{"id":"https://openalex.org/W34488157","doi":null,"title":"[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy].","display_name":"[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy].","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W34488157","mag":"34488157","pmid":"https://pubmed.ncbi.nlm.nih.gov/18822888"},"language":"tr","primary_location":{"id":"pmid:18822888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18822888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mikrobiyoloji bulteni","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"U\u011fur Arslan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"U\u011fur Arslan","raw_affiliation_strings":["Sel\u00e7uk Universitesi Meram Tip Fak\u00fcltesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Konya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sel\u00e7uk Universitesi Meram Tip Fak\u00fcltesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Konya","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004037115","display_name":"Onur Ural","orcid":"https://orcid.org/0000-0003-1355-7572","observed_orcids":["https://orcid.org/0000-0003-1355-7572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Onur Ural","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071392053","display_name":"Duygu F\u0131nd\u0131k","orcid":"https://orcid.org/0000-0002-0342-0364","observed_orcids":["https://orcid.org/0000-0002-0342-0364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duygu Findik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.00526957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"42","issue":"3","first_page":"445","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamivudine-resistance","display_name":"lamivudine resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/reverse-transcriptase-mutations","display_name":"reverse transcriptase mutations","score":0.8989999890327454},{"id":"https://openalex.org/keywords/adefovir","display_name":"adefovir","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antiviral-therapy-monitoring","display_name":"antiviral therapy monitoring","score":0.5809999704360962},{"id":"https://openalex.org/keywords/line-probe-assay","display_name":"line probe assay","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.8347102403640747},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7029908299446106},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5860109329223633},{"id":"https://openalex.org/C2779517838","wikidata":"https://www.wikidata.org/wiki/Q353551","display_name":"Adefovir","level":5,"score":0.5047603845596313},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5021710395812988},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4344470202922821},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4327922761440277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3962826132774353},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3884913921356201},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3840060234069824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3510296940803528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.321861207485199},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1815003752708435}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18822888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18822888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mikrobiyoloji bulteni","raw_type":"English Abstract"},{"id":"mag:34488157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18822888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1228630810","https://openalex.org/W1953061348","https://openalex.org/W1979242398","https://openalex.org/W1982468089","https://openalex.org/W1992819142","https://openalex.org/W1997134323","https://openalex.org/W2001512833","https://openalex.org/W2006513124","https://openalex.org/W2022702105","https://openalex.org/W2035670587","https://openalex.org/W2036538049","https://openalex.org/W2042122216","https://openalex.org/W2043930670","https://openalex.org/W2044634606","https://openalex.org/W2048162184","https://openalex.org/W2051900223","https://openalex.org/W2060955538","https://openalex.org/W2065277986","https://openalex.org/W2065762344","https://openalex.org/W2065826491","https://openalex.org/W2071233026","https://openalex.org/W2075642775","https://openalex.org/W2077289205","https://openalex.org/W2116749397","https://openalex.org/W2130231032","https://openalex.org/W2145352021","https://openalex.org/W2154251878","https://openalex.org/W2160738241","https://openalex.org/W2191363078","https://openalex.org/W2216660685","https://openalex.org/W2320345494","https://openalex.org/W2380453961","https://openalex.org/W2476492766","https://openalex.org/W2509245130","https://openalex.org/W2580147412","https://openalex.org/W2592097997","https://openalex.org/W2762140251","https://openalex.org/W2772067551","https://openalex.org/W2783365519","https://openalex.org/W2790542267","https://openalex.org/W2792480419","https://openalex.org/W2883465058","https://openalex.org/W2887144386","https://openalex.org/W2892611345","https://openalex.org/W2898212589","https://openalex.org/W2910059751","https://openalex.org/W2946304374","https://openalex.org/W3007720044","https://openalex.org/W3013534520","https://openalex.org/W3088805237","https://openalex.org/W4256501431","https://openalex.org/W6774547200"],"related_works":["https://openalex.org/W6999829441","https://openalex.org/W2039721854","https://openalex.org/W1535324229","https://openalex.org/W2392587674","https://openalex.org/W2365069172","https://openalex.org/W2353166032","https://openalex.org/W2026054006","https://openalex.org/W2084475682","https://openalex.org/W2025206059","https://openalex.org/W3210069089"],"abstract_inverted_index":{"Lamivudine":[0],"resistance":[1,58,212,218,246],"is":[2,222],"a":[3],"result":[4],"of":[5,24,30,84,125,147,181,210,216,226,239,254],"mutations":[6],"in":[7,10,48,74,122,167,177,189,252],"YMDD":[8,45,114,136,155,161,171,182,197],"motif":[9,46,115,137,152],"which":[11],"rt203-206th":[12],"codons":[13],"(Y:":[14],"tyrosine;":[15],"M:":[16],"methionin;":[17],"D:":[18,21],"aspartic":[19,22],"acid;":[20],"acid)":[23],"reverse":[25],"trancriptase;":[26],"the":[27,44,75,82,85,148,214,229,237,255],"catalytic":[28],"part":[29],"hepatitis":[31,50,240,257],"B":[32,51,258],"polymerase":[33,62,119],"enzyme,":[34],"takes":[35],"place.":[36],"In":[37,131,192],"this":[38],"study":[39],"we":[40],"aimed":[41],"to":[42,60,112,142,228],"show":[43],"variants":[47,116,138,153,198],"chronic":[49,256],"patients":[52,71,86,127,259],"who":[53],"have":[54],"presumably":[55],"developed":[56],"lamivudine":[57,66,69],"due":[59],"viral":[61,118],"gene":[63,120],"mutation":[64],"during":[65,219],"therapy.":[67,262],"Twenty":[68],"treated":[70],"were":[72,139,154,187,199],"included":[73],"study,":[76],"and":[77,128,157],"HBV-DNA":[78,123,195],"was":[79,110,165,175],"extracted":[80],"from":[81],"sera":[83],"by":[87],"using":[88],"extraction":[89],"kit":[90],"(Invisorb,":[91],"Instant":[92],"Spin":[93],"DNA/RNA":[94],"Virus":[95],"Mini":[96],"Kit,":[97],"Germany).":[98],"A":[99],"line":[100],"probe":[101],"assay":[102],"(INNO-LIPA":[103],"HBV":[104],"DR;":[105],"INNOGENETICS":[106],"N.V,":[107],"Ghent,":[108],"Belgium)":[109],"used":[111],"determine":[113],"at":[117,231],"fragment":[121],"samples":[124,135,150,196],"these":[126],"evaluated":[129],"colorimetrically.":[130],"12":[132,149],"(60%)":[133],"patients'":[134],"detected":[140,188],"leading":[141],"lamivudin":[143,220,245,261],"resistance.":[144],"Eleven":[145],"(91.6%)":[146],"having":[151],"variant":[156],"wild-type":[158],"combination.":[159],"While":[160],"+":[162,172,183,185],"YIDD":[163,186],"combination":[164,174,180],"determined":[166,176],"only":[168],"one":[169],"specimen,":[170],"YVDD":[173,184],"six.":[178],"Mixed":[179],"four":[190],"samples.":[191],"8":[193],"(66.6%)":[194],"accompanied":[200],"with":[201,241],"L180M":[202],"variants.":[203],"It":[204],"can":[205],"be":[206,248],"concluded":[207],"that":[208],"determination":[209],"genotypic":[211],"before":[213],"expression":[215],"phenotypic":[217],"therapy":[221,230],"important":[223],"since":[224],"addition":[225],"adefovir":[227],"an":[232],"early":[233],"stage":[234],"will":[235],"prevent":[236],"occurence":[238],"mutant":[242],"species.":[243],"Thus":[244],"should":[247],"followed":[249],"up":[250],"regularly":[251],"all":[253],"under":[260]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}