{"id":"https://openalex.org/W34665004","doi":null,"title":"Evolution of enantioselectivity: selection of improved hydrolase variants","display_name":"Evolution of enantioselectivity: selection of improved hydrolase variants","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W34665004","mag":"34665004"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire/e9d241b3-c267-474f-adf8-e37b82caae6d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e9d241b3-c267-474f-adf8-e37b82caae6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boersma, Y L 2007, 'Evolution of enantioselectivity : selection of improved hydrolase variants', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.rug.nl/en/publications/e9d241b3-c267-474f-adf8-e37b82caae6d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030477074","display_name":"Ykelien L. Boersma","orcid":"https://orcid.org/0000-0001-9317-2327","observed_orcids":["https://orcid.org/0000-0001-9317-2327"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ykelien L. Boersma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9317-2327","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030477074"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.7269999980926514},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.6079999804496765},{"id":"https://openalex.org/keywords/asymmetric-catalysis","display_name":"asymmetric catalysis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5762273669242859},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45714476704597473},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.4544825553894043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41100651025772095},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4009562134742737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3719164729118347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3710594177246094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27158910036087036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22444096207618713},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1815560758113861}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire/e9d241b3-c267-474f-adf8-e37b82caae6d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e9d241b3-c267-474f-adf8-e37b82caae6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boersma, Y L 2007, 'Evolution of enantioselectivity : selection of improved hydrolase variants', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:rug:oai:pure.rug.nl:publications/e9d241b3-c267-474f-adf8-e37b82caae6d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e9d241b3-c267-474f-adf8-e37b82caae6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:34665004","doi":null,"is_oa":false,"landing_page_url":"https://pure.rug.nl/ws/files/14452554/titlecon.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.rug.nl:openaire/e9d241b3-c267-474f-adf8-e37b82caae6d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e9d241b3-c267-474f-adf8-e37b82caae6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boersma, Y L 2007, 'Evolution of enantioselectivity : selection of improved hydrolase variants', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":228,"referenced_works":["https://openalex.org/W11949986","https://openalex.org/W263710205","https://openalex.org/W387554466","https://openalex.org/W1503820853","https://openalex.org/W1511264264","https://openalex.org/W1517594500","https://openalex.org/W1539796472","https://openalex.org/W1570633311","https://openalex.org/W1591386965","https://openalex.org/W1594839899","https://openalex.org/W1602857691","https://openalex.org/W1605802977","https://openalex.org/W1607256581","https://openalex.org/W1652052270","https://openalex.org/W1676277789","https://openalex.org/W1726891850","https://openalex.org/W1752811377","https://openalex.org/W1825789202","https://openalex.org/W1839045771","https://openalex.org/W1898560826","https://openalex.org/W1925468999","https://openalex.org/W1963722789","https://openalex.org/W1964145947","https://openalex.org/W1964270102","https://openalex.org/W1964351457","https://openalex.org/W1966757283","https://openalex.org/W1967242375","https://openalex.org/W1967830896","https://openalex.org/W1967863865","https://openalex.org/W1968914373","https://openalex.org/W1969021085","https://openalex.org/W1970168006","https://openalex.org/W1970654358","https://openalex.org/W1971486985","https://openalex.org/W1971850577","https://openalex.org/W1972625140","https://openalex.org/W1973266002","https://openalex.org/W1974466835","https://openalex.org/W1975040376","https://openalex.org/W1976299542","https://openalex.org/W1976308284","https://openalex.org/W1976410590","https://openalex.org/W1977479052","https://openalex.org/W1979025327","https://openalex.org/W1980163204","https://openalex.org/W1980322091","https://openalex.org/W1984684698","https://openalex.org/W1986188851","https://openalex.org/W1986715524","https://openalex.org/W1986860173","https://openalex.org/W1986914760","https://openalex.org/W1987823655","https://openalex.org/W1987951295","https://openalex.org/W1989309915","https://openalex.org/W1990763341","https://openalex.org/W1991998089","https://openalex.org/W1994240720","https://openalex.org/W1995431522","https://openalex.org/W1995946170","https://openalex.org/W1996440854","https://openalex.org/W1996877809","https://openalex.org/W1997339519","https://openalex.org/W1997996516","https://openalex.org/W1998109786","https://openalex.org/W1998454764","https://openalex.org/W1999195584","https://openalex.org/W1999851613","https://openalex.org/W2000063610","https://openalex.org/W2000102285","https://openalex.org/W2003788979","https://openalex.org/W2003850007","https://openalex.org/W2005167964","https://openalex.org/W2005189804","https://openalex.org/W2007697108","https://openalex.org/W2010685876","https://openalex.org/W2011513747","https://openalex.org/W2011744948","https://openalex.org/W2012588426","https://openalex.org/W2015642465","https://openalex.org/W2016596397","https://openalex.org/W2016677993","https://openalex.org/W2016789574","https://openalex.org/W2017983905","https://openalex.org/W2018497120","https://openalex.org/W2018690450","https://openalex.org/W2019766440","https://openalex.org/W2019994402","https://openalex.org/W2020734518","https://openalex.org/W2022058405","https://openalex.org/W2024226674","https://openalex.org/W2024383780","https://openalex.org/W2024641272","https://openalex.org/W2025890368","https://openalex.org/W2026117532","https://openalex.org/W2026196512","https://openalex.org/W2026899249","https://openalex.org/W2029845463","https://openalex.org/W2030209364","https://openalex.org/W2030390483","https://openalex.org/W2030476352","https://openalex.org/W2031343644","https://openalex.org/W2039262558","https://openalex.org/W2040273318","https://openalex.org/W2041019044","https://openalex.org/W2044646870","https://openalex.org/W2044952215","https://openalex.org/W2045736818","https://openalex.org/W2046578757","https://openalex.org/W2046623943","https://openalex.org/W2047065095","https://openalex.org/W2047458942","https://openalex.org/W2048066285","https://openalex.org/W2048358490","https://openalex.org/W2049624805","https://openalex.org/W2050466522","https://openalex.org/W2051655976","https://openalex.org/W2052207497","https://openalex.org/W2052781717","https://openalex.org/W2052951144","https://openalex.org/W2054163716","https://openalex.org/W2054374729","https://openalex.org/W2055264790","https://openalex.org/W2056255325","https://openalex.org/W2057713800","https://openalex.org/W2060587154","https://openalex.org/W2061208926","https://openalex.org/W2061820011","https://openalex.org/W2062317058","https://openalex.org/W2062767843","https://openalex.org/W2064078356","https://openalex.org/W2064127935","https://openalex.org/W2064216759","https://openalex.org/W2065245548","https://openalex.org/W2065905617","https://openalex.org/W2068491510","https://openalex.org/W2068538012","https://openalex.org/W2070569816","https://openalex.org/W2070906120","https://openalex.org/W2071488197","https://openalex.org/W2072554779","https://openalex.org/W2073911234","https://openalex.org/W2074133083","https://openalex.org/W2074526941","https://openalex.org/W2074588113","https://openalex.org/W2075266254","https://openalex.org/W2077023971","https://openalex.org/W2077582218","https://openalex.org/W2077640701","https://openalex.org/W2078787129","https://openalex.org/W2079220149","https://openalex.org/W2081835258","https://openalex.org/W2081927863","https://openalex.org/W2083996663","https://openalex.org/W2085081967","https://openalex.org/W2087379542","https://openalex.org/W2089016671","https://openalex.org/W2089607452","https://openalex.org/W2089856357","https://openalex.org/W2091439684","https://openalex.org/W2093308983","https://openalex.org/W2093475422","https://openalex.org/W2095417541","https://openalex.org/W2095561521","https://openalex.org/W2095571453","https://openalex.org/W2096697992","https://openalex.org/W2097985831","https://openalex.org/W2098529872","https://openalex.org/W2100837269","https://openalex.org/W2100882223","https://openalex.org/W2101870257","https://openalex.org/W2102686773","https://openalex.org/W2108316612","https://openalex.org/W2108364209","https://openalex.org/W2109155760","https://openalex.org/W2110015158","https://openalex.org/W2111382437","https://openalex.org/W2111537738","https://openalex.org/W2112257018","https://openalex.org/W2115232091","https://openalex.org/W2116165495","https://openalex.org/W2117018426","https://openalex.org/W2118383750","https://openalex.org/W2120474060","https://openalex.org/W2121092629","https://openalex.org/W2121351614","https://openalex.org/W2121398756","https://openalex.org/W2121839643","https://openalex.org/W2122589838","https://openalex.org/W2124230467","https://openalex.org/W2125257680","https://openalex.org/W2127549210","https://openalex.org/W2128660550","https://openalex.org/W2133906308","https://openalex.org/W2133908811","https://openalex.org/W2134875787","https://openalex.org/W2135637024","https://openalex.org/W2137518394","https://openalex.org/W2138487150","https://openalex.org/W2139768110","https://openalex.org/W2139869842","https://openalex.org/W2140483478","https://openalex.org/W2141469073","https://openalex.org/W2144634347","https://openalex.org/W2146382788","https://openalex.org/W2146956869","https://openalex.org/W2148612893","https://openalex.org/W2149093225","https://openalex.org/W2149614036","https://openalex.org/W2150371887","https://openalex.org/W2151658471","https://openalex.org/W2152781456","https://openalex.org/W2154818827","https://openalex.org/W2154998149","https://openalex.org/W2155498712","https://openalex.org/W2155960002","https://openalex.org/W2157410466","https://openalex.org/W2158082808","https://openalex.org/W2158885329","https://openalex.org/W2159052590","https://openalex.org/W2160379886","https://openalex.org/W2161327229","https://openalex.org/W2164501001","https://openalex.org/W2167633523","https://openalex.org/W2171443261","https://openalex.org/W2172051761","https://openalex.org/W2398538521","https://openalex.org/W2411710474","https://openalex.org/W4297092563"],"related_works":["https://openalex.org/W2998149116","https://openalex.org/W3084612063","https://openalex.org/W2154843371","https://openalex.org/W2565469904","https://openalex.org/W1971850577","https://openalex.org/W2102636127","https://openalex.org/W2581929828","https://openalex.org/W1558685160","https://openalex.org/W7018921355","https://openalex.org/W2013597102"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
