{"id":"https://openalex.org/W345197978","doi":null,"title":"Phenylephrine preconditioning of isolated ventricular myocytes involves modulation of KATP channels through activation of survival kinases","display_name":"Phenylephrine preconditioning of isolated ventricular myocytes involves modulation of KATP channels through activation of survival kinases","publication_year":2009,"publication_date":"2009-10-23","ids":{"openalex":"https://openalex.org/W345197978","mag":"345197978"},"language":"en","primary_location":{"id":"pmh:oai:lra.le.ac.uk:2381/8685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/8685","pdf_url":"http://hdl.handle.net/2381/8685","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2381/8685","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111672215","display_name":"Helen E. Turrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Helen E. Turrell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111672215"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pharmacological-preconditioning","display_name":"pharmacological preconditioning","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.8059999942779541},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pkcdelta","display_name":"PKC\u03b4","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pkc-epsilon","display_name":"protein kinase C epsilon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9179999828338623},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9399999976158142},{"id":"https://openalex.org/keywords/camkk","display_name":"CaMKK","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8379999995231628},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/contractile-recovery","display_name":"contractile recovery","score":0.746999979019165},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.753000020980835},{"id":"https://openalex.org/keywords/membrane-hyperpolarization","display_name":"membrane hyperpolarization","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.7219773530960083},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5465060472488403},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4372062683105469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39827319979667664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.397217333316803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3238236904144287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28771036863327026},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2735995948314667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26844650506973267},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:lra.le.ac.uk:2381/8685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/8685","pdf_url":"http://hdl.handle.net/2381/8685","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/975498","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/975498","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:figshare.com:article/10097894","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Phenylephrine_preconditioning_of_isolated_ventricular_myocytes_involves_modulation_of_KATP_channels_through_activation_of_survival_kinases/10097894","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:345197978","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/525737","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lra.le.ac.uk:2381/8685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/8685","pdf_url":"http://hdl.handle.net/2381/8685","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W345197978.pdf","grobid_xml":"https://content.openalex.org/works/W345197978.grobid-xml"},"referenced_works_count":316,"referenced_works":["https://openalex.org/W1481175","https://openalex.org/W14273916","https://openalex.org/W169179504","https://openalex.org/W176383802","https://openalex.org/W197144613","https://openalex.org/W335807055","https://openalex.org/W1269302828","https://openalex.org/W1519513753","https://openalex.org/W1524299374","https://openalex.org/W1530529896","https://openalex.org/W1530888481","https://openalex.org/W1535725499","https://openalex.org/W1547005412","https://openalex.org/W1565234800","https://openalex.org/W1569948360","https://openalex.org/W1573979120","https://openalex.org/W1577233398","https://openalex.org/W1580135653","https://openalex.org/W1788426598","https://openalex.org/W1889002087","https://openalex.org/W1892154908","https://openalex.org/W1934994215","https://openalex.org/W1946846565","https://openalex.org/W1964272274","https://openalex.org/W1964436832","https://openalex.org/W1964769632","https://openalex.org/W1966638935","https://openalex.org/W1967526945","https://openalex.org/W1967594564","https://openalex.org/W1968306825","https://openalex.org/W1971701575","https://openalex.org/W1972013105","https://openalex.org/W1973542307","https://openalex.org/W1974646396","https://openalex.org/W1975463322","https://openalex.org/W1975842822","https://openalex.org/W1975974673","https://openalex.org/W1976385326","https://openalex.org/W1977017927","https://openalex.org/W1977239487","https://openalex.org/W1977375646","https://openalex.org/W1977596244","https://openalex.org/W1977661035","https://openalex.org/W1978052737","https://openalex.org/W1978221784","https://openalex.org/W1978237064","https://openalex.org/W1980449739","https://openalex.org/W1982613447","https://openalex.org/W1985185771","https://openalex.org/W1986406106","https://openalex.org/W1986804446","https://openalex.org/W1987378063","https://openalex.org/W1987664769","https://openalex.org/W1988581797","https://openalex.org/W1988592848","https://openalex.org/W1988848089","https://openalex.org/W1989255509","https://openalex.org/W1989347772","https://openalex.org/W1989945824","https://openalex.org/W1990253313","https://openalex.org/W1990768361","https://openalex.org/W1991280668","https://openalex.org/W1991490958","https://openalex.org/W1991714532","https://openalex.org/W1993302751","https://openalex.org/W1993352831","https://openalex.org/W1993353490","https://openalex.org/W1994041994","https://openalex.org/W1994442108","https://openalex.org/W1994823083","https://openalex.org/W1995327987","https://openalex.org/W1996140321","https://openalex.org/W1996831972","https://openalex.org/W1996898511","https://openalex.org/W1998016052","https://openalex.org/W1998349282","https://openalex.org/W1999631310","https://openalex.org/W2001333805","https://openalex.org/W2002179621","https://openalex.org/W2002564316","https://openalex.org/W2002620791","https://openalex.org/W2003805549","https://openalex.org/W2003873419","https://openalex.org/W2004617058","https://openalex.org/W2004886717","https://openalex.org/W2006317835","https://openalex.org/W2006844568","https://openalex.org/W2007101922","https://openalex.org/W2007294454","https://openalex.org/W2007348055","https://openalex.org/W2007612684","https://openalex.org/W2007812094","https://openalex.org/W2008682907","https://openalex.org/W2008728680","https://openalex.org/W2009574988","https://openalex.org/W2010444181","https://openalex.org/W2011172201","https://openalex.org/W2011827945","https://openalex.org/W2012978268","https://openalex.org/W2013870358","https://openalex.org/W2015122598","https://openalex.org/W2015300033","https://openalex.org/W2016640448","https://openalex.org/W2016866290","https://openalex.org/W2016952530","https://openalex.org/W2018113738","https://openalex.org/W2018896819","https://openalex.org/W2019980095","https://openalex.org/W2020076608","https://openalex.org/W2020895828","https://openalex.org/W2022135851","https://openalex.org/W2022546498","https://openalex.org/W2023494473","https://openalex.org/W2023511860","https://openalex.org/W2023590619","https://openalex.org/W2023650478","https://openalex.org/W2023972740","https://openalex.org/W2025171522","https://openalex.org/W2025975686","https://openalex.org/W2026313838","https://openalex.org/W2027108488","https://openalex.org/W2028526641","https://openalex.org/W2028565349","https://openalex.org/W2028794166","https://openalex.org/W2029819431","https://openalex.org/W2029843923","https://openalex.org/W2030470230","https://openalex.org/W2030590419","https://openalex.org/W2031002779","https://openalex.org/W2031693554","https://openalex.org/W2033590064","https://openalex.org/W2033594768","https://openalex.org/W2033858209","https://openalex.org/W2034139295","https://openalex.org/W2035277080","https://openalex.org/W2035589569","https://openalex.org/W2037210083","https://openalex.org/W2039147530","https://openalex.org/W2041428804","https://openalex.org/W2041884974","https://openalex.org/W2042143995","https://openalex.org/W2042584010","https://openalex.org/W2045984578","https://openalex.org/W2047604959","https://openalex.org/W2047680711","https://openalex.org/W2047876380","https://openalex.org/W2048020247","https://openalex.org/W2048181009","https://openalex.org/W2050824263","https://openalex.org/W2051273609","https://openalex.org/W2051896709","https://openalex.org/W2053010478","https://openalex.org/W2053600793","https://openalex.org/W2054220851","https://openalex.org/W2054475515","https://openalex.org/W2054669238","https://openalex.org/W2057257618","https://openalex.org/W2057909972","https://openalex.org/W2057994986","https://openalex.org/W2058093835","https://openalex.org/W2059044152","https://openalex.org/W2059328843","https://openalex.org/W2060805255","https://openalex.org/W2060949250","https://openalex.org/W2061052988","https://openalex.org/W2061669724","https://openalex.org/W2063098872","https://openalex.org/W2063953032","https://openalex.org/W2064953660","https://openalex.org/W2065907781","https://openalex.org/W2066297191","https://openalex.org/W2068118359","https://openalex.org/W2068342714","https://openalex.org/W2070385915","https://openalex.org/W2070518020","https://openalex.org/W2071221015","https://openalex.org/W2072091889","https://openalex.org/W2072232908","https://openalex.org/W2072612222","https://openalex.org/W2073261922","https://openalex.org/W2074166702","https://openalex.org/W2074301028","https://openalex.org/W2074907054","https://openalex.org/W2076293142","https://openalex.org/W2076515241","https://openalex.org/W2076598630","https://openalex.org/W2077172545","https://openalex.org/W2079565440","https://openalex.org/W2081048275","https://openalex.org/W2083707111","https://openalex.org/W2083708483","https://openalex.org/W2083771740","https://openalex.org/W2084097342","https://openalex.org/W2086083619","https://openalex.org/W2086991052","https://openalex.org/W2087739792","https://openalex.org/W2087805943","https://openalex.org/W2087865480","https://openalex.org/W2088256405","https://openalex.org/W2089271830","https://openalex.org/W2090966442","https://openalex.org/W2091673674","https://openalex.org/W2091958169","https://openalex.org/W2095707818","https://openalex.org/W2097550685","https://openalex.org/W2098368476","https://openalex.org/W2100405364","https://openalex.org/W2100438302","https://openalex.org/W2104258421","https://openalex.org/W2104998210","https://openalex.org/W2109314119","https://openalex.org/W2109659042","https://openalex.org/W2110245053","https://openalex.org/W2111912915","https://openalex.org/W2112149657","https://openalex.org/W2112616057","https://openalex.org/W2113849978","https://openalex.org/W2114266263","https://openalex.org/W2114853537","https://openalex.org/W2116084832","https://openalex.org/W2116286593","https://openalex.org/W2116899872","https://openalex.org/W2117071870","https://openalex.org/W2118815080","https://openalex.org/W2119046076","https://openalex.org/W2119393589","https://openalex.org/W2119894901","https://openalex.org/W2119950193","https://openalex.org/W2119970745","https://openalex.org/W2120329167","https://openalex.org/W2121473554","https://openalex.org/W2121722537","https://openalex.org/W2121962823","https://openalex.org/W2122057254","https://openalex.org/W2122501550","https://openalex.org/W2122948256","https://openalex.org/W2123338440","https://openalex.org/W2123709832","https://openalex.org/W2124047072","https://openalex.org/W2125595015","https://openalex.org/W2126171035","https://openalex.org/W2126636055","https://openalex.org/W2126681184","https://openalex.org/W2127632261","https://openalex.org/W2127652330","https://openalex.org/W2128676004","https://openalex.org/W2129812461","https://openalex.org/W2129917446","https://openalex.org/W2130497617","https://openalex.org/W2131655209","https://openalex.org/W2131704472","https://openalex.org/W2131755434","https://openalex.org/W2132494613","https://openalex.org/W2133396714","https://openalex.org/W2135826150","https://openalex.org/W2135905945","https://openalex.org/W2135956470","https://openalex.org/W2136009429","https://openalex.org/W2136542710","https://openalex.org/W2136556999","https://openalex.org/W2137664405","https://openalex.org/W2138298723","https://openalex.org/W2139834613","https://openalex.org/W2140631005","https://openalex.org/W2142333871","https://openalex.org/W2142845167","https://openalex.org/W2144099695","https://openalex.org/W2144640999","https://openalex.org/W2145047965","https://openalex.org/W2146217294","https://openalex.org/W2147821795","https://openalex.org/W2148107316","https://openalex.org/W2149785020","https://openalex.org/W2150753478","https://openalex.org/W2150990549","https://openalex.org/W2151388489","https://openalex.org/W2153834892","https://openalex.org/W2157109878","https://openalex.org/W2157171390","https://openalex.org/W2157651064","https://openalex.org/W2157817576","https://openalex.org/W2159453909","https://openalex.org/W2159454962","https://openalex.org/W2159620999","https://openalex.org/W2160778929","https://openalex.org/W2164183838","https://openalex.org/W2165226803","https://openalex.org/W2165537841","https://openalex.org/W2165690002","https://openalex.org/W2166527628","https://openalex.org/W2166898187","https://openalex.org/W2166968378","https://openalex.org/W2168251353","https://openalex.org/W2169682503","https://openalex.org/W2169806115","https://openalex.org/W2170347547","https://openalex.org/W2170679542","https://openalex.org/W2171137464","https://openalex.org/W2171297304","https://openalex.org/W2182948511","https://openalex.org/W2184146953","https://openalex.org/W2186345844","https://openalex.org/W2186893608","https://openalex.org/W2189709850","https://openalex.org/W2217333788","https://openalex.org/W2221859654","https://openalex.org/W2223303062","https://openalex.org/W2236561572","https://openalex.org/W2316354035","https://openalex.org/W2321452482","https://openalex.org/W2321460069","https://openalex.org/W2327849469","https://openalex.org/W2355832760","https://openalex.org/W2400966514","https://openalex.org/W2418319916","https://openalex.org/W4406057023"],"related_works":["https://openalex.org/W2020314433","https://openalex.org/W2098975412","https://openalex.org/W2129167542","https://openalex.org/W2982264082","https://openalex.org/W7074186625","https://openalex.org/W1994470880","https://openalex.org/W2157817576","https://openalex.org/W1946846565","https://openalex.org/W2463977240","https://openalex.org/W2086184661"],"abstract_inverted_index":{"Pretreatment":[0],"with":[1,84,104],"the":[2,30,34,87,193,232,242,251],"\u03b11-adrenoceptor":[3],"agonist":[4],"phenylephrine":[5,48,85,116,142,155,171,178,218,262],"has":[6],"been":[7],"shown":[8],"to":[9,141,189,230],"protect":[10],"cardiac":[11],"tissue":[12],"from":[13],"a":[14,132,146],"subsequent":[15],"period":[16],"of":[17,33,39,67,72,90,115,125,135,175,196,222,241,261],"ischaemia.":[18],"This":[19],"phenomenon,":[20],"known":[21],"as":[22],"pharmacological":[23],"preconditioning,":[24,143,172],"decreases":[25],"infarct":[26],"size":[27],"and":[28,42,65,81,97,99,137,144,164,173,185,220,246,257,268],"increases":[29],"functional":[31],"recovery":[32,89,120,260],"intact":[35],"heart.":[36],"The":[37,70,112],"role":[38,71,148],"protein":[40],"kinases":[41],"ATP-sensitive":[43],"potassium":[44],"channels":[45,199,204],"(KATP)":[46],"in":[47,52,107,139,192,234,254],"preconditioning":[49,117,156,179,219],"was":[50,75,101,121,152,215,228],"investigated":[51],"isolated":[53,91],"ventricular":[54,92,264],"myocytes":[55,93,265],"using":[56,77],"whole":[57],"cell":[58],"patch":[59],"clamp,":[60],"western":[61],"blotting,":[62],"fluorescence":[63],"imaging":[64],"measurement":[66],"contractile":[68,88,119,259],"activity.":[69],"PKC":[73,79,127],"isoforms":[74],"examined":[76],"isoform-specific":[78],"activator":[80],"inhibitor":[82],"peptides.\\nPreconditioning":[83],"increased":[86,159,216],"following":[94,217,266],"simulated":[95],"ischaemia":[96,267],"reperfusion,":[98],"this":[100],"also":[102,158],"correlated":[103],"an":[105],"improvement":[106],"calcium":[108,255],"homeostasis":[109],"during":[110],"reperfusion.":[111,269],"protective":[113,147,194],"effect":[114],"on":[118],"abolished":[122],"by":[123,177,212],"inhibition":[124,214,221],"\u03b11-adrenoceptors,":[126],"or":[128,201,225],"KATP.":[129],"We":[130],"observed":[131,252],"sustained":[133],"activation":[134,174],"PKC\u03b5":[136],"\u03b4":[138],"response":[140],"identified":[145],"for":[149,154,170,250],"PKC\u03b5.":[150],"PKC\u03b4":[151],"required":[153,169,180],"but":[157],"reperfusion":[160],"injury.":[161],"CaMKK,":[162],"AMPK":[163,176,224],"p38":[165,226],"MAPK":[166,227],"were":[167],"all":[168],"PKC\u03b4.":[181],"However,":[182],"both":[183],"JNK":[184],"ERK":[186],"appear":[187],"not":[188],"be":[190,248],"involved":[191],"effect.\\nInhibition":[195],"sarcolemmal":[197],"KATP":[198,203],"(sarcKATP)":[200],"mitochondrial":[202],"(mitoKATP)":[205],"prevented":[206],"preconditioning.":[207],"Peak":[208],"sarcKATP":[209,236],"current":[210,237],"activated":[211],"metabolic":[213],"PKC\u03b4,":[223],"sufficient":[229],"prevent":[231],"increase":[233],"current.\\nIncreased":[235],"can":[238],"enhance":[239],"hyperpolarisation":[240],"resting":[243],"membrane":[244],"potential,":[245],"may":[247],"responsible":[249],"decrease":[253],"loading":[256],"improved":[258],"preconditioned":[263]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}