{"id":"https://openalex.org/W344649506","doi":"https://doi.org/10.1097/aln.0b013e3182567fab","title":"The Potential Role of \u03b12Agonists for Noncardiac Surgery","display_name":"The Potential Role of \u03b12Agonists for Noncardiac Surgery","publication_year":2012,"publication_date":"2012-04-08","ids":{"openalex":"https://openalex.org/W344649506","doi":"https://doi.org/10.1097/aln.0b013e3182567fab","mag":"344649506","pmid":"https://pubmed.ncbi.nlm.nih.gov/22487866"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0b013e3182567fab","doi":"https://doi.org/10.1097/aln.0b013e3182567fab","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e3182567fab","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/116/6/1192/257562/0000542-201206000-00013.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/116/6/1192/257562/0000542-201206000-00013.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040874215","display_name":"Philip James Devereaux","orcid":"https://orcid.org/0000-0003-2935-637X","observed_orcids":["https://orcid.org/0000-0003-2935-637X"]},"institutions":[{"id":"https://openalex.org/I2802834092","display_name":"Population Health Research Institute","ror":"https://ror.org/03kwaeq96","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802834092"]},{"id":"https://openalex.org/I76442945","display_name":"Hamilton Health Sciences","ror":"https://ror.org/02dqdxm48","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I76442945"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P.\u00a0J. Devereaux","raw_affiliation_strings":["Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada, and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada","Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada, and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. philipj@mcmaster.ca","Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Can-"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada, and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I2802834092","https://openalex.org/I76442945","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada, and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. philipj@mcmaster.ca","institution_ids":["https://openalex.org/I2802834092","https://openalex.org/I76442945","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Can-","institution_ids":["https://openalex.org/I76442945","https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel\u00a0I. Sessler","raw_affiliation_strings":["Population Health Research Institute, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Research Institute, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"6","first_page":"1192","last_page":"1194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8640000224113464},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.7889999747276306},{"id":"https://openalex.org/keywords/noncardiac-surgery","display_name":"non-cardiac surgery","score":0.9570000171661377},{"id":"https://openalex.org/keywords/opioid-sparing-analgesia","display_name":"opioid-sparing analgesia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/multimodal-analgesia","display_name":"multimodal analgesia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":0.828000009059906},{"id":"https://openalex.org/keywords/postoperative-pain-scores","display_name":"postoperative pain scores","score":0.5929999947547913},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.6520000100135803},{"id":"https://openalex.org/keywords/postoperative-recovery","display_name":"postoperative recovery","score":0.3790000081062317},{"id":"https://openalex.org/keywords/postoperative-mobilization","display_name":"postoperative mobilization","score":0.5019999742507935},{"id":"https://openalex.org/keywords/postoperative-delirium","display_name":"postoperative delirium","score":0.5929999947547913},{"id":"https://openalex.org/keywords/postoperative-hypotension","display_name":"postoperative hypotension","score":0.6340000033378601},{"id":"https://openalex.org/keywords/postoperative-hyperthermia","display_name":"postoperative hyperthermia","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9804465174674988}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058647","descriptor_name":"Adrenergic alpha-2 Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0b013e3182567fab","doi":"https://doi.org/10.1097/aln.0b013e3182567fab","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e3182567fab","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/116/6/1192/257562/0000542-201206000-00013.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:22487866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22487866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1097/aln.0b013e3182567fab","doi":"https://doi.org/10.1097/aln.0b013e3182567fab","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e3182567fab","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/116/6/1192/257562/0000542-201206000-00013.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W344649506.pdf","grobid_xml":"https://content.openalex.org/works/W344649506.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2005295476","https://openalex.org/W2047173081","https://openalex.org/W2063738853","https://openalex.org/W2091722909","https://openalex.org/W2117294447","https://openalex.org/W2119605658","https://openalex.org/W2122659928","https://openalex.org/W2133774931","https://openalex.org/W2141857327","https://openalex.org/W2161344815"],"related_works":["https://openalex.org/W2141857327","https://openalex.org/W4249141336","https://openalex.org/W2768269004","https://openalex.org/W2601086140","https://openalex.org/W3199245467","https://openalex.org/W3022696467","https://openalex.org/W2004172393","https://openalex.org/W2143682128","https://openalex.org/W7163956406","https://openalex.org/W2083347584"],"abstract_inverted_index":{"ACUTE":[0],"pain":[1,42,49,54,136,169,300,327,348,361,383,403,414,457,486,500,1042,1192,1221,1301],"after":[2,43,247,1023,1044,1163,1195],"noncardiac":[3,44,141,248,1024,1045,1147,1228,1267],"surgery":[4,45,1148,1229],"provokes":[5],"suffering,":[6],"activates":[7],"the":[8,28,36,74,123,253,416,429,453,460,475,492,640,643,651,689,692,715,721,750,777,794,804,902,910,945,959,966,999,1056,1075,1083,1088,1095,1120,1131,1185,1260],"sympathetic":[9],"nervous":[10],"system":[11,100,288],"which":[12,153,718,1223,1277],"augments":[13],"myocardial":[14,906,1158],"demand,":[15],"delays":[16],"mobilization":[17],"and":[18,20,38,62,80,93,102,110,116,134,157,171,175,190,208,232,265,286,292,314,335,451,459,499,513,521,527,577,627,694,734,754,796,809,825,837,844,853,914,947,1030,1041,1062,1115,1138,1156,1175,1206,1243,1273,1303,1307],"recovery,":[19],"may":[21,166,179,980,1037,1230,1246,1298,1311],"result":[22,386,925],"in":[23,35,138,244,347,359,382,387,400,433,469,474,484,608,745,768,786,875,936,1106,1144,1264,1288],"chronic":[24,1190,1321],"postoperative":[25,53,65,131,198,221,268,299,326,845,876,1191,1322],"pain.":[26,66],"Although":[27,634,1064],"last":[29],"50":[30],"yr":[31],"have":[32,69,180,799,819,887,920,981,1214,1312],"witnessed":[33],"advances":[34],"prevention":[37],"management":[39],"of":[40,76,107,118,126,152,363,373,431,477,494,509,537,544,562,581,631,642,645,653,666,686,691,806,861,904,912,926,933,961,969,1001,1058,1077,1082,1097,1111,1133,1187,1262],"acute":[41,48,64,168,1179,1300],"(e.g.":[46,748,939,1172,1177,1319],",":[47,749,940,1173,1178,1320],"services,":[50],"patient-controlled":[51],"analgesia),":[52],"remains":[55],"common.1Physicians":[56],"regularly":[57],"use":[58,79,133],"opioids":[59],"to":[60,503,507,518,586,624,698,726,759,779,802,818,919,944,954,958,1008,1018,1093],"prevent":[61],"manage":[63],"Many":[67],"authors":[68],"advocated":[70],"multimodal":[71],"analgesia":[72],"with":[73,551,655,696,791,832,872,1184],"goal":[75],"sparing":[77,246,498],"opioid":[78,132,173,245,461,497,1039,1305],"thus":[81],"presumably":[82],"reducing":[83],"potential":[84,274,560,801],"opioid-related":[85,257],"adverse":[86,258],"effects,":[87,824],"including":[88,280,684,1218],"respiratory":[89,281],"depression,":[90,282],"hypotension,":[91],"nausea":[92,269],"vomiting,":[94],"bradycardia,":[95],"delirium,":[96,283],"hypothermia,":[97,284],"hyperalgesia,":[98,285],"immune":[99,287],"compromise,":[101],"constipation.":[103],"In":[104],"this":[105,446,598,787],"issue":[106,805],"ANESTHESIOLOGY,":[108],"Blaudszun":[109,189,291,512,753,836,1029,1086,1272],"colleagues":[111,191,293,514,755,838,1031,1274],"present":[112],"a":[113,240,303,343,351,379,388,439,480,559,567,569,579,629,707,740,746,892,898,924,1065,1123,1193],"systematic":[114,143,599,708,1026,1269],"review":[115,144,600,709,1027,1270],"meta-analyses":[117,520,619,638,654,751,769,1084],"randomized":[119,147,1127],"controlled":[120,1128],"trials":[121,610,626,668,678,742,775,816,1011,1092,1238,1253],"addressing":[122],"important":[124,185,242,345,398,410,441,482,928,1007,1060,1079,1250,1280,1317],"topic":[125],"whether":[127],"systemic":[128],"\u03b12agonists":[129,165,467,495,523,1036,1054,1098,1263,1297],"reduce":[130,1038],"improve":[135,167,1299],"control":[137],"patients":[139,148,432,478,607,1205,1226,1265],"having":[140,1227],"surgery.2This":[142],"included":[145,621,744,757],"1,792":[146],"from":[149,406,1232],"30":[150,609,1021,1161],"trials,":[151,717],"19":[154],"evaluated":[155,159,1275],"clonidine":[156,194,264,296,841,1071,1135,1188],"11":[158],"dexmedetomidine.\u201cTheir":[160],"work":[161,1293],"offers":[162,1032,1294],"hope":[163,1295],"that":[164,176,193,217,255,263,295,322,357,384,466,508,536,592,620,704,770,814,840,897,979,1012,1035,1052,1225,1241,1283,1296,1308],"scores":[170,301,328,349,362,458,501,1043,1302],"minimize":[172,1304],"usage":[174,1040,1306],"these":[177,1233,1309],"outcomes":[178,186,615,1017,1310,1318],"an":[181,397,401,409,470,873,1279,1313],"impact":[182,506,860,1000,1096,1132,1314],"on":[183,496,618,688,863,989,1099,1119,1189,1315],"other":[184,510,519,1316],"\u2026\u201dMeta-analyses":[187],"by":[188,202,226,290,308,329,752,835,1028,1085,1271],"demonstrated":[192,216,262,294,321,839,896],"administration":[195,219,297,324],"reduced":[196,220,267,298,325,901],"average":[197,222],"cumulative":[199,223],"morphine":[200,224,526],"equivalents":[201,225],"9.8":[203],"mg":[204,210,228,234],"at":[205,211,229,235,311,317,332,338,639,1019,1160],"12":[206,230,312],"h":[207,231,313,334],"4.1":[209],"24":[212,236,318,339],"h.":[213,237,319,340],"Meta-analyses":[214,320],"also":[215,1050,1167],"dexmedetomidine":[218,266,323,862],"6.0":[227],"14.5":[233],"What":[238,341],"represents":[239,342,396,408],"clinically":[241,344,440,481,927,1059,1078],"decrease":[243],"surgery?":[249],"One":[250],"answer":[251],"is":[252,449,502,575,584,601,703,731,735,1006,1105,1153,1278],"dose":[254],"reduces":[256],"effects.":[259],"The":[260,664,859,930,1150,1165],"investigators":[261,693,705],"but":[270,533,675,868,908],"not":[271,278,712,764,784,866,963,1073,1247],"vomiting.":[272],"Other":[273],"opioid-sparing":[275],"effects":[276,529,984],"were":[277,611,616],"reported,":[279,867],"compromise.Meta-analyses":[289],"(on":[302],"10-cm":[304],"visual":[305,352],"analog":[306,353],"scale)":[307],"1.5":[309],"cm":[310,316,331,337,365,375],"0.7":[315],"1.4":[330],"1":[333,364],"0.6":[336],"change":[346,399,442],"using":[350],"scale?":[354],"Studies":[355],"suggest":[356,522,1051,1224],"decreases":[358,372],"individual":[360],"represent":[366,378],"minimal":[367],"or":[368,376,539,673,773],"little":[369],"change,":[370],"whereas":[371],"2":[374,1212],"more":[377,826,1202],"substantial":[380,800],"reduction":[381,483],"can":[385,886],"decreased":[389],"need":[390,1089],"for":[391,490,572,681,728,1090],"rescue":[392],"pain-relief":[393],"medication.3However,":[394],"what":[395,407],"individual's":[402],"score":[404],"differs":[405],"difference":[411],"between":[412,424,455],"group":[413,425,436,456,1110],"scores.Unfortunately,":[415],"\u03b12agonist":[417],"data":[418],"are":[419,669,679,743,783,1117],"reported":[420,614],"only":[421,622,661,739],"as":[422,558,923,1255],"differences":[423,454],"scores,":[426],"rather":[427],"than":[428,530,535,1203],"percentage":[430],"each":[434],"treatment":[435,823],"who":[437],"experienced":[438],"being":[443],"reported.":[444],"Despite":[445],"limitation,":[447],"it":[448,554,869,1005],"possible,":[450],"considering":[452],"sparing-effects,":[462],"perhaps":[463],"even":[464],"probable,":[465],"resulted":[468],"appreciable":[471],"relative":[472],"increase":[473,874,1055,1074],"number":[476],"experiencing":[479],"their":[485,505,516,1048],"scores.An":[487],"alternative":[488],"method":[489],"assessing":[491,998],"effect":[493,986,1186],"compare":[504,515],"drugs.":[511],"results":[517,652,665,830,1049,1081,1325],"provide":[524],"greater":[525],"pain-sparing":[528],"does":[531,1072],"acetaminophen":[532],"less":[534],"ketamine":[538],"nonsteroidal":[540],"antiinflammatory":[541],"medications.4This":[542],"sort":[543],"nonsystematic":[545],"indirect":[546,573],"comparison":[547],"must":[548],"be":[549],"considered":[550],"caution":[552],"because":[553,776],"cannot":[555],"exclude":[556],"chance":[557],"explanation":[561],"any":[563,1002],"apparent":[564],"differences.":[565],"At":[566],"minimum,":[568],"network":[570],"meta-analysis":[571,747,1067],"comparisons":[574,583],"required,":[576],"ideally,":[578],"trial":[580,789,895,1129,1166,1198],"direct":[582],"needed":[585],"inform":[587,1248],"such":[588,1254],"questions.Another":[589],"relevant":[590,1015],"point":[591],"readers":[593],"should":[594,649,1207],"consider":[595,1013],"when":[596,658,738,974,997],"interpreting":[597],"that,":[602],"although":[603],"overall":[604],"nearly":[605],"1,800":[606],"considered,":[612],"most":[613],"based":[617],"three":[623,758],"five":[625,760],"typically":[628,710,756],"total":[630],"100\u2013400":[632],"patients.":[633],"many":[635,676,1215],"epidemiologists":[636],"place":[637],"top":[641],"hierarchy":[644],"evidence":[646,1034],"pyramid,":[647],"physicians":[648,962],"view":[650],"healthy":[656],"skepticism":[657],"they":[659,971],"include":[660,771],"small":[662,677,815],"trials.":[663,1291,1328],"large":[667,833,893,1010,1091,1108,1237,1289],"almost":[670,736],"always":[671],"published":[672],"available,":[674],"not,":[680],"various":[682,982,1170],"reasons,":[683],"loss":[685],"interest":[687],"part":[690],"challenges":[695],"trying":[697],"publish":[699],"neutral":[700],"results.5The":[701],"difficulty":[702],"conducting":[706],"do":[711],"know":[713],"about":[714],"unpublished":[716],"potentially":[719],"biases":[720],"results.":[722],"Unfortunately,":[723],"our":[724],"ability":[725],"assess":[727,780],"publication":[729,766,781,807],"bias":[730,767,782,808],"generally":[732],"low":[733],"nonexistent":[737],"few":[741],"trials).":[761],"Experts":[762],"recommend":[763],"evaluating":[765,1130],"10":[772],"fewer":[774],"tests":[778],"reliable":[785],"situation.6Although":[788],"registration":[790],"details":[792],"regarding":[793],"protocol":[795],"preplanned":[797],"analyses":[798],"overcome":[803],"selective":[810],"outcome":[811,1152,1282],"reporting,7research":[812],"demonstrates":[813],"tend":[817],"lower":[820],"methodologic":[821],"quality,8larger":[822],"commonly":[827],"statistically":[828],"significant":[829],"compared":[831],"trials.9Meta-analyses":[834],"increased":[842,909],"intraoperative":[843],"hypotension":[846,864,1061],"(risk":[847,878],"ratios,":[848],"4.75;":[849],"95%":[850,855,881],"CI,":[851,856,882],"2.17\u201310.43":[852],"3.37;":[854],"1.27\u20138.92,":[857],"respectively).":[858],"was":[865,870],"associated":[871],"bradycardia":[877],"ratio,":[879],"17.0;":[880],"2.35\u2013123.10).":[883],"Perioperative":[884],"interventions":[885,970,975],"unintended":[888],"consequences.":[889],"For":[890],"example,":[891],"international":[894,1109],"\u03b2":[899],"blocker":[900],"risk":[903,911,960,1057,1076],"perioperative":[905,937,1003,1053,1070,1220,1281],"infarction":[907,1159],"stroke":[913],"death.10These":[915],"unanticipated":[916],"consequences":[917,968],"appeared":[918],"occurred":[921],"primarily":[922],"hypotension.":[929],"fragmented":[931],"nature":[932],"physician":[934],"involvement":[935,942,952],"care":[938,949,991],"anesthesiologist":[941],"confined":[943,953],"operating":[946],"postanesthetic":[948],"unit,":[950],"internist":[951],"preoperative":[955],"assessment)":[956],"contributes":[957],"completely":[964],"appreciating":[965],"full":[967],"initiate,":[972],"especially":[973],"involve":[976],"long-acting":[977],"drugs":[978],"clinical":[983,1290],"(or":[985],"magnitude),":[987],"depending":[988],"patient":[990],"environments.":[992],"These":[993],"points":[994],"highlight":[995,1087],"why,":[996],"intervention,":[1004],"undertake":[1009],"all":[1014,1100],"patient-important":[1016,1101],"least":[1020],"days":[1022,1162],"surgery.The":[1025,1268],"encouraging":[1033],"surgery.":[1046,1164,1196],"However,":[1047,1235],"bradycardia.":[1063],"larger":[1066,1327],"suggests":[1068],"low-dose":[1069,1134,1139],"hypotension,11the":[1080],"evaluate":[1094,1169],"outcomes.":[1102,1251],"Fortunately,":[1103],"one":[1104],"progress.A":[1107],"anesthesiologists,":[1112],"cardiologists,":[1113],"internists,":[1114],"surgeons":[1116],"collaborating":[1118],"POISE-2":[1121,1256],"Trial,":[1122],"10,000-patient,":[1124],"blinded,":[1125],"factorial":[1126],"versus":[1136,1142],"placebo":[1137,1143],"acetyl-salicylic":[1140],"acid":[1141],"adults":[1145],"undergoing":[1146,1266],"(NCT01082874).":[1149],"primary":[1151],"all-cause":[1154],"mortality":[1155],"nonfatal":[1157],"will":[1168,1257],"vascular":[1171],"stroke)":[1174],"renal":[1176],"kidney":[1180],"injury)":[1181],"outcomes,":[1182],"along":[1183],"year":[1194],"This":[1197],"has":[1199,1284],"already":[1200],"recruited":[1201],"3,500":[1204],"complete":[1208],"recruitment":[1209],"within":[1210],"another":[1211],"yr.\u03b12Agonists":[1213],"attractive":[1216],"properties,":[1217],"enhanced":[1219],"control,":[1222],"benefit":[1231],"agents.":[1234],"previous":[1236],"remind":[1239],"us":[1240],"physiologic":[1242],"surrogate":[1244],"endpoints":[1245],"patient-":[1249],"Large":[1252],"help":[1258],"clarify":[1259],"role":[1261],"pain,":[1276],"received":[1285],"inadequate":[1286],"attention":[1287],"Their":[1292],"pain).":[1323],"Definitive":[1324],"await":[1326]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
