{"id":"https://openalex.org/W35061713","doi":null,"title":"How T-cells influence microglia to form a feedback loop that accelerates disease progression in Parkinson\u2019s disease","display_name":"How T-cells influence microglia to form a feedback loop that accelerates disease progression in Parkinson\u2019s disease","publication_year":2011,"publication_date":"2011-01-28","ids":{"openalex":"https://openalex.org/W35061713","mag":"35061713"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/193880","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/193880","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/193880","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006485310","display_name":"Floris C. Loeff","orcid":"https://orcid.org/0000-0001-7059-2038","observed_orcids":["https://orcid.org/0000-0001-7059-2038"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"F.C. Loeff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006485310"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.23960000276565552,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8709999918937683},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/sporadic-parkinson-s-disease","display_name":"sporadic Parkinson's disease","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7818683385848999},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6279881596565247},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5935965776443481},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5777194499969482},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.466897577047348},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.4440467655658722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3402473032474518},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3218528628349304},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23485758900642395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17806139588356018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15596523880958557},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11432364583015442},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11141791939735413},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07262814044952393},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.05625039339065552}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/193880","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/193880","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:35061713","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/193880/0424625_thesis.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/193880","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/193880","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W17149418","https://openalex.org/W62603772","https://openalex.org/W74388523","https://openalex.org/W96427772","https://openalex.org/W99762335","https://openalex.org/W1521854746","https://openalex.org/W1523213544","https://openalex.org/W1535546167","https://openalex.org/W1558808632","https://openalex.org/W1601542379","https://openalex.org/W1611449349","https://openalex.org/W1820596764","https://openalex.org/W1942668068","https://openalex.org/W1966818758","https://openalex.org/W1966918485","https://openalex.org/W1967640115","https://openalex.org/W1968998365","https://openalex.org/W1969999276","https://openalex.org/W1970095022","https://openalex.org/W1971668430","https://openalex.org/W1973937050","https://openalex.org/W1974924674","https://openalex.org/W1975331070","https://openalex.org/W1976749972","https://openalex.org/W1978429445","https://openalex.org/W1979217137","https://openalex.org/W1984379998","https://openalex.org/W1985337246","https://openalex.org/W1987446689","https://openalex.org/W1988317772","https://openalex.org/W1989734927","https://openalex.org/W1990203556","https://openalex.org/W1991805788","https://openalex.org/W1993829231","https://openalex.org/W1996574563","https://openalex.org/W1996630962","https://openalex.org/W1998000193","https://openalex.org/W2001408101","https://openalex.org/W2003870617","https://openalex.org/W2006814519","https://openalex.org/W2008155801","https://openalex.org/W2014182955","https://openalex.org/W2016293419","https://openalex.org/W2016905315","https://openalex.org/W2017605183","https://openalex.org/W2018356836","https://openalex.org/W2023572125","https://openalex.org/W2028098121","https://openalex.org/W2029146247","https://openalex.org/W2032139930","https://openalex.org/W2036600670","https://openalex.org/W2036742353","https://openalex.org/W2038042834","https://openalex.org/W2044137812","https://openalex.org/W2044407202","https://openalex.org/W2051144591","https://openalex.org/W2059718548","https://openalex.org/W2060457554","https://openalex.org/W2061995199","https://openalex.org/W2064376469","https://openalex.org/W2066430727","https://openalex.org/W2068576129","https://openalex.org/W2073845471","https://openalex.org/W2075411991","https://openalex.org/W2078056296","https://openalex.org/W2084441631","https://openalex.org/W2086774548","https://openalex.org/W2088067322","https://openalex.org/W2091265794","https://openalex.org/W2091582185","https://openalex.org/W2107496222","https://openalex.org/W2108237688","https://openalex.org/W2109759840","https://openalex.org/W2110939383","https://openalex.org/W2111132370","https://openalex.org/W2112670248","https://openalex.org/W2112959592","https://openalex.org/W2113007696","https://openalex.org/W2116605894","https://openalex.org/W2116993524","https://openalex.org/W2118309500","https://openalex.org/W2118353064","https://openalex.org/W2121080034","https://openalex.org/W2122113931","https://openalex.org/W2128928835","https://openalex.org/W2133759882","https://openalex.org/W2134947892","https://openalex.org/W2136570995","https://openalex.org/W2137849205","https://openalex.org/W2140595333","https://openalex.org/W2148945613","https://openalex.org/W2151280274","https://openalex.org/W2152348254","https://openalex.org/W2155395884","https://openalex.org/W2159732419","https://openalex.org/W2160031422","https://openalex.org/W2164627569","https://openalex.org/W2166438464","https://openalex.org/W2166776351","https://openalex.org/W2168189622","https://openalex.org/W2172466148","https://openalex.org/W2326164100","https://openalex.org/W2335011627","https://openalex.org/W2335158689","https://openalex.org/W2408083963","https://openalex.org/W2416871384","https://openalex.org/W2792448780"],"related_works":["https://openalex.org/W2051835142","https://openalex.org/W4320167825","https://openalex.org/W7214753626","https://openalex.org/W4414561306","https://openalex.org/W4214927840","https://openalex.org/W2887509324","https://openalex.org/W7043798683","https://openalex.org/W4411340592","https://openalex.org/W7099216160","https://openalex.org/W1992743838"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1],"(PD)":[2],"is":[3],"a":[4,47],"movement":[5],"disorder":[6],"characterized":[7],"by":[8,106],"extensive":[9],"degeneration":[10],"of":[11,31,34,36,50,55,69,76,84,94,99],"dopaminergic":[12],"neurons":[13],"in":[14,96],"the":[15,56,70,74,77,82,92,97],"nigrostriatal":[16],"pathway.":[17],"Although":[18],"several":[19],"gene":[20],"mutations":[21],"and":[22,28,52,117],"toxins":[23],"are":[24],"correlated":[25],"with":[26],"inherited":[27],"induced":[29],"forms":[30],"PD,":[32],"causes":[33],"initiation":[35],"sporadic":[37],"PD":[38,51,59,105],"remains":[39],"debated.":[40],"In":[41],"this":[42],"thesis":[43],"I":[44,64],"will":[45,65,88,120],"give":[46,66],"general":[48],"introduction":[49],"an":[53,67],"overview":[54,68],"literature":[57,72],"on":[58,81,91],"initiation.":[60],"However":[61],"most":[62],"importantly,":[63],"recent":[71],"discussing":[73],"involvement":[75,93],"adaptive":[78],"immune":[79],"system":[80],"progression":[83],"PD.":[85,100],"Here":[86],"we":[87],"specifically":[89],"focus":[90],"T-cells":[95],"pathogenesis":[98],"Also,":[101],"possibilities":[102],"to":[103],"influence":[104],"inducing":[107],"differential":[108],"T-cell":[109],"subtypes,":[110],"such":[111],"as":[112],"Thelper1":[113],"cells,":[114,116,119],"Thelper2":[115],"Tregulatory":[118],"be":[121],"discussed.":[122]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}