-032-2_20","doi":"https://doi.org/10.1007/978-1-59259-032-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-032-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Molecular Regulation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4300000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W97536107","https://openalex.org/W1986578326","https://openalex.org/W2007048730","https://openalex.org/W2015252965","https://openalex.org/W2039175485","https://openalex.org/W2068113812","https://openalex.org/W2068733538","https://openalex.org/W2085124463","https://openalex.org/W2089017130","https://openalex.org/W2091550771","https://openalex.org/W2124295934","https://openalex.org/W2136657922","https://openalex.org/W3159915152"],"related_works":["https://openalex.org/W2225423085","https://openalex.org/W2896050208","https://openalex.org/W2955077061","https://openalex.org/W193259180","https://openalex.org/W2089607963","https://openalex.org/W4390967420","https://openalex.org/W2041329416","https://openalex.org/W2419554788","https://openalex.org/W2089345875","https://openalex.org/W2285463653"],"abstract_inverted_index":{"Estrogens,":[0],"progestins,":[1,48],"androgens,":[2,50],"glucocorticoids,":[3],"and":[4,31,44,49,59,79,116,139,148],"mineralocorticoids":[5],"are":[6,35,54,76],"a":[7,19,99],"group":[8],"of":[9,18,22,41,61,86,93,96,103,112,121,127,130],"structurally":[10],"similar":[11,78],"lipophilic":[12],"steroids":[13],"responsible":[14,55],"for":[15,33,56],"the":[16,39,51,57,73,84,94,119,128,142,149,155],"regulation":[17,40],"wide":[20],"variety":[21],"cellular":[23,42],"processes":[24],"in":[25,38],"different":[26,66],"target":[27],"organs.":[28],"The":[29,101],"glucocorticoids":[30],"mineralocorticoids,":[32],"instance,":[34],"primarily":[36],"involved":[37],"homeostasis":[43],"metabolism":[45],"whereas":[46],"estrogens,":[47],"sex":[52],"steroids,":[53],"development":[58],"maintenance":[60],"reproductive":[62],"function.":[63],"Despite":[64],"their":[65],"roles,":[67],"it":[68],"has":[69,89],"become":[70],"apparent":[71],"that":[72,80],"steroid":[74,113,131],"hormones":[75],"mechanistically":[77],"insights":[81,123],"gleaned":[82],"from":[83],"study":[85],"each":[87],"hormone":[88,114],"advanced":[90],"our":[91,125],"understanding":[92,126],"class":[95],"molecules":[97],"as":[98,154],"whole.":[100],"objective":[102],"this":[104],"chapter":[105],"is":[106,146],"to":[107,117],"provide":[108],"an":[109],"updated":[110,153],"model":[111],"action":[115],"discuss":[118],"impact":[120],"recent":[122],"on":[124],"pharmacology":[129],"hormones.":[132],"These":[133],"keywords":[134,150],"were":[135],"added":[136],"by":[137,141],"machine":[138],"not":[140],"authors.":[143],"This":[144],"process":[145],"experimental":[147],"may":[151],"be":[152],"learning":[156],"algorithm":[157],"improves.":[158]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
