{"id":"https://openalex.org/W34934669","doi":null,"title":"Identification of a mutant bovine herpesvirus-1 (BHV-1) in post-arrival outbreaks of IBR in feedlot calves and protection with conventional vaccination.","display_name":"Identification of a mutant bovine herpesvirus-1 (BHV-1) in post-arrival outbreaks of IBR in feedlot calves and protection with conventional vaccination.","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W34934669","mag":"34934669","pmid":"https://pubmed.ncbi.nlm.nih.gov/11346260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:216241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084967847","display_name":"Sylvia van Drunen Littel\u2010van den Hurk","orcid":"https://orcid.org/0000-0002-8214-2031","observed_orcids":["https://orcid.org/0000-0002-8214-2031"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S van Drunen Littel-van den Hurk","raw_affiliation_strings":["Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada. vandenhurk@sask.usask.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada. vandenhurk@sask.usask.ca","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112714032","display_name":"P A Doig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Doig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007852277","display_name":"Brenda Karvonen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Karvonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015057768","display_name":"Monique Habermehl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Habermehl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111991298","display_name":"LORNE A. BABIUK","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Babiuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089370531","display_name":"Murray D. Jelinski","orcid":"https://orcid.org/0000-0001-6239-4496","observed_orcids":["https://orcid.org/0000-0001-6239-4496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jelinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057684776","display_name":"Joyce Van Donkersgoed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Van Donkersgoed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Schlesinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Schlesinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C Rinehart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Rinehart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5986,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.68970857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"2","first_page":"81","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-herpesvirus-1","display_name":"bovine herpesvirus 1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/infectious-bovine-rhinotracheitis","display_name":"infectious bovine rhinotracheitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/feedlot-calves","display_name":"feedlot calves","score":0.800000011920929},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vaccine-protection","display_name":"vaccine protection","score":0.7129999995231628},{"id":"https://openalex.org/keywords/challenge-studies","display_name":"challenge studies","score":0.43799999356269836},{"id":"https://openalex.org/keywords/humoral-and-cellular-immune-response","display_name":"humoral and cellular immune response","score":0.8389999866485596},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"viral shedding","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2777594917","wikidata":"https://www.wikidata.org/wiki/Q478428","display_name":"Bovine herpesvirus 1","level":5,"score":0.787465512752533},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.7770333290100098},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7731764316558838},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7138848900794983},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6609193086624146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.589195966720581},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49407699704170227},{"id":"https://openalex.org/C2779329348","wikidata":"https://www.wikidata.org/wiki/Q1400937","display_name":"Feedlot","level":2,"score":0.4939902424812317},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3461075723171234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3235589563846588},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.23487010598182678},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.2215082049369812},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.05907559394836426}],"mesh":[{"descriptor_ui":"D000416","descriptor_name":"Alberta","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007117","descriptor_name":"Immunization, Secondary","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D007241","descriptor_name":"Infectious Bovine Rhinotracheitis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007241","descriptor_name":"Infectious Bovine Rhinotracheitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007241","descriptor_name":"Infectious Bovine Rhinotracheitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D007242","descriptor_name":"Herpesvirus 1, Bovine","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007242","descriptor_name":"Herpesvirus 1, Bovine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007242","descriptor_name":"Herpesvirus 1, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007242","descriptor_name":"Herpesvirus 1, Bovine","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:216241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1189653","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Vet Res","raw_type":"Text"},{"id":"pmid:11346260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11346260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","raw_type":"Journal Article"},{"id":"mag:34934669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11346260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:216241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1189653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W6917144","https://openalex.org/W193942178","https://openalex.org/W1523499267","https://openalex.org/W1529182333","https://openalex.org/W1561945694","https://openalex.org/W1578427147","https://openalex.org/W1585818695","https://openalex.org/W1893732581","https://openalex.org/W2009867644","https://openalex.org/W2045086064","https://openalex.org/W2065620854","https://openalex.org/W2185510411","https://openalex.org/W2205633700","https://openalex.org/W2401871948","https://openalex.org/W2415372371"],"related_works":["https://openalex.org/W2353864816","https://openalex.org/W3157364222","https://openalex.org/W2012490231","https://openalex.org/W4388951942","https://openalex.org/W1984988118","https://openalex.org/W2167551746","https://openalex.org/W3195279768","https://openalex.org/W2014180195","https://openalex.org/W938772","https://openalex.org/W340520035"],"abstract_inverted_index":{"Outbreaks":[0],"of":[1,24,37,43,51,58,76,83,88,92,94,122,139,156,166,169,172,217],"infectious":[2],"bovine":[3],"rhinotracheitis":[4],"(IBR)":[5],"have":[6],"recently":[7],"been":[8],"observed":[9],"in":[10,14,102,112,134,141,223,232],"vaccinated":[11,104,177,244],"feedlot":[12],"calves":[13,34,103,124,150,178,225,243],"Alberta":[15],"a":[16,40,70,106,135,162,246],"few":[17],"months":[18,145],"post-arrival.":[19],"To":[20],"investigate":[21],"the":[22,48,77,84,120,123,147,157,170,210,215,228,236,256,259],"cause":[23,100],"these":[25,62,95],"outbreaks,":[26],"lung":[27],"and":[28,127,187,194],"tracheal":[29],"tissues":[30],"were":[31,151],"collected":[32],"from":[33,55,252],"that":[35,242],"died":[36],"IBR":[38,108,248],"during":[39],"post-arrival":[41],"outbreak":[42],"disease.":[44],"Bovine":[45],"herpesvirus-1":[46],"(BHV-1),":[47],"causative":[49],"agent":[50],"IBR,":[52],"was":[53,110,214,221],"isolated":[54],"6":[56,63],"out":[57],"15":[59],"tissues.":[60],"Of":[61],"isolates,":[64],"5":[65],"failed":[66],"to":[67,99],"react":[68],"with":[69,105,154,161,227,235,245,254],"monoclonal":[71],"antibody":[72],"specific":[73],"for":[74,175],"one":[75,82,93,118,155],"epitopes":[78],"on":[79],"glycoprotein":[80],"D,":[81],"most":[85],"important":[86],"antigens":[87],"BHV-1.":[89,167],"The":[90,201],"ability":[91],"mutant":[96,158,229,257],"BHV-1":[97],"isolates":[98,159],"disease":[101],"modified-live":[107,247],"vaccine":[109,249],"assessed":[111],"an":[113],"experimental":[114],"challenge":[115,164,212,253],"study.":[116],"After":[117],"vaccination,":[119,149],"majority":[121],"developed":[125],"humoral":[126],"cellular":[128],"immune":[129],"responses.":[130],"Secondary":[131],"vaccination":[132],"resulted":[133],"substantially":[136],"enhanced":[137],"level":[138],"immunity":[140],"all":[142],"animals.":[143,200],"Three":[144],"after":[146],"second":[148],"either":[152,255],"challenged":[153,226,234],"or":[160,258],"conventional":[163,237,260],"strain":[165],"Regardless":[168],"type":[171],"virus":[173,197,218,230],"used":[174],"challenge,":[176],"experienced":[179],"significantly":[180],"(P":[181,205],"<":[182,206],"0.05)":[183,207],"less":[184,196],"weight":[185],"loss":[186],"temperature":[188],"rises,":[189],"had":[190],"lower":[191],"nasal":[192],"scores,":[193],"shed":[195],"than":[198,231],"non-vaccinated":[199,224],"only":[202],"statistically":[203],"significant":[204],"difference":[208],"between":[209],"2":[211],"viruses":[213],"amount":[216],"shed,":[219],"which":[220],"higher":[222],"those":[233],"virus.":[238,261],"These":[239],"data":[240],"show":[241],"are":[250],"protected":[251]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}