{"id":"https://openalex.org/W346379645","doi":null,"title":"Diminished T-cell response to influenza virus in aged mice.","display_name":"Diminished T-cell response to influenza virus in aged mice.","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W346379645","mag":"346379645","pmid":"https://pubmed.ncbi.nlm.nih.gov/6602091","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454174"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454174","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012688898","display_name":"Rita B. Effros","orcid":"https://orcid.org/0000-0003-0636-3569","observed_orcids":["https://orcid.org/0000-0003-0636-3569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Effros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023063001","display_name":"R. L. Walford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Walford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0063,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.75698006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"49","issue":"2","first_page":"387","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.8740000128746033},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5080000162124634},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/age-related-immune-decline","display_name":"age-related immune decline","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.8146086931228638},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.665337085723877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6639654040336609},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.629635214805603},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6078214049339294},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6069576740264893},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.549379289150238},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5031852126121521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48676371574401855},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.4815519154071808},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.4732314348220825},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.467693567276001},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.46667587757110596},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.41215580701828003},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.360338032245636},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.19435349106788635},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1454174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:6602091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6602091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:346379645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6602091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W40843633","https://openalex.org/W167981432","https://openalex.org/W1500434476","https://openalex.org/W1528683573","https://openalex.org/W1582142061","https://openalex.org/W1626291558","https://openalex.org/W1646649946","https://openalex.org/W1896844633","https://openalex.org/W1967714537","https://openalex.org/W1969297445","https://openalex.org/W1987710610","https://openalex.org/W1993022990","https://openalex.org/W1997269985","https://openalex.org/W2004385298","https://openalex.org/W2030912556","https://openalex.org/W2032479717","https://openalex.org/W2032599239","https://openalex.org/W2071404290","https://openalex.org/W2075573523","https://openalex.org/W2084224249","https://openalex.org/W2089455714","https://openalex.org/W2112981534","https://openalex.org/W2120601962","https://openalex.org/W2136045853","https://openalex.org/W2415222462"],"related_works":["https://openalex.org/W2002712477","https://openalex.org/W2044489248","https://openalex.org/W1983132680","https://openalex.org/W2953841314","https://openalex.org/W2056160750","https://openalex.org/W2415913335","https://openalex.org/W2422002828","https://openalex.org/W1538764015","https://openalex.org/W4400182128","https://openalex.org/W2100820493"],"abstract_inverted_index":{"Declining":[0],"immunity":[1,66],"in":[2,26,41,47,70,90,101,140,160,183,195],"aged":[3,71,102,142],"individuals":[4],"has":[5],"been":[6],"repeatedly":[7],"verified.":[8],"However,":[9],"many":[10],"of":[11,37,110,127,131,152,191],"the":[12,22,42,76,108,111,117,128,141,153,163,168,192],"studies":[13],"have":[14,50],"focused":[15],"on":[16],"functions":[17],"not":[18],"directly":[19],"relevant":[20],"to":[21,62,67,83,180],"antigens":[23],"normally":[24],"encountered":[25],"vivo.":[27],"For":[28],"example,":[29],"although":[30],"infectious":[31],"agents":[32],"represent":[33],"a":[34,125,136],"significant":[35],"cause":[36],"morbidity":[38],"and":[39,189],"mortality":[40],"elderly,":[43],"age-related":[44,193],"immune":[45],"responses":[46,130],"such":[48],"diseases":[49],"received":[51],"very":[52],"little":[53],"experimental":[54],"attention.":[55],"The":[56,144,186],"present":[57],"study":[58],"was,":[59],"therefore,":[60],"initiated":[61],"examine":[63],"T":[64,79,170],"cell-mediated":[65],"influenza":[68],"virus":[69],"mice.":[72,103,143,185],"We":[73],"observed":[74,149,182],"that":[75,99,107,116,181],"primary":[77],"cytotoxic":[78],"lymphocyte":[80],"(CTL)":[81],"response":[82,112,146,165],"influenza,":[84],"which":[85],"peaks":[86],"at":[87,98,121],"day":[88],"5":[89],"young":[91,184],"adult":[92],"mice,":[93],"is":[94],"almost":[95],"completely":[96],"absent":[97],"timepoint":[100],"Our":[104],"experiments":[105],"indicate":[106],"kinetics":[109],"are":[113,199],"shifted,":[114],"so":[115],"maximum":[118],"activity":[119,198],"appears":[120],"days":[122],"7-9.":[123],"Furthermore,":[124],"comparison":[126],"peak":[129],"both":[132],"age":[133],"groups":[134],"reveals":[135],"significantly":[137],"lower":[138],"magnitude":[139],"diminished":[145],"was":[147,166,178],"also":[148],"for":[150,173],"most":[151],"old":[154],"mice":[155],"when":[156],"antigenic":[157],"stimulation":[158],"occurred":[159],"vitro.":[161],"Although":[162],"overall":[164],"diminished,":[167],"characteristic":[169],"cell":[171],"cross-reactivity":[172],"all":[174],"A":[175],"strain":[176],"viruses":[177],"similar":[179],"possible":[187],"causes":[188],"consequences":[190],"decline":[194],"influenza-specific":[196],"CTL":[197],"discussed.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
