{"id":"https://openalex.org/W344079643","doi":null,"title":"Investigating Notch Signaling and Sequential Segmentation in the Fairy Shrimp, Thamnocephalus platyurus","display_name":"Investigating Notch Signaling and Sequential Segmentation in the Fairy Shrimp, Thamnocephalus platyurus","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W344079643","mag":"344079643"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1488","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/475","pdf_url":"https://digitalrepository.trincoll.edu/theses/475","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalrepository.trincoll.edu/theses/475","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010969238","display_name":"Sara Izzat Khalil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sara Izzat Khalil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010969238"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sequential-segmentation","display_name":"sequential segmentation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/thamnocephalus-platyurus","display_name":"Thamnocephalus platyurus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anostraca","display_name":"Anostraca","score":0.9509999752044678},{"id":"https://openalex.org/keywords/crustacean-development","display_name":"crustacean development","score":0.8399999737739563},{"id":"https://openalex.org/keywords/growth-zone","display_name":"growth zone","score":0.8640000224113464},{"id":"https://openalex.org/keywords/somitogenesis","display_name":"somitogenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/molecular-oscillators","display_name":"molecular oscillators","score":0.8119999766349792},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4350000023841858},{"id":"https://openalex.org/keywords/comparative-development","display_name":"comparative development","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2776841996","wikidata":"https://www.wikidata.org/wiki/Q1517781","display_name":"Shrimp","level":2,"score":0.4707033336162567},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.46829384565353394},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.4418216347694397},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40671101212501526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3535659611225128},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3227885961532593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2375812828540802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15085262060165405},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.1324203908443451}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1488","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/475","pdf_url":"https://digitalrepository.trincoll.edu/theses/475","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},{"id":"mag:344079643","doi":null,"is_oa":false,"landing_page_url":"https://digitalrepository.trincoll.edu/cgi/viewcontent.cgi?article=1488&context=theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1488","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/475","pdf_url":"https://digitalrepository.trincoll.edu/theses/475","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W344079643.pdf","grobid_xml":"https://content.openalex.org/works/W344079643.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W184054902","https://openalex.org/W1634376377","https://openalex.org/W1957574764","https://openalex.org/W1977277568","https://openalex.org/W1984857869","https://openalex.org/W1986741562","https://openalex.org/W1992698098","https://openalex.org/W1994245587","https://openalex.org/W1995872370","https://openalex.org/W1997882261","https://openalex.org/W2002093986","https://openalex.org/W2004798786","https://openalex.org/W2041791362","https://openalex.org/W2047920420","https://openalex.org/W2061164604","https://openalex.org/W2064546612","https://openalex.org/W2067284166","https://openalex.org/W2077341997","https://openalex.org/W2082694975","https://openalex.org/W2101296021","https://openalex.org/W2102910500","https://openalex.org/W2154861644","https://openalex.org/W2167415035","https://openalex.org/W2787423186","https://openalex.org/W7140265840"],"related_works":["https://openalex.org/W1957574764","https://openalex.org/W1977277568","https://openalex.org/W2103931867","https://openalex.org/W6945235243","https://openalex.org/W2570063051","https://openalex.org/W2559413716","https://openalex.org/W2063431283","https://openalex.org/W1979900422","https://openalex.org/W7221481177","https://openalex.org/W2064546612"],"abstract_inverted_index":{"Segmentation":[0],"is":[1],"a":[2,23,37,46,62,72,87,93,160],"key":[3],"feature":[4],"of":[5,26,98,136,146,163],"arthropod":[6,15],"diversity":[7],"and":[8,44,80,122,154],"evolution.":[9],"In":[10,82,130],"the":[11,27,41,101,110,117,125,164],"standard":[12],"model":[13],"for":[14],"development,":[16],"Drosophila":[17],"melanogaster,":[18],"segments":[19,34],"develop":[20],"simultaneously":[21],"by":[22,158],"progressive":[24],"subdivision":[25],"embryo.":[28],"By":[29],"contrast,":[30],"most":[31],"arthropods":[32,65,79],"add":[33],"sequentially":[35,77],"from":[36],"posterior":[38],"region":[39],"called":[40],"growth":[42],"zone":[43],"in":[45,64,108,124,138,151],"manner":[47],"similar":[48],"to":[49,113,132],"vertebrates.\\nRecent":[50],"work,":[51],"mainly":[52],"focused":[53],"on":[54,106],"insects,":[55],"suggests":[56],"that":[57,66,90],"Notch":[58,120,147,165],"signaling":[59,121],"might":[60],"play":[61],"role":[63],"segment":[67],"sequentially.":[68],"These":[69],"studies":[70],"document":[71],"potential":[73],"regulatory":[74],"similarity":[75],"between":[76,119],"segmenting":[78],"vertebrates.":[81],"vertebrates,":[83],"somite":[84],"formation":[85],"involves":[86],"molecular":[88],"oscillator":[89],"functions":[91,157],"as":[92],"pacemaker,":[94],"driving":[95],"periodic":[96],"expression":[97,145],"genes":[99,149],"along":[100],"anterior-posterior":[102],"axis.\\nHere":[103],"we":[104,141],"focus":[105],"segmentation":[107,123,137],"crustaceans,":[109],"sister":[111],"taxon":[112],"insects.":[114],"We":[115],"investigate":[116],"relationship":[118],"fairy":[126],"shrimp,":[127],"Thamnocephalus":[128],"platyurus.":[129],"order":[131],"explore":[133],"gene":[134],"regulation":[135],"these":[139],"animals,":[140],"will":[142],"be":[143],"tracing":[144],"pathway":[148],"using":[150,159],"situ":[152],"hybridization":[153],"investigating":[155],"their":[156],"chemical":[161],"inhibitor":[162],"pathway.":[166]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}