{"id":"https://openalex.org/W34635389","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","title":"High NaCl or urea inhibits glycerophosphocholine (GPC) phosphodiesterase (GDPD5) activity and reduces phosphorylation of GDPD5\u2010T587","display_name":"High NaCl or urea inhibits glycerophosphocholine (GPC) phosphodiesterase (GDPD5) activity and reduces phosphorylation of GDPD5\u2010T587","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W34635389","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","mag":"34635389"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.817.9","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032390743","display_name":"Supachai Topanurak","orcid":"https://orcid.org/0000-0002-4452-7651","observed_orcids":["https://orcid.org/0000-0002-4452-7651"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supachai Topanurak","raw_affiliation_strings":["NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005054637","display_name":"Morgan Gallazzini","orcid":"https://orcid.org/0000-0002-7185-7162","observed_orcids":["https://orcid.org/0000-0002-7185-7162"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Gallazzini","raw_affiliation_strings":["NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051074151","display_name":"Joan D. Ferraris","orcid":"https://orcid.org/0000-0003-4696-2347","observed_orcids":["https://orcid.org/0000-0003-4696-2347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan D Ferraris","raw_affiliation_strings":["NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice B Burg","raw_affiliation_strings":["NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00283952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycerophosphocholine","display_name":"glycerophosphocholine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"phosphodiesterase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.7179999947547913},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.9700000286102295},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8560000061988831},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7983071804046631},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7582641839981079},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6460263729095459},{"id":"https://openalex.org/C127160389","wikidata":"https://www.wikidata.org/wiki/Q415608","display_name":"Osmolyte","level":2,"score":0.5128610134124756},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.45841145515441895},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.42224496603012085},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.4179993271827698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.386627733707428},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3854336142539978},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10608085989952087},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.09398213028907776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.817.9","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.817.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290288272","https://openalex.org/W2084976551","https://openalex.org/W2091494318","https://openalex.org/W166402091","https://openalex.org/W2404266032","https://openalex.org/W600211004","https://openalex.org/W2064293313","https://openalex.org/W2180007197","https://openalex.org/W2401621255","https://openalex.org/W2019100689"],"abstract_inverted_index":{"Glycerophosphocholine":[0],"(GPC)":[1],"is":[2,82],"an":[3],"osmoprotective":[4],"renal":[5],"medullary":[6],"organic":[7],"osmolyte.":[8],"We":[9,49],"previously":[10],"found":[11],"that":[12,21,29,51,95],"high":[13],"NaCl":[14],"or":[15],"urea":[16],"(hyperosmolality)":[17],"increases":[18],"GPC":[19,31],"and":[20],"post":[22,46],"translational":[23,47],"inhibition":[24],"of":[25,38,55,62,77,92],"the":[26,39,45,90],"phosphodiesterase":[27],"(GDPD5)":[28],"degrades":[30],"contributes":[32],"to":[33,43],"this":[34],"increase.":[35],"The":[36],"purpose":[37],"present":[40],"studies":[41],"was":[42],"identify":[44],"modification.":[48],"find":[50],"hyperosmolality":[52],"reduces":[53],"phosphorylation":[54,76,93],"GDPD5":[56,78,98],"(less":[57],"retardation":[58],"in":[59],"Western":[60],"blots":[61],"phospho\u2010affinity":[63],"polyacrylamide":[64],"gels).":[65],"Mass":[66],"spectrometry":[67],"(LTQ\u2010iontrap":[68],"with":[69],"targeted":[70],"ion":[71],"selective":[72],"label\u2010free":[73],"quantification)":[74],"demonstrates":[75],"on":[79,97],"T587":[80],"which":[81],"decreased":[83],"by":[84],"hyperosmolality.":[85],"Current":[86],"experiments":[87],"are":[88],"testing":[89],"role":[91],"at":[94],"site":[96],"activity.":[99]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}