{"id":"https://openalex.org/W350385335","doi":null,"title":"Sympathetic stimulation of corneal epithelial proliferation in wounded and nonwounded rat eyes.","display_name":"Sympathetic stimulation of corneal epithelial proliferation in wounded and nonwounded rat eyes.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W350385335","mag":"350385335","pmid":"https://pubmed.ncbi.nlm.nih.gov/8977468"},"language":"en","primary_location":{"id":"pmid:8977468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8977468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M A Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Jones","raw_affiliation_strings":["Northwest Center for Medical Education, Indiana University School of Medicine, Gary 46408, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwest Center for Medical Education, Indiana University School of Medicine, Gary 46408, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005534999","display_name":"Carl F. Marfurt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Marfurt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.299,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.76800591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"37","issue":"13","first_page":"2535","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-epithelial-proliferation","display_name":"corneal epithelial proliferation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/superior-cervical-ganglionectomy","display_name":"superior cervical ganglionectomy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9089999794960022},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/sympathetic-innervation","display_name":"sympathetic innervation","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2776650652","wikidata":"https://www.wikidata.org/wiki/Q5521150","display_name":"Ganglionectomy","level":3,"score":0.9078234434127808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.703323245048523},{"id":"https://openalex.org/C2778993773","wikidata":"https://www.wikidata.org/wiki/Q1493493","display_name":"Superior cervical ganglion","level":2,"score":0.653178334236145},{"id":"https://openalex.org/C2779190097","wikidata":"https://www.wikidata.org/wiki/Q6128790","display_name":"Sympathectomy","level":2,"score":0.6485878229141235},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.5589432716369629},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4618237614631653},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.4608213007450104},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.4309881925582886},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.4233691096305847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.387138307094574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3625906705856323},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2057434320449829},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.19506001472473145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19083517789840698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1837117075920105},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002057","descriptor_name":"Burns, Chemical","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005126","descriptor_name":"Eye Burns","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005126","descriptor_name":"Eye Burns","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015171","descriptor_name":"Ganglionectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019850","descriptor_name":"Heptanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8977468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8977468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:350385335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8977468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2547795874","display_name":"CORNEAL INNERVATION AND WOUND HEALING","funder_award_id":"R01EY005717","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2609152534","https://openalex.org/W2040589698","https://openalex.org/W182095982","https://openalex.org/W2074420838","https://openalex.org/W2002476529","https://openalex.org/W2462516165","https://openalex.org/W191647465","https://openalex.org/W1984321117","https://openalex.org/W2024069034","https://openalex.org/W1999921554"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,14,35,38,73,145,154,165,224],"effect":[4,147],"of":[5,37,72,131,139,148,153,198,206,226],"ocular":[6,149,211],"sympathetic":[7,75,118,141,180],"nerves":[8,181,203,213],"on":[9,110],"corneal":[10,31,184,193],"epithelial":[11,32,122,185],"proliferation":[12,123,186],"in":[13,26,46,94,102,124,157,221],"rat.":[15],"METHODS:":[16],"Osmotic":[17],"pumps":[18],"filled":[19],"with":[20,51,159,209],"bromodeoxyuridine":[21],"(BrdU)":[22],"were":[23,49,61,105],"implanted":[24],"subcutaneously":[25],"adult":[27],"rats":[28],"to":[29,63,133,171,216,223],"label":[30],"cells":[33],"entering":[34],"S-phase":[36],"cell":[39,108],"cycle":[40],"during":[41,192],"a":[42],"24-hour":[43],"period.":[44],"Corneas":[45],"some":[47],"animals":[48,60,172],"wounded":[50,127],"n-heptanol.":[52],"Several":[53],"days":[54],"or":[55,86],"weeks":[56],"before":[57],"pump":[58],"implantation,":[59],"subjected":[62],"either":[64],"unilateral":[65,70,82,87,160,175],"superior":[66],"cervical":[67,74,115],"ganglionectomy":[68,116],"(SCGectomy),":[69],"transection":[71],"trunk":[76],"(sympathetic":[77],"decentralization),":[78],"bilateral":[79],"SCGectomy":[80,88,176],"plus":[81,89],"topical":[83],"norepinephrine":[84,132],"administration,":[85],"systemic":[90],"capsaicin":[91],"administration.":[92],"Differences":[93],"BrdU-labeling":[95],"indices":[96],"between":[97],"experimental":[98],"and":[99,117,126,191,214],"control":[100],"eyes":[101,134],"each":[103],"group":[104],"determined":[106],"from":[107],"counts":[109],"paraffin":[111],"sections.":[112],"RESULTS:":[113],"Superior":[114],"decentralization":[119],"significantly":[120],"decreased":[121],"nonwounded":[125],"corneas.":[128],"Topical":[129],"applications":[130],"that":[135,173],"had":[136],"been":[137],"deprived":[138],"their":[140],"innervation":[142],"completely":[143],"reversed":[144],"antiproliferative":[146],"sympathectomy.":[150],"Systemic":[151],"administration":[152],"neurotoxin":[155],"capsaicin,":[156],"conjunction":[158],"SCGectomy,":[161],"did":[162],"not":[163],"alter":[164],"proliferative":[166],"rate;":[167],"comparison":[168],"was":[169],"made":[170],"received":[174],"only.":[177],"CONCLUSIONS:":[178],"Ocular":[179],"stimulate":[182],"rat":[183],"under":[187],"normal":[188],"physiological":[189],"conditions":[190],"wound":[194],"healing.":[195],"The":[196],"promotion":[197],"DNA":[199],"synthesis":[200],"by":[201],"these":[202],"occurs":[204],"independently":[205],"functional":[207],"interactions":[208],"capsaicin-sensitive,":[210],"sensory":[212],"appears":[215],"be":[217],"related,":[218],"at":[219],"least":[220],"part,":[222],"release":[225],"norepinephrine.":[227]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}