{"id":"https://openalex.org/W35148275","doi":null,"title":"Technical study of the leucocyte migration inhibition test in agarose. Application to PPD and to hepatitis B antigen.","display_name":"Technical study of the leucocyte migration inhibition test in agarose. Application to PPD and to hepatitis B antigen.","publication_year":1974,"publication_date":"1974-11-01","ids":{"openalex":"https://openalex.org/W35148275","mag":"35148275","pmid":"https://pubmed.ncbi.nlm.nih.gov/4619978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537987"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537987","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537987","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068819292","display_name":"Philippe Erard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P Erard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068819292"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.619,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.91972978,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"3","first_page":"439","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucocyte-migration-inhibition-test","display_name":"leucocyte migration inhibition test","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hepatitis-b-antigen","display_name":"hepatitis B antigen","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.824999988079071},{"id":"https://openalex.org/keywords/lymphomonocytes","display_name":"lymphomonocytes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/acute-hepatitis-b","display_name":"acute hepatitis B","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immune-response-to-antigens","display_name":"immune response to antigens","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7440754175186157},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.6722869277000427},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.6096013188362122},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5647793412208557},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4542544186115265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4318857789039612},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3388941287994385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3044520616531372},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2446993589401245}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006506","descriptor_name":"Hepatitis A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006511","descriptor_name":"Hepatitis B Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012685","descriptor_name":"Sepharose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014373","descriptor_name":"Tuberculin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1537987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537987","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:4619978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4619978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:35148275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4619978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537987","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1645219326","https://openalex.org/W1752706135","https://openalex.org/W1998299275","https://openalex.org/W2020600345","https://openalex.org/W2050451935","https://openalex.org/W2055465637","https://openalex.org/W2072595338","https://openalex.org/W2074784999","https://openalex.org/W2140459571","https://openalex.org/W2163233389","https://openalex.org/W2417019539","https://openalex.org/W4231176252","https://openalex.org/W4313316408"],"related_works":["https://openalex.org/W6996881334","https://openalex.org/W3195091853","https://openalex.org/W2418504774","https://openalex.org/W2118971705","https://openalex.org/W2417019539","https://openalex.org/W2067583902","https://openalex.org/W2403008577","https://openalex.org/W1502632527","https://openalex.org/W2065294100","https://openalex.org/W2157798467"],"abstract_inverted_index":{"A":[0],"modification":[1],"of":[2,53,56,62,66,76,79,85,97,112,133,149,158,198,230,238,246,257,267,281,284,293],"the":[3,22,45,54,57,63,77,82,86,98,106,113,124,141,147,159,196,236,239,244,247,265,290],"leucocyte":[4,248],"migration":[5,46,249],"inhibition":[6,134,173,185,208,221,250],"test,":[7],"in":[8,12,47,105,152,176,190,211,225,233,252,260],"which":[9],"cells":[10,100],"migrate":[11,104],"an":[13,220],"agarose":[14,107,253],"layer,":[15],"was":[16,27,69,118,137,174,186,209,222],"proposed":[17],"by":[18],"Clausen":[19],"(1971).":[20],"In":[21,139],"present":[23],"study,":[24],"this":[25,150,184,282],"method":[26],"applied":[28],"to":[29,95,103,128,161,287],"PPD":[30,167,177,191,288],"and":[31,36,71,91,121,279],"hepatitis":[32,200,217,277],"B":[33,278],"antigen":[34,136,145],"(HBAg),":[35],"its":[37],"advantages":[38],"were":[39,89,101],"reassessed.":[40],"From":[41],"a":[42,48,51,74,130,170,206,228],"technical":[43],"standpoint,":[44],"monolayer":[49],"facilitated":[50,146],"study":[52],"morphology":[55],"migrating":[58,67,87],"cells.":[59],"The":[60,109],"proportion":[61],"different":[64],"kinds":[65],"leucocytes":[68,88],"calculated":[70],"expressed":[72],"as":[73,168,204],"function":[75],"distance":[78],"migration.":[80],"On":[81],"whole,":[83],"92%":[84],"polymorphonuclears":[90],"8%":[92],"lymphomonocytes.":[93],"Three":[94],"10%":[96],"incubated":[99],"shown":[102],"layer.":[108],"surface":[110],"area":[111],"controls":[114],"(migration":[115],"without":[116,227],"inhibition)":[117],"sufficiently":[119],"constant":[120],"large":[122],"(on":[123],"average":[125],"13":[126],"mm(2))":[127],"allow":[129],"clear":[131],"assessment":[132],"when":[135],"added.":[138],"addition,":[140],"small":[142],"requirement":[143],"for":[144,254,271],"use":[148],"test":[151,251],"experimentation":[153],"with":[154,166],"purified":[155],"HBAg.":[156],"Application":[157],"technique":[160],"clinical":[162],"problems":[163],"revealed":[164],"that,":[165],"antigen,":[169,205],"highly":[171],"significant":[172,188,207],"obtained":[175,210],"skin":[178,192],"test-positive":[179,193],"normal":[180],"individuals":[181,212,226],"(0\u00b70025<P<0\u00b7005).":[182],"But":[183],"not":[187,223],"(0\u00b705<P<0\u00b71)":[189],"patients":[194,234],"during":[195,235,289],"course":[197,237],"acute":[199,216,276,291],"B.":[201,218],"With":[202],"HBAg":[203,272],"having":[213],"recovered":[214],"from":[215,275],"Such":[219],"demonstrable":[224],"history":[229],"hepatitis,":[231],"nor":[232],"disease.":[240],"These":[241],"results":[242],"demonstrate":[243],"suitability":[245],"routine":[255],"detection":[256],"cell-mediated":[258,268],"immunity":[259,269],"man.":[261],"They":[262],"further":[263],"suggest":[264],"development":[266],"specific":[270],"after":[273],"recovery":[274],"impairment":[280],"type":[283],"immune":[285],"response":[286],"phase":[292],"hepatitis.":[294]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
