{"id":"https://openalex.org/W34324356","doi":null,"title":"Costimulation of human natural killer cell proliferation: role of accessory cytokines and cell contact-dependent signals.","display_name":"Costimulation of human natural killer cell proliferation: role of accessory cytokines and cell contact-dependent signals.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W34324356","mag":"34324356","pmid":"https://pubmed.ncbi.nlm.nih.gov/9390270"},"language":"en","primary_location":{"id":"pmid:9390270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9390270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural immunity","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076249181","display_name":"Michael J. Robertson","orcid":"https://orcid.org/0000-0003-2610-680X","observed_orcids":["https://orcid.org/0000-0003-2610-680X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Robertson","raw_affiliation_strings":["Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, Mass., USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842475","display_name":"Christine A. Cameron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919470","display_name":"S Lazo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Lazo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110355346","display_name":"K Cochran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J Cochran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032126905","display_name":"Stephan D. Voss","orcid":"https://orcid.org/0000-0002-2092-2219","observed_orcids":["https://orcid.org/0000-0002-2092-2219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S D Voss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008718116","display_name":"Jerome Ritz","orcid":"https://orcid.org/0000-0001-5526-4669","observed_orcids":["https://orcid.org/0000-0001-5526-4669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ritz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6359,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.65917012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"5","first_page":"213","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/nk-cell-proliferation","display_name":"NK cell proliferation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9240000247955322},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.996999979019165},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.8939999938011169},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/natural-killing","display_name":"natural killing","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nk-cell-expansion","display_name":"NK cell expansion","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5884298086166382},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5325080156326294},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.5318626165390015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5210304260253906},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5187532901763916},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.48359817266464233},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4664556086063385},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.4362718462944031},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4336933493614197},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.4137672185897827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40934208035469055},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3331374526023865},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3130995035171509},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1585390269756317},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.067676842212677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015759","descriptor_name":"Ionomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019002","descriptor_name":"CD56 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9390270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9390270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural immunity","raw_type":"Journal Article"},{"id":"mag:34324356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9390270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G267955542","display_name":"REGULATION OF HUMAN NK CELL FUNCTION","funder_award_id":"R01CA041619","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8163536223","display_name":"CLINICAL ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM","funder_award_id":"K12CA001730","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W127185585","https://openalex.org/W802912623","https://openalex.org/W1969764584","https://openalex.org/W1970127494","https://openalex.org/W1974544564","https://openalex.org/W1977494988","https://openalex.org/W1979544533","https://openalex.org/W1981368803","https://openalex.org/W1982161876","https://openalex.org/W1984652279","https://openalex.org/W1987378110","https://openalex.org/W1988628412","https://openalex.org/W1991561423","https://openalex.org/W1999783956","https://openalex.org/W2007395042","https://openalex.org/W2008521719","https://openalex.org/W2012962352","https://openalex.org/W2016728478","https://openalex.org/W2017471920","https://openalex.org/W2019915259","https://openalex.org/W2030995301","https://openalex.org/W2031004957","https://openalex.org/W2040168985","https://openalex.org/W2052109573","https://openalex.org/W2059118514","https://openalex.org/W2068161718","https://openalex.org/W2073872893","https://openalex.org/W2074572409","https://openalex.org/W2078896745","https://openalex.org/W2083222334","https://openalex.org/W2083287340","https://openalex.org/W2152534072","https://openalex.org/W2154492684","https://openalex.org/W2154531412","https://openalex.org/W2189078301","https://openalex.org/W2221750675","https://openalex.org/W2328476661","https://openalex.org/W2331238623","https://openalex.org/W2515066368","https://openalex.org/W2528483640","https://openalex.org/W2530968343","https://openalex.org/W2552739483","https://openalex.org/W2586200100","https://openalex.org/W2602580349","https://openalex.org/W2614060490","https://openalex.org/W2757553505","https://openalex.org/W2789678516","https://openalex.org/W2790999712","https://openalex.org/W2806816366","https://openalex.org/W2887155840","https://openalex.org/W2895501969","https://openalex.org/W2905494386","https://openalex.org/W2909957824","https://openalex.org/W2937305554","https://openalex.org/W2954641846","https://openalex.org/W2981176960","https://openalex.org/W2981893130","https://openalex.org/W3007638527","https://openalex.org/W3010731941","https://openalex.org/W3013257643","https://openalex.org/W3020893804","https://openalex.org/W3034362529","https://openalex.org/W3046187348","https://openalex.org/W3093318156","https://openalex.org/W3138491239","https://openalex.org/W4232122843","https://openalex.org/W4245997153"],"related_works":["https://openalex.org/W1516931470","https://openalex.org/W1475256780","https://openalex.org/W2329999778","https://openalex.org/W1568710114","https://openalex.org/W2066496166","https://openalex.org/W2038260086","https://openalex.org/W1698900496","https://openalex.org/W7095553766","https://openalex.org/W1541215592","https://openalex.org/W131954432"],"abstract_inverted_index":{"Despite":[0],"the":[1,9,12,30,99,115,223,258,286,295,313],"importance":[2],"of":[3,14,32,39,91,104,143,165,175,197,222,249,285,298,309,315],"natural":[4,176,279],"killer":[5],"(NK)":[6],"cells":[7,41,106,110,199,236,266],"in":[8,76,240,268,312],"immune":[10],"response,":[11],"regulation":[13,297],"human":[15,234,316],"NK":[16,40,73,105,144,170,191,198,225,235,265,274,290,299],"cell":[17,60,74,126,150,155,171,192,226,262,275,291,300],"growth":[18,301],"has":[19],"not":[20,130,159,168,184,201],"been":[21],"well":[22,46],"characterized.":[23],"We":[24],"have":[25],"hypothesized":[26],"that,":[27],"similar":[28],"to":[29,71,78,161,203,230,256],"proliferation":[31,38,75,292],"T":[33,136,210],"and":[34,59,67,86,93,128,152,251,254,270,277,281,302],"B":[35],"lymphocytes,":[36],"optimal":[37],"requires":[42,124],"costimulatory":[43,89,116,188,227,287],"signals":[44,288],"as":[45,47,246],"a":[48,187,247],"primary":[49,79],"mitogenic":[50,80],"stimulus.":[51],"Evidence":[52],"for":[53,114,190,261,289],"costimulation":[54,142,196],"by":[55,98,119,122,132],"both":[56],"soluble":[57],"cytokines":[58,253],"contact-dependent":[61,141,195,263],"factors":[62],"is":[63,95,129],"presented.":[64],"Soluble":[65],"IL-1":[66,92],"TNF":[68,94],"were":[69,158],"found":[70,160],"augment":[72,169],"response":[77],"cytokines,":[81],"including":[82,212],"IL-2,":[83],"IL-4,":[84],"IL-7,":[85],"IL-12.":[87],"The":[88,219],"effect":[90],"strongly":[96],"enhanced":[97],"calcium":[100],"ionophore":[101],"ionomycin.":[102,120],"Coculture":[103],"with":[107],"irradiated":[108],"K562":[109,123],"can":[111,138,208],"largely":[112],"substitute":[113],"signal":[117,189],"provided":[118],"Costimulation":[121],"intimate":[125],"contact":[127],"reconstituted":[131],"cell-free":[133],"supernatants.":[134],"Activated":[135],"lymphocytes":[137,311],"also":[139],"mediate":[140,278],"cells;":[145],"resting":[146],"PBMC,":[147],"several":[148],"NK-sensitive":[149],"lines,":[151],"all":[153],"NK-resistant":[154],"lines":[156],"tested":[157],"be":[162,231,238],"costimulatory.":[163],"Engagement":[164],"CD16":[166],"did":[167],"proliferation.":[172,193],"Thus,":[173],"triggering":[174],"killing":[177,280],"or":[178,217],"antibody-dependent":[179],"cell-mediated":[180],"cytotoxicity":[181],"(ADCC)":[182],"does":[183,200],"consistently":[185],"provide":[186],"Cell":[194],"appear":[202],"involve":[204],"known":[205],"receptors":[206],"that":[207],"costimulate":[209],"cells,":[211],"CD2,":[213],"CD27,":[214],"CD28,":[215],"CD29,":[216],"LFA-1.":[218],"molecular":[220],"nature":[221],"putative":[224,259],"receptor":[228,260],"remains":[229],"elucidated.":[232],"Nevertheless,":[233],"could":[237],"expanded":[239,267],"vitro":[241],"using":[242],"leukocyte-conditioned":[243],"medium":[244],"(LCM)":[245],"source":[248],"IL-2":[250],"accessory":[252],"ionomycin":[255,271],"bypass":[257],"costimulation.":[264],"LCM":[269],"express":[272],"typical":[273],"antigens":[276],"ADCC.":[282],"Further":[283],"characterization":[284],"may":[293,303],"elucidate":[294],"physiologic":[296],"ultimately":[304],"allow":[305],"more":[306],"effective":[307],"manipulation":[308],"these":[310],"immunotherapy":[314],"diseases.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}