{"id":"https://openalex.org/W352619735","doi":"https://doi.org/10.1371/journal.pone.0127237","title":"Cost-Effectiveness of Extended-Release Methylphenidate in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder Sub-Optimally Treated with Immediate Release Methylphenidate","display_name":"Cost-Effectiveness of Extended-Release Methylphenidate in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder Sub-Optimally Treated with Immediate Release Methylphenidate","publication_year":2015,"publication_date":"2015-05-29","ids":{"openalex":"https://openalex.org/W352619735","doi":"https://doi.org/10.1371/journal.pone.0127237","mag":"352619735","pmid":"https://pubmed.ncbi.nlm.nih.gov/26024479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449164"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0127237","doi":"https://doi.org/10.1371/journal.pone.0127237","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0127237","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127237&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127237&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001137200","display_name":"Jurjen van der Schans","orcid":"https://orcid.org/0000-0001-6170-1191","observed_orcids":["https://orcid.org/0000-0001-6170-1191","https://orcid.org/0000-0001-7489-6231"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jurjen van der Schans","raw_affiliation_strings":["Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074079949","display_name":"Nikolaos Kotsopoulos","orcid":"https://orcid.org/0000-0002-8248-7697","observed_orcids":["https://orcid.org/0000-0002-8248-7697"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nikos Kotsopoulos","raw_affiliation_strings":["Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039838663","display_name":"Pieter J. Hoekstra","orcid":"https://orcid.org/0000-0003-1018-9954","observed_orcids":["https://orcid.org/0000-0003-1018-9954","https://orcid.org/0000-0001-7260-4119"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter J. Hoekstra","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033079155","display_name":"Eelko Hak","orcid":"https://orcid.org/0000-0003-0849-7210","observed_orcids":["https://orcid.org/0000-0003-0849-7210"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eelko Hak","raw_affiliation_strings":["Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016565734","display_name":"Maarten Jacobus Postma","orcid":"https://orcid.org/0000-0002-6306-3653","observed_orcids":["https://orcid.org/0000-0002-6306-3653"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Maarten J. Postma","raw_affiliation_strings":["Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Institute of Science in Healthy Aging & healthcaRE, Groningen, the Netherlands","Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands","University of Groningen, University Medical Center Groningen, Institute of Science in Healthy Aging & healthcaRE, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Institute of Science in Healthy Aging & healthcaRE, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen (RUG), Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Institute of Science in Healthy Aging & healthcaRE, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001137200","https://openalex.org/A5016565734"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1285,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75217975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"5","first_page":"e0127237","last_page":"e0127237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/extended-release-methylphenidate","display_name":"extended-release methylphenidate","score":0.984000027179718},{"id":"https://openalex.org/keywords/immediate-release-methylphenidate","display_name":"immediate-release methylphenidate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.8090000152587891},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.6579999923706055},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9599999785423279},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5199999809265137},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.6449999809265137},{"id":"https://openalex.org/keywords/osmotic-release-oral-system","display_name":"osmotic-release oral system","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.8691688776016235},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.6787369251251221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5217757821083069},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4403587877750397},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.4394943118095398},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43338489532470703},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.15697070956230164}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0127237","doi":"https://doi.org/10.1371/journal.pone.0127237","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0127237","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127237&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4449164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449164","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26024479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26024479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.94","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.94","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/71/40/pone.0127237.PMC4449164.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0127237","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127237","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:83e970773a24405da2ef97c529c248c0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/83e970773a24405da2ef97c529c248c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 5, p e0127237 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1430876","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Cost_Effectiveness_of_Extended_Release_Methylphenidate_in_Children_and_Adolescents_with_Attention_Deficit_Hyperactivity_Disorder_Sub_Optimally_Treated_with_Immediate_Release_Methylphenidate_/1430876","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.rug.nl:openaire/b120274f-abc4-456c-bb40-92f2b0eba430","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/b120274f-abc4-456c-bb40-92f2b0eba430","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van der Schans, J, Kotsopoulos, N, Hoekstra, P J, Hak, E & Postma, M J 2015, 'Cost-Effectiveness of Extended-Release Methylphenidate in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder Sub-Optimally Treated with Immediate Release Methylphenidate', PLoS ONE, vol. 10, no. 5, e0127237. https://doi.org/10.1371/journal.pone.0127237","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/b120274f-abc4-456c-bb40-92f2b0eba430","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/b120274f-abc4-456c-bb40-92f2b0eba430","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10(5):e0127237. PUBLIC LIBRARY SCIENCE","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0127237","doi":"https://doi.org/10.1371/journal.pone.0127237","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0127237","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127237&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2781077058","display_name":null,"funder_award_id":"836011014","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W352619735.pdf","grobid_xml":"https://content.openalex.org/works/W352619735.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W85469694","https://openalex.org/W96453995","https://openalex.org/W123597899","https://openalex.org/W1988459953","https://openalex.org/W1990010425","https://openalex.org/W1996548671","https://openalex.org/W2012924701","https://openalex.org/W2029807247","https://openalex.org/W2031947904","https://openalex.org/W2035768785","https://openalex.org/W2036696167","https://openalex.org/W2039929950","https://openalex.org/W2046837347","https://openalex.org/W2066299057","https://openalex.org/W2068607934","https://openalex.org/W2071698221","https://openalex.org/W2102388069","https://openalex.org/W2102713705","https://openalex.org/W2111643633","https://openalex.org/W2115469350","https://openalex.org/W2121519528","https://openalex.org/W2122664355","https://openalex.org/W2126271209","https://openalex.org/W2138613917","https://openalex.org/W2162215180","https://openalex.org/W2163503966","https://openalex.org/W2165266539","https://openalex.org/W2902468262","https://openalex.org/W4390960950"],"related_works":["https://openalex.org/W7100315674","https://openalex.org/W96453995","https://openalex.org/W2086068703","https://openalex.org/W2091699214","https://openalex.org/W1980365057","https://openalex.org/W2007359526","https://openalex.org/W2063410187","https://openalex.org/W2176379477","https://openalex.org/W2001763447","https://openalex.org/W7222806850"],"abstract_inverted_index":{"BACKGROUND:":[0],"Attention-Deficit/Hyperactivity":[1],"Disorder":[2],"(ADHD)":[3],"is":[4,16],"a":[5,54,73,77,95,194],"common":[6],"psychiatric":[7],"disorder":[8],"in":[9,83,141,207,209],"children":[10],"and":[11,32,46,64,116,129,136,144,163,190],"adolescents.":[12],"Immediate-release":[13],"methylphenidate":[14,123],"(IR-MPH)":[15],"the":[17,70,142,164,210],"medical":[18],"treatment":[19,196],"of":[20,51,76,97,188,203,213],"first":[21],"choice.":[22],"The":[23],"necessity":[24],"to":[25,41,81,178,185,221,229,232],"use":[26],"several":[27],"IR-MPH":[28,52,80,177,231],"tablets":[29],"per":[30],"day":[31],"associated":[33],"potential":[34],"social":[35],"stigma":[36],"at":[37],"school":[38],"often":[39],"leads":[40],"reduced":[42],"compliance,":[43],"sub-optimal":[44,111],"treatment,":[45,115],"therefore":[47],"economic":[48,65,219],"loss.":[49],"Replacement":[50],"with":[53,200,224,226],"single-dose":[55],"extended":[56],"release":[57,125],"(ER-MPH)":[58],"formulation":[59],"may":[60],"improve":[61],"drug":[62],"response":[63,228],"efficiency.":[66],"OBJECTIVE:":[67],"To":[68],"evaluate":[69],"cost-effectiveness":[71,169],"from":[72,79,176],"societal":[74],"perspective":[75],"switch":[78],"ER-MPH":[82,120,234],"patients":[84,175,223],"who":[85],"are":[86],"sub-optimally":[87,173],"treated.":[88],"METHODS:":[89],"A":[90],"daily":[91],"Markov-cycle":[92],"model":[93],"covering":[94],"time-span":[96],"10":[98],"years":[99,151],"was":[100],"developed":[101],"including":[102],"four":[103],"different":[104],"health":[105],"states:":[106],"(1)":[107],"optimal":[108],"response,":[109,112],"(2)":[110],"(3)":[113],"discontinued":[114],"(4)":[117],"natural":[118],"remission.":[119],"options":[121],"included":[122,140],"osmotic":[124],"oral":[126],"system":[127],"(MPH-OROS)":[128],"Equasym":[130,181],"XL/Medikinet":[131,182],"CR.":[132],"Both":[133],"direct":[134],"costs":[135,138],"indirect":[137],"were":[139,146,161,167],"analysis,":[143],"effects":[145],"expressed":[147],"as":[148,155,157],"quality-adjusted":[149],"life":[150],"(QALYs).":[152],"Univariate,":[153],"multivariate":[154],"well":[156],"probabilistic":[158],"sensitivity":[159],"analysis":[160,199],"conducted":[162],"main":[165],"outcomes":[166],"incremental":[168],"ratios.":[170],"RESULTS:":[171],"Switching":[172],"treated":[174],"MPH-OROS":[179],"or":[180],"CR":[183],"led":[184],"per-patient":[186],"cost-savings":[187,208],"\u20ac4200":[189],"\u20ac5400,":[191],"respectively,":[192],"over":[193],"10-year":[195],"span.":[197],"Sensitivity":[198],"plausible":[201],"variations":[202],"input":[204],"parameters":[205],"resulted":[206],"vast":[211],"majority":[212],"estimations.":[214],"CONCLUSIONS:":[215],"This":[216],"study":[217],"lends":[218],"support":[220],"switching":[222],"ADHD":[225],"suboptimal":[227],"short-acting":[230],"long-acting":[233],"regimens.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
