{"id":"https://openalex.org/W344690696","doi":null,"title":"Engineering protein kinase A to identify novel : PKA substrates","display_name":"Engineering protein kinase A to identify novel : PKA substrates","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W344690696","mag":"344690696"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt8rs6q53k","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8rs6q53k","pdf_url":"https://escholarship.org/uc/item/8rs6q53k","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/8rs6q53k","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079979970","display_name":"Sharmin Schauble","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sharmin Schauble","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079979970"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.871999979019165},{"id":"https://openalex.org/keywords/chemical-genetics","display_name":"chemical genetics","score":0.609000027179718},{"id":"https://openalex.org/keywords/catalytic-subunit","display_name":"catalytic subunit","score":0.5910000205039978},{"id":"https://openalex.org/keywords/mitochondrial-protein-import","display_name":"mitochondrial protein import","score":0.5149999856948853},{"id":"https://openalex.org/keywords/protein-myristoylation","display_name":"myristoylation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/mia40","display_name":"Mia40","score":0.7490000128746033},{"id":"https://openalex.org/keywords/erv1","display_name":"Erv1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.734000027179718},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7812753915786743},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.665091335773468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6165674924850464},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5975728034973145},{"id":"https://openalex.org/C175738201","wikidata":"https://www.wikidata.org/wiki/Q5198255","display_name":"Cyclin-dependent kinase complex","level":5,"score":0.484235018491745},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4661841094493866},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41595935821533203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40474432706832886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40447527170181274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32563427090644836},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.2887992262840271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12348952889442444}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt8rs6q53k","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8rs6q53k","pdf_url":"https://escholarship.org/uc/item/8rs6q53k","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:344690696","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt8rs6q53k/qt8rs6q53k.pdf?t=lq67vl","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt8rs6q53k","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8rs6q53k","pdf_url":"https://escholarship.org/uc/item/8rs6q53k","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W344690696.pdf","grobid_xml":"https://content.openalex.org/works/W344690696.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1490238718","https://openalex.org/W1527636592","https://openalex.org/W1551027803","https://openalex.org/W1561853718","https://openalex.org/W1568303936","https://openalex.org/W1670966041","https://openalex.org/W1963705823","https://openalex.org/W1968214151","https://openalex.org/W1971442726","https://openalex.org/W1972235557","https://openalex.org/W1974644558","https://openalex.org/W1975734895","https://openalex.org/W1976662277","https://openalex.org/W1978696795","https://openalex.org/W1979033389","https://openalex.org/W1979484538","https://openalex.org/W1995720011","https://openalex.org/W2000990496","https://openalex.org/W2002419494","https://openalex.org/W2012243761","https://openalex.org/W2014126697","https://openalex.org/W2015391531","https://openalex.org/W2022257442","https://openalex.org/W2030205108","https://openalex.org/W2032225851","https://openalex.org/W2038770351","https://openalex.org/W2040777218","https://openalex.org/W2045919621","https://openalex.org/W2050386164","https://openalex.org/W2051891646","https://openalex.org/W2055043387","https://openalex.org/W2056099910","https://openalex.org/W2062574001","https://openalex.org/W2066867262","https://openalex.org/W2075767774","https://openalex.org/W2077469282","https://openalex.org/W2078142395","https://openalex.org/W2082516237","https://openalex.org/W2085415089","https://openalex.org/W2088656604","https://openalex.org/W2090895449","https://openalex.org/W2094110989","https://openalex.org/W2095675477","https://openalex.org/W2105420524","https://openalex.org/W2106882534","https://openalex.org/W2107222257","https://openalex.org/W2108174107","https://openalex.org/W2113031685","https://openalex.org/W2114341896","https://openalex.org/W2118390137","https://openalex.org/W2122395913","https://openalex.org/W2127101467","https://openalex.org/W2128859932","https://openalex.org/W2129742695","https://openalex.org/W2132023176","https://openalex.org/W2133796240","https://openalex.org/W2139514626","https://openalex.org/W2141524439","https://openalex.org/W2147042017","https://openalex.org/W2147343486","https://openalex.org/W2149049196","https://openalex.org/W2149238710","https://openalex.org/W2154535504","https://openalex.org/W2157193327","https://openalex.org/W2158730778","https://openalex.org/W2171041527"],"related_works":["https://openalex.org/W1973274378","https://openalex.org/W7100397903","https://openalex.org/W1977621221","https://openalex.org/W2123211463","https://openalex.org/W1971734782","https://openalex.org/W2286036094","https://openalex.org/W2525844153","https://openalex.org/W2022162351","https://openalex.org/W2160698838","https://openalex.org/W131842945"],"abstract_inverted_index":{"Protein":[0],"kinases":[1,73],"regulate":[2,342],"numerous":[3,72],"activities":[4],"in":[5,74,93,156,174,206,208,218,329],"eukaryotic":[6],"cells":[7],"by":[8,282],"phosphorylation":[9,263,335],"of":[10,19,26,67,100,103,112,161,235,253,339,344],"substrates.":[11,87,224],"Cyclic-AMP-":[12],"dependent":[13],"protein":[14,28,40,295,323,346],"kinase":[15,35],"(PKA)":[16],"is":[17,54,82,90,115,265,280,289,303,324],"one":[18,234],"the":[20,57,64,71,75,97,101,118,148,157,162,236,294,297,300,322,330,337,345],"most":[21],"important":[22],"and":[23,142,179,185,196,215,245,275,319,326],"well":[24],"studied":[25],"these":[27],"kinases.":[29],"In":[30],"its":[31],"inactive":[32],"form,":[33],"this":[34,113],"exists":[36],"as":[37],"a":[38,42,129,255,259,267,276,283,313],"tetrameric":[39],"with":[41,78,135,172,211],"regulatory":[43,65],"(R)":[44],"subunit":[45,121],"dimer":[46],"bound":[47],"to":[48,63,70,84,116,122,143,154,169,176,191,220,230,292,296,347],"two":[49,104],"catalytic":[50,120,163],"(C)":[51],"subunits.":[52],"PKA":[53,94,119,262,334],"activated":[55],"when":[56],"second-":[58],"messenger":[59],"cAMP":[60],"binds":[61],"cooperatively":[62],"subunits":[66],"PKA.":[68],"Due":[69],"cell,":[76],"many":[77],"overlapping":[79],"substrates,":[80],"it":[81],"difficult":[83],"find":[85,221],"novel":[86,145,222],"Our":[88],"lab":[89],"particularly":[91],"interested":[92],"substrates":[95,146],"at":[96,147],"mitochondria":[98],"because":[99],"discovery":[102],"Dual":[105],"A-Kinase":[106],"Anchoring":[107],"Proteins":[108],"(AKAPs).":[109],"The":[110,165,181,286],"goal":[111],"dissertation":[114],"engineer":[117],"accept":[123],"bulky":[124],"N6-substituted":[125],"ATP":[126,158],"analogs,":[127,189],"using":[128,242],"chemical":[130],"genetics":[131],"approach":[132],"initially":[133],"pioneered":[134],"v-Src":[136],"(Shah,":[137],"Liu":[138],"et":[139],"al.":[140],"1997),":[141],"identify":[144],"mitochondria.":[149],"Methionine":[150],"120":[151],"was":[152,228,240],"mutated":[153],"alanine":[155],"binding":[159],"pocket":[160],"subunit.":[164],"mutant":[166,182],"C-subunit":[167,214],"had":[168],"be":[170,177],"expressed":[171],"PDK1":[173],"order":[175,219],"soluble":[178],"phosphorylated.":[180],"preferred":[183],"N6(benzyl)-ATP":[184,217],"N6(phenethyl)-ATP":[186],"over":[187],"other":[188],"according":[190],"results":[192],"obtained":[193],"through":[194],"qualitative":[195],"kinetic":[197],"analyses.":[198],"Mitochondria":[199],"isolated":[200],"from":[201],"mouse":[202],"brain":[203],"were":[204],"used":[205,229],"an":[207,272],"vitro":[209],"assay":[210],"recombinant":[212],"M120G":[213],"radiolabeled":[216],"direct":[223],"Two-dimensional":[225],"gel":[226],"electrophoresis":[227],"separate":[231],"proteins.":[232],"From":[233],"phosphorylated":[237],"spots,":[238],"ChChd3":[239,248,311,340],"identified":[241],"mass":[243],"spectrometry":[244],"subsequently":[246],"characterized.":[247],"has":[249,271],"three":[250],"motifs/":[251],"domains":[252],"interest:":[254],"myristylation":[256,287],"motif,":[257],"where":[258,321],"highly":[260],"conserved":[261],"site":[264],"located;":[266],"DUF737":[268],"domain,":[269,278],"which":[270,279],"unknown":[273],"function;":[274],"CHCH":[277,301],"characterized":[281],"Cys-X9-Cys":[284],"motif.":[285],"motif":[288],"not":[290],"sufficient":[291],"target":[293],"mitochondria,":[298],"however,":[299],"domain":[302],"necessary":[304],"for":[305],"mitochondrial":[306,314,332],"localization.":[307],"We":[308],"propose":[309],"that":[310],"uses":[312],"import":[315],"mechanism":[316],"involving":[317],"Mia40":[318],"Erv1":[320],"disulfide-bonded":[325],"folded":[327],"once":[328],"inner":[331],"space.":[333],"on":[336],"N-terminus":[338],"may":[341],"targeting":[343],"membranes":[348]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}
