{"id":"https://openalex.org/W34330877","doi":null,"title":"Hypothalamic control of certain aspects of natural immunity in the mouse.","display_name":"Hypothalamic control of certain aspects of natural immunity in the mouse.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W34330877","mag":"34330877","pmid":"https://pubmed.ncbi.nlm.nih.gov/3679287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453985"},"language":"en","primary_location":{"id":"pmid:3679287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3679287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453985/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009375394","display_name":"Natale Belluardo","orcid":"https://orcid.org/0000-0001-7626-1416","observed_orcids":["https://orcid.org/0000-0001-7626-1416"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N Belluardo","raw_affiliation_strings":["Institute of Human Physiology, University of Catania, Italy","University of Catania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"University of Catania","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058892129","display_name":"Giuseppa Mud\u00f2","orcid":"https://orcid.org/0000-0002-3275-9981","observed_orcids":["https://orcid.org/0000-0002-3275-9981"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Mud\u00f3","raw_affiliation_strings":["University of Catania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020865570","display_name":"Silvano Gabriele Cella","orcid":"https://orcid.org/0000-0001-6884-3766","observed_orcids":["https://orcid.org/0000-0001-6884-3766"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Cella","raw_affiliation_strings":["University of Catania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024871281","display_name":"Angela Santoni","orcid":"https://orcid.org/0000-0003-1206-7731","observed_orcids":["https://orcid.org/0000-0003-1206-7731"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Santoni","raw_affiliation_strings":["Istituto Neurologico Mediterraneo Neuromed"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Neurologico Mediterraneo Neuromed","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113612286","display_name":"G Forni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Forni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081672686","display_name":"Mauro Bindoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bindoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6097,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83764117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"62","issue":"2","first_page":"321","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/natural-immunity","display_name":"natural immunity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/large-granular-lymphocytes","display_name":"large granular lymphocytes","score":0.890999972820282},{"id":"https://openalex.org/keywords/natural-cytotoxicity","display_name":"natural cytotoxicity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neuroendocrine-immune-regulation","display_name":"neuroendocrine-immune regulation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.7720000147819519},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7214851379394531},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7079805135726929},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5956375002861023},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5491235852241516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5132217407226562},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5099059343338013},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49886441230773926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49360334873199463},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.42219799757003784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40891003608703613},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32532021403312683},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2774020731449127},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22358295321464539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18618160486221313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1477172076702118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10623276233673096}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:3679287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3679287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1453985","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453985/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/390540","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1987K286200023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:34330877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3679287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453985","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1453985/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W188556095","https://openalex.org/W1481256029","https://openalex.org/W1538787399","https://openalex.org/W1583233550","https://openalex.org/W1676250666","https://openalex.org/W1833019092","https://openalex.org/W1978155692","https://openalex.org/W1986242942","https://openalex.org/W1997604810","https://openalex.org/W2007400263","https://openalex.org/W2007791929","https://openalex.org/W2016052374","https://openalex.org/W2025635872","https://openalex.org/W2030973578","https://openalex.org/W2033558534","https://openalex.org/W2050802204","https://openalex.org/W2052333855","https://openalex.org/W2056679023","https://openalex.org/W2061864654","https://openalex.org/W2062532405","https://openalex.org/W2066428058","https://openalex.org/W2084093106","https://openalex.org/W2164416194","https://openalex.org/W2413165420","https://openalex.org/W2426725544","https://openalex.org/W4300665542","https://openalex.org/W4313313358"],"related_works":["https://openalex.org/W2404984892","https://openalex.org/W1991819422","https://openalex.org/W50388094","https://openalex.org/W2034450006","https://openalex.org/W2088550434","https://openalex.org/W2074302157","https://openalex.org/W2052333855","https://openalex.org/W2039928411","https://openalex.org/W2030973578","https://openalex.org/W2064984857"],"abstract_inverted_index":{"Electrothermocoagulation":[0],"(ETC)":[1],"of":[2,6,10,27,35,57,73,82,94],"the":[3,7,11,15,24,33,74,95,136],"individual":[4],"nuclei":[5],"median":[8],"region":[9],"hypothalamus":[12],"(MH)":[13],"in":[14,23,66,97,114,135],"C57BL/6":[16],"mouse":[17],"leads":[18],"to":[19,86],"a":[20,131],"significant":[21,64],"reduction":[22],"cytotoxic":[25,105],"activity":[26,68,84,106],"natural":[28],"killer":[29],"cells":[30],"(NK)":[31],"and":[32,125],"number":[34],"large":[36],"granular":[37],"lymphocytes":[38],"(LGL)":[39],"compared":[40],"with":[41],"intact":[42],"or":[43,77,116,118],"sham-operated":[44],"controls.":[45],"This":[46],"effect,":[47],"however,":[48],"is":[49,90,128],"less":[50],"than":[51],"that":[52,123],"observed":[53],"after":[54,71,110],"simultaneous":[55],"destruction":[56,89],"all":[58],"MH":[59,88],"nuclei.":[60],"By":[61],"contrast,":[62],"no":[63],"change":[65,96],"NK":[67,83],"was":[69,107],"noted":[70],"ETC":[72],"anterior":[75],"(AH)":[76],"posterior":[78],"(PH)":[79],"regions.":[80],"Diminution":[81],"due":[85],"nuclear":[87],"not":[91],"an":[92],"outcome":[93],"adenohypophysis":[98],"secretion":[99],"provoked":[100],"by":[101,130],"hypothalamic":[102],"lesion.":[103],"Natural":[104],"markedly":[108],"increased":[109],"ETG":[111],"located":[112],"either":[113],"AH,":[115],"MH,":[117],"PH.":[119],"These":[120],"results":[121],"indicate":[122],"NK-":[124],"NC-mediated":[126],"immunity":[127],"governed":[129],"control":[132],"mechanism":[133],"situated":[134],"hypothalamus.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}