{"id":"https://openalex.org/W34930438","doi":null,"title":"Sequential responses of the renin-angiotensin-aldosterone axis to acute postural change: effect of dietary sodium.","display_name":"Sequential responses of the renin-angiotensin-aldosterone axis to acute postural change: effect of dietary sodium.","publication_year":1975,"publication_date":"1975-11-01","ids":{"openalex":"https://openalex.org/W34930438","mag":"34930438","pmid":"https://pubmed.ncbi.nlm.nih.gov/1185036"},"language":"en","primary_location":{"id":"pmid:1185036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1185036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103678463","display_name":"M L Tuck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Tuck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050304089","display_name":"Robert George Dluhy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Dluhy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113551032","display_name":"Gordon H. Williams","orcid":"https://orcid.org/0000-0002-4804-1093","observed_orcids":["https://orcid.org/0000-0002-4804-1093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G H Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1567,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.94455989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"86","issue":"5","first_page":"754","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dietary-sodium","display_name":"dietary sodium","score":0.6880000233650208},{"id":"https://openalex.org/keywords/low-sodium-diet","display_name":"sodium restriction","score":0.7900000214576721},{"id":"https://openalex.org/keywords/postural-changes","display_name":"postural changes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/upright-posture","display_name":"upright posture","score":0.9110000133514404},{"id":"https://openalex.org/keywords/metabolic-clearance-rate","display_name":"metabolic clearance rate","score":0.6869999766349792},{"id":"https://openalex.org/keywords/aldosterone-secretion-rate","display_name":"aldosterone secretion rate","score":0.8100000023841858},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/intravascular-volume","display_name":"intravascular volume","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8658162355422974},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.7955099940299988},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.7862764000892639},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7443762421607971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7310565710067749},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6706638336181641},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.6166110038757324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5373455882072449},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5090043544769287},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4901193082332611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42254117131233215},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1185036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1185036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:34930438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1185036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1578357314","https://openalex.org/W1605461675","https://openalex.org/W1656929032","https://openalex.org/W1964315523","https://openalex.org/W1972360651","https://openalex.org/W1979751615","https://openalex.org/W1981512243","https://openalex.org/W1993863744","https://openalex.org/W2004886833","https://openalex.org/W2007634515","https://openalex.org/W2021441410","https://openalex.org/W2025371271","https://openalex.org/W2037606593","https://openalex.org/W2039143650","https://openalex.org/W2045142938","https://openalex.org/W2055523901","https://openalex.org/W2064487876","https://openalex.org/W2065973763","https://openalex.org/W2091774189","https://openalex.org/W2107120406","https://openalex.org/W2115968906","https://openalex.org/W2120551112","https://openalex.org/W2122762225","https://openalex.org/W2123502833","https://openalex.org/W2132156574","https://openalex.org/W2143361929","https://openalex.org/W2143625779","https://openalex.org/W2145356697","https://openalex.org/W2154035412","https://openalex.org/W2157970472","https://openalex.org/W2171035485","https://openalex.org/W2331913619","https://openalex.org/W2509377147","https://openalex.org/W2521471789","https://openalex.org/W2590472825","https://openalex.org/W2597091415","https://openalex.org/W2605048570","https://openalex.org/W2607425454","https://openalex.org/W2752896839","https://openalex.org/W2763783563","https://openalex.org/W2800178103","https://openalex.org/W2803601478","https://openalex.org/W2830941850","https://openalex.org/W2897588295","https://openalex.org/W2910353615","https://openalex.org/W2915636862","https://openalex.org/W2922143627","https://openalex.org/W2967176962","https://openalex.org/W2970953638","https://openalex.org/W2986681918","https://openalex.org/W2998293885","https://openalex.org/W3042689819","https://openalex.org/W3044400890","https://openalex.org/W3122490491","https://openalex.org/W4243841175"],"related_works":["https://openalex.org/W2067876949","https://openalex.org/W1973115368","https://openalex.org/W2087679727","https://openalex.org/W2094674579","https://openalex.org/W2191583533","https://openalex.org/W2326226178","https://openalex.org/W2261856045","https://openalex.org/W2030134665","https://openalex.org/W7095788053","https://openalex.org/W2038291206"],"abstract_inverted_index":{"The":[0,47,103,135,226],"simultaneous":[1],"levels":[2,107,128],"of":[3,27,49,51,65,69,98,117,138,175,177,183,205,211,216,269],"plasma":[4],"renin":[5],"activity":[6],"(PRA),":[7],"angiotensin":[8],"II":[9,73],"(A":[10],"II),":[11],"and":[12,40,71,91,147,173,189,258],"aldosterone":[13,52,139],"(PA)":[14],"were":[15,108,119,130],"frequently":[16],"assessed":[17],"in":[18,59,164,196,207,233,241,265],"13":[19],"normal":[20],"subjects":[21],"following":[22,209],"acute":[23,231,273],"postural":[24,274],"change":[25],"(assumption":[26],"upright":[28,166],"posture":[29,234],"or":[30,243],"returning":[31],"to":[32,81,93,111,123,160,220,223,272],"the":[33,60,84,96,99,143,150,165,171,181,184,197,203,214,259,266],"supine":[34,212],"position)":[35],"on":[36,74,142,149],"low":[37],"(10":[38],"mEq.)":[39,43],"high":[41],"(200":[42],"sodium":[44,76,260],"(Na+)":[45],"intakes.":[46],"rate":[48,63,137,172,204],"response":[50,176],"secretion":[53,136],"was":[54,191,218],"also":[55,129],"correlated":[56,239],"with":[57,237],"changes":[58,232,240],"metabolic":[61],"clearance":[62],"(MCR)":[64],"aldosterone.":[66],"Significant":[67],"increments":[68],"PRA":[70,188,208,217,242],"A":[72,244],"either":[75],"intake":[77,154],"occurred":[78,87],"within":[79,88],"5":[80],"20":[82,122],"minutes;":[83],"peak":[85,106,127],"values":[86],"90":[89,133],"minutes":[90],"tended":[92],"plateau":[94],"until":[95],"end":[97],"study":[100,228],"(240":[101],"minutes).":[102],"mean":[104],"absolute":[105],"approximately":[109],"2":[110],"3.5-fold":[112],"greater":[113],"than":[114,193,199],"control.":[115],"Increments":[116],"PA":[118,190],"initially":[120],"delayed":[121],"30":[124,159],"minutes,":[125],"but":[126],"achieved":[131],"by":[132],"minutes.":[134,225],"increased":[140],"4-fold":[141,194],"10":[144],"mEq.":[145,152],"Na+":[146,153],"2-fold":[148],"200":[151],"even":[155],"though":[156],"MCR":[157],"declined":[158],"40":[161],"per":[162],"cent":[163],"posture.":[167],"Sodium":[168],"restriction":[169],"enhanced":[170],"magnitude":[174],"all":[178],"parameters.":[179],"Specifically,":[180],"slope":[182],"regression":[185],"relationship":[186],"between":[187],"more":[192],"steeper":[195],"sodium-restricted":[198],"sodium-loaded":[200],"subjects.":[201],"From":[202],"decline":[206],"resumption":[210],"posture,":[213],"half-life":[215],"estimated":[219],"be":[221],"14":[222],"15":[224],"present":[227],"demonstrates":[229],"that":[230,251],"are":[235],"associated":[236],"closely":[238],"II.":[245],"To":[246],"varying":[247],"degrees,":[248],"it":[249],"appeared":[250],"sympathetic":[252],"activity,":[253],"intravascular":[254],"volume,":[255],"diurnal":[256],"secretion,":[257],"ion":[261],"play":[262],"a":[263],"role":[264],"sequential":[267],"responses":[268],"these":[270],"parameters":[271],"alterations.":[275]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
