{"id":"https://openalex.org/W347994159","doi":null,"title":"Methylation of CpG Island in Aging Lens Epithelial Cells And During Oxidative Stress Affects Sp1 Binding And Activity in LEDGF Promoter","display_name":"Methylation of CpG Island in Aging Lens Epithelial Cells And During Oxidative Stress Affects Sp1 Binding And Activity in LEDGF Promoter","publication_year":2013,"publication_date":"2013-06-16","ids":{"openalex":"https://openalex.org/W347994159","mag":"347994159"},"language":"en","primary_location":{"id":"mag:347994159","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2149709","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101836695","display_name":"Dhirendra P. Singh","orcid":"https://orcid.org/0000-0003-3311-2191","observed_orcids":["https://orcid.org/0000-0003-3311-2191"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhirendra P. Singh","raw_affiliation_strings":["Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE"],"raw_orcid":"https://orcid.org/0000-0003-3311-2191","affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010780653","display_name":"Bhavana Chhunchha","orcid":"https://orcid.org/0000-0001-9613-8765","observed_orcids":["https://orcid.org/0000-0001-9613-8765"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavana Chhunchha","raw_affiliation_strings":["Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE"],"raw_orcid":"https://orcid.org/0000-0001-9613-8765","affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007671278","display_name":"Biju Bhargavan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biju Bhargavan","raw_affiliation_strings":["Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072279870","display_name":"Eri Kubo","orcid":"https://orcid.org/0000-0001-6789-9311","observed_orcids":["https://orcid.org/0000-0001-6789-9311"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Kubo","raw_affiliation_strings":["Ophthalmology, Kanazawa Medical University, Kanazawa, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6789-9311","affiliations":[{"raw_affiliation_string":"Ophthalmology, Kanazawa Medical University, Kanazawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103416824","display_name":"Nigar Fatma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigar Fatma","raw_affiliation_strings":["Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, Univ of Neb Med Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.1492,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53499389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"54","issue":"15","first_page":"481","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.9589999914169312},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ledgf","display_name":"LEDGF","score":0.7699999809265137},{"id":"https://openalex.org/keywords/promoter-activity","display_name":"promoter activity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7805050611495972},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7744641304016113},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7533597946166992},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5661323666572571},{"id":"https://openalex.org/C2775871807","wikidata":"https://www.wikidata.org/wiki/Q24963883","display_name":"Promoter activity","level":5,"score":0.5192247033119202},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.450091689825058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43528488278388977},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.41632360219955444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36468034982681274},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2039792835712433},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16482433676719666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15778136253356934},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08056998252868652}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:347994159","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2149709","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W781902879","https://openalex.org/W4399916933","https://openalex.org/W802646084","https://openalex.org/W807360280","https://openalex.org/W2994180232","https://openalex.org/W875538379","https://openalex.org/W2017181541","https://openalex.org/W2993257589","https://openalex.org/W3022044108","https://openalex.org/W854851607"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}