{"id":"https://openalex.org/W34408814","doi":null,"title":"Effects of S-methylmethionine (vitamin U) on experimental nephrotic hyperlipidemia.","display_name":"Effects of S-methylmethionine (vitamin U) on experimental nephrotic hyperlipidemia.","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W34408814","mag":"34408814","pmid":"https://pubmed.ncbi.nlm.nih.gov/583214"},"language":"en","primary_location":{"id":"pmid:583214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109053720","display_name":"Kenji Seri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Seri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112164233","display_name":"K Amemiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Amemiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108528297","display_name":"Hiromi Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Sugimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073424076","display_name":"T Kato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"29","issue":"10","first_page":"1517","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-u","display_name":"vitamin U","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.925000011920929},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.9539999961853027},{"id":"https://openalex.org/keywords/plasma-phospholipids","display_name":"plasma phospholipids","score":0.9639999866485596},{"id":"https://openalex.org/keywords/urinary-protein-excretion","display_name":"urinary protein excretion","score":0.9670000076293945},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.878000020980835},{"id":"https://openalex.org/keywords/nephroprotective-therapy","display_name":"nephroprotective therapy","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.9011144638061523},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.8875216841697693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6250249147415161},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5728628039360046},{"id":"https://openalex.org/C2777040163","wikidata":"https://www.wikidata.org/wiki/Q423240","display_name":"Sulfonium","level":3,"score":0.5337805151939392},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4976024925708771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46712878346443176},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.45346155762672424},{"id":"https://openalex.org/C2781175652","wikidata":"https://www.wikidata.org/wiki/Q6995207","display_name":"Nephrosis","level":2,"score":0.45142263174057007},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4335739016532898},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4188317656517029},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3983648419380188},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004327","descriptor_name":"Drinking Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009401","descriptor_name":"Nephrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009401","descriptor_name":"Nephrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014814","descriptor_name":"Vitamin U","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:583214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},{"id":"mag:34408814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/583214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W3014529666","https://openalex.org/W2098976315","https://openalex.org/W2157107389","https://openalex.org/W1753159784","https://openalex.org/W2177799539","https://openalex.org/W2970471469","https://openalex.org/W2725104381","https://openalex.org/W2141668442","https://openalex.org/W1633354984","https://openalex.org/W1994325411","https://openalex.org/W2067757114","https://openalex.org/W2089389631","https://openalex.org/W2132021704","https://openalex.org/W2758089352","https://openalex.org/W2949031329","https://openalex.org/W2897801949","https://openalex.org/W3048016000","https://openalex.org/W2945775515","https://openalex.org/W2517700447","https://openalex.org/W1964544797","https://openalex.org/W2329990487","https://openalex.org/W2790677694","https://openalex.org/W2133662619","https://openalex.org/W3080493485","https://openalex.org/W3047193582","https://openalex.org/W2102118575","https://openalex.org/W2561998310","https://openalex.org/W1963947860","https://openalex.org/W2147331510","https://openalex.org/W2167083255","https://openalex.org/W1973143946"],"related_works":["https://openalex.org/W2401296888","https://openalex.org/W2418034410","https://openalex.org/W2397824541","https://openalex.org/W2022934558","https://openalex.org/W2409005226","https://openalex.org/W4231536426","https://openalex.org/W1984297670","https://openalex.org/W2430365247","https://openalex.org/W2463328759","https://openalex.org/W2414599353"],"abstract_inverted_index":{"The":[0,59],"effects":[1],"of":[2,23,32,49,55],"S-methylmethionine":[3],"sulfonium":[4],"chloride":[5],"(MMSC,":[6],"vitamin":[7],"U)":[8],"on":[9],"aminonucleoside-induced":[10],"nephrotic":[11,42,74],"hyperlipidemia":[12,79],"in":[13],"rats":[14],"were":[15],"investigated.":[16],"We":[17],"found":[18],"that":[19,62],"repeated":[20],"oral":[21],"administration":[22],"MMSC":[24,63],"(dose:":[25],"daily":[26],"1000":[27],"mg/kg)":[28],"exhibited":[29],"significant":[30],"amelioration":[31],"plasma":[33],"chloresterol":[34],"and":[35,52,76],"phospholipids":[36],"levels.":[37],"Also,":[38],"the":[39],"treatment":[40],"improved":[41],"syndrome":[43,75],"itself":[44],"by":[45],"producing":[46],"an":[47],"increase":[48],"urinary":[50,56],"volume":[51],"a":[53,81],"decrease":[54],"protein":[57],"excretion.":[58],"results":[60],"suggest":[61],"may":[64],"be":[65],"useful":[66],"as":[67,80],"single":[68],"or":[69],"combined":[70],"therapy":[71],"for":[72],"human":[73],"its":[77],"related":[78],"safety":[82],"drug.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}