{"id":"https://openalex.org/W343738323","doi":null,"title":"MicroRNAs as predictive biomarkers and therapeutic targets in prostate cancer.","display_name":"MicroRNAs as predictive biomarkers and therapeutic targets in prostate cancer.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W343738323","mag":"343738323","pmid":"https://pubmed.ncbi.nlm.nih.gov/25374924","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219315"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4219315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219315","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100662367","display_name":"Xin Wen","orcid":"https://orcid.org/0000-0001-6513-8623","observed_orcids":["https://orcid.org/0000-0001-6513-8623"]},"institutions":[{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Wen","raw_affiliation_strings":["Center for Health Informatics and Bioinformatics, New York University School of Medicine New York, NY 10016 ; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Informatics and Bioinformatics, New York University School of Medicine New York, NY 10016 ; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine New York, NY 10016","institution_ids":["https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072062044","display_name":"Fang\u2010Ming Deng","orcid":"https://orcid.org/0000-0002-1156-0930","observed_orcids":["https://orcid.org/0000-0002-1156-0930"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang-Ming Deng","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100339648","display_name":"Jinhua Wang","orcid":"https://orcid.org/0000-0001-8367-0787","observed_orcids":["https://orcid.org/0000-0001-8367-0787"]},"institutions":[{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhua Wang","raw_affiliation_strings":["Center for Health Informatics and Bioinformatics, New York University School of Medicine New York, NY 10016 ; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine New York, NY 10016 ; Department of Pediatrics, New York University School of Medicine New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Informatics and Bioinformatics, New York University School of Medicine New York, NY 10016 ; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine New York, NY 10016 ; Department of Pediatrics, New York University School of Medicine New York, NY 10016","institution_ids":["https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0424,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.85373544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"3","first_page":"219","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.996999979019165},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.5109999775886536},{"id":"https://openalex.org/keywords/aggressive-disease","display_name":"aggressive disease","score":0.625},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8850409984588623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7255130410194397},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7089797854423523},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5835116505622864},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.5833106637001038},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.55877685546875},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4933251440525055},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.46279051899909973},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.457713782787323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4260335862636566},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42035233974456787},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4163356423377991},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.41029077768325806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21406212449073792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18014314770698547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4219315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},{"id":"pmid:25374924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25374924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental urology","raw_type":"Journal Article"},{"id":"mag:343738323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25374924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4219315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W1481189688","https://openalex.org/W1492802015","https://openalex.org/W1551304092","https://openalex.org/W1890374229","https://openalex.org/W1963691340","https://openalex.org/W1963800590","https://openalex.org/W1964314383","https://openalex.org/W1964641660","https://openalex.org/W1966101011","https://openalex.org/W1967515816","https://openalex.org/W1969671165","https://openalex.org/W1971204432","https://openalex.org/W1971623350","https://openalex.org/W1973752700","https://openalex.org/W1977372263","https://openalex.org/W1977808594","https://openalex.org/W1978320741","https://openalex.org/W1979427314","https://openalex.org/W1983453097","https://openalex.org/W1983675397","https://openalex.org/W1984248406","https://openalex.org/W1985123329","https://openalex.org/W1989498301","https://openalex.org/W1991034124","https://openalex.org/W1992430198","https://openalex.org/W1993908286","https://openalex.org/W2005958584","https://openalex.org/W2006797972","https://openalex.org/W2010040408","https://openalex.org/W2012476517","https://openalex.org/W2017270642","https://openalex.org/W2023536614","https://openalex.org/W2025422678","https://openalex.org/W2025895935","https://openalex.org/W2026570544","https://openalex.org/W2030888171","https://openalex.org/W2033681249","https://openalex.org/W2035937780","https://openalex.org/W2036169252","https://openalex.org/W2036446168","https://openalex.org/W2037715998","https://openalex.org/W2038204964","https://openalex.org/W2039606711","https://openalex.org/W2040182688","https://openalex.org/W2040191060","https://openalex.org/W2040204759","https://openalex.org/W2041401635","https://openalex.org/W2043879482","https://openalex.org/W2044512288","https://openalex.org/W2044832480","https://openalex.org/W2046409229","https://openalex.org/W2048603557","https://openalex.org/W2050869737","https://openalex.org/W2051846980","https://openalex.org/W2059073003","https://openalex.org/W2060104650","https://openalex.org/W2067012955","https://openalex.org/W2067364214","https://openalex.org/W2075110522","https://openalex.org/W2078845383","https://openalex.org/W2080893011","https://openalex.org/W2083365530","https://openalex.org/W2083381199","https://openalex.org/W2084185995","https://openalex.org/W2084343070","https://openalex.org/W2092263801","https://openalex.org/W2094253263","https://openalex.org/W2095236629","https://openalex.org/W2097226448","https://openalex.org/W2097325727","https://openalex.org/W2097397785","https://openalex.org/W2099692224","https://openalex.org/W2102107106","https://openalex.org/W2104218502","https://openalex.org/W2108417458","https://openalex.org/W2110387915","https://openalex.org/W2111783800","https://openalex.org/W2112192177","https://openalex.org/W2114689877","https://openalex.org/W2116661471","https://openalex.org/W2121936213","https://openalex.org/W2123128328","https://openalex.org/W2123188794","https://openalex.org/W2124488916","https://openalex.org/W2129931962","https://openalex.org/W2132578562","https://openalex.org/W2133719858","https://openalex.org/W2135836598","https://openalex.org/W2142471892","https://openalex.org/W2144038313","https://openalex.org/W2149785901","https://openalex.org/W2153234291","https://openalex.org/W2154018173","https://openalex.org/W2154085311","https://openalex.org/W2155979487","https://openalex.org/W2156843318","https://openalex.org/W2157155706","https://openalex.org/W2157754963","https://openalex.org/W2161053574","https://openalex.org/W2162112386","https://openalex.org/W2167290557","https://openalex.org/W2168465557","https://openalex.org/W2170446948","https://openalex.org/W2170476899","https://openalex.org/W2170647698","https://openalex.org/W2170685293","https://openalex.org/W2275002414"],"related_works":["https://openalex.org/W3136136801","https://openalex.org/W207954756","https://openalex.org/W4313491557","https://openalex.org/W2552237430","https://openalex.org/W2251776775","https://openalex.org/W2895979054","https://openalex.org/W7168285560","https://openalex.org/W1998466267","https://openalex.org/W2076954411","https://openalex.org/W3044527804"],"abstract_inverted_index":{"Prostatectomy":[0],"or":[1],"irradiation":[2],"is":[3],"the":[4,14,25,34,53,78],"most":[5],"common":[6],"traditional":[7],"treatments":[8],"for":[9,28,61,108,118],"localized":[10],"prostate":[11],"cancer.":[12],"In":[13,98],"event":[15],"of":[16,55,113,120],"recurrence":[17],"and/or":[18],"metastasis,":[19],"androgen":[20],"ablation":[21],"therapy":[22],"has":[23],"been":[24],"mainstay":[26],"treatment":[27],"many":[29,86],"years.":[30],"Although":[31],"initially":[32],"effective,":[33],"cancer":[35],"inevitably":[36],"recurs":[37],"as":[38,111,129],"androgen-independent":[39],"PCa,":[40],"a":[41],"disease":[42,115],"with":[43],"limited":[44],"effective":[45],"treatments.":[46],"Enhanced":[47],"predictive":[48],"biomarkers":[49,130],"are":[50,64,88],"needed":[51],"at":[52,77],"time":[54],"diagnosis":[56],"to":[57,72],"better":[58],"tailor":[59],"therapies":[60],"patients.":[62],"MicroRNAs":[63],"short":[65],"nucleotide":[66],"sequences":[67],"which":[68],"can":[69],"complementary":[70],"bind":[71],"and":[73,116,131],"control":[74],"gene":[75],"expression":[76],"post-transcriptional":[79],"level.":[80],"Recent":[81],"studies":[82],"have":[83],"demonstrated":[84],"that":[85,105],"miRNAs":[87,104],"variably":[89],"expressed":[90],"in":[91],"cancers":[92],"vs.":[93],"normal":[94],"tissues,":[95],"including":[96],"PCa.":[97],"this":[99],"review,":[100],"we":[101,123],"summarize":[102],"PCa-specific":[103],"show":[106],"potential":[107,126],"their":[109,125],"utilization":[110],"identifiers":[112],"aggressive":[114],"predictors":[117],"risk":[119],"recurrence.":[121],"Additionally,":[122],"discuss":[124],"clinical":[127],"applications":[128],"therapeutic":[132],"targets.":[133]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
