{"id":"https://openalex.org/W34522353","doi":null,"title":"Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis.","display_name":"Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis.","publication_year":1984,"publication_date":"1984-09-01","ids":{"openalex":"https://openalex.org/W34522353","mag":"34522353","pmid":"https://pubmed.ncbi.nlm.nih.gov/6471808"},"language":"en","primary_location":{"id":"pmid:6471808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6471808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065587017","display_name":"Kirsten Madsen","orcid":"https://orcid.org/0000-0002-1427-602X","observed_orcids":["https://orcid.org/0000-0002-1427-602X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Madsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000218151","display_name":"C. Craig Tisher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C C Tisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6147,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.97432686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"51","issue":"3","first_page":"268","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intercalated-cells","display_name":"intercalated cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/outer-medullary-collecting-duct","display_name":"outer medullary collecting duct","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chronic-metabolic-acidosis","display_name":"chronic metabolic acidosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hydrogen-ion-secretion","display_name":"hydrogen ion secretion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/principal-cells","display_name":"principal cells","score":0.6779999732971191},{"id":"https://openalex.org/keywords/apical-membrane","display_name":"apical membrane","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tubulovesicular-structures","display_name":"tubulovesicular structures","score":0.8790000081062317},{"id":"https://openalex.org/keywords/proton-pump","display_name":"proton pump","score":0.6919999718666077},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.5009999871253967},{"id":"https://openalex.org/keywords/mitochondria-rich-cells","display_name":"mitochondria-rich cells","score":0.75},{"id":"https://openalex.org/keywords/ammonium-chloride","display_name":"ammonium chloride","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2910744950","wikidata":"https://www.wikidata.org/wiki/Q452419","display_name":"Intercalated Cell","level":3,"score":0.8011887669563293},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5541940927505493},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5295608639717102},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.5267659425735474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5214390158653259},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.49032118916511536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4581318497657776},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.43201518058776855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41813671588897705},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36536139249801636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3410070538520813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2995172142982483},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2678629755973816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1496833860874176}],"mesh":[{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6471808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6471808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:34522353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6471808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W2107152832","https://openalex.org/W2147376247","https://openalex.org/W2998554366","https://openalex.org/W2049254053","https://openalex.org/W2334938219","https://openalex.org/W2070436936","https://openalex.org/W1976958420","https://openalex.org/W129305155","https://openalex.org/W2157994386","https://openalex.org/W2909996064","https://openalex.org/W2157255799","https://openalex.org/W2908893606","https://openalex.org/W2042332688","https://openalex.org/W2110242161","https://openalex.org/W2150466929","https://openalex.org/W2335000292","https://openalex.org/W1952760672","https://openalex.org/W2890406182","https://openalex.org/W2888749478","https://openalex.org/W3092158340","https://openalex.org/W61588624","https://openalex.org/W2500473094","https://openalex.org/W2788933461","https://openalex.org/W2125043133","https://openalex.org/W2784390711","https://openalex.org/W3013405708","https://openalex.org/W1976156597","https://openalex.org/W2116751364","https://openalex.org/W2092818583","https://openalex.org/W2166192281","https://openalex.org/W2164361769","https://openalex.org/W2607422466","https://openalex.org/W2028443048","https://openalex.org/W2171322695","https://openalex.org/W1978080752","https://openalex.org/W2902821147","https://openalex.org/W2096984801","https://openalex.org/W2055248983","https://openalex.org/W2143229788","https://openalex.org/W2020345545"],"related_works":["https://openalex.org/W2399607310","https://openalex.org/W2466949800","https://openalex.org/W2033001871","https://openalex.org/W2054024370","https://openalex.org/W2411361413","https://openalex.org/W2410146750","https://openalex.org/W2143267028","https://openalex.org/W1953103940","https://openalex.org/W2338614417","https://openalex.org/W2411204195"],"abstract_inverted_index":{"The":[0],"outer":[1,83,155],"medullary":[2,84],"collecting":[3,85],"duct":[4,86],"which":[5],"is":[6,14,30,209],"composed":[7],"of":[8,26,120,148,167,177,186,221],"both":[9,153],"principal":[10,144],"and":[11,42,54,102,133,156],"intercalated":[12,63,150,223],"cells":[13,64,151],"involved":[15],"in":[16,35,81,95,128,142,152,163,181,197],"hydrogen":[17,27],"ion":[18,28],"secretion.":[19],"In":[20],"the":[21,36,57,62,66,82,123,143,149,154,164,168,178,182,187,212,217,222],"turtle":[22],"urinary":[23],"bladder":[24],"stimulation":[25],"secretion":[29],"associated":[31],"with":[32,131,173,189],"ultrastructural":[33],"changes":[34,79,139],"mitochondria-rich":[37,67],"cells,":[38,68],"suggesting":[39],"that":[40,196],"membrane":[41,171,214,220],"possibly":[43,204],"a":[44,104,160,174,206],"proton":[45,207],"pump":[46],"are":[47],"being":[48],"transferred":[49],"from":[50,211],"apical":[51,58,169,183,218],"tubulovesicular":[52,179,213],"structures":[53,180],"inserted":[55],"into":[56],"plasma":[59,170,184,219],"membrane.":[60],"Since":[61],"resemble":[65],"this":[69],"study":[70],"was":[71],"initiated":[72],"to":[73,199,216],"determine":[74],"whether":[75],"or":[76],"not":[77],"similar":[78],"occur":[80],"during":[87],"chronic":[88,190,200],"metabolic":[89,191,201],"acidosis.":[90,192],"Rats":[91],"received":[92,114],"ammonium":[93],"chloride":[94],"their":[96],"drinking":[97],"water":[98],"for":[99,107,135],"15":[100],"days":[101,109],"as":[103],"daily":[105],"gavage":[106],"3":[108],"before":[110],"sacrifice.":[111],"Control":[112],"rats":[113],"regular":[115],"tap":[116],"water.":[117],"After":[118],"collection":[119],"physiologic":[121],"data":[122],"kidneys":[124],"were":[125,140],"fixed":[126],"by":[127],"vivo":[129],"perfusion":[130],"glutaraldehyde":[132],"processed":[134],"electron":[136],"microscopy.":[137],"No":[138],"observed":[141],"cells.":[145],"Morphometric":[146],"analyses":[147],"inner":[157],"stripe":[158],"revealed":[159],"significant":[161],"increase":[162],"surface":[165],"density":[166],"concomitant":[172],"striking":[175],"depletion":[176],"region":[185],"cell":[188],"These":[193],"findings":[194],"suggest":[195],"response":[198],"acidosis":[202],"membrane,":[203],"containing":[205],"pump,":[208],"transported":[210],"compartment":[215],"cell.":[224]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}