{"id":"https://openalex.org/W345372262","doi":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","title":"M-Ras, a Widely Expressed 29-kD Homologue of p21 Ras: Expression of a Constitutively Active Mutant Results in Factor-Independent Growth of an Interleukin-3\u2013Dependent Cell Line","display_name":"M-Ras, a Widely Expressed 29-kD Homologue of p21 Ras: Expression of a Constitutively Active Mutant Results in Factor-Independent Growth of an Interleukin-3\u2013Dependent Cell Line","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W345372262","doi":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","mag":"345372262","pmid":"https://pubmed.ncbi.nlm.nih.gov/10498616"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v94.7.2433.419k31_2433_2444","doi":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057051360","display_name":"G\u00f6tz R. A. Ehrhardt","orcid":"https://orcid.org/0000-0002-5868-5191","observed_orcids":["https://orcid.org/0000-0002-5868-5191"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Go\u0308tz R.A. Ehrhardt","raw_affiliation_strings":["From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111596035","display_name":"Kevin B. Leslie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kevin B. Leslie","raw_affiliation_strings":["From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020462895","display_name":"Frances Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Frances Lee","raw_affiliation_strings":["From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083221616","display_name":"James S. Wieler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James S. Wieler","raw_affiliation_strings":["From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050259451","display_name":"John W. Schrader","orcid":"https://orcid.org/0000-0002-3381-3695","observed_orcids":["https://orcid.org/0000-0002-3381-3695"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John W. Schrader","raw_affiliation_strings":["From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.3407,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.78013421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"94","issue":"7","first_page":"2433","last_page":"2444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/m-ras","display_name":"M-Ras","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interleukin-3-dependence","display_name":"interleukin-3 dependence","score":0.7789999842643738},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ralgds","display_name":"RalGDS","score":0.9940000176429749},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.4830000102519989},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/morphological-transformation","display_name":"morphological transformation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6144852638244629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6078082323074341},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6063268184661865},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5288879871368408},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.509522020816803},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.5018880367279053},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4241061210632324},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36880433559417725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2831994891166687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24614137411117554},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.16331014037132263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11378711462020874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10241886973381042}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v94.7.2433.419k31_2433_2444","doi":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v94.7.2433.419k31_2433_2444","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10498616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10498616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W18630108","https://openalex.org/W152667517","https://openalex.org/W1493438883","https://openalex.org/W1562863690","https://openalex.org/W1583116012","https://openalex.org/W1585517331","https://openalex.org/W1824220821","https://openalex.org/W1960601813","https://openalex.org/W1979027806","https://openalex.org/W1980981080","https://openalex.org/W1983481482","https://openalex.org/W1989710374","https://openalex.org/W1991760443","https://openalex.org/W1991992481","https://openalex.org/W1992864103","https://openalex.org/W1997257161","https://openalex.org/W2000269495","https://openalex.org/W2012189464","https://openalex.org/W2031610264","https://openalex.org/W2032013475","https://openalex.org/W2044919350","https://openalex.org/W2045500858","https://openalex.org/W2058015528","https://openalex.org/W2058333572","https://openalex.org/W2062427243","https://openalex.org/W2065927746","https://openalex.org/W2070001832","https://openalex.org/W2078011486","https://openalex.org/W2078425071","https://openalex.org/W2078792023","https://openalex.org/W2084135506","https://openalex.org/W2090051314","https://openalex.org/W2095416319","https://openalex.org/W2097302279","https://openalex.org/W2117669008","https://openalex.org/W2135242575","https://openalex.org/W2136222819","https://openalex.org/W2142454421","https://openalex.org/W2145963061","https://openalex.org/W2149344188","https://openalex.org/W2150756957","https://openalex.org/W2154546525","https://openalex.org/W2158608327","https://openalex.org/W2159594827","https://openalex.org/W2176636090","https://openalex.org/W2330700669","https://openalex.org/W2397312377","https://openalex.org/W2409920262","https://openalex.org/W2466097962"],"related_works":["https://openalex.org/W2267754754","https://openalex.org/W2047008186","https://openalex.org/W2329084487","https://openalex.org/W113592412","https://openalex.org/W151869274","https://openalex.org/W2316510587","https://openalex.org/W2009635345","https://openalex.org/W2397127057","https://openalex.org/W2046972939","https://openalex.org/W2333641896"],"abstract_inverted_index":{"M-Ras,":[0,174],"a":[1,77,136,182,239],"recently":[2],"identified":[3],"homologue":[4],"of":[5,13,28,34,57,72,85,99,119,130,135,138,150,165,168,173,185,187,233,254,265],"p21":[6,29,200,234,266],"Ras,":[7],"is":[8],"widely":[9],"expressed,":[10],"with":[11],"levels":[12],"the":[14,55,83,120,127,151,166,176,188,220,229],"29-kD":[15],"protein":[16],"in":[17,42,51,54,61,68,82,102,106,213,260],"spleen,":[18],"thymus,":[19],"and":[20,39,93,109,123,132,199,207,231,238,247],"NIH":[21],"3T3":[22],"fibroblasts":[23,104],"equaling":[24],"or":[25],"exceeding":[26],"those":[27,263],"Ras.":[30,235,267],"A":[31],"G22V":[32,101,116,140],"mutant":[33,137,172],"M-Ras":[35,73,89,100,115,139,159,198,216,237],"was":[36,142,181,217],"constitutively":[37,192],"active":[38,193],"its":[40],"expression":[41,66],"an":[43],"interleukin-3":[44],"(IL-3)-dependent":[45],"mast":[46],"cell/megakaryocyte":[47],"cell":[48,113],"line":[49],"resulted":[50,105],"increased":[52,59],"survival":[53],"absence":[56],"IL-3,":[58,86],"growth":[60,81,110],"IL-4,":[62],"and,":[63],"at":[64],"high":[65],"levels,":[67],"factor-independent":[69],"growth.":[70,97],"Expression":[71,98,134],"G22V,":[74],"however,":[75],"had":[76],"negative":[78,94],"effect":[79],"on":[80,96],"presence":[84],"suggesting":[87,157,196],"that":[88,141,158,197,258],"has":[90],"both":[91],"positive":[92],"effects":[95],"NIH-3T3":[103],"morphological":[107],"transformation":[108],"to":[111,126,210,227,251,262],"higher":[112],"densities.":[114],"induced":[117],"activation":[118,149,186,253],"c-fos":[121,152,189],"promoter,":[122],"bound":[124],"weakly":[125],"Ras-binding":[128],"domains":[129],"Raf-1":[131],"RalGDS.":[133],"no":[143],"longer":[144],"membrane-bound":[145],"partially":[146],"inhibited":[147],"(40%)":[148],"promoter":[153,190],"by":[154,191,219],"N-Ras":[155],"Q61K,":[156],"shared":[160,202],"some,":[161],"but":[162],"not":[163],"all,":[164],"effectors":[167],"N-Ras.":[169],"An":[170],"S27N":[171],"like":[175],"analogous":[177],"H-Ras":[178],"S17N":[179],"mutant,":[180],"dominant":[183],"inhibitor":[184],"Src":[194],"Y527F,":[195],"Ras":[201],"guanine":[203],"nucleotide":[204],"exchange":[205],"factors":[206],"are":[208,249],"likely":[209,250],"be":[211],"activated":[212],"parallel.":[214],"Moreover,":[215],"recognized":[218],"monoclonal":[221],"anti-Ras":[222],"antibody":[223],"Y13-259,":[224],"commonly":[225],"used":[226],"study":[228],"function":[230,259],"activity":[232],"Mammalian":[236],"Caenorhabditis":[240],"elegans":[241],"orthologue":[242],"exhibit":[243],"conserved":[244],"structural":[245],"features,":[246],"these":[248],"mediate":[252],"distinctive":[255],"signaling":[256],"paths":[257],"parallel":[261],"downstream":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
