{"id":"https://openalex.org/W34582051","doi":null,"title":"Crohn's disease as a risk factor for the outcome of pregnancy.","display_name":"Crohn's disease as a risk factor for the outcome of pregnancy.","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W34582051","mag":"34582051","pmid":"https://pubmed.ncbi.nlm.nih.gov/11149010"},"language":"en","primary_location":{"id":"pmid:11149010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11149010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Morales","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Geneva University Hospital, Geneva, Switzerland. michel.a.morales@hcuge.ch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Geneva University Hospital, Geneva, Switzerland. michel.a.morales@hcuge.ch","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085077185","display_name":"Thierry Berney","orcid":"https://orcid.org/0000-0002-4230-9378","observed_orcids":["https://orcid.org/0000-0002-4230-9378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Berney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043006048","display_name":"Alexandra Jenny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Jenny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524705","display_name":"Philippe Morel","orcid":"https://orcid.org/0000-0002-4826-7818","observed_orcids":["https://orcid.org/0000-0002-4826-7818","https://orcid.org/0000-0003-1690-8032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Morel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067115341","display_name":"Philippe Extermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Extermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8193,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.85392778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"47","issue":"36","first_page":"1595","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pregnancy-outcomes","display_name":"pregnancy outcomes","score":0.7609999775886536},{"id":"https://openalex.org/keywords/disease-reactivation","display_name":"disease reactivation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.8510000109672546},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fetal-malformations","display_name":"fetal malformations","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pregnancy-as-risk-factor","display_name":"pregnancy as risk factor","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.8549404144287109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8495458960533142},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.8372821807861328},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7513731718063354},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.6094292402267456},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6055015325546265},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46968844532966614},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4652370512485504},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.41801396012306213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3388766050338745},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:11149010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11149010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:55302","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:55302","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0172-6390","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:unige:55302","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:55302","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0172-6390","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:34582051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11149010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W573397770","https://openalex.org/W1576809876","https://openalex.org/W1868630228","https://openalex.org/W1967383774","https://openalex.org/W1967516512","https://openalex.org/W1968322176","https://openalex.org/W1970374913","https://openalex.org/W1977671452","https://openalex.org/W1978457925","https://openalex.org/W1988423146","https://openalex.org/W1990733961","https://openalex.org/W2002837940","https://openalex.org/W2003151061","https://openalex.org/W2007743440","https://openalex.org/W2008257508","https://openalex.org/W2026527234","https://openalex.org/W2035353547","https://openalex.org/W2041741136","https://openalex.org/W2042464260","https://openalex.org/W2045019081","https://openalex.org/W2045278366","https://openalex.org/W2056965544","https://openalex.org/W2064230225","https://openalex.org/W2065773869","https://openalex.org/W2066504840","https://openalex.org/W2068081016","https://openalex.org/W2074548663","https://openalex.org/W2076111136","https://openalex.org/W2096972992","https://openalex.org/W2115740633","https://openalex.org/W2123383239","https://openalex.org/W2125012645","https://openalex.org/W2134893181","https://openalex.org/W2149392345","https://openalex.org/W2220475175","https://openalex.org/W2255644836","https://openalex.org/W2277909760","https://openalex.org/W2312373852","https://openalex.org/W2471143596","https://openalex.org/W2517033709","https://openalex.org/W2523686550","https://openalex.org/W2556490932","https://openalex.org/W2560795873","https://openalex.org/W2594059806","https://openalex.org/W2725319235","https://openalex.org/W2751088406","https://openalex.org/W2751568380","https://openalex.org/W2768247437","https://openalex.org/W2783919717","https://openalex.org/W2805504202","https://openalex.org/W2889615530","https://openalex.org/W2981202794","https://openalex.org/W2996578100","https://openalex.org/W3008394508","https://openalex.org/W3020528808","https://openalex.org/W6764972943","https://openalex.org/W7075674172"],"related_works":["https://openalex.org/W1571521809","https://openalex.org/W2022533453","https://openalex.org/W7124456842","https://openalex.org/W2082764205","https://openalex.org/W2011848078","https://openalex.org/W2564105513","https://openalex.org/W174851336","https://openalex.org/W2125514548","https://openalex.org/W4288057314","https://openalex.org/W2409843888"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"To":[1],"study":[2],"the":[3,9,14,19,58,68,151,165,183,192],"effects":[4],"of":[5,11,16,21,27,80,91,131,147,153,167,173,182,194],"Crohn's":[6,22,34,49,87,132,148,168,174,185,189],"disease":[7,35,50,63,133,149,175,186,190],"on":[8,18],"course":[10,26,90,166],"pregnancy":[12,17,92,135,177,199,205],"and":[13,64,117],"influence":[15,164],"activity":[20,146],"disease.":[23,88,169],"METHODOLOGY:":[24],"The":[25,89,170],"35":[28],"pregnancies":[29,45,60,70],"in":[30,99],"23":[31],"women":[32,85],"with":[33,61,71,86,95,120,129,145],"were":[36],"reviewed":[37],"over":[38],"a":[39,76,96],"12":[40],"years":[41],"period.":[42],"RESULTS:":[43],"Nine":[44],"(25%)":[46],"started":[47],"when":[48],"was":[51,93,126,142],"active.":[52],"We":[53,103],"observed":[54,104],"2":[55,118],"exacerbations":[56,66],"among":[57,67],"9":[59],"active":[62],"7":[65],"26":[69],"quiescent":[72],"disease:":[73],"this":[74],"represents":[75],"total":[77],"exacerbation":[78],"rate":[79,172],"26%":[81],"similar":[82,179],"to":[83,163,180],"non-pregnant":[84],"normal":[94],"full-term":[97],"delivery":[98,125],"22":[100],"cases":[101],"(63%).":[102],"5":[105,109],"premature":[106],"deliveries":[107],"(14%),":[108,112],"spontaneous":[110],"abortions":[111],"1":[113],"induced":[114],"abortion":[115],"(3%)":[116],"liveborns":[119],"severe":[121],"malformations":[122],"(6%).":[123],"Preterm":[124],"significantly":[127,143],"associated":[128,144],"reactivation":[130,197],"during":[134,176,198],"(P":[136,155],"=":[137,156],"0.009),":[138],"whereas":[139],"fetal":[140],"loss":[141],"at":[150,191],"time":[152,193],"conception":[154,195],"0.015).":[157],"CONCLUSIONS:":[158],"Pregnancy":[159],"does":[160],"not":[161],"appear":[162],"relapse":[171],"is":[178],"that":[181],"general":[184],"population.":[187],"Active":[188],"or":[196],"are":[200],"risk":[201],"factors":[202],"for":[203],"abnormal":[204],"outcome.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":62},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}