{"id":"https://openalex.org/W345758106","doi":null,"title":"\u4e0d\u540c\u4f50\u5242\u5bf9\u968f\u673a\u7ec4\u5408\u591a\u8868\u4f4d\u6076\u6027\u759f\u75be\u75ab\u82d7M. RCAg-1\u7684\u514d\u75ab\u539f\u6027\u53ca\u4f53\u5916\u6291\u866b\u7387\u5f71\u54cd\u7684\u7814\u7a76","display_name":"\u4e0d\u540c\u4f50\u5242\u5bf9\u968f\u673a\u7ec4\u5408\u591a\u8868\u4f4d\u6076\u6027\u759f\u75be\u75ab\u82d7M. RCAg-1\u7684\u514d\u75ab\u539f\u6027\u53ca\u4f53\u5916\u6291\u866b\u7387\u5f71\u54cd\u7684\u7814\u7a76","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W345758106","mag":"345758106"},"language":"zh","primary_location":{"id":"mag:345758106","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95714X/201112/41040395.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541225","display_name":"\u4e2d\u534e\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u6742\u5fd7","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060617034","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0001-6745-9068","observed_orcids":["https://orcid.org/0000-0001-6745-9068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6745-9068","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034927213","display_name":"\u853a\u4e9a\u8f89","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u853a\u4e9a\u8f89","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049002229","display_name":"\u5b59\u6210\u91d1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5b59\u6210\u91d1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042286361","display_name":"\u674e\u8389\u8389","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u8389\u8389","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034328753","display_name":"\u9648\u7965\u9e4f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9648\u7965\u9e4f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068882254","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-1406-2734","observed_orcids":["https://orcid.org/0000-0002-1406-2734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1406-2734","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004701429","display_name":"\u738b\u6052","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u738b\u6052","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004036702","display_name":"\u5f20\u632f\u9f99","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u632f\u9f99","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05354469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"12","first_page":"1117","last_page":"1123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.8119999766349792},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.8830000162124634},{"id":"https://openalex.org/keywords/aluminum-hydroxide","display_name":"aluminum hydroxide","score":0.7689999938011169},{"id":"https://openalex.org/keywords/freund-s-adjuvant","display_name":"Freund's adjuvant","score":0.9169999957084656},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8949999809265137},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.4779999852180481},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7870000004768372},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.503000020980835},{"id":"https://openalex.org/keywords/in-vitro-antimalarial-activity","display_name":"in vitro antimalarial activity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/3d7-strain","display_name":"3D7 strain","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dd2-strain","display_name":"Dd2 strain","score":0.8669999837875366},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.33500000834465027},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8849999904632568},{"id":"https://openalex.org/keywords/serological-cross-reactivity","display_name":"serological cross-reactivity","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3475576639175415}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:345758106","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95714X/201112/41040395.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541225","display_name":"\u4e2d\u534e\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W904862292","https://openalex.org/W2398317130","https://openalex.org/W999359301","https://openalex.org/W597548927","https://openalex.org/W873986551","https://openalex.org/W3031570320","https://openalex.org/W2754258151","https://openalex.org/W1983335073","https://openalex.org/W3029997201","https://openalex.org/W2081488264"],"abstract_inverted_index":{"\u76ee\u7684":[0],"\u7814\u7a76\u5f17\u6c0f\u4f50\u5242\u53ca3\u79cd\u4eba\u7528\u4f50\u5242[Al\uff08OH\uff093\u3001Montanide":[1],"ISA720\u3001Montanide":[2],"ISA51]\u5bf9\u91cd\u7ec4\u591a\u8868\u4f4d\u86cb\u767dM.RCAg-1\uff08malaria":[3],"random":[4],"constructed":[5],"antigen-1\uff09\u5728BALB/c\u5c0f\u9f20\u53ca\u65b0\u897f\u5170\u5927\u767d\u5154\u4f53\u5185\u4ea7\u751f\u514d\u75ab\u6548\u679c\u7684\u5f71\u54cd.\u65b9\u6cd5":[6],"\u4ee5\u5f17\u6c0f\u4f50\u5242\u3001Al\uff08":[7],"OH\uff093\u4f50\u5242\u3001Montanide":[8],"ISA720\u4ee5\u53caMontanideISA51\u4f50\u5242\u5206\u522b\u4e0eM.RCAg-1\u86cb\u767d\u8fdb\u884c\u914d\u4f0d,\u5206\u522b\u514d\u75abBALB/c\u5c0f\u9f20\u53ca\u65b0\u897f\u5170\u767d\u5154\uff1b\u91c7\u7528ELISA\u6cd5\u68c0\u6d4bM.RCAg-1\u86cb\u767d\u53ca\u5176\u6240\u7ec4\u6210\u5404\u4e2a\u8868\u4f4d\u7279\u5f02\u7684\u8840\u6e05IgG\u542b\u91cf\uff1b\u95f4\u63a5\u8367\u5149\u514d\u75ab\u8bd5\u9a8c\u5206\u6790\u4e0d\u540c\u914d\u4f0d\u7ec4\u514d\u75ab\u8840\u6e05\u5bf9\u5929\u7136\u759f\u539f\u866b\u6297\u539f\u7684\u8bc6\u522b\uff1b\u9176\u8054\u514d\u75ab\u6591\u70b9\u8bd5\u9a8c\uff08ELISPOT\uff09\u68c0\u6d4b\u7279\u5f02\u6027\u9f20T\u6dcb\u5df4\u7ec6\u80de\u7684\u6d3b\u5316\uff1b\u53e6\u501f\u52a9\u751f\u7269\u4f20\u611f\u5668\u8bc4\u4ef7\u6297\u539f\u4e0e\u4e0d\u540c\u4f50\u5242\u914d\u4f0d\u7ec4\u8840\u6e05\u7684\u4eb2\u548c\u529b,\u5e76\u7528\u4f53\u5916\u751f\u957f\u6291\u5236\u8bd5\u9a8c\uff08GIA\uff09\u5bf9\u6076\u6027\u759f\u539f\u866b\u7684\u4f53\u5916\u751f\u957f\u7684\u5f71\u54cd\u8fdb\u884c\u8bc4\u4ef7.\u7ed3\u679c":[9],"\u4e0d\u540c\u4f50\u5242\u53ef\u8bf1\u53d1\u4e0d\u540c\u6c34\u5e73\u7684\u6297\u4f53\u6ef4\u5ea6,Montanide":[10],"ISA51\u4f50\u5242\u914d\u4f0d\u7ec4\u7684\u6548\u679c\u4e0e\u5f17\u6c0f\u4f50\u5242\u7ec4\u6700\u4e3a\u63a5\u8fd1,\u5e76\u53ef\u4f7f\u86cb\u767d\u5305\u542b\u768411\u4e2a\u8868\u4f4d\u80bd\u80fd\u90fd\u8f83\u597d\u8bf1\u53d1\u51fa\u7279\u5f02\u6027\u6297\u4f53,\u53ef\u6709\u6548\u6fc0\u53d1\u4ee5IFN-\u03b3\u4e3a\u4e3b\u7684\u7ec6\u80de\u514d\u75ab\u5e94\u7b54,\u800c\u4e14Montanide":[11],"ISA51\u4f50\u5242\u7ec4\u514d\u75ab\u4ea7\u751f\u7684\u6297\u4f53\u548cM.RCAg-1\u86cb\u767d\u8d28\u7684\u4eb2\u548c\u529b\u9ad8\u4e8e\u5176\u4ed6\u4e24\u79cd\u4f50\u5242\uff1b\u800cMontanide":[12],"ISA720\u4f50\u5242\u548cAl\uff08OH\uff093\u4f50\u5242\u514d\u75ab\u7ec4\u4e0d\u80fd\u8bf1\u53d1\u5c0f\u9f20\u4ea7\u751f\u663e\u8457\u7684IFN-\u03b3\u53cd\u5e94\uff08P\uff1e0.05\uff09.Montanide":[13],"ISA51\u914d\u4f0d\u86cb\u767d\u8d28\u514d\u75ab\u4ea7\u751f\u7684IgG\u5728\u6d53\u5ea6\u4e3a2mg/ml\u65f6\u5bf93D7\u548cDd2\u7684\u6291\u5236\u7387\u5206\u522b\u4e3a60%\u548c100%,Al\uff08OH\uff093\u4f50\u5242\u7ec4\u514d\u75ab\u5154\u8840\u6e05IgG\u4f53\u5916\u6291\u866b\u7387\u8f83\u4f4e\uff0810%\u5de6\u53f3\uff09,\u800cMontanide":[14],"ISA720\u4f50\u5242\u514d\u75ab\u7ec4\u8840\u6e05\u4e0d\u80fd\u6709\u6548\u6291\u5236\u759f\u539f\u866b\u751f\u957f.\u7ed3\u8bba":[15],"\u901a\u8fc7\u6bd4\u8f833\u79cd\u4eba\u7528\u4f50\u5242\u548c\u5f17\u6c0f\u4f50\u5242\u5bf9BALB/c\u5c0f\u9f20\u548c\u65b0\u897f\u5170\u5154\u7684\u514d\u75ab\u8f85\u52a9\u6548\u80fd\u663e\u793a,Montanide":[16],"ISA51\u4f50\u5242\u80fd\u5f88\u597d\u7684\u8f85\u52a9M.RCAg-1\u86cb\u767d\u75ab\u82d7\u8bf1\u53d1\u52a8\u7269\u4f53\u5185\u7684\u4f53\u6db2\u514d\u75ab\u548c\u7ec6\u80de\u514d\u75ab\u5e94\u7b54,\u53ef\u505a\u4e3a\u75ab\u82d7\u7684\u5019\u9009\u4f50\u5242\u4e4b\u4e00.":[17]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}